              SEQUENCE LISTING

<110> HIFIBIO (HK) LIMITED

<120> Anti-OX40 Monoclonal Antibody and Methods of Use Thereof

<130> 131206-00920

<140>
<141>

<150> US 63/216,189
<151> 2021-06-29

<160> 34

<170> BiSSAP 1.3.6

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VH CDR1 A.A. Sequence

<400> 1
Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               

<210> 2
<211> 8
<212> PRT
<213> Artifical Sequence

<220> 
<223> HFB10-1E1hG1 VH CDR2 A.A. Sequence

<400> 2
Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               

<210> 3
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VH CDR3 A.A. Sequence

<400> 3
Ala Arg Asp Leu Ser Ser Ser Trp Tyr Leu Asp Ala Phe Asp Ile 
1               5                   10                  15  

<210> 4
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VH A.A. Sequence

<400> 4
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Leu Ser Ser Ser Trp Tyr Leu Asp Ala Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         

<210> 5
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 HC Constant Region A.A. Sequence

<400> 5
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 6
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 HC Signal Peptide Sequence

<400> 6
Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      
Leu Val Ala Ala Pro Arg Trp Val Leu Ser 
            20                  25      

<210> 7
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 HC Full-Length A.A. Sequence (no Signal Peptide)

<400> 7
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Leu Ser Ser Ser Trp Tyr Leu Asp Ala Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210> 8
<211> 478
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 HC Full-length A.A. Sequence (with Signal Peptide)

<400> 8
Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      
Leu Val Ala Ala Pro Arg Trp Val Leu Ser Glu Val Gln Leu Leu Glu 
            20                  25                  30          
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
    50                  55                  60                  
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser 
65                  70                  75                  80  
Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      
Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Ser Ser 
        115                 120                 125             
Ser Trp Tyr Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
    130                 135                 140                 
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                165                 170                 175     
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            180                 185                 190         
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        195                 200                 205             
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    210                 215                 220                 
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
225                 230                 235                 240 
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                245                 250                 255     
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 
Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VL CDR1 A.A. Sequence

<400> 9
Gln Gly Ile Ser Ser Trp 
1               5       

<210> 10
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VL CDR2 A.A. Sequence

<400> 10
Ala Ala Ser 
1               

<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VL CDR3 A.A. Sequence

<400> 11
Gln Gln Ala Asn Ser Phe Pro Leu Thr 
1               5                   

<210> 12
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VL A.A. Sequence

<400> 12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 13
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 LC Constant Region A.A. Sequence

<400> 13
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210> 14
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 LC Signal Peptide Sequence

<400> 14
Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      
Leu Val Ala Ala Pro Arg Trp Val Leu Ser 
            20                  25      

<210> 15
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 LC Full-length A.A. Sequence (no Signal Peptide)

<400> 15
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 16
<211> 240
<212> PRT
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 LC Full-length Sequence (with Signal Peptide)

<400> 16
Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      
Leu Val Ala Ala Pro Arg Trp Val Leu Ser Asp Ile Gln Met Thr Gln 
            20                  25                  30          
Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              
Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
65                  70                  75                  80  
Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         
Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr 
        115                 120                 125             
Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 
Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 
Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             
Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 
Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 

<210> 17
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VH CDR1 N.A. Sequence

<400> 17
ggcttcacct tctcctctta cgcc                                           24

<210> 18
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VH CDR2 N.A. Sequence

<400> 18
atctccggct ctggcggatc tacc                                           24

<210> 19
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VH CDR3 N.A. Sequence

<400> 19
gccagagatc tgtcctcctc ctggtatctg gacgcctttg atatc                     45

<210> 20
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VH N.A. Sequence

<400> 20
gaagttcagc tgctggaatc tggcggagga ctggttcagc ctggcggctc tttgagactg      60

tcttgtgccg cctctggctt caccttctcc tcttacgcca tgtcctgggt ccgacaggct     120

cctggaaaag gactggaatg ggtgtccgct atctccggct ctggcggatc tacctactac     180

gccgactccg tgaagggcag attcaccatc agccgggaca actccaagaa caccctgtac     240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc cagagatctg     300

tcctcctcct ggtatctgga cgcctttgat atctggggcc agggcaccat ggtcaccgtg     360

tcctct                                                                366

<210> 21
<211> 990
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 HC Constant Region N.A. Sequence

