               SEQUENCE LISTING

<110> ANDREMACON S.R.L. 

<120> ANTI-ERYTHROPOIETIN ANTIBODY

<130> P022430WO-01

<160> 17

<170> BiSSAP 1.3.6

<210> 1
<211> 30
<212> DNA
<213> Homo sapiens


<220> 
<223> VL-CDR1

<400> 1
gaaagtgttg actattatgg cacaggttta                                     30


<210> 2
<211> 27
<212> DNA
<213> Homo sapiens


<220> 
<223> VL-CDR3

<400> 2
cagcaaacta ggaaggttcc ttcgacg                                        27


<210> 3
<211> 333
<212> DNA
<213> Homo sapiens


<220> 
<223> VL DNA sequence

<400> 3
gatatcgttc tcactcaatc tccagcttct ttggctgtgt ctctagggca gagagccacc      60

atctcctgca gagccagtga aagtgttgac tattatggca caggtttaat gcagtggtac     120

caacagagac caggacagcc acccaaactc ctcatctatg gtgcatccaa cgtaggatct     180

ggggtccctg ccaggtttag cggcagtggg tctgggacag acttcagcct caacatccat     240

cctgtggagg gggatgatat tgcaatgtat ttctgtcagc aaactaggaa ggttccttcg     300

acgttcggtg gaggcaccaa gttggaaatc aaa                                  333


<210> 4
<211> 10
<212> PRT
<213> Homo sapiens


<220> 
<223> VL-CDR1

<400> 4
Glu Ser Val Asp Tyr Tyr Gly Thr Gly Leu 
1               5                   10  

<210> 5
<211> 9
<212> PRT
<213> Homo sapiens


<220> 
<223> VL-CDR3

<400> 5
Gln Gln Thr Arg Lys Val Pro Ser Thr 
1               5                   

<210> 6
<211> 111
<212> PRT
<213> Homo sapiens


<220> 
<223> VL amino acid sequence

<400> 6
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr 
            20                  25                  30          
Gly Thr Gly Leu Met Gln Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Gly Ala Ser Asn Val Gly Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Gly Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Thr Arg 
                85                  90                  95      
Lys Val Pro Ser Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 7
<211> 24
<212> DNA
<213> Homo sapiens


<220> 
<223> VH-CDR1

<400> 7
ggattcactt tcagtaccta tacc                                           24


<210> 8
<211> 24
<212> DNA
<213> Homo sapiens


<220> 
<223> VH-CDR2

<400> 8
attagtaatg gtggtgatag aacc                                           24


<210> 9
<211> 42
<212> DNA
<213> Homo sapiens


<220> 
<223> VH-CDR3

<400> 9
gcaagacata atattactac ggttcccttt actatggact ac                        42


<210> 10
<211> 363
<212> DNA
<213> Homo sapiens


<220> 
<223> VH DNA Sequence

<400> 10
gaggtgaagc tgcaggagtc tgggggaggt ttagtgcagc ctggagggtc cctgaaactc      60

tcctgtgcag cctctggatt cactttcagt acctatacca tgtcttgggt tcgccagact     120

ccagagaaga ggctggagtg ggtcgcatac attagtaatg gtggtgatag aacctactat     180

ccagacactg taaagggccg attcaccatc tccagagacg atgccaagaa caccctgttc     240

ctgcaaatga gcagtctgaa gtctgaggac acggccatgt attactgtgc aagacataat     300

attactacgg ttccctttac tatggactac tggggtcaag gaacctcagt caccgtctcc     360

tca                                                                   363


<210> 11
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> VH-CDR1

<400> 11
Gly Phe Thr Phe Ser Thr Tyr Thr 
1               5               

<210> 12
<211> 8
<212> PRT
<213> Homo sapiens


<220> 
<223> VH-CDR2

<400> 12
Ile Ser Asn Gly Gly Asp Arg Thr 
1               5               

<210> 13
<211> 14
<212> PRT
<213> Homo sapiens


<220> 
<223> VH-CDR3

<400> 13
Ala Arg His Asn Ile Thr Thr Val Pro Phe Thr Met Asp Tyr 
1               5                   10                  

<210> 14
<211> 121
<212> PRT
<213> Homo sapiens


<220> 
<223> VH amino acid sequence

<400> 14
Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Asn Gly Gly Asp Arg Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Asn Ile Thr Thr Val Pro Phe Thr Met Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     

<210> 15
<211> 193
<212> PRT
<213> Homo sapiens


<220> 
<223> EPO amino acid sequence (N-terminal signal peptide + protein
      chain) aa 1-193

<400> 15
Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      
Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          
Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              
Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  
Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  
Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      
Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         
Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             
Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 
Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 
Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     
Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         
Arg 
    

<210> 16
<211> 166
<212> PRT
<213> Homo sapiens


<220> 
<223> EPO mature peptide amino acid sequence (aa 28-193)

<400> 16
Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      
Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          
Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              
Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  
Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  
Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      
Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         
Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             
Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 
Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 
Cys Arg Thr Gly Asp Arg 
                165     

