                         SEQUENCE LISTING

<110>  DIOSYNVAX LTD et al
 
<120>  Beta-coronavirus Vaccines

<130>  P/83611.WO01

<150>  GB 2109285.3
<151>  2021-06-28

<150>  GB 2112499.5
<151>  2021-09-02

<150>  GB 2114321.9
<151>  2021-10-06

<150>  GB 2201060.7
<151>  2022-01-27

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS1_RBD (AY274119_RBD)

<400>  1

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp 
    210             


<210>  2
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS1_M7

<400>  2

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Asn Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp 
    210             


<210>  3
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS1_M7

<400>  3
agagtggtgc ctagcggaga tgttgtgcgc ttccctaata ttaccaacct ctgtccattc       60

ggggaagtct ttaacgccac aaagttcccc agcgtgtacg cttgggagcg caaaaagatt      120

tccaactgtg tggccgatta ctccgtcctg tataactcca ccttcttttc cacgttcaaa      180

tgttacgggg tgtcagccac aaagctcaac gatctgtgtt ttagcaatgt ctacgccgac      240

tccttcgtcg tgaagggcga cgatgttcgc cagatcgctc caggacaaac aggcgtgatc      300

gctgactata attacaaact cccggacgat ttcatgggat gcgtgctggc ctggaatacc      360

cggaacatcg atgccacctc caccgggaac tataactaca agtacagata cctgcggcac      420

ggcaagctgc ggccctttga gagggatatc tccaacgtgc cattcagccc cgacggcaag      480

ccatgtacac ctccagcact gaattgctac tggcccctga acgattacgg cttctacacc      540

accaccggca tcggctatca gccctatcgt gtggtggtcc tgtcctttga gctgctgaac      600

gctaacgcta ccgtgtgtgg cccaaagctg agcaccgatt ga                         642


<210>  4
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestor_SARS1_M7

<400>  4

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Glu Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
                165                 170                 175     


Tyr Gly Phe Tyr Thr Thr Ser Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Asn Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Leu Ser Thr Asp 
    210                 


<210>  5
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ancestor_SARS1_M7

<400>  5
agagtggtgc ctagcggaga tgttgtgcgc ttccctaata ttaccaacct ctgtccattc       60

ggggaagtct ttaacgccac aaagttcccc agcgtgtacg cttgggagag aaagcggatc      120

tccaactgtg tggctgatta ctccgtgctc tacaactcca cctccttctc cacattcaaa      180

tgttatggcg tcagcgccac caagctcaat gatctgtgtt ttagcaatgt ctacgccgac      240

tccttcgtcg tgaagggcga cgatgttcgc cagatcgctc caggacaaac aggcgtgatc      300

gctgactata attacaaact cccggacgat ttcatgggat gcgtgctggc ctggaatacc      360

cggaacatcg atgccacctc caccgggaac tataactaca agtacagata cctgcggcac      420

ggcaagctgc ggccctttga gagggatatc tccaacgtgc cattcagccc tgacggcaag      480

ccttgcacac ctcctgaggc tctgaattgc tactggcccc tgaacgatta cggcttctac      540

accacaagcg gcatcggcta tcagccctat cgcgtggtgg tcctgtcctt tgagctgctg      600

aatgccaacg ctaccgtgtg tggcccaaag ctgagcaccg attga                      645


<210>  6
<211>  1254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WIV16

<400>  6

Met Phe Ile Phe Leu Phe Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Glu Ser Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Pro Gln 
            20                  25                  30          


His Ser Ser Ser Arg Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Arg Phe Asp Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Val Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Thr 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ser Phe Ser Leu Asp Val Ala Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Ile Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Leu Pro 
225                 230                 235                 240 


Ala Gln Asp Thr Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Ala Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Ala Pro Ser Lys Glu Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Thr Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Gln 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Ser Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Phe Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Ile Thr Asn Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Leu Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ser Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Ser Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Val Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Asp Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Ser Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Val Trp Leu  Gly Phe Ile 
    1190                 1195                 1200             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Leu  Leu Cys Cys 
    1205                 1210                 1215             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Ala Cys  Ser Cys Gly 
    1220                 1225                 1230             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1235                 1240                 1245             


Gly Val  Lys Leu His Tyr 
    1250                 


<210>  7
<211>  3765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WIV16

<400>  7
atgtttattt tcttattctt tctcactctc actagtggta gtgaccttga gagttgtacc       60

acttttgatg atgttcaagc ccctaattac cctcaacact cttcatccag gagaggggtt      120

tattatcctg atgaaatctt tagatcagac actctttatt taactcagga tctatttctt      180

ccattctatt ctaatgtcac agggtttcat actattaatc ataggtttga caaccctgtc      240

atacctttta aggatggtgt ttattttgct gccactgaga aatcaaatgt tgtccgtggt      300

tgggtttttg gctctaccat gaacaacaag tctcagtcgg tgattatcat caataattct      360

actaatgttg ttatacgagc atgtaatttt gagttgtgtg acaacccttt ctttgctgtc      420

tctaaaccta cgggaacaca gacacacact atgatattcg acaatgcatt taattgcact      480

ttcgaataca tatcagactc cttttcgctc gatgttgctg aaaagtcagg taattttaaa      540

cacttacgag agtttgtgtt taaaaataag gatgggtttc tctatgttta caagggttat      600

caacctatag acgtagtccg tgatctacca tctggcttta atattttgaa acctattttt      660

aagttacctc ttggtattaa cattacaaat tttagagcca ttcttacagc atttttgcct      720

gctcaagaca cttggggtac atcagctgct gcttattttg ttggctattt aaagccagct      780

acattcatgc ttaagtatga tgaaaatggt acaatcacag atgctgttga ttgttctcaa      840

aatccccttg ctgaactcaa atgttctgtt aaaagttttg agattgataa aggaatttac      900

caaacctcca attttagggt agcaccctca aaggaagttg tgaggttccc taatattaca      960

aacctgtgtc cttttgggga ggtttttaat gctactacat ttccttctgt ctatgcatgg     1020

gagaggaaaa gaatttctaa ttgtgttgct gattactctg tactctacaa ctcaacatct     1080

ttttcaactt ttaagtgtta tggcgtttct gccactaagc tgaatgatct ttgcttctcc     1140

aatgtctatg cagattcatt tgtagtcaaa ggagacgatg taaggcaaat agcaccagga     1200

cagaccggtg ttattgctga ttataattac aaattgccag atgatttcac gggttgtgtc     1260

cttgcttgga atactaggaa cattgatgct actcaaactg gtaattataa ttataaatat     1320

agatctctca gacatggcaa gcttaggcct tttgagagag atatttctaa tgtgcctttc     1380

tctcctgatg gcaaaccttg taccccacct gcttttaatt gttattggcc attaaatgat     1440

tatggttttt acatcactaa tggcataggc taccaacctt atagagttgt agttctttct     1500

tttgaacttc taaatgcacc tgctacggtt tgtggaccaa aattgtccac tgaccttatt     1560

aaaaatcaat gtgtcaattt taactttaat ggactcactg gtactggtgt gttaactcct     1620

tcttcaaaga gatttcaacc atttcaacaa tttggtcgtg atgttttgga tttcactgat     1680

tcagttcgag atccgaagac gtctgaaata ttagacattt caccttgctc ttttggcggt     1740

gtaagtgtaa tcacacctgg aacaaatact tcatcagaag ttgctgttct atatcaagat     1800

gttaactgca ctgatgttcc tgtagcaatc catgcagacc aactcacacc ttcttggcgc     1860

gtatactcta ctggaaataa tgtatttcaa acccaggcag gctgtcttat aggagctgag     1920

catgtcgaca cttcttatga gtgcgacatt cctattggag ctggcatttg tgctagttac     1980

catacagttt cttcattacg tagtactagc caaaaatcta ttgtggctta tactatgtct     2040

ttaggtgctg atagttcaat tgcttactct aataacacca ttgctatacc tactaacttt     2100

tcaattagca ttactacaga agtaatgcct gtttctatgg ctaaaacctc tgtagattgt     2160

aatatgtaca tctgcggaga ttctactgaa tgtgctaatt tgcttctcca atatggtagc     2220

ttttgcacac aactaaatcg tgcactctca ggtattgctg ttgaacagga tcgcaacaca     2280

cgtgaagtgt tcgctcaagt caaacaaatg tacaaaaccc caactttgaa agattttggt     2340

ggttttaatt tttcacaaat attacctgac cctctaaagc caactaagag gtcttttatt     2400

gaggacttgc tctttaataa ggtgacactc gctgatgctg gctttatgaa gcaatatggc     2460

gaatgcctag gtgatattaa tgctagagat ctcatttgtg cgcagaagtt caatggactt     2520

acagtgctgc cacctctgct cactgatgat atgattgctg cctacactgc tgctctagtt     2580

agtggtactg ccactgctgg atggacattc ggtgctggcg ctgctcttca aatacctttt     2640

gctatgcaaa tggcatatag gttcaatggc attggagtta ctcaaaatgt tctctatgag     2700

aaccaaaaac aaatcgccaa tcaatttaac aaggcgatca gccaaattca agaatcactc     2760

acaacaacat ccactgcatt gggcaagctg caagatgtcg tcaaccagaa tgctcaagca     2820

ttaaacacac ttgttaaaca acttagctcc aattttggtg cgatttcaag tgtgctaaat     2880

gatatccttt cgcgacttga taaagtcgag gcagaggtac aaattgacag gttaattaca     2940

ggcagactgc aaagccttca aacctatgta acacaacaac taatcagggc tgctgaaatc     3000

agggcttctg ctaatcttgc tgctactaaa atgtctgagt gtgttcttgg acaatcaaaa     3060

agagttgact tttgcggaaa gggctaccat cttatgtcct tcccacaagc agccccgcat     3120

ggtgttgtct tcctacatgt cacatatgtg ccatctcaag agagaaactt caccacagcg     3180

ccagcaattt gtcatgaagg caaagcatac ttccctcgtg aaggtgtttt tgtgtttaat     3240

ggcacttcgt ggtttattac acagaggaac ttcttttctc cacaaataat tactacagac     3300

aatacatttg tctccggaag ttgtgatgtc gtaattggca tcattaacaa tacagtttat     3360

gatcctctgc aacctgagct tgactcattc aaagaagagc tggacaagta cttcaaaaat     3420

cacacatcac cagatgttga tcttggcgac atttcaggca ttaacgcttc tgtcgtcaac     3480

attcaaaaag aaattgaccg cctcaatgag gtcgctaaaa atttaaatga atcactcatt     3540

gaccttcaag aattgggaaa atatgagcaa tatattaaat ggccttggta tgtttggctc     3600

ggcttcattg ctggactaat tgccatcgtc atggttacaa tcttgctttg ttgcatgact     3660

agttgttgca gttgcctcaa gggtgcatgc tcttgtggtt cttgctgcaa gtttgatgag     3720

gatgactctg agccagttct caagggtgtc aaattacatt acaca                     3765


<210>  8
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS2_RBD (EPI_ISL_402119_RBD)

<400>  8

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn 
    210                 


<210>  9
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS2_RBD_M7

<400>  9

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Asn Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn 
    210                 


<210>  10
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS2_RBD_M7

<400>  10
cgggtgcagc ccaccgaatc catcgtgcgg ttccccaata tcaccaatct gtgccccttc       60

ggcgaggtgt tcaatgccac cagattcgcc tctgtgtacg cctggaaccg gaagcggatc      120

agcaattgcg tggccgacta ctccgtgctg tacaactccg ccagcttcag caccttcaag      180

tgctacggcg tgtcccctac caagctgaac gacctgtgct tcacaaacgt gtacgccgac      240

agcttcgtga tccggggaga tgaagtgcgg cagattgccc ctggacagac aggcaagatc      300

gccgactaca actacaagct gcccgacgac ttcaccggct gtgtgattgc ctggaacagc      360

aacaacctgg actccaaagt cggcggcaac tacaattacc tgtaccggct gttccggaag      420

tccaatctga agcccttcga gcgggacatc agcaccgaaa tctatcaggc cggcagcacc      480

ccttgcaacg gcgtggaagg cttcaactgc tacttcccac tgcaaagcta cggctttcag      540

cccacaaatg gcgtgggcta ccagccttac agagtggtgg tgctgagctt cgagctgctg      600

catgctaacg ccacagtgtg cggccctaag aaatccacca at                         642


<210>  11
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2_17

<400>  11

Arg Val Ala Pro Thr Lys Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Asn Asn Ile Asp Ser Thr Thr Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Ser Leu Arg Lys Ser Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Ser Asp Ile Tyr Ser Pro Gly Gly Lys 
145                 150                 155                 160 


Pro Cys Ser Gly Val Glu Gly Phe Asn Cys Tyr Tyr Pro Leu Arg Ser 
                165                 170                 175     


Tyr Gly Phe Phe Pro Thr Asn Gly Thr Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Leu Ser Thr Asp 
    210                 