<400> 21
gcttctacca agggaccctc tgtgttccct ctggctcctt cctctaaatc cacctctggt      60

ggcaccgctg ctctgggctg tctggtcaag gattacttcc ctgagcctgt gaccgtgtct     120

tggaactctg gtgctctgac ctccggcgtg cacacattcc ctgctgtgct gcagtcctct     180

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcta gctctctggg cacccagacc     240

tacatctgca acgtgaacca caagccttcc aacaccaagg tggacaagaa ggtggaaccc     300

aagtcctgcg acaagaccca cacctgtcct ccatgtccag ctccagaact gctcggcgga     360

ccttccgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatctc tcggacccct     420

gaagtgacct gcgtggtggt ggatgtgtct cacgaggacc cagaagtgaa gttcaattgg     480

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagtacaac     540

tccacctaca gagtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa     600

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctatcgaaaa gaccatctct     660

aaggccaagg gccagcctcg cgaacctcag gtttacaccc tgcctccaag ccgggaagag     720

atgaccaaga accaggtgtc cctgacctgc ctggttaagg gcttctaccc ctccgatatc     780

gccgtggaat gggagtctaa cggccagcct gagaacaact acaagacaac ccctcctgtg     840

ctggactccg acggctcatt cttcctgtac tccaagctga cagtggacaa gtccagatgg     900

cagcagggca acgtgttctc ctgttctgtg atgcacgagg ccctgcacaa ccactacaca     960

cagaagtccc tgtctctgtc ccctggcaag                                      990

<210> 22
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 HC Signal Peptide N.A. Sequence

<400> 22
atggacctgc tgcacaagaa catgaagcac ctgtggttct ttctgctgct ggtggccgct     60

cctagatggg tgctgtct                                                   78

<210> 23
<211> 1356
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 HC Full-length N.A. Sequence (no Signal Peptide)

<400> 23
gaagttcagc tgctggaatc tggcggagga ctggttcagc ctggcggctc tttgagactg      60

tcttgtgccg cctctggctt caccttctcc tcttacgcca tgtcctgggt ccgacaggct     120

cctggaaaag gactggaatg ggtgtccgct atctccggct ctggcggatc tacctactac     180

gccgactccg tgaagggcag attcaccatc agccgggaca actccaagaa caccctgtac     240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc cagagatctg     300

tcctcctcct ggtatctgga cgcctttgat atctggggcc agggcaccat ggtcaccgtg     360

tcctctgctt ctaccaaggg accctctgtg ttccctctgg ctccttcctc taaatccacc     420

tctggtggca ccgctgctct gggctgtctg gtcaaggatt acttccctga gcctgtgacc     480

gtgtcttgga actctggtgc tctgacctcc ggcgtgcaca cattccctgc tgtgctgcag     540

tcctctggcc tgtactctct gtcctctgtc gtgaccgtgc cttctagctc tctgggcacc     600

cagacctaca tctgcaacgt gaaccacaag ccttccaaca ccaaggtgga caagaaggtg     660

gaacccaagt cctgcgacaa gacccacacc tgtcctccat gtccagctcc agaactgctc     720

ggcggacctt ccgtgttcct gtttcctcca aagcctaagg acaccctgat gatctctcgg     780

acccctgaag tgacctgcgt ggtggtggat gtgtctcacg aggacccaga agtgaagttc     840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag     900

tacaactcca cctacagagt ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac     960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat cgaaaagacc    1020

atctctaagg ccaagggcca gcctcgcgaa cctcaggttt acaccctgcc tccaagccgg    1080

gaagagatga ccaagaacca ggtgtccctg acctgcctgg ttaagggctt ctacccctcc    1140

gatatcgccg tggaatggga gtctaacggc cagcctgaga acaactacaa gacaacccct    1200

cctgtgctgg actccgacgg ctcattcttc ctgtactcca agctgacagt ggacaagtcc    1260

agatggcagc agggcaacgt gttctcctgt tctgtgatgc acgaggccct gcacaaccac    1320

tacacacaga agtccctgtc tctgtcccct ggcaag                              1356

<210> 24
<211> 1434
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 HC Full-length N.A. Sequence (with Signal Peptide)