<210> 17
<211> 2901
<212> DNA
<213> Homo sapiens


<220> 
<223> EPO gene sequence

<400> 17
cccggagccg gaccggggcc accgcgcccg ctctgctccg acaccgcgcc ccctggacag      60

ccgccctctc ctccaggccc gtggggctgg ccctgcaccg ccgagcttcc cgggatgagg     120

gcccccggtg tggtcacccg gcgcgcccca ggtcgctgag ggaccccggc caggcgcgga     180

gatgggggtg cacggtgagt actcgcgggc tgggcgctcc cgcccgcccg ggtccctgtt     240

tgagcgggga tttagcgccc cggctattgg ccaggaggtg gctgggttca aggaccggcg     300

acttgtcaag gaccccggaa gggggagggg ggtggggcag cctccacgtg ccagcgggga     360

cttgggggag tccttgggga tggcaaaaac ctgacctgtg aaggggacac agtttggggg     420

ttgaggggaa gaaggtttgg gggttctgct gtgccagtgg agaggaagct gataagctga     480

taacctgggc gctggagcca ccacttatct gccagagggg aagcctctgt cacaccagga     540

ttgaagtttg gccggagaag tggatgctgg tagctggggg tggggtgtgc acacggcagc     600

aggattgaat gaaggccagg gaggcagcac ctgagtgctt gcatggttgg ggacaggaag     660

gacgagctgg ggcagagacg tggggatgaa ggaagctgtc cttccacagc cacccttctc     720

cctccccgcc tgactctcag cctggctatc tgttctagaa tgtcctgcct ggctgtggct     780

tctcctgtcc ctgctgtcgc tccctctggg cctcccagtc ctgggcgccc caccacgcct     840

catctgtgac agccgagtcc tggagaggta cctcttggag gccaaggagg ccgagaatat     900

cacggtgaga ccccttcccc agcacattcc acagaactca cgctcagggc ttcagggaac     960

tcctcccaga tccaggaacc tggcacttgg tttggggtgg agttgggaag ctagacactg    1020

cccccctaca taagaataag tctggtggcc ccaaaccata cctggaaact aggcaaggag    1080

caaagccagc agatcctacg gcctgtgggc cagggccaga gccttcaggg acccttgact    1140

ccccgggctg tgtgcatttc agacgggctg tgctgaacac tgcagcttga atgagaatat    1200

cactgtccca gacaccaaag ttaatttcta tgcctggaag aggatggagg tgagttcctt    1260

tttttttttt tttcctttct tttggagaat ctcatttgcg agcctgattt tggatgaaag    1320

ggagaatgat cgagggaaag gtaaaatgga gcagcagaga tgaggctgcc tgggcgcaga    1380

ggctcacgtc tataatccca ggctgagatg gccgagatgg gagaattgct tgagccctgg    1440

agtttcagac caacctaggc agcatagtga gatcccccat ctctacaaac atttaaaaaa    1500

attagtcagg tgaggtggtg catggtggta gtcccagata tttggaaggc tgaggcggga    1560

ggatcgcttg agcccaggaa tttgaggctg cagtgagctg tgatcacacc actgcactcc    1620

agcctcagtg acagagtgag gccctgtctc aaaaaagaaa agaaaaaaga aaaataatga    1680

gggctgtatg gaatacattc attattcatt cactcactca ctcactcact cattcattca    1740

ttcattcatt caacaagtct tattgcatac cttctgtttg ctcagcttgg tgcttggggc    1800

tgctgagggg caggagggag agggtgacat gggtcagctg actcccagag tccactccct    1860

gtaggtcggg cagcaggccg tagaagtctg gcagggcctg gccctgctgt cggaagctgt    1920

cctgcggggc caggccctgt tggtcaactc ttcccagccg tgggagcccc tgcagctgca    1980

tgtggataaa gccgtcagtg gccttcgcag cctcaccact ctgcttcggg ctctgggagc    2040

ccaggtgagt aggagcggac acttctgctt gccctttctg taagaagggg agaagggtct    2100

tgctaaggag tacaggaact gtccgtattc cttccctttc tgtggcactg cagcgacctc    2160

ctgttttctc cttggcagaa ggaagccatc tcccctccag atgcggcctc agctgctcca    2220

ctccgaacaa tcactgctga cactttccgc aaactcttcc gagtctactc caatttcctc    2280

cggggaaagc tgaagctgta cacaggggag gcctgcagga caggggacag atgaccaggt    2340

gtgtccacct gggcatatcc accacctccc tcaccaacat tgcttgtgcc acaccctccc    2400

ccgccactcc tgaaccccgt cgaggggctc tcagctcagc gccagcctgt cccatggaca    2460

ctccagtgcc agcaatgaca tctcaggggc cagaggaact gtccagagag caactctgag    2520

atctaaggat gtcacagggc caacttgagg gcccagagca ggaagcattc agagagcagc    2580

tttaaactca gggacagagc catgctggga agacgcctga gctcactcgg caccctgcaa    2640

aatttgatgc caggacacgc tttggaggcg atttacctgt tttcgcacct accatcaggg    2700

acaggatgac ctggataact taggtggcaa gctgtgactt ctccaggtct cacgggcatg    2760

ggcactccct tggtggcaag agcccccttg acaccggggt ggtgggaacc atgaagacag    2820

gatgggggct ggcctctggc tctcatgggg tccaagtttt gtgtattctt caacctcatt    2880

gacaagaact gaaaccacca a                                              2901