<210>  12
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2_17

<400>  12
agagtggccc ctaccaaaga agtcgtgcgg ttccccaaca tcaccaatct gtgccctttc       60

ggcgaggtgt tcaacgccac caagtttccc tctgtgtacg cctgggagcg caaaaagatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccagcttcag caccttcaag      180

tgctacggcg tgtcacccac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      240

agcttcgtga tcagaggcga cgaagtgcgg cagattgccc ctggacaaac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ctggaacacc      360

aacaacatcg acagcaccac cggcggcaac tacaactacc tgtacagaag cctgcggaag      420

tctaagctga agcccttcga gcgggacatc agcagcgaca tctatagccc tggcggcaag      480

ccttgttctg gcgtggaagg cttcaactgc tactaccctc tgcggagcta cggcttcttc      540

cccacaaatg gcacaggcta ccagccttac agagtggtgg tcctgagctt cgagctgctg      600

aatgcccctg ccacagtgtg tggccctaag ctgtctaccg ac                         642


<210>  13
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MERS_RBD

<400>  13

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 


Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr 
225                 230                 235                 240 


<210>  14
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MERS_RBD

<400>  14
gaagctaaac cttctggctc tgtggtggaa caggccgaag gcgtggaatg cgatttcagc       60

cctctgctgt ctggcacccc tcctcaggtg tacaacttca agcggctggt gttcaccaac      120

tgcaactaca acctgaccaa gctgctgagc ctgttcagcg tgaacgactt cacctgtagc      180

cagatcagcc ctgccgccat tgccagcaac tgttacagca gcctgatcct ggactacttc      240

agctaccctc tgagcatgaa gtccgacctg agcgtgtcaa gcgccggacc tatcagccag      300

ttcaactaca agcagagctt cagcaaccct acctgcctga ttctggccac cgtgcctcac      360

aatctgacca ccatcaccaa gcctctgaag tacagctaca tcaacaagtg cagcagactg      420

ctgagcgacg acagaaccga agtgccccag ctggtcaacg ccaaccagta cagcccttgc      480

gtgtccatcg tgcctagcac cgtttgggag gacggcgact actaccggaa gcagctgtct      540

ccacttgaag gcggaggatg gctggtggcc tctggatcta cagtggccat gacagagcag      600

ctgcagatgg gctttggcat caccgtgcag tacggcaccg acaccaatag cgtgtgccct      660

aagctggaat tcgccaacga caccaagatc gcctctcagc tcggatga                   708


<210>  15
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MERS_RBD_M7

<400>  15

Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr 
1               5                   10                  15      


Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
            20                  25                  30          


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr 
        35                  40                  45              


Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser 
    50                  55                  60                  


Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu 
65                  70                  75                  80  


Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser 
                85                  90                  95      


Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu 
            100                 105                 110         


Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser 
        115                 120                 125             


Arg Phe Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala 
    130                 135                 140                 


Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu 
145                 150                 155                 160 


Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly 
                165                 170                 175     


Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln 
            180                 185                 190         


Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Asn Asp Thr Asn Ser Val 
        195                 200                 205             


Cys Pro Lys Leu 
    210         


<210>  16
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MERS_RBD_M7

<400>  16
caggctgaag gcgtggaatg cgatttcagc cctctgctgt ctggcacccc tcctcaggtg       60

tacaacttca agcggctggt gttcaccaac tgcaattaca acctgaccaa gctgctgagc      120

ctgttcagcg tgaacgattt cacctgtagc cagatcagcc ctgccgccat tgccagcaac      180

tgttacagca gcctgatcct ggactacttc agctaccctc tgagcatgaa gtccgacctg      240

tccgtgtcta gcgccggacc aatcagccag ttcaattaca agcagtcctt cagcaaccct      300

acctgcctga ttctggccac cgtgcctcac aatctgacca ccatcaccaa gcctctgaag      360

tacagctaca tcaacaagtg cagccggttc ctgagcgacg acagaacaga ggtgccccag      420

ctggtcaacg ccaatcagta cagcccttgc gtgtccatcg tgccctctac cgtttgggag      480

gacggcgact actaccggaa gcagctgtct cctttggaag gcggcggatg gctggttgcc      540

tctggatcta cagtggccat gaccgagcag ctccagatgg gctttggcat cacagtgcag      600

tacggcaacg acaccaacag cgtgtgtcct aagctttga                             639


<210>  17
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestor_MERS_M7

<400>  17

Gln Pro Asn Ser Val Glu Cys Asp Phe Ser Pro Met Leu Ser Gly Thr 
1               5                   10                  15      


Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
            20                  25                  30          


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Met Val Asn Glu Phe Ser 
        35                  40                  45              


Cys Asn Gly Ile Ser Pro Asp Ala Ile Ala Arg Gly Cys Tyr Ser Ser 
    50                  55                  60                  


Leu Thr Val Asp Tyr Phe Ala Tyr Pro Leu Ser Met Lys Ser Tyr Met 
65                  70                  75                  80  


Gln Pro Gly Ser Ala Gly Val Ile Ser Gln Tyr Asn Tyr Lys Gln Ser 
                85                  90                  95      


Phe Ala Asn Pro Thr Cys Arg Ile Phe Ala Thr Val Pro Ala Asn Leu 
            100                 105                 110         


Thr Thr Ile Thr Lys Pro Ser Ser Tyr Ser Tyr Ile Ser Lys Cys Ser 
        115                 120                 125             


Arg Leu Thr Gly Asp Asn Gln His Ile Glu Thr Pro Ile Val Ile Asn 
    130                 135                 140                 


Pro Gly Glu Tyr Ser Ile Cys Arg Asn Phe Ala Pro Asn Gly Phe Ser 
145                 150                 155                 160 


Glu Asp Gly Gln Tyr Phe Thr Arg Gln Leu Ser Gln Leu Glu Gly Gly 
                165                 170                 175     


Gly Ile Leu Val Gly Val Gly Ser Thr Val Pro Met Thr Asp Asn Leu 
            180                 185                 190         


Gln Met Gly Phe Ile Ile Ser Val Gln Tyr Gly Asn Asp Thr Asn Ser 
        195                 200                 205             


Val Cys Pro Met Leu 
    210             


<210>  18
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ancestor_MERS_M7

<400>  18
cagcccaaca gcgtggaatg cgactttagc cccatgctgt ctggcacccc tccacaggtg       60

tacaacttca agcggctggt gttcaccaac tgcaattaca acctgaccaa gctgctgagc      120

ctgttcatgg tcaacgagtt cagctgcaac ggcatcagcc ccgacgctat cgccagaggc      180

tgttactcta gcctgaccgt ggactacttc gcctatcctc tgagcatgaa gtcctacatg      240

cagcccggat ctgccggcgt gatcagccag tacaattaca agcagagctt cgccaatcct      300

acctgccgga tctttgccac cgtgcctgcc aatctgacca ccatcacaaa gcccagcagc      360

tacagctaca tcagcaagtg cagcagactg accggcgaca accagcacat cgagacaccc      420

atcgtgatca accccggcga gtacagcatc tgccggaact tcgcccctaa cggctttagc      480

gaggacggcc agtacttcac cagacagctg agccaactgg aaggcggcgg aatccttgtt      540

ggcgtgggaa gcacagtgcc catgaccgac aatctccaga tgggcttcat catcagcgtg      600

cagtacggca acgacaccaa tagcgtgtgc cctatgcttt ga                         642


<210>  19
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS_complex_dimer

<400>  19

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Arg Val Val Pro Ser Gly 
    210                 215                 220                 


Asp Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
225                 230                 235                 240 


Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys 
                245                 250                 255     


Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr 
            260                 265                 270         


Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn 
        275                 280                 285             


Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly 
    290                 295                 300                 


Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp 
305                 310                 315                 320 


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala Trp 
                325                 330                 335     


Asn Thr Arg Asn Ile Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
            340                 345                 350         


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
        355                 360                 365             


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
    370                 375                 380                 


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
385                 390                 395                 400 


Asn Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
                405                 410                 415     


Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr Asp 
            420                 425                 430         


Leu Ile Lys Asn Gln 
        435         


<210>  20
<211>  1314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS_complex_dimer

<400>  20
agagtggtgc ctagcggaga tgttgtgcgg ttccccaaca tcaccaatct gtgccctttc       60

ggcgaggtgt tcaacgccac caagtttccc tctgtgtacg cctgggagcg caaaaagatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccttcttcag cacctttaag      180

tgctacggcg tgtccgccac aaagctgaac gacctgtgct tcagcaacgt gtacgccgac      240

agcttcgtgg tcaagggcga cgatgttcgg cagattgccc ctggacagac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcatgggct gtgtgctggc ctggaacacc      360

cggaacatcg atgccacaag caccggcaac tacaattaca agtaccgcta cctgcggcac      420

ggcaagctga ggccttttga gagggacatc tccaacgtgc cattcagccc cgatggcaag      480

ccttgcacac ctcctgctct gaactgctac tggcccctga acgactacgg cttctacacc      540

acaaccggca tcggctacca gccttacaga gtggtggtgc tgagcttcga gctgctgaat      600

gcccctgcca cagtgtgtgg ccctaagctg tctaccgacc tgatcaagaa ccagcgcgtg      660

gtgccttctg gcgacgttgt cagattcccg aatatcacaa acctgtgtcc attcggggaa      720

gtctttaatg ccacaaagtt ccccagcgtc tacgcttggg agcgtaaaaa gatttccaat      780

tgcgtcgcag actactccgt cctgtacaat tccacattct tctccacctt caaatgttac      840

ggcgtcagcg ccaccaaact gaatgatctg tgtttctcca atgtctacgc cgactccttt      900

gtcgtgaaag gcgacgacgt gcgccagatc gctccaggac aaactggcgt tatcgctgac      960

tataattaca aactcccgga tgatttcatg ggatgcgtcc tcgcttggaa taccagaaac     1020

atcgacagca aagtcggcgg gaactacaac tacctgtacc ggctgttccg gaagtccaac     1080

ctgaagcctt tcgagcgcga catcagcacc gaaatctacc aggccggcag caccccttgc     1140

aatggcgtgg aaggcttcaa ttgctacttc ccactgcaaa gctacggctt tcagcccacc     1200

aacggcattg gatatcagcc ctatcgcgtg gtggtcctgt cttttgaact gctgaacgct     1260

cccgctaccg tgtgcggacc taaactgagc accgatctca tcaagaatca atga           1314


<210>  21
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MERS_complex_dimer

<400>  21

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 


Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr 
225                 230                 235                 240 


Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
                245                 250                 255     


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            260                 265                 270         


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        275                 280                 285             


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    290                 295                 300                 


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
305                 310                 315                 320 


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                325                 330                 335     


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            340                 345                 350         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        355                 360                 365             


Ser Asn Tyr Ala Tyr Leu Thr Glu Cys Tyr Lys Thr Ser Ala Tyr Gly 
    370                 375                 380                 


Lys Asn Tyr Leu Tyr Asn Ala Pro Gly Ala Tyr Thr Pro Cys Leu Ser 
385                 390                 395                 400 


Leu Ala Ser Arg Gly Phe Ser Thr Lys Tyr Gln Ser His Ser Asp Gly 
                405                 410                 415     


Glu Leu Thr Thr Thr Gly Tyr Ile Tyr Pro Val Thr Gly Asn Leu Gln 
            420                 425                 430         


Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val 
        435                 440                 445             


Cys Pro Lys Leu Glu Phe Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu 
    450                 455                 460                 


Gly Asn Cys Val Glu Tyr 
465                 470 


<210>  22
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MERS_complex_dimer

<400>  22
gaggccaagc cttctggatc tgtggttgaa caggccgaag gcgtggaatg cgacttcagc       60

cctctgctgt ctggcacacc acctcaggtg tacaacttca agcggctggt gttcaccaac      120

tgtaactaca acctgaccaa gctgctgagc ctgttcagcg tgaacgactt cacctgtagc      180

cagatcagcc ctgccgccat tgcctccaac tgttacagca gcctgatcct ggactacttc      240

agctaccctc tgagcatgaa gtccgacctg tccgtgtcta gcgccggacc aatcagccag      300

ttcaactata agcagagctt tagcaacccg acctgcctga ttctggccac cgtgcctcac      360

aatctgacca ccatcaccaa gcctctgaag tacagctaca tcaacaagtg cagccggttc      420

ctgagcgacg acagaacaga ggtgccccag ctggtcaacg ccaaccagta cagcccttgc      480

gtgtccatcg tgcctagcac cgtttgggag gacggcgact actaccggaa gcagctgtct      540

ccacttgaag gcggcggatg gctggttgcc tctggatcta cagtggccat gaccgagcag      600

ctccagatgg gctttggcat cacagtgcag tacggcaccg acaccaatag cgtgtgccca      660

aagctggaat tcgccaacga caccaagatc gccagccagc tgggcaactg tgtggaatac      720

gaggccaaac ctagcggcag cgttgtcgag caagctgaag gcgtcgagtg tgacttttca      780

cccctgctga gcggaacccc tccacaggtc tacaatttca aacgcctcgt ctttacgaac      840

tgcaactata atctcacgaa gctcctcagc ctcttctccg tcaacgattt cacatgctcc      900

cagatttccc cagccgctat cgctagcaac tgctacagct ctctgatcct cgattacttt      960

tcctatccgc tgtctatgaa gtctgatctg agcgtgtcca gcgcaggccc catctctcag     1020

tttaattaca agcagtcctt cagcaatccc acctgtctca tcctggcaac agtgccccat     1080

aacctgacaa caatcacaaa gcccagcaac tacgcctacc tgaccgagtg ctacaagacc     1140

agcgcctacg gcaagaatta cctgtacaac gcccctggcg cctacacacc ttgtctgtct     1200

ctggccagca ggggctttag caccaagtac cagagccact ccgatggcga gctgacaacc     1260

accggctaca tctacccagt gaccggcaac ctgcaaatgg gcttcggaat taccgtccag     1320

tatgggaccg ataccaactc cgtgtgtccc aagcttgagt ttgccaatga tacgaagatc     1380

gcctctcagc tgggaaattg cgttgagtac tga                                  1413


<210>  23
<211>  1352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HKU5

<400>  23

Met Ile Arg Ser Val Leu Val Leu Met Cys Ser Leu Thr Phe Ile Gly 
1               5                   10                  15      