<400> 24
atggacctgc tgcacaagaa catgaagcac ctgtggttct ttctgctgct ggtggccgct      60

cctagatggg tgctgtctga agttcagctg ctggaatctg gcggaggact ggttcagcct     120

ggcggctctt tgagactgtc ttgtgccgcc tctggcttca ccttctcctc ttacgccatg     180

tcctgggtcc gacaggctcc tggaaaagga ctggaatggg tgtccgctat ctccggctct     240

ggcggatcta cctactacgc cgactccgtg aagggcagat tcaccatcag ccgggacaac     300

tccaagaaca ccctgtacct gcagatgaac tccctgagag ccgaggacac cgccgtgtac     360

tactgtgcca gagatctgtc ctcctcctgg tatctggacg cctttgatat ctggggccag     420

ggcaccatgg tcaccgtgtc ctctgcttct accaagggac cctctgtgtt ccctctggct     480

ccttcctcta aatccacctc tggtggcacc gctgctctgg gctgtctggt caaggattac     540

ttccctgagc ctgtgaccgt gtcttggaac tctggtgctc tgacctccgg cgtgcacaca     600

ttccctgctg tgctgcagtc ctctggcctg tactctctgt cctctgtcgt gaccgtgcct     660

tctagctctc tgggcaccca gacctacatc tgcaacgtga accacaagcc ttccaacacc     720

aaggtggaca agaaggtgga acccaagtcc tgcgacaaga cccacacctg tcctccatgt     780

ccagctccag aactgctcgg cggaccttcc gtgttcctgt ttcctccaaa gcctaaggac     840

accctgatga tctctcggac ccctgaagtg acctgcgtgg tggtggatgt gtctcacgag     900

gacccagaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc     960

aagcctagag aggaacagta caactccacc tacagagtgg tgtccgtgct gaccgtgctg    1020

caccaggatt ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct    1080

gctcctatcg aaaagaccat ctctaaggcc aagggccagc ctcgcgaacc tcaggtttac    1140

accctgcctc caagccggga agagatgacc aagaaccagg tgtccctgac ctgcctggtt    1200

aagggcttct acccctccga tatcgccgtg gaatgggagt ctaacggcca gcctgagaac    1260

aactacaaga caacccctcc tgtgctggac tccgacggct cattcttcct gtactccaag    1320

ctgacagtgg acaagtccag atggcagcag ggcaacgtgt tctcctgttc tgtgatgcac    1380

gaggccctgc acaaccacta cacacagaag tccctgtctc tgtcccctgg caag          1434

<210> 25
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VL CDR1 N.A. Sequence

<400> 25
cagggcatct ctagctgg                                                  18

<210> 26
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VL CDR2 N.A. Sequence

<400> 26
gccagttct                                                       9

<210> 27
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VL CDR3 N.A. Sequence

<400> 27
cagcaggcca acagcttccc tctgacc                                        27

<210> 28
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 VL N.A. Sequence

<400> 28
gacatccaga tgacccagtc tccatcctcc gtgtctgcct ctgtgggcga cagagtgacc      60

atcacctgta gagcctctca gggcatctct agctggctgg cctggtatca gcagaagcct     120

ggaaaggccc ctaagctgct gatctacgct gccagttctc tgcagtctgg cgtgccctct     180

agattctctg gctctggatc tggcaccgac ttcaccctga caatctctag cctgcagcct     240

gaggacttcg ccacctacta ctgtcagcag gccaacagct tccctctgac ctttggcggc     300

ggaacaaagc tggaaatcaa g                                               321

<210> 29
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 LC Constant Region N.A. Sequence