Asn Leu Thr Arg Gly Gln Ser Val Asp Met Gly His Asn Gly Thr Gly 
            20                  25                  30          


Ser Cys Leu Asp Ser Gln Val Gln Pro Asp Tyr Phe Glu Ser Val His 
        35                  40                  45              


Thr Thr Trp Pro Met Pro Ile Asp Thr Ser Lys Ala Glu Gly Val Ile 
    50                  55                  60                  


Tyr Pro Asn Gly Lys Ser Tyr Ser Asn Ile Thr Leu Thr Tyr Thr Gly 
65                  70                  75                  80  


Leu Tyr Pro Lys Ala Asn Asp Leu Gly Lys Gln Tyr Leu Phe Ser Asp 
                85                  90                  95      


Gly His Ser Ala Pro Gly Arg Leu Asn Asn Leu Phe Val Ser Asn Tyr 
            100                 105                 110         


Ser Ser Gln Val Glu Ser Phe Asp Asp Gly Phe Val Val Arg Ile Gly 
        115                 120                 125             


Ala Ala Ala Asn Lys Thr Gly Thr Thr Val Ile Ser Gln Ser Thr Phe 
    130                 135                 140                 


Lys Pro Ile Lys Lys Ile Tyr Pro Ala Phe Leu Leu Gly His Ser Val 
145                 150                 155                 160 


Gly Asn Tyr Thr Pro Ser Asn Arg Thr Gly Arg Tyr Leu Asn His Thr 
                165                 170                 175     


Leu Val Ile Leu Pro Asp Gly Cys Gly Thr Ile Leu His Ala Phe Tyr 
            180                 185                 190         


Cys Val Leu His Pro Arg Thr Gln Gln Asn Cys Ala Gly Glu Thr Asn 
        195                 200                 205             


Phe Lys Ser Leu Ser Leu Trp Asp Thr Pro Ala Ser Asp Cys Val Ser 
    210                 215                 220                 


Gly Ser Tyr Asn Gln Glu Ala Thr Leu Gly Ala Phe Lys Val Tyr Phe 
225                 230                 235                 240 


Asp Leu Ile Asn Cys Thr Phe Arg Tyr Asn Tyr Thr Ile Thr Glu Asp 
                245                 250                 255     


Glu Asn Ala Glu Trp Phe Gly Ile Thr Gln Asp Thr Gln Gly Val His 
            260                 265                 270         


Leu Tyr Ser Ser Arg Lys Glu Asn Val Phe Arg Asn Asn Met Phe His 
        275                 280                 285             


Phe Ala Thr Leu Pro Val Tyr Gln Lys Ile Leu Tyr Tyr Thr Val Ile 
    290                 295                 300                 


Pro Arg Ser Ile Arg Ser Pro Phe Asn Asp Arg Lys Ala Trp Ala Ala 
305                 310                 315                 320 


Phe Tyr Ile Tyr Lys Leu His Pro Leu Thr Tyr Leu Leu Asn Phe Asp 
                325                 330                 335     


Val Glu Gly Tyr Ile Thr Lys Ala Val Asp Cys Gly Tyr Asp Asp Leu 
            340                 345                 350         


Ala Gln Leu Gln Cys Ser Tyr Glu Ser Phe Glu Val Glu Thr Gly Val 
        355                 360                 365             


Tyr Ser Val Ser Ser Phe Glu Ala Ser Pro Arg Gly Glu Phe Ile Glu 
    370                 375                 380                 


Gln Ala Thr Thr Gln Glu Cys Asp Phe Thr Pro Met Leu Thr Gly Thr 
385                 390                 395                 400 


Pro Pro Pro Ile Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
                405                 410                 415     


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Gln Val Ser Glu Phe Ser 
            420                 425                 430         


Cys His Gln Val Ser Pro Ser Ser Leu Ala Thr Gly Cys Tyr Ser Ser 
        435                 440                 445             


Leu Thr Val Asp Tyr Phe Ala Tyr Ser Thr Asp Met Ser Ser Tyr Leu 
    450                 455                 460                 


Gln Pro Gly Ser Ala Gly Ala Ile Val Gln Phe Asn Tyr Lys Gln Asp 
465                 470                 475                 480 


Phe Ser Asn Pro Thr Cys Arg Val Leu Ala Thr Val Pro Gln Asn Leu 
                485                 490                 495     


Thr Thr Ile Thr Lys Pro Ser Asn Tyr Ala Tyr Leu Thr Glu Cys Tyr 
            500                 505                 510         


Lys Thr Ser Ala Tyr Gly Lys Asn Tyr Leu Tyr Asn Ala Pro Gly Ala 
        515                 520                 525             


Tyr Thr Pro Cys Leu Ser Leu Ala Ser Arg Gly Phe Ser Thr Lys Tyr 
    530                 535                 540                 


Gln Ser His Ser Asp Gly Glu Leu Thr Thr Thr Gly Tyr Ile Tyr Pro 
545                 550                 555                 560 


Val Thr Gly Asn Leu Gln Met Ala Phe Ile Ile Ser Val Gln Tyr Gly 
                565                 570                 575     


Thr Asp Thr Asn Ser Val Cys Pro Met Gln Ala Leu Arg Asn Asp Thr 
            580                 585                 590         


Ser Ile Glu Asp Lys Leu Asp Val Cys Val Glu Tyr Ser Leu His Gly 
        595                 600                 605             


Ile Thr Gly Arg Gly Val Phe His Asn Cys Thr Ser Val Gly Leu Arg 
    610                 615                 620                 


Asn Gln Arg Phe Val Tyr Asp Thr Phe Asp Asn Leu Val Gly Tyr His 
625                 630                 635                 640 


Ser Asp Asn Gly Asn Tyr Tyr Cys Val Arg Pro Cys Val Ser Val Pro 
                645                 650                 655     


Val Ser Val Ile Tyr Asp Lys Ala Ser Asn Ser His Ala Thr Leu Phe 
            660                 665                 670         


Gly Ser Val Ala Cys Ser His Val Thr Thr Met Met Ser Gln Phe Ser 
        675                 680                 685             


Arg Met Thr Lys Thr Asn Leu Leu Ala Arg Thr Thr Pro Gly Pro Leu 
    690                 695                 700                 


Gln Thr Thr Val Gly Cys Ala Met Gly Phe Ile Asn Ser Ser Met Val 
705                 710                 715                 720 


Val Asp Glu Cys Gln Leu Pro Leu Gly Gln Ser Leu Cys Ala Ile Pro 
                725                 730                 735     


Pro Thr Thr Ser Ser Arg Val Arg Arg Ala Thr Ser Gly Ala Ser Asp 
            740                 745                 750         


Val Phe Gln Ile Ala Thr Leu Asn Phe Thr Ser Pro Leu Thr Leu Ala 
        755                 760                 765             


Pro Ile Asn Ser Thr Gly Phe Val Val Ala Val Pro Thr Asn Phe Thr 
    770                 775                 780                 


Phe Gly Val Thr Gln Glu Phe Ile Glu Thr Thr Ile Gln Lys Ile Thr 
785                 790                 795                 800 


Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Lys Lys Cys Glu Asp 
                805                 810                 815     


Leu Leu Lys Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn Gln Ala Leu 
            820                 825                 830         


His Gly Ala Asn Leu Arg Gln Asp Glu Ser Ile Ala Asn Leu Phe Ser 
        835                 840                 845             


Ser Ile Lys Thr Gln Asn Thr Gln Pro Leu Gln Ala Gly Leu Asn Gly 
    850                 855                 860                 


Asp Phe Asn Leu Thr Met Leu Gln Ile Pro Gln Val Thr Thr Gly Glu 
865                 870                 875                 880 


Arg Lys Tyr Arg Ser Thr Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                885                 890                 895     


Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Glu Cys Met Gln Gln 
            900                 905                 910         


Gly Pro Gln Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr Val Ala Gly 
        915                 920                 925             


Tyr Lys Val Leu Pro Pro Leu Tyr Asp Pro Tyr Met Glu Ala Ala Tyr 
    930                 935                 940                 


Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Ala Ser Trp Thr Ala Gly 
945                 950                 955                 960 


Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile Phe Tyr Arg 
                965                 970                 975     


Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu Asn Gln Lys 
            980                 985                 990         


Ile Ile Ala Asn Lys Phe Asn Gln  Ala Leu Gly Ala Met  Gln Thr Gly 
        995                 1000                 1005             


Phe Thr  Thr Thr Asn Leu Ala  Phe Asn Lys Val Gln  Asp Ala Val 
    1010                 1015                 1020             


Asn Ala  Asn Ala Met Ala Leu  Ser Lys Leu Ala Ala  Glu Leu Ser 
    1025                 1030                 1035             


Asn Thr  Phe Gly Ala Ile Ser  Ser Ser Ile Ser Asp  Ile Leu Ala 
    1040                 1045                 1050             


Arg Leu  Asp Thr Val Glu Gln  Glu Ala Gln Ile Asp  Arg Leu Ile 
    1055                 1060                 1065             


Asn Gly  Arg Leu Thr Ser Leu  Asn Ala Phe Val Ala  Gln Gln Leu 
    1070                 1075                 1080             


Val Arg  Thr Glu Ala Ala Ala  Arg Ser Ala Gln Leu  Ala Gln Asp 
    1085                 1090                 1095             


Lys Val  Asn Glu Cys Val Lys  Ser Gln Ser Lys Arg  Asn Gly Phe 
    1100                 1105                 1110             


Cys Gly  Thr Gly Thr His Ile  Val Ser Phe Ala Ile  Asn Ala Pro 
    1115                 1120                 1125             


Asn Gly  Leu Tyr Phe Phe His  Val Gly Tyr Gln Pro  Thr Ser His 
    1130                 1135                 1140             


Val Asn  Ala Thr Ala Ala Tyr  Gly Leu Cys Asn Thr  Glu Asn Pro 
    1145                 1150                 1155             


Gln Lys  Cys Ile Ala Pro Ile  Asp Gly Tyr Phe Val  Leu Asn Gln 
    1160                 1165                 1170             


Thr Thr  Ser Thr Val Ala Asp  Ser Asp Gln Gln Trp  Tyr Tyr Thr 
    1175                 1180                 1185             


Gly Ser  Ser Phe Phe His Pro  Glu Pro Ile Thr Glu  Ala Asn Ser 
    1190                 1195                 1200             


Lys Tyr  Val Ser Met Asp Val  Lys Phe Glu Asn Leu  Thr Asn Arg 
    1205                 1210                 1215             


Leu Pro  Pro Pro Leu Leu Ser  Asn Ser Thr Asp Leu  Asp Phe Lys 
    1220                 1225                 1230             


Glu Glu  Leu Glu Glu Phe Phe  Lys Asn Val Ser Ser  Gln Gly Pro 
    1235                 1240                 1245             


Asn Phe  Gln Glu Ile Ser Lys  Ile Asn Thr Thr Leu  Leu Asn Leu 
    1250                 1255                 1260             


Asn Thr  Glu Leu Met Val Leu  Ser Glu Val Val Lys  Gln Leu Asn 
    1265                 1270                 1275             


Glu Ser  Tyr Ile Asp Leu Lys  Glu Leu Gly Asn Tyr  Thr Phe Tyr 
    1280                 1285                 1290             


Gln Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1295                 1300                 1305             


Val Ala  Leu Ala Leu Cys Val  Phe Phe Ile Leu Cys  Cys Thr Gly 
    1310                 1315                 1320             


Cys Gly  Thr Ser Cys Leu Gly  Lys Leu Lys Cys Asn  Arg Cys Cys 
    1325                 1330                 1335             


Asp Ser  Tyr Asp Glu Tyr Glu  Val Glu Lys Ile His  Val His 
    1340                 1345                 1350         