<400> 29
agaaccgtgg ctgccccttc cgtgttcatc ttcccaccat ctgacgagca gctgaagtcc      60

ggcacagctt ctgtcgtgtg cctgctgaac aacttctacc ctcgggaagc caaggtgcag     120

tggaaggtgg acaatgccct gcagtccggc aactcccaag agtctgtgac cgagcaggac     180

tccaaggact ctacctacag cctgtcctcc acactgaccc tgtctaaggc cgactacgag     240

aagcacaagg tgtacgcctg tgaagtgacc caccagggac tgtctagccc cgtgaccaag     300

tctttcaaca gaggcgagtg c                                               321

<210> 30
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 LC Signal Peptide N.A. Sequence

<400> 30
atggacctgc tgcacaagaa catgaagcac ctgtggttct ttctgctgct ggtggccgct     60

cctagatggg tgctgtct                                                   78

<210> 31
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 LC Full-length N.A. Sequence (no Signal Peptide)

<400> 31
gacatccaga tgacccagtc tccatcctcc gtgtctgcct ctgtgggcga cagagtgacc      60

atcacctgta gagcctctca gggcatctct agctggctgg cctggtatca gcagaagcct     120

ggaaaggccc ctaagctgct gatctacgct gccagttctc tgcagtctgg cgtgccctct     180

agattctctg gctctggatc tggcaccgac ttcaccctga caatctctag cctgcagcct     240

gaggacttcg ccacctacta ctgtcagcag gccaacagct tccctctgac ctttggcggc     300

ggaacaaagc tggaaatcaa gagaaccgtg gctgcccctt ccgtgttcat cttcccacca     360

tctgacgagc agctgaagtc cggcacagct tctgtcgtgt gcctgctgaa caacttctac     420

cctcgggaag ccaaggtgca gtggaaggtg gacaatgccc tgcagtccgg caactcccaa     480

gagtctgtga ccgagcagga ctccaaggac tctacctaca gcctgtcctc cacactgacc     540

ctgtctaagg ccgactacga gaagcacaag gtgtacgcct gtgaagtgac ccaccaggga     600

ctgtctagcc ccgtgaccaa gtctttcaac agaggcgagt gc                        642

<210> 32
<211> 720
<212> DNA
<213> Artificial Sequence

<220> 
<223> HFB10-1E1hG1 LC Full-length N.A. Sequence (with Signal Peptide)

<400> 32
atggacctgc tgcacaagaa catgaagcac ctgtggttct ttctgctgct ggtggccgct      60

cctagatggg tgctgtctga catccagatg acccagtctc catcctccgt gtctgcctct     120

gtgggcgaca gagtgaccat cacctgtaga gcctctcagg gcatctctag ctggctggcc     180

tggtatcagc agaagcctgg aaaggcccct aagctgctga tctacgctgc cagttctctg     240

cagtctggcg tgccctctag attctctggc tctggatctg gcaccgactt caccctgaca     300

atctctagcc tgcagcctga ggacttcgcc acctactact gtcagcaggc caacagcttc     360

cctctgacct ttggcggcgg aacaaagctg gaaatcaaga gaaccgtggc tgccccttcc     420

gtgttcatct tcccaccatc tgacgagcag ctgaagtccg gcacagcttc tgtcgtgtgc     480

ctgctgaaca acttctaccc tcgggaagcc aaggtgcagt ggaaggtgga caatgccctg     540

cagtccggca actcccaaga gtctgtgacc gagcaggact ccaaggactc tacctacagc     600

ctgtcctcca cactgaccct gtctaaggcc gactacgaga agcacaaggt gtacgcctgt     660

gaagtgaccc accagggact gtctagcccc gtgaccaagt ctttcaacag aggcgagtgc     720

<210>  33
<211>  277
<212>  PRT
<213>  H. sapien

<400>  33

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      

Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          

Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              

Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  

Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  

Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      

Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         

Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             

Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 

Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 

Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     

Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         

Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             

Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 

Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     

Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         

Thr Leu Ala Lys Ile 
        275         

<210>  34
<211>  19
<212>  PRT
<213>  H. sapien

<400>  34

Cys Ser Arg Ser Gln Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe 
1               5                   10                  15      

Tyr Asn Asp 