<210>  24
<211>  4056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HKU5

<400>  24
atgatacgct cagtgttagt actgatgtgc tcgttaactt ttataggaaa cctcacaaga       60

ggtcaaagtg ttgatatggg acacaatggc actggttcat gtttagattc ccaggtacaa      120

cctgattatt ttgaatctgt gcatactact tggcccatgc ctattgacac gagtaaggct      180

gaaggtgtca tttatcctaa tggcaagtcc tactctaata ttactctaac ttatacggga      240

ctgtacccca aggctaatga ccttggtaaa cagtatttat tctctgacgg acatagtgcc      300

ccaggacgtc ttaataactt atttgtcagt aattactcct cacaagtgga gtcctttgat      360

gatggctttg tggtccgtat tggtgctgct gccaataaaa ctggaaccac tgtcatatct      420

caatccacat ttaaacccat taagaaaatc tatccagcct ttttgcttgg acattctgtg      480

ggtaattata caccgtccaa taggacaggt cgttatctca accacacgct tgtcatccta      540

ccggatggct gtggtactat tttacatgca ttctattgtg ttcttcaccc tcgcacacaa      600

caaaattgtg ctggtgaaac aaatttcaaa tccctctcgc tttgggatac tcctgcatca      660

gactgtgtct ctggttctta taaccaagaa gccacattag gtgctttcaa agtgtatttt      720

gacttgatta attgcacgtt cagatacaat tatactataa cagaggatga aaacgctgag      780

tggttcggca ttacccaaga cacacaaggc gttcacctct attcatctcg aaaagagaac      840

gtgttcagaa ataacatgtt ccactttgct actttacctg tgtaccagaa aatcctctat      900

tacacagtca ttcctcgcag catccgaagt cctttcaatg acagaaaagc ctgggctgca      960

ttctacattt ataaactaca tccactcaca tatttgctaa attttgatgt ggagggctat     1020

ataactaaag ctgtagactg tggctacgat gatctagcac agctacaatg ttcctacgaa     1080

tccttcgaag tcgaaacagg cgtttattcc gtttcatcgt tcgaagcttc tcctagaggt     1140

gagttcattg aacaggcaac aactcaagag tgtgatttca cacctatgtt gactggtaca     1200

cctcctccta tatataattt caaaaggttg gtcttcacca attgcaatta caacttaaca     1260

aaactccttt cactgtttca agtgagcgag ttttcttgtc atcaagtttc acctagtagt     1320

cttgctaccg gttgttactc ttctcttaca gtggactatt tcgcttattc cactgatatg     1380

agttcttacc tgcaacctgg ctccgctgga gcaattgtgc agtttaatta caaacaagac     1440

tttagcaatc ccacgtgtag agtgcttgct actgttccac aaaatcttac tacaattact     1500

aaacctagta attatgctta tcttacagag tgttataaaa ccagtgcata tggcaagaat     1560

tacttgtaca atgcgcctgg cgcttacact ccttgcttat ctttagcctc tcgtgggttc     1620

tctactaaat accagtcaca tagtgatggc gagctaacca ctactggtta catttatcct     1680

gtcactggaa atcttcaaat ggctttcata atttctgttc agtatggaac tgacactaac     1740

agtgtctgcc ccatgcaagc attaagaaat gatactagca ttgaagataa gctagacgtt     1800

tgtgttgaat actcgctcca tggtataact ggaagggggg ttttccacaa ttgcacatct     1860

gttggactga gaaaccagcg gtttgtgtat gatactttcg acaatttagt tggttaccat     1920

tctgacaatg gtaattacta ttgtgtcaga ccttgtgtca gtgtgcctgt ctctgtgatt     1980

tacgacaagg catctaattc tcatgctaca ttattcggaa gcgttgcatg ttcgcacgtt     2040

accacaatga tgtcgcaatt ttcacgcatg accaaaacta atttgctcgc gcgtacaact     2100

ccaggtccat tgcaaactac tgttggttgt gcaatgggct ttatcaattc ctcaatggta     2160

gttgacgaat gtcaacttcc gcttggtcaa tcactttgtg ctattccacc aactacttct     2220

tcacgcgttc gacgtgctac ttctggtgca tctgatgtgt ttcaaatcgc cactcttaac     2280

tttactagtc cattaacact cgcaccaata aattctactg gatttgttgt tgctgtgccg     2340

actaatttca catttggtgt cactcaagaa ttcattgaga ctaccattca aaagattact     2400

gtcgattgca agcagtacgt ttgtaatggt tttaagaagt gcgaagactt gctcaaagaa     2460

tatggccagt tttgctctaa aattaaccag gctcttcatg gtgcaaacct acgtcaagac     2520

gagtctattg ctaatctatt ttcaagtatt aaaacccaga atacccagcc tcttcaggcg     2580

ggattgaatg gtgattttaa cttgactatg cttcaaatac ctcaagttac tacaggtgaa     2640

cgtaagtaca ggagtactat cgaagacctt cttttcaata aggttactat tgctgatcct     2700

ggctatatgc aaggctatga tgaatgtatg cagcaaggtc ctcagtcagc tcgagacttg     2760

atctgtgcac aatatgttgc tggctacaaa gtgctgccac ccttatatga cccctatatg     2820

gaagctgctt acacttcttc cctattgggc agtattgctg gtgctagttg gacagcaggt     2880

ctgtcgtctt tcgcagcaat accatttgca caaagtatct tttatcgctt gaatggtgtt     2940

ggcatcactc agcaggttct gtctgagaat cagaagatca ttgccaacaa attcaatcaa     3000

gctcttggtg ccatgcaaac tggctttact actactaacc ttgctttcaa caaggttcag     3060

gatgcagtaa atgctaatgc aatggctctt tccaaactag ctgcggaatt gtctaacact     3120

ttcggtgcta tttcatcatc aatcagtgac atccttgcaa ggcttgacac tgttgaacaa     3180

gaggctcaaa ttgatcggtt gatcaatgga cgtcttacat cccttaacgc attcgttgcg     3240

caacaactcg tgcgtactga agctgctgct agatctgccc aattggctca agataaggtc     3300

aatgagtgcg tgaagtcgca atccaaacgg aatggattct gcggaactgg cacacatatt     3360

gtttcatttg ccattaatgc tcctaatggc ctctacttct tccatgttgg ttaccagcca     3420

acatcccatg tcaatgcaac tgccgcttat ggcctttgca acactgaaaa tccacaaaag     3480

tgcattgcac ctattgatgg atacttcgtc ttaaaccaaa ctaccagcac tgtcgcagac     3540

agtgaccaac aatggtatta tactggtagt tccttcttcc atcctgaacc catcacagaa     3600

gcaaattcta agtatgtgtc catggatgta aaattcgaaa acctcactaa taggcttcct     3660

ccaccgctcc ttagtaattc aacagatttg gatttcaagg aagagctgga agaattcttc     3720

aaaaacgtct cctcacaagg accaaacttc caggagattt ctaagattaa cactacactg     3780

cttaacctca acacagagtt gatggtgctg agtgaagttg ttaaacaatt aaatgaatcc     3840

tatatcgact tgaaagagtt ggggaattat actttttacc aaaaatggcc atggtatata     3900

tggcttggct ttattgcagg gcttgttgct cttgctcttt gtgtgttctt catcttatgc     3960

tgtactggct gtggtactag ctgtttgggg aaactaaaat gtaatcgttg ttgtgactcg     4020

tatgatgagt atgaggtcga gaagatccat gttcat                               4056


<210>  25
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  String 1

<400>  25

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ala Arg Val Gln Pro Thr Glu Ser 
            20                  25                  30          


Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val 
        35                  40                  45              


Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg 
    50                  55                  60                  


Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser 
65                  70                  75                  80  


Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp 
                85                  90                  95      


Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp 
            100                 105                 110         


Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr 
        115                 120                 125             


Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn 
    130                 135                 140                 


Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr 
145                 150                 155                 160 


Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser 
                165                 170                 175     


Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly 
            180                 185                 190         


Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn 
        195                 200                 205             


Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu 
    210                 215                 220                 


Leu His Ala Asn Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Gly 
225                 230                 235                 240 


Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
                245                 250                 255     


Asn Pro Gly Pro Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu 
            260                 265                 270         


Leu Leu Cys Gly Ala Val Phe Val Ser Pro Ser Ala Ala Gln Ala Glu 
        275                 280                 285             


Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln 
    290                 295                 300                 


Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu 
305                 310                 315                 320 


Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln 
                325                 330                 335     


Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu 
            340                 345                 350         


Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser 
        355                 360                 365             


Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn 
    370                 375                 380                 


Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile 
385                 390                 395                 400 


Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu 
                405                 410                 415     


Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr 
            420                 425                 430         


Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp 
        435                 440                 445             


Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val 
    450                 455                 460                 


Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe 
465                 470                 475                 480 


Gly Ile Thr Val Gln Tyr Gly Asn Asp Thr Asn Ser Val Cys Pro Lys 
                485                 490                 495     


Leu Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
            500                 505                 510         


Val Glu Glu Asn Pro Gly Pro Met Asp Ala Met Lys Arg Gly Leu Cys 
        515                 520                 525             


Cys Val Leu Leu Leu Cys Gly Ala Val Phe Val Ser Pro Ser Ala Ala 
    530                 535                 540                 


Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
545                 550                 555                 560 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
                565                 570                 575     


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            580                 585                 590         


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        595                 600                 605             


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
    610                 615                 620                 


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
625                 630                 635                 640 


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
                645                 650                 655     


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
            660                 665                 670         


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
        675                 680                 685             


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
    690                 695                 700                 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
705                 710                 715                 720 


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
                725                 730                 735     


Val Leu Ser Phe Glu Leu Leu Asn Ala Asn Ala Thr Val Cys Gly Pro 
            740                 745                 750         


Lys Leu Ser Thr Asp 
        755         


<210>  26
<211>  2274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  String 1

<400>  26
atggatgcta tgaagagggg cctgtgctgc gtgctgcttc tgtgtggcgc tgtgtttgtg       60

tctcctagcg ccgctagagt gcagcccaca gagtctatcg tgcggttccc caacatcacc      120

aatctgtgcc ctttcggcga ggtgttcaac gccaccagat tcgcctctgt gtacgcctgg      180

aaccggaagc ggatcagcaa ttgcgtggcc gactacagcg tgctgtacaa cagcgccagc      240

ttcagcacct tcaagtgcta cggcgtgtcc cctaccaagc tgaacgacct gtgcttcacc      300

aacgtgtacg ccgacagctt cgtgatcaga ggcgacgaag tgcggcagat tgcccctgga      360

cagacaggca agatcgccga ttacaactac aagctgcccg acgacttcac cggctgtgtg      420

attgcctgga acagcaacaa cctggacagc aaagtcggcg gcaactacaa ctacctgtac      480

cggctgttcc ggaagtccaa cctgaagcct ttcgagcggg acatcagcac cgaaatctac      540

caggccggca gcaccccttg caatggcgtg gaaggcttca actgctactt cccactgcaa      600

agctacggct tccagcctac aaacggcgtg ggctaccagc cttacagagt ggtggtgctg      660

agcttcgaac tgctgcacgc caatgccaca gtgtgcggcc ctaagaagtc taccaacggc      720

tctggcgaag gcagaggcag ccttctgaca tgtggcgacg tggaagagaa ccccggacct      780

atggacgcaa tgaagcgcgg actgtgttgt gtcctgctgc tgtgcggagc cgtctttgtg      840

tcaccatctg ccgctcaggc tgaaggcgtg gaatgcgatt tcagccctct gctgtctggc      900

acccctcctc aggtgtacaa cttcaagcgg ctggtgttca ccaactgcaa ttacaacctg      960

accaagctgc tgagcctgtt cagcgtgaac gatttcacct gtagccagat cagccctgcc     1020

gccattgcca gcaactgtta cagcagcctg atcctggact acttcagcta ccctctgagc     1080

atgaagtccg acctgtccgt gtctagcgcc ggaccaatca gccagttcaa ttacaagcag     1140

tccttcagca accctacctg cctgattctg gccaccgtgc ctcacaatct gaccaccatc     1200

accaagcctc tgaagtacag ctacatcaac aagtgcagcc ggttcctgag cgacgacaga     1260

acagaggtgc cccagctggt caacgccaat cagtacagcc cttgcgtgtc catcgtgccc     1320

tctaccgttt gggaggacgg cgactactac cggaagcagc tgtctccttt ggaaggcggc     1380

ggatggctgg ttgcctctgg atctacagtg gccatgaccg agcagctcca gatgggcttt     1440

ggcatcacag tgcagtacgg caacgacacc aacagcgtgt gtcctaagct tggcagcggc     1500

gccaccaatt tcagcctgct gaaacaggcc ggcgacgtcg aagagaatcc tggtccaatg     1560

gatgccatga agcgagggct ctgctgtgtg ctcttgctct gcggagcagt gttcgtgtcc     1620

ccaagtgctg caagagtggt gcctagcgga gatgttgtgc gcttccctaa tattaccaac     1680

ctctgtccat tcggggaagt ctttaacgcc acaaagttcc ccagcgtgta cgcttgggag     1740

cgcaaaaaga tttccaactg tgtggccgat tactccgtcc tgtataactc caccttcttt     1800

tccacgttca aatgttacgg ggtgtcagcc acaaagctca acgatctgtg ttttagcaat     1860

gtctacgccg actccttcgt cgtgaagggc gacgatgttc gccagatcgc tccaggacaa     1920

acaggcgtga tcgctgacta taattacaaa ctcccggacg atttcatggg atgcgtgctg     1980

gcctggaata cccggaacat cgatgccacc tccaccggga actataacta caagtacaga     2040

tacctgcggc acggcaagct gcggcccttt gagagggata tctccaacgt gccattcagc     2100

cccgacggca agccatgtac acctccagca ctgaattgct actggcccct gaacgattac     2160

ggcttctaca ccaccaccgg catcggctat cagccctatc gtgtggtggt cctgtccttt     2220

gagctgctga acgctaacgc taccgtgtgt ggcccaaagc tgagcaccga ttga           2274


<210>  27
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  String 2

<400>  27

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ala Arg Val Ala Pro Thr Lys Glu 
            20                  25                  30          


Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val 
        35                  40                  45              


Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys 
    50                  55                  60                  


Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Ser 
65                  70                  75                  80  


Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp 
                85                  90                  95      


Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp 
            100                 105                 110         


Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr 
        115                 120                 125             


Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn 
    130                 135                 140                 


Thr Asn Asn Ile Asp Ser Thr Thr Gly Gly Asn Tyr Asn Tyr Leu Tyr 
145                 150                 155                 160 


Arg Ser Leu Arg Lys Ser Lys Leu Lys Pro Phe Glu Arg Asp Ile Ser 
                165                 170                 175     


Ser Asp Ile Tyr Ser Pro Gly Gly Lys Pro Cys Ser Gly Val Glu Gly 
            180                 185                 190         


Phe Asn Cys Tyr Tyr Pro Leu Arg Ser Tyr Gly Phe Phe Pro Thr Asn 
        195                 200                 205             


Gly Thr Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu 
    210                 215                 220                 


Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr Asp Gly 
225                 230                 235                 240 


Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
                245                 250                 255     


Asn Pro Gly Pro Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu 
            260                 265                 270         


Leu Leu Cys Gly Ala Val Phe Val Ser Pro Ser Ala Ala Gln Pro Asn 
        275                 280                 285             


Ser Val Glu Cys Asp Phe Ser Pro Met Leu Ser Gly Thr Pro Pro Gln 
    290                 295                 300                 


Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu 
305                 310                 315                 320 


Thr Lys Leu Leu Ser Leu Phe Met Val Asn Glu Phe Ser Cys Asn Gly 
                325                 330                 335     


Ile Ser Pro Asp Ala Ile Ala Arg Gly Cys Tyr Ser Ser Leu Thr Val 
            340                 345                 350         


Asp Tyr Phe Ala Tyr Pro Leu Ser Met Lys Ser Tyr Met Gln Pro Gly 
        355                 360                 365             


Ser Ala Gly Val Ile Ser Gln Tyr Asn Tyr Lys Gln Ser Phe Ala Asn 
    370                 375                 380                 


Pro Thr Cys Arg Ile Phe Ala Thr Val Pro Ala Asn Leu Thr Thr Ile 
385                 390                 395                 400 


Thr Lys Pro Ser Ser Tyr Ser Tyr Ile Ser Lys Cys Ser Arg Leu Thr 
                405                 410                 415     


Gly Asp Asn Gln His Ile Glu Thr Pro Ile Val Ile Asn Pro Gly Glu 
            420                 425                 430         


Tyr Ser Ile Cys Arg Asn Phe Ala Pro Asn Gly Phe Ser Glu Asp Gly 
        435                 440                 445             


Gln Tyr Phe Thr Arg Gln Leu Ser Gln Leu Glu Gly Gly Gly Ile Leu 
    450                 455                 460                 


Val Gly Val Gly Ser Thr Val Pro Met Thr Asp Asn Leu Gln Met Gly 
465                 470                 475                 480 


Phe Ile Ile Ser Val Gln Tyr Gly Asn Asp Thr Asn Ser Val Cys Pro 
                485                 490                 495     


Met Leu 
        


<210>  28
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  String 2

<400>  28
atggatgcta tgaagagggg cctgtgctgc gtgctgcttc tgtgtggcgc tgtgtttgtg       60

tctcctagcg ccgctagagt ggcccctacc aaagaagtcg tgcggttccc caacatcacc      120

aatctgtgcc ctttcggcga ggtgttcaac gccaccaagt ttccctctgt gtacgcctgg      180

gagcgcaaaa agatcagcaa ctgcgtggcc gactacagcg tgctgtacaa cagcaccagc      240

ttcagcacct tcaagtgcta cggcgtgtca cccaccaagc tgaacgacct gtgcttcacc      300

aacgtgtacg ccgacagctt cgtgatcaga ggcgacgaag tgcggcagat tgcccctgga      360

caaacaggcg tgatcgccga ttacaactac aagctgcccg acgacttcac cggctgtgtg      420

atcgcctgga acaccaacaa catcgacagc accaccggcg gcaactacaa ctacctgtac      480

agaagcctgc ggaagtctaa gctgaagccc ttcgagcggg acatcagcag cgacatctat      540

agccctggcg gcaagccttg ttctggcgtg gaaggcttca actgctacta ccctctgcgg      600

agctacggct tcttccccac aaatggcaca ggctaccagc cttacagagt ggtggtcctg      660

agcttcgagc tgctgaatgc ccctgccaca gtgtgtggcc ctaagctgtc tacagatggc      720

agcggcgaag gcagaggcag ccttcttaca tgtggcgacg tggaagagaa ccccggacct      780

atggacgcaa tgaagcgcgg actgtgttgt gtcctgctgc tgtgcggagc cgtctttgtg      840

tcaccttctg ccgctcagcc caacagcgtg gaatgcgact ttagccccat gctgtctggc      900

acccctccac aggtgtacaa cttcaagcgg ctggtgttca ccaactgcaa ttacaacctg      960

accaagctgc tgagcctgtt catggtcaac gagttcagct gcaacggcat cagccccgac     1020

gccattgcca gaggctgtta ctctagcctg accgtggact acttcgccta tcctctgagc     1080

atgaagtcct acatgcagcc cggatctgcc ggcgtgatca gccagtacaa ttataagcag     1140

agcttcgcca atcctacctg ccggatcttt gccaccgtgc ctgccaatct gaccaccatc     1200

acaaagccca gcagctacag ctacatcagc aagtgcagca gactgaccgg cgacaaccag     1260

cacatcgaga cacccatcgt gatcaacccc ggcgagtaca gcatctgccg gaacttcgcc     1320

cctaacggct ttagcgagga cggccagtac ttcaccagac agctgagcca actggaaggc     1380

ggcggaatcc ttgttggcgt gggaagcaca gtgcccatga ccgacaatct ccagatgggc     1440

ttcatcatca gcgtgcagta cggcaacgac accaatagcg tgtgccctat gctctga        1497


<210>  29
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  String 3

<400>  29

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ala Arg Val Gln Pro Thr Glu Ser 
            20                  25                  30          


Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val 
        35                  40                  45              


Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg 
    50                  55                  60                  


Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser 
65                  70                  75                  80  


Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp 
                85                  90                  95      


Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp 
            100                 105                 110         


Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr 
        115                 120                 125             


Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn 
    130                 135                 140                 


Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr 
145                 150                 155                 160 


Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser 
                165                 170                 175     


Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly 
            180                 185                 190         


Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn 
        195                 200                 205             


Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu 
    210                 215                 220                 


Leu His Ala Asn Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Gly 
225                 230                 235                 240 


Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
                245                 250                 255     


Asn Pro Gly Pro Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu 
            260                 265                 270         


Leu Leu Cys Gly Ala Val Phe Val Ser Pro Ser Ala Ala Gln Pro Asn 
        275                 280                 285             


Ser Val Glu Cys Asp Phe Ser Pro Met Leu Ser Gly Thr Pro Pro Gln 
    290                 295                 300                 


Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu 
305                 310                 315                 320 


Thr Lys Leu Leu Ser Leu Phe Met Val Asn Glu Phe Ser Cys Asn Gly 
                325                 330                 335     


Ile Ser Pro Asp Ala Ile Ala Arg Gly Cys Tyr Ser Ser Leu Thr Val 
            340                 345                 350         


Asp Tyr Phe Ala Tyr Pro Leu Ser Met Lys Ser Tyr Met Gln Pro Gly 
        355                 360                 365             


Ser Ala Gly Val Ile Ser Gln Tyr Asn Tyr Lys Gln Ser Phe Ala Asn 
    370                 375                 380                 


Pro Thr Cys Arg Ile Phe Ala Thr Val Pro Ala Asn Leu Thr Thr Ile 
385                 390                 395                 400 


Thr Lys Pro Ser Ser Tyr Ser Tyr Ile Ser Lys Cys Ser Arg Leu Thr 
                405                 410                 415     


Gly Asp Asn Gln His Ile Glu Thr Pro Ile Val Ile Asn Pro Gly Glu 
            420                 425                 430         


Tyr Ser Ile Cys Arg Asn Phe Ala Pro Asn Gly Phe Ser Glu Asp Gly 
        435                 440                 445             


Gln Tyr Phe Thr Arg Gln Leu Ser Gln Leu Glu Gly Gly Gly Ile Leu 
    450                 455                 460                 


Val Gly Val Gly Ser Thr Val Pro Met Thr Asp Asn Leu Gln Met Gly 
465                 470                 475                 480 


Phe Ile Ile Ser Val Gln Tyr Gly Asn Asp Thr Asn Ser Val Cys Pro 
                485                 490                 495     


Met Leu Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
            500                 505                 510         


Asp Val Glu Glu Asn Pro Gly Pro Met Asp Ala Met Lys Arg Gly Leu 
        515                 520                 525             


Cys Cys Val Leu Leu Leu Cys Gly Ala Val Phe Val Ser Pro Ser Ala 
    530                 535                 540                 


Ala Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
545                 550                 555                 560 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                565                 570                 575     


Val Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            580                 585                 590         


Ser Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        595                 600                 605             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    610                 615                 620                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
625                 630                 635                 640 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                645                 650                 655     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            660                 665                 670         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        675                 680                 685             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    690                 695                 700                 


Lys Pro Cys Thr Pro Pro Glu Ala Leu Asn Cys Tyr Trp Pro Leu Asn 
705                 710                 715                 720 


Asp Tyr Gly Phe Tyr Thr Thr Ser Gly Ile Gly Tyr Gln Pro Tyr Arg 
                725                 730                 735     


Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Asn Ala Thr Val Cys 
            740                 745                 750         


Gly Pro Lys Leu Ser Thr Asp 
        755                 


<210>  30
<211>  2280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  String 3

<400>  30
atggatgcta tgaagagggg cctgtgctgc gtgctgcttc tgtgtggcgc tgtgtttgtg       60

tctcctagcg ccgctagagt gcagcccaca gagtctatcg tgcggttccc caacatcacc      120

aatctgtgcc ctttcggcga ggtgttcaac gccaccagat tcgcctctgt gtacgcctgg      180

aaccggaagc ggatcagcaa ttgcgtggcc gactacagcg tgctgtacaa cagcgccagc      240

ttcagcacct tcaagtgcta cggcgtgtcc cctaccaagc tgaacgacct gtgcttcacc      300

aacgtgtacg ccgacagctt cgtgatcaga ggcgacgaag tgcggcagat tgcccctgga      360

cagacaggca agatcgccga ttacaactac aagctgcccg acgacttcac cggctgtgtg      420

attgcctgga acagcaacaa cctggacagc aaagtcggcg gcaactacaa ctacctgtac      480

cggctgttcc ggaagtccaa cctgaagcct ttcgagcggg acatcagcac cgaaatctac      540

caggccggca gcaccccttg caatggcgtg gaaggcttca actgctactt cccactgcaa      600

agctacggct tccagcctac aaacggcgtg ggctaccagc cttacagagt ggtggtgctg      660

agcttcgaac tgctgcacgc caatgccaca gtgtgcggcc ctaagaagtc taccaacggc      720

tctggcgaag gcagaggcag ccttctgaca tgtggcgacg tggaagagaa ccccggacct      780

atggacgcaa tgaagcgcgg actgtgttgt gtcctgctgc tgtgcggagc cgtctttgtg      840

tcaccttctg ccgctcagcc caacagcgtg gaatgcgact ttagccccat gctgtctggc      900

acccctccac aggtgtacaa cttcaagcgg ctggtgttca ccaactgcaa ttacaacctg      960

accaagctgc tgagcctgtt catggtcaac gagttcagct gcaacggcat cagccccgac     1020

gctatcgcca gaggctgtta ctctagcctg accgtggact acttcgccta tcctctgagc     1080

atgaagtcct acatgcagcc cggatctgcc ggcgtgatca gccagtacaa ttacaagcag     1140

agcttcgcca atcctacctg ccggatcttt gccaccgtgc ctgccaatct gaccaccatc     1200

acaaagccca gcagctacag ctacatcagc aagtgcagca gactgaccgg cgacaaccag     1260

cacatcgaga cacccatcgt gatcaacccc ggcgagtaca gcatctgccg gaacttcgcc     1320

cctaacggct ttagcgagga cggccagtac ttcaccagac agctgagcca actggaaggc     1380

ggcggaatcc ttgttggcgt gggaagcaca gtgcccatga ccgacaatct ccagatgggc     1440

ttcatcatca gcgtgcagta cggcaacgac accaatagcg tgtgccctat gcttggcagc     1500

ggcgccacaa atttcagcct gctgaaacag gccggcgacg tcgaagagaa tcctggtcca     1560

atggatgcca tgaagcgagg gctctgctgt gtgctcttgc tctgcggagc agtgttcgtg     1620

tccccatctg ctgctagagt ggtgcctagc ggagatgttg tgcgcttccc taatattacc     1680

aacctctgtc cattcgggga agtctttaac gccacaaagt tccccagcgt gtacgcttgg     1740

gagagaaagc ggatctccaa ctgtgtggct gattactccg tgctctacaa ctccacctcc     1800

ttctccacat tcaaatgtta tggcgtcagc gccaccaagc tcaatgatct gtgttttagc     1860

aatgtctacg ccgactcctt cgtcgtgaag ggcgacgatg ttcgccagat cgctccagga     1920

caaacaggcg tgatcgctga ctataattac aaactcccgg acgatttcat gggatgcgtg     1980

ctggcctgga atacccggaa catcgatgcc acctccaccg ggaactataa ctacaagtac     2040

agatacctgc ggcacggcaa gctgcggccc tttgagaggg atatctccaa cgtgccattc     2100

agccctgacg gcaagccttg cacacctcct gaggctctga attgctactg gcccctgaac     2160

gattacggct tctacaccac aagcggcatc ggctatcagc cctatcgcgt ggtggtcctg     2220

tcctttgagc tgctgaatgc caacgctacc gtgtgtggcc caaagctgag caccgattga     2280


<210>  31
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  String 4

<400>  31

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ala Arg Val Val Pro Ser Gly Asp 
            20                  25                  30          


Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val 
        35                  40                  45              


Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys 
    50                  55                  60                  


Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe 
65                  70                  75                  80  


Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp 
                85                  90                  95      


Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp 
            100                 105                 110         


Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr 
        115                 120                 125             


Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn 
    130                 135                 140                 


Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr 
145                 150                 155                 160 


Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser 
                165                 170                 175     


Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu 
            180                 185                 190         


Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly 
        195                 200                 205             


Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
    210                 215                 220                 


Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Ile 
225                 230                 235                 240 


Lys Asn Gln Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn 
                245                 250                 255     


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe 
            260                 265                 270         


Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala 
        275                 280                 285             


Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys 
    290                 295                 300                 


Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val 
305                 310                 315                 320 


Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala 
                325                 330                 335     


Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
            340                 345                 350         


Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ser 
        355                 360                 365             


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
    370                 375                 380                 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
385                 390                 395                 400 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
                405                 410                 415     


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Ile Gly Tyr Gln Pro 
            420                 425                 430         


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr 
        435                 440                 445             


Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Gly Ser 
    450                 455                 460                 


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
465                 470                 475                 480 


Pro Gly Pro Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu 
                485                 490                 495     


Leu Cys Gly Ala Val Phe Val Ser Pro Ser Ala Ala Glu Ala Lys Pro 
            500                 505                 510         


Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp Phe Ser 
        515                 520                 525             


Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu 
    530                 535                 540                 


Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe 
545                 550                 555                 560 


Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala 
                565                 570                 575     


Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu 
            580                 585                 590         


Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile Ser Gln 
        595                 600                 605             


Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala 
    610                 615                 620                 


Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser 
625                 630                 635                 640 


Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg Thr Glu Val 
                645                 650                 655     


Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile Val 
            660                 665                 670         


Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser 
        675                 680                 685             


Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr Val Ala 
    690                 695                 700                 


Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln Tyr Gly 
705                 710                 715                 720 


Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn Asp Thr 
                725                 730                 735     


Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Glu Ala Lys Pro 
            740                 745                 750         


Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp Phe Ser 
        755                 760                 765             


Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu 
    770                 775                 780                 


Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe 
785                 790                 795                 800 


Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala 
                805                 810                 815     


Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu 
            820                 825                 830         


Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile Ser Gln 
        835                 840                 845             


Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala 
    850                 855                 860                 


Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Ser Asn Tyr Ala 
865                 870                 875                 880 


Tyr Leu Thr Glu Cys Tyr Lys Thr Ser Ala Tyr Gly Lys Asn Tyr Leu 
                885                 890                 895     


Tyr Asn Ala Pro Gly Ala Tyr Thr Pro Cys Leu Ser Leu Ala Ser Arg 
            900                 905                 910         


Gly Phe Ser Thr Lys Tyr Gln Ser His Ser Asp Gly Glu Leu Thr Thr 
        915                 920                 925             


Thr Gly Tyr Ile Tyr Pro Val Thr Gly Asn Leu Gln Met Gly Phe Gly 
    930                 935                 940                 


Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu 
945                 950                 955                 960 


Glu Phe Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val 
                965                 970                 975     


Glu Tyr 
        


<210>  32
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  String 4

<400>  32
atggatgcta tgaagagggg cctgtgctgc gtgctgcttc tgtgtggcgc tgtgtttgtg       60

tctcctagcg ccgctagagt ggtgcctagc ggagatgttg tgcggttccc caacatcacc      120

aatctgtgcc ctttcggcga ggtgttcaac gccaccaagt ttccctctgt gtacgcctgg      180

gagcgcaaaa agatcagcaa ctgcgtggcc gactacagcg tgctgtacaa cagcaccttc      240

ttcagcacct ttaagtgcta cggcgtgtcc gccacaaagc tgaacgacct gtgcttcagc      300

aacgtgtacg ccgacagctt cgtggtcaag ggcgacgatg ttcggcagat tgcccctgga      360

cagacaggcg tgatcgccga ttacaactac aagctgcccg acgacttcat gggctgtgtg      420

ctggcctgga acacccggaa catcgatgcc acaagcaccg gcaactacaa ttacaagtac      480

cgctacctgc ggcacggcaa gctgaggcct tttgagaggg acatctccaa cgtgccattc      540

agccccgatg gcaagccttg cacacctcct gctctgaact gctactggcc cctgaacgac      600

tacggcttct acaccacaac cggcatcggc taccagcctt acagagtggt ggtgctgagc      660

ttcgagctgc tgaatgcccc tgccacagtg tgtggcccta agctgtctac cgacctgatc      720

aagaaccagc gcgtggtgcc ttctggcgac gttgtcagat tcccgaatat cacaaacctg      780

tgtccattcg gggaagtctt taatgccaca aagttcccca gcgtctacgc ttgggagcgt      840

aaaaagattt ccaattgcgt cgcagactac tccgtcctgt acaattccac attcttctcc      900

accttcaaat gttacggcgt cagcgccacc aaactgaatg atctgtgttt ctccaatgtc      960

tacgccgact cctttgtcgt gaaaggcgac gacgtgcgcc agatcgctcc aggacaaact     1020

ggcgttatcg ctgactataa ttacaaactc ccggatgatt tcatgggatg cgtcctcgct     1080

tggaatacca gaaacatcga cagcaaagtc ggcgggaact acaactacct gtaccggctg     1140

ttccggaagt ccaacctgaa gcctttcgag cgcgacatca gcaccgaaat ctaccaggcc     1200

ggcagcaccc cttgcaatgg cgtggaaggc ttcaattgct acttcccact gcaaagctac     1260

ggctttcagc ccaccaacgg cattggatat cagccctatc gcgtggtggt cctgtctttt     1320

gaactgctga acgctcccgc taccgtgtgc ggacctaaac tgagcaccga tctcatcaag     1380

aatcaaggca gcggcgaagg cagaggcagc ctgcttacat gtggggacgt cgaagagaac     1440

cccggaccta tggacgcaat gaagcgcgga ctgtgttgtg tcctgctgct gtgcggagcc     1500

gtctttgtgt caccttctgc cgccgaggcc aagccttctg gatctgtggt tgaacaggcc     1560

gaaggcgtgg aatgcgactt cagccctctg ctgtctggca caccacctca ggtgtacaac     1620

ttcaagcggc tggtgttcac caactgtaac tacaacctga ccaagctgct gagcctgttc     1680

agcgtgaacg acttcacctg tagccagatc agccctgccg ccattgcctc caactgttac     1740

agcagcctga tcctggacta cttcagctac cctctgagca tgaagtccga cctgtccgtg     1800

tctagcgccg gaccaatcag ccagttcaac tataagcaga gctttagcaa cccgacctgc     1860

ctgattctgg ccaccgtgcc tcacaatctg accaccatca ccaagcctct gaagtacagc     1920

tacatcaaca agtgcagccg gttcctgagc gacgacagaa cagaggtgcc ccagctggtc     1980

aacgccaacc agtacagccc ttgcgtgtcc atcgtgccta gcaccgtttg ggaggacggc     2040

gactactacc ggaagcagct gtctccactt gaaggcggcg gatggctggt tgcctctgga     2100

tctacagtgg ccatgaccga gcagctccag atgggctttg gcatcacagt gcagtacggc     2160

accgacacca atagcgtgtg cccaaagctg gaattcgcca acgacaccaa gatcgccagc     2220

cagctgggca actgtgtgga atacgaggcc aaacctagcg gcagcgttgt cgagcaagct     2280

gaaggcgtcg agtgtgactt ttcacccctg ctgagcggaa cccctccaca ggtctacaat     2340

ttcaaacgcc tcgtctttac gaactgcaac tataatctca cgaagctcct cagcctcttc     2400

tccgtcaacg atttcacatg ctcccagatt tccccagccg ctatcgctag caactgctac     2460

agctctctga tcctcgatta cttttcctat ccgctgtcta tgaagtctga tctgagcgtg     2520

tccagcgcag gccccatctc tcagtttaat tacaagcagt ccttcagcaa tcccacctgt     2580

ctcatcctgg caacagtgcc ccataacctg acaacaatca caaagcccag caactacgcc     2640

tacctgaccg agtgctacaa gaccagcgcc tacggcaaga attacctgta caacgcccct     2700

ggcgcctaca caccttgtct gtctctggcc agcaggggct ttagcaccaa gtaccagagc     2760

cactccgatg gcgagctgac aaccaccggc tacatctacc cagtgaccgg caacctgcaa     2820

atgggcttcg gaattaccgt ccagtatggg accgatacca actccgtgtg tcccaagctt     2880

gagtttgcca atgatacgaa gatcgcctct cagctgggaa attgcgttga gtactga        2937


<210>  33
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence of pEVAC Multiple Cloning Site

<400>  33
acagactgtt cctttccatg ggtcttttct gcagtcaccg tcggtaccgt cgacacgtgt       60

gatcatctag aggatccgcg gccgcagatc t                                      91


<210>  34
<211>  4405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEVAC

<400>  34
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcggtaccgt cgacacgtgt gatcatctag aggatccgcg     1380

gccgcagatc tgctgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc     1440

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     1500

catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     1560

agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggcta     1620

cccaggtgct gaagaattga cccggttcct cctgggccag aaagaagcag gcacatcccc     1680

ttctctgtga cacaccctgt ccacgcccct ggttcttagt tccagcccca ctcataggac     1740

actcatagct caggagggct ccgccttcaa tcccacccgc taaagtactt ggagcggtct     1800

ctccctccct catcagccca ccaaaccaaa cctagcctcc aagagtggga agaaattaaa     1860

gcaagatagg ctattaagtg cagagggaga gaaaatgcct ccaacatgtg aggaagtaat     1920

gagagaaatc atagaatttt aaggccatga tttaaggcca tcatggcctt aatcttccgc     1980

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca     2040

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg     2100

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     2160

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     2220

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     2280

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     2340

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     2400

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     2460

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     2520

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     2580

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     2640

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     2700

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     2760

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     2820

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     2880

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc     2940

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactcgggg ggggggggcg     3000

ctgaggtctg cctcgtgaag aaggtgttgc tgactcatac caggcctgaa tcgccccatc     3060

atccagccag aaagtgaggg agccacggtt gatgagagct ttgttgtagg tggaccagtt     3120

ggtgattttg aacttttgct ttgccacgga acggtctgcg ttgtcgggaa gatgcgtgat     3180

ctgatccttc aactcagcaa aagttcgatt tattcaacaa agccgccgtc ccgtcaagtc     3240

agcgtaatgc tctgccagtg ttacaaccaa ttaaccaatt ctgattagaa aaactcatcg     3300

agcatcaaat gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa     3360

agccgtttct gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc     3420

tggtatcggt ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg     3480

tcaaaaataa ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat     3540

ggcaaaagct tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca     3600

tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgagacga     3660

aatacgcgat cgctgttaaa aggacaatta caaacaggaa tcgaatgcaa ccggcgcagg     3720

aacactgcca gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg     3780

aatgctgttt tcccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata     3840

aaatgcttga tggtcggaag aggcataaat tccgtcagcc agtttagtct gaccatctca     3900

tctgtaacat cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg     3960

ggcttcccat acaatcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat     4020

ttatacccat ataaatcagc atccatgttg gaatttaatc gcggcctcga gcaagacgtt     4080

tcccgttgaa tatggctcat aacacccctt gtattactgt ttatgtaagc agacagtttt     4140

attgttcatg atgatatatt tttatcttgt gcaatgtaac atcagagatt ttgagacaca     4200

acgtggcttt cccccccccc ccattattga agcatttatc agggttattg tctcatgagc     4260

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc     4320

cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac ctataaaaat     4380

aggcgtatca cgaggccctt tcgtc                                           4405


<210>  35
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD

<400>  35

Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly Ala Val Phe 
1               5                   10                  15      


Val Ser Pro Ser Ala Ala Arg Val Gln Pro Thr Glu Ser Ile Val Arg 
            20                  25                  30          


Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
        35                  40                  45              


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
    50                  55                  60                  


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
65                  70                  75                  80  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
                85                  90                  95      


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
            100                 105                 110         


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
        115                 120                 125             


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
    130                 135                 140                 


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
145                 150                 155                 160 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
                165                 170                 175     


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
            180                 185                 190         


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
        195                 200                 205             


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
    210                 215                 220                 


Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Gly Gly Ser Gly 
225                 230                 235                 240 


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Ser 
                245                 250                 255     


His His His His His His 
            260         


<210>  36
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Consensus Kozak sequence

<400>  36
accaug                                                                   6


<210>  37
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Elongated Kozak sequence

<400>  37
gccaccaug                                                                9


<210>  38
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS2 S protein signal sequence

<400>  38

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Ala Ala 
            20                  25  


<210>  39
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First 2A self-cleaving peptide sequence

<400>  39

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  40
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second 2A self-cleaving peptide sequence

<400>  40

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  41
<211>  5102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2_17 + pEVAC

<400>  41
cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg atgccgggag       60

cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggct ggcttaacta      120

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag      180

atgcgtaagg agaaaatacc gcatcagatt ggctattggc cattgcatac gttgtatcca      240

tatcataata tgtacattta tattggctca tgtccaacat taccgccatg ttgacattga      300

ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg      360

gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc      420

cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat      480

tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat      540

catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat      600

gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc      660

gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac      720

tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa      780

aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt      840

aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcgcc      900

tggagacgcc atccacgctg ttttgacctc catagaagac accgggaccg atccagcctc      960

catcggctcg catctctcct tcacgcgccc gccgccctac ctgaggccgc catccacgcc     1020

ggttgagtcg cgttctgccg cctcccgcct gtggtgcctc ctgaactgcg tccgccgtct     1080

aggtaagttt aaagctcagg tcgagaccgg gcctttgtcc ggcgctccct tggagcctac     1140

ctagactcag ccggctctcc acgctttgcc tgaccctgct tgctcaactc tagttaacgg     1200

tggagggcag tgtagtctga gcagtactcg ttgctgccgc gcgcgccacc agacataata     1260

gctgacagac taacagactg ttcctttcca tgggtctttt ctgcagtcac cgtcggtacc     1320

gccaccatgg atgctatgaa gaggggcctg tgctgcgtgc tgcttctgtg tggcgctgtg     1380

tttgtgtctc ctagcgccgc tagagtggcc cctaccaaag aagtcgtgcg gttccccaac     1440

atcaccaatc tgtgcccttt cggcgaggtg ttcaacgcca ccaagtttcc ctctgtgtac     1500

gcctgggagc gcaaaaagat cagcaactgc gtggccgact acagcgtgct gtacaacagc     1560

accagcttca gcaccttcaa gtgctacggc gtgtcaccca ccaagctgaa cgacctgtgc     1620

ttcaccaacg tgtacgccga cagcttcgtg atcagaggcg acgaagtgcg gcagattgcc     1680

cctggacaaa caggcgtgat cgccgattac aactacaagc tgcccgacga cttcaccggc     1740

tgtgtgatcg cctggaacac caacaacatc gacagcacca ccggcggcaa ctacaactac     1800

ctgtacagaa gcctgcggaa gtctaagctg aagcccttcg agcgggacat cagcagcgac     1860

atctatagcc ctggcggcaa gccttgttct ggcgtggaag gcttcaactg ctactaccct     1920

ctgcggagct acggcttctt ccccacaaat ggcacaggct accagcctta cagagtggtg     1980

gtcctgagct tcgagctgct gaatgcccct gccacagtgt gtggccctaa gctgtctacc     2040

gactgagcgg ccgcagatct gctgtgcctt ctagttgcca gccatctgtt gtttgcccct     2100

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     2160

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     2220

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     2280

ctatggctac ccaggtgctg aagaattgac ccggttcctc ctgggccaga aagaagcagg     2340

cacatcccct tctctgtgac acaccctgtc cacgcccctg gttcttagtt ccagccccac     2400

tcataggaca ctcatagctc aggagggctc cgccttcaat cccacccgct aaagtacttg     2460

gagcggtctc tccctccctc atcagcccac caaaccaaac ctagcctcca agagtgggaa     2520

gaaattaaag caagataggc tattaagtgc agagggagag aaaatgcctc caacatgtga     2580

ggaagtaatg agagaaatca tagaatttta aggccatgat ttaaggccat catggcctta     2640

atcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt     2700

atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa     2760

gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc     2820

gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     2880

gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     2940

gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     3000

aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     3060

ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     3120

taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     3180

tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     3240

gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt     3300

taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     3360

tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     3420

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     3480

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     3540

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     3600

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactcggggg     3660

gggggggcgc tgaggtctgc ctcgtgaaga aggtgttgct gactcatacc aggcctgaat     3720

cgccccatca tccagccaga aagtgaggga gccacggttg atgagagctt tgttgtaggt     3780

ggaccagttg gtgattttga acttttgctt tgccacggaa cggtctgcgt tgtcgggaag     3840

atgcgtgatc tgatccttca actcagcaaa agttcgattt attcaacaaa gccgccgtcc     3900

cgtcaagtca gcgtaatgct ctgccagtgt tacaaccaat taaccaattc tgattagaaa     3960

aactcatcga gcatcaaatg aaactgcaat ttattcatat caggattatc aataccatat     4020

ttttgaaaaa gccgtttctg taatgaagga gaaaactcac cgaggcagtt ccataggatg     4080

gcaagatcct ggtatcggtc tgcgattccg actcgtccaa catcaataca acctattaat     4140

ttcccctcgt caaaaataag gttatcaagt gagaaatcac catgagtgac gactgaatcc     4200

ggtgagaatg gcaaaagctt atgcatttct ttccagactt gttcaacagg ccagccatta     4260

cgctcgtcat caaaatcact cgcatcaacc aaaccgttat tcattcgtga ttgcgcctga     4320

gcgagacgaa atacgcgatc gctgttaaaa ggacaattac aaacaggaat cgaatgcaac     4380

cggcgcagga acactgccag cgcatcaaca atattttcac ctgaatcagg atattcttct     4440

aatacctgga atgctgtttt cccggggatc gcagtggtga gtaaccatgc atcatcagga     4500

gtacggataa aatgcttgat ggtcggaaga ggcataaatt ccgtcagcca gtttagtctg     4560

accatctcat ctgtaacatc attggcaacg ctacctttgc catgtttcag aaacaactct     4620

ggcgcatcgg gcttcccata caatcgatag attgtcgcac ctgattgccc gacattatcg     4680

cgagcccatt tatacccata taaatcagca tccatgttgg aatttaatcg cggcctcgag     4740

caagacgttt cccgttgaat atggctcata acaccccttg tattactgtt tatgtaagca     4800

gacagtttta ttgttcatga tgatatattt ttatcttgtg caatgtaaca tcagagattt     4860

tgagacacaa cgtggctttc cccccccccc cattattgaa gcatttatca gggttattgt     4920

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     4980

acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc     5040

tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa     5100

aa                                                                    5102


<210>  42
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YP_009724397.2/1-419 nucleocapsid phosphoprotein [SARS-CoV-2] 
       (reference sequence)

<400>  42

Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg 
            20                  25                  30          


Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  


Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro 
65                  70                  75                  80  


Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly 
                85                  90                  95      


Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
            100                 105                 110         


Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp 
        115                 120                 125             


Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
    130                 135                 140                 


His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln 
145                 150                 155                 160 


Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
                165                 170                 175     


Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn 
            180                 185                 190         


Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
        195                 200                 205             


Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu 
    210                 215                 220                 


Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln 
225                 230                 235                 240 


Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
                245                 250                 255     


Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln 
            260                 265                 270         


Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
        275                 280                 285             


Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
    290                 295                 300                 


Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile 
305                 310                 315                 320 


Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala 
                325                 330                 335     


Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu 
            340                 345                 350         


Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro 
        355                 360                 365             


Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln 
    370                 375                 380                 


Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser 
                405                 410                 415     


Thr Gln Ala 
            


<210>  43
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV_N_T2_1/1-418 Node1b 321-323 deleted

<400>  43

Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Ser Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Gly Pro Ser Asp Ser Thr Asp Asn Asn Gln Asn Gly Glu Arg 
            20                  25                  30          


Ser Gly Ala Arg Pro Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  


Arg Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Gly Lys 
65                  70                  75                  80  


Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Val Arg Gly 
                85                  90                  95      


Gly Asp Gly Lys Met Lys Glu Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
            100                 105                 110         


Leu Gly Thr Gly Pro Glu Ala Ala Leu Pro Tyr Gly Ala Asn Lys Glu 
        115                 120                 125             


Gly Ile Val Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
    130                 135                 140                 


His Ile Gly Thr Arg Asn Pro Asn Asn Asn Ala Ala Ile Val Leu Gln 
145                 150                 155                 160 


Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
                165                 170                 175     


Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Gly 
            180                 185                 190         


Asn Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
        195                 200                 205             


Arg Met Ala Ser Gly Gly Gly Asp Thr Ala Leu Ala Leu Leu Leu Leu 
    210                 215                 220                 


Asp Arg Leu Asn Gln Leu Glu Ser Lys Val Ser Gly Lys Gly Gln Gln 
225                 230                 235                 240 


Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
                245                 250                 255     


Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Gln Tyr Asn Val Thr Gln 
            260                 265                 270         


Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
        275                 280                 285             


Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
    290                 295                 300                 


Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Glu 
305                 310                 315                 320 


Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr His Gly Ala Ile Lys Leu 
                325                 330                 335     


Asp Asp Lys Asp Pro Gln Phe Lys Asp Asn Val Ile Leu Leu Asn Lys 
            340                 345                 350         


His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro Lys Lys Asp 
        355                 360                 365             


Lys Lys Lys Lys Ala Asp Glu Ala Gln Pro Leu Pro Gln Arg Gln Lys 
    370                 375                 380                 


Lys Gln Pro Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe 
385                 390                 395                 400 


Ser Lys Gln Leu Gln Asn Ser Met Ser Gly Ala Ser Ala Asp Ser Thr 
                405                 410                 415     


Gln Ala 
        


<210>  44
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV_N_T2_1 Nucleic Acid Sequence

<400>  44
atgagcgata acggccctca gaaccagaga agcgccccta gaatcacctt tggcggccct       60

agcgacagca ccgacaacaa ccagaatggc gagagaagcg gcgccagacc taagcagaga      120

aggcctcaag gcctgcctaa caacaccgcc agctggttca cagccctgac acagcacggc      180

aaagaggacc tgagattccc tagaggacag ggcgtgccca tcaacaccaa cagcggcaag      240

gatgaccaga tcggctacta cagacgggcc accagaagag ttagaggcgg cgacggcaag      300

atgaaggaac tgagccccag atggtacttc tactacctcg gcacaggccc agaagccgca      360

cttccttacg gcgccaacaa agagggcatc gtctgggttg caacagaagg cgccctgaac      420

acccctaagg accacatcgg caccagaaat cccaacaaca acgccgccat cgtgctccag      480

ttgcctcagg gaacaacact gcccaagggc ttctacgccg agggatctag aggcggatct      540

caggccagca gcagaagcag ctctagaagc agaggcaaca gccggaatag cacccctggc      600

agctccagag gaacaagccc tgctagaatg gctagcggcg gaggcgatac agctctggct      660

ctgttgctgc tggaccggct gaatcagctg gaaagcaagg tgtccggcaa gggacagcag      720

cagcagggac agaccgtgac caagaaatct gccgccgagg ccagcaagaa gcccagacag      780

aagagaaccg ccacaaagca gtacaacgtg acccaggcct tcggcagaag aggcccagag      840

cagacccagg gcaatttcgg cgatcaagag ctgatcagac agggcaccga ctacaagcac      900

tggcctcaga tcgcccagtt tgccccttct gccagcgcct tctttggcat gagcagggaa      960

gtgaccccta gcggcacatg gctgacatat cacggcgcca tcaagctgga cgacaaggac     1020

cctcagttca aggacaacgt gatcctgctg aacaagcaca tcgacgccta caagacattc     1080

cctccaaccg agcctaagaa ggacaagaag aagaaggccg acgaggccca gcctctgcct     1140

cagaggcaaa agaaacagcc caccgtgaca ctgctgccag ccgctgatct ggacgacttc     1200

agcaagcagc tgcaaaacag catgagcggc gcctctgccg atagcacaca ggct           1254


<210>  45
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV_N_T2_2/1-417 epitope optimised 321-323 deleted

<400>  45

Met Thr Asp Asn Gly Gln Gln Gly Pro Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Val Ser Asp Asn Phe Asp Asn Asn Gln Asp Gly Gly Arg Ser 
            20                  25                  30          


Gly Ala Arg Pro Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn Thr 
        35                  40                  45              


Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu Arg 
    50                  55                  60                  


Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro Asp 
65                  70                  75                  80  


Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly Gly 
                85                  90                  95      


Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr Leu 
            100                 105                 110         


Gly Thr Gly Pro Glu Ala Ala Leu Pro Tyr Gly Ala Asn Lys Glu Gly 
        115                 120                 125             


Ile Val Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp His 
    130                 135                 140                 


Ile Gly Thr Arg Asn Pro Asn Asn Asn Ala Ala Ile Val Leu Gln Leu 
145                 150                 155                 160 


Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser Arg 
                165                 170                 175     


Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn Ser 
            180                 185                 190         


Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala Arg 
        195                 200                 205             


Asn Leu Gln Ala Gly Gly Asp Thr Ala Leu Ala Leu Leu Leu Leu Asp 
    210                 215                 220                 


Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln Gln 
225                 230                 235                 240 


Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys Lys 
                245                 250                 255     


Pro Arg Gln Lys Arg Thr Ala Thr Lys Gln Tyr Asn Val Thr Gln Ala 
            260                 265                 270         


Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp Gln 
        275                 280                 285             


Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys Gln Trp Pro Gln Ile Ala 
    290                 295                 300                 


Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Glu Val 
305                 310                 315                 320 


Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala Ile Lys Leu Asp 
                325                 330                 335     


Asp Lys Asp Pro Gln Phe Lys Asp Asn Val Ile Leu Leu Asn Lys His 
            340                 345                 350         


Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro Lys Lys Asp Lys 
        355                 360                 365             


Lys Lys Lys Ala Asp Glu Ala Gln Pro Leu Pro Gln Arg Gln Lys Lys 
    370                 375                 380                 


Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe Ser 
385                 390                 395                 400 


Arg Gln Leu Gln Asn Ser Met Ser Gly Ala Ser Ala Asp Ser Thr Gln 
                405                 410                 415     


Ala 
    


<210>  46
<211>  1251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV_N_T2_2

<400>  46
atgaccgata atggccagca gggccctaga aacgccccta gaatcacctt cggcgtgtcc       60

gacaacttcg acaacaacca ggatggcggc agaagcggcg ccagacctaa acagagaagg      120

cctcagggcc tgcctaacaa caccgccagc tggtttacag ccctgacaca gcacggcaaa      180

gaggacctga gattccctag aggacagggc gtgcccatca acaccaacag cagccccgat      240

gaccagatcg gctactacag acgggccacc agaagaatca gaggcggcga cggcaagatg      300

aaggatctga gccccagatg gtacttctac tacctcggca caggacccga agccgctttg      360

ccttatggcg ccaacaaaga gggcatcgtc tgggttgcaa cagaaggcgc cctgaacacc      420

cctaaggacc acatcggcac cagaaatccc aacaacaacg ccgccatcgt gctccagttg      480

ccacagggaa caacactgcc caagggcttc tatgccgagg gctctagagg cggctctcag      540

gcttctagca gaagcagcag ccggtccaga aacagctccc ggaatagcac acctggcagc      600

agcagaggca caagccctgc cagaaatctg caagccggcg gagatacagc tctggctttg      660

ctgctgctgg acagactgaa tcagctggaa agcaagatga gcggcaaggg ccagcagcaa      720

cagggccaga cagtgaccaa aaagtctgcc gccgaggcca gcaagaagcc cagacagaag      780

agaaccgcca caaagcagta caacgtgacc caggccttcg gcagaagggg accagaacag      840

acccagggca acttcggcga ccaagagctg atcagacagg gcaccgacta caagcagtgg      900

cctcagatcg cccagtttgc ccctagcgcc tctgccttct ttggcatgag cagagaagtg      960

acccctagcg gcacctggct gacatataca ggcgccatca agctggacga caaggaccct     1020

cagttcaagg acaacgtgat cctgctgaac aagcacatcg acgcctacaa gacattccct     1080

ccaaccgagc ctaagaagga caagaagaag aaggccgacg aggcccagcc tctgccacag     1140

aggcaaaaga aacagcagac cgtgacactg ctgcccgctg ccgatctcga cgatttctct     1200

agacagctcc agaacagcat gagcggcgcc tccgctgatt ctacacaggc t              1251


<210>  47
<211>  5639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEVAC-COV_N_T2_1

<400>  47
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcggtaccgc caccatgagc gataacggcc ctcagaacca     1380

gagaagcgcc cctagaatca cctttggcgg ccctagcgac agcaccgaca acaaccagaa     1440

tggcgagaga agcggcgcca gacctaagca gagaaggcct caaggcctgc ctaacaacac     1500

cgccagctgg ttcacagccc tgacacagca cggcaaagag gacctgagat tccctagagg     1560

acagggcgtg cccatcaaca ccaacagcgg caaggatgac cagatcggct actacagacg     1620

ggccaccaga agagttagag gcggcgacgg caagatgaag gaactgagcc ccagatggta     1680

cttctactac ctcggcacag gcccagaagc cgcacttcct tacggcgcca acaaagaggg     1740

catcgtctgg gttgcaacag aaggcgccct gaacacccct aaggaccaca tcggcaccag     1800

aaatcccaac aacaacgccg ccatcgtgct ccagttgcct cagggaacaa cactgcccaa     1860

gggcttctac gccgagggat ctagaggcgg atctcaggcc agcagcagaa gcagctctag     1920

aagcagaggc aacagccgga atagcacccc tggcagctcc agaggaacaa gccctgctag     1980

aatggctagc ggcggaggcg atacagctct ggctctgttg ctgctggacc ggctgaatca     2040

gctggaaagc aaggtgtccg gcaagggaca gcagcagcag ggacagaccg tgaccaagaa     2100

atctgccgcc gaggccagca agaagcccag acagaagaga accgccacaa agcagtacaa     2160

cgtgacccag gccttcggca gaagaggccc agagcagacc cagggcaatt tcggcgatca     2220

agagctgatc agacagggca ccgactacaa gcactggcct cagatcgccc agtttgcccc     2280

ttctgccagc gccttctttg gcatgagcag ggaagtgacc cctagcggca catggctgac     2340

atatcacggc gccatcaagc tggacgacaa ggaccctcag ttcaaggaca acgtgatcct     2400

gctgaacaag cacatcgacg cctacaagac attccctcca accgagccta agaaggacaa     2460

gaagaagaag gccgacgagg cccagcctct gcctcagagg caaaagaaac agcccaccgt     2520

gacactgctg ccagccgctg atctggacga cttcagcaag cagctgcaaa acagcatgag     2580

cggcgcctct gccgatagca cacaggctta agcggccgca gatctgctgt gccttctagt     2640

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     2700

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     2760

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     2820

aggcatgctg gggatgcggt gggctctatg gctacccagg tgctgaagaa ttgacccggt     2880

tcctcctggg ccagaaagaa gcaggcacat ccccttctct gtgacacacc ctgtccacgc     2940

ccctggttct tagttccagc cccactcata ggacactcat agctcaggag ggctccgcct     3000

tcaatcccac ccgctaaagt acttggagcg gtctctccct ccctcatcag cccaccaaac     3060

caaacctagc ctccaagagt gggaagaaat taaagcaaga taggctatta agtgcagagg     3120

gagagaaaat gcctccaaca tgtgaggaag taatgagaga aatcatagaa ttttaaggcc     3180

atgatttaag gccatcatgg ccttaatctt ccgcttcctc gctcactgac tcgctgcgct     3240

cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca     3300

cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga     3360

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     3420

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     3480

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     3540

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     3600

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     3660

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     3720

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     3780

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg     3840

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     3900

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     3960

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     4020

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga     4080

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt     4140

ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt     4200

catccatagt tgcctgactc gggggggggg ggcgctgagg tctgcctcgt gaagaaggtg     4260

ttgctgactc ataccaggcc tgaatcgccc catcatccag ccagaaagtg agggagccac     4320

ggttgatgag agctttgttg taggtggacc agttggtgat tttgaacttt tgctttgcca     4380

cggaacggtc tgcgttgtcg ggaagatgcg tgatctgatc cttcaactca gcaaaagttc     4440

gatttattca acaaagccgc cgtcccgtca agtcagcgta atgctctgcc agtgttacaa     4500

ccaattaacc aattctgatt agaaaaactc atcgagcatc aaatgaaact gcaatttatt     4560

catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa     4620

ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg     4680

tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa     4740

atcaccatga gtgacgactg aatccggtga gaatggcaaa agcttatgca tttctttcca     4800

gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc     4860

gttattcatt cgtgattgcg cctgagcgag acgaaatacg cgatcgctgt taaaaggaca     4920

attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt     4980

ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccgg ggatcgcagt     5040

ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat     5100

aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc     5160

tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt     5220

cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat     5280

gttggaattt aatcgcggcc tcgagcaaga cgtttcccgt tgaatatggc tcataacacc     5340

ccttgtatta ctgtttatgt aagcagacag ttttattgtt catgatgata tatttttatc     5400

ttgtgcaatg taacatcaga gattttgaga cacaacgtgg ctttcccccc ccccccatta     5460

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa     5520

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga     5580

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtc      5639


<210>  48
<211>  5636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEVAC-COV_N_T2_2

<400>  48
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcggtaccgc caccatgacc gataatggcc agcagggccc     1380

tagaaacgcc cctagaatca ccttcggcgt gtccgacaac ttcgacaaca accaggatgg     1440

cggcagaagc ggcgccagac ctaaacagag aaggcctcag ggcctgccta acaacaccgc     1500

cagctggttt acagccctga cacagcacgg caaagaggac ctgagattcc ctagaggaca     1560

gggcgtgccc atcaacacca acagcagccc cgatgaccag atcggctact acagacgggc     1620

caccagaaga atcagaggcg gcgacggcaa gatgaaggat ctgagcccca gatggtactt     1680

ctactacctc ggcacaggac ccgaagccgc tttgccttat ggcgccaaca aagagggcat     1740

cgtctgggtt gcaacagaag gcgccctgaa cacccctaag gaccacatcg gcaccagaaa     1800

tcccaacaac aacgccgcca tcgtgctcca gttgccacag ggaacaacac tgcccaaggg     1860

cttctatgcc gagggctcta gaggcggctc tcaggcttct agcagaagca gcagccggtc     1920

cagaaacagc tcccggaata gcacacctgg cagcagcaga ggcacaagcc ctgccagaaa     1980

tctgcaagcc ggcggagata cagctctggc tttgctgctg ctggacagac tgaatcagct     2040

ggaaagcaag atgagcggca agggccagca gcaacagggc cagacagtga ccaaaaagtc     2100

tgccgccgag gccagcaaga agcccagaca gaagagaacc gccacaaagc agtacaacgt     2160

gacccaggcc ttcggcagaa ggggaccaga acagacccag ggcaacttcg gcgaccaaga     2220

gctgatcaga cagggcaccg actacaagca gtggcctcag atcgcccagt ttgcccctag     2280

cgcctctgcc ttctttggca tgagcagaga agtgacccct agcggcacct ggctgacata     2340

tacaggcgcc atcaagctgg acgacaagga ccctcagttc aaggacaacg tgatcctgct     2400

gaacaagcac atcgacgcct acaagacatt ccctccaacc gagcctaaga aggacaagaa     2460

gaagaaggcc gacgaggccc agcctctgcc acagaggcaa aagaaacagc agaccgtgac     2520

actgctgccc gctgccgatc tcgacgattt ctctagacag ctccagaaca gcatgagcgg     2580

cgcctccgct gattctacac aggcttaagc ggccgcagat ctgctgtgcc ttctagttgc     2640

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     2700

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     2760

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     2820

catgctgggg atgcggtggg ctctatggct acccaggtgc tgaagaattg acccggttcc     2880

tcctgggcca gaaagaagca ggcacatccc cttctctgtg acacaccctg tccacgcccc     2940

tggttcttag ttccagcccc actcatagga cactcatagc tcaggagggc tccgccttca     3000

atcccacccg ctaaagtact tggagcggtc tctccctccc tcatcagccc accaaaccaa     3060

acctagcctc caagagtggg aagaaattaa agcaagatag gctattaagt gcagagggag     3120

agaaaatgcc tccaacatgt gaggaagtaa tgagagaaat catagaattt taaggccatg     3180

atttaaggcc atcatggcct taatcttccg cttcctcgct cactgactcg ctgcgctcgg     3240

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     3300

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3360

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3420

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3480

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3540

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3600

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3660

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3720

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3780

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta     3840

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3900

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3960

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     4020

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     4080

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     4140

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     4200

ccatagttgc ctgactcggg gggggggggc gctgaggtct gcctcgtgaa gaaggtgttg     4260

ctgactcata ccaggcctga atcgccccat catccagcca gaaagtgagg gagccacggt     4320

tgatgagagc tttgttgtag gtggaccagt tggtgatttt gaacttttgc tttgccacgg     4380

aacggtctgc gttgtcggga agatgcgtga tctgatcctt caactcagca aaagttcgat     4440

ttattcaaca aagccgccgt cccgtcaagt cagcgtaatg ctctgccagt gttacaacca     4500

attaaccaat tctgattaga aaaactcatc gagcatcaaa tgaaactgca atttattcat     4560

atcaggatta tcaataccat atttttgaaa aagccgtttc tgtaatgaag gagaaaactc     4620

accgaggcag ttccatagga tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc     4680

aacatcaata caacctatta atttcccctc gtcaaaaata aggttatcaa gtgagaaatc     4740

accatgagtg acgactgaat ccggtgagaa tggcaaaagc ttatgcattt ctttccagac     4800

ttgttcaaca ggccagccat tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt     4860

attcattcgt gattgcgcct gagcgagacg aaatacgcga tcgctgttaa aaggacaatt     4920

acaaacagga atcgaatgca accggcgcag gaacactgcc agcgcatcaa caatattttc     4980

acctgaatca ggatattctt ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt     5040

gagtaaccat gcatcatcag gagtacggat aaaatgcttg atggtcggaa gaggcataaa     5100

ttccgtcagc cagtttagtc tgaccatctc atctgtaaca tcattggcaa cgctaccttt     5160

gccatgtttc agaaacaact ctggcgcatc gggcttccca tacaatcgat agattgtcgc     5220

acctgattgc ccgacattat cgcgagccca tttataccca tataaatcag catccatgtt     5280

ggaatttaat cgcggcctcg agcaagacgt ttcccgttga atatggctca taacacccct     5340

tgtattactg tttatgtaag cagacagttt tattgttcat gatgatatat ttttatcttg     5400

tgcaatgtaa catcagagat tttgagacac aacgtggctt tccccccccc cccattattg     5460

aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa     5520

taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac     5580

cattattatc atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtc         5636


