﻿                         序列表

<110>  南京蓝盾生物科技有限公司

<120>  一种靶向mesothelin的嵌合抗原受体及其应用

<160>  9

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  123
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Thr Pro Glu Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Ala Tyr Ile Tyr Asn Ser Gly Thr Thr Lys Phe Asn Pro Ser 
    50                  55                  60                  
Leu Lys Gly Arg Val Thr Ile Ser Met Asp Ala Ser Lys Asn Gln Leu 
65                  70                  75                  80  
Ser Met Lys Leu Ser Ser Val Thr Ser Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      
Cys Ala Arg Asp Gln Gly Asn Ser Pro Tyr Pro Asp Ala Phe Asp Val 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  2
<211>  110
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      
Asn Asn Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 

<210>  3
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Arg Arg Gln Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  
Arg Arg Gly Gln Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         

<210>  4
<211>  21
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro 
            20      

<210>  5
<211>  45
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  

<210>  6
<211>  24
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      
Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  

<210>  7
<211>  41
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          
Pro Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40      

<210>  8
<211>  491
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          
Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
        35                  40                  45              
Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Thr Pro 
    50                  55                  60                  
Glu Lys Gly Leu Glu Trp Ile Ala Tyr Ile Tyr Asn Ser Gly Thr Thr 
65                  70                  75                  80  
Lys Phe Asn Pro Ser Leu Lys Gly Arg Val Thr Ile Ser Met Asp Ala 
                85                  90                  95      
Ser Lys Asn Gln Leu Ser Met Lys Leu Ser Ser Val Thr Ser Ala Asp 
            100                 105                 110         
Thr Ala Val Tyr Phe Cys Ala Arg Asp Gln Gly Asn Ser Pro Tyr Pro 
        115                 120                 125             
Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 
Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln Ser 
                165                 170                 175     
Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn 
            180                 185                 190         
Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met 
        195                 200                 205             
Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 
Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln 
225                 230                 235                 240 
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn 
                245                 250                 255     
Asn Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Thr Thr Thr 
            260                 265                 270         
Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             
Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 
His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 
Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     
Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             
Arg Phe Pro Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Gln Asn 
            420                 425                 430         
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Gln Gly 
    450                 455                 460                 
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     

<210>  9
<211>  1473
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  9
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgcccgc        60
ccccagctgc agctgcagga gagcggcccc ggcctggtga agcccagcga gaccctgagc       120
ctgacctgca ccgtgagcgg cggcagcatc agcagcagca gctactactg gggctggatc       180
cgccagaccc ccgagaaggg cctggagtgg atcgcctaca tctacaacag cggcaccacc       240
aagttcaacc ccagcctgaa gggccgcgtg accatcagca tggacgccag caagaaccag       300
ctgagcatga agctgagcag cgtgaccagc gccgacaccg ccgtgtactt ctgcgcccgc       360
gaccagggca acagccccta ccccgacgcc ttcgacgtgt ggggccaggg caccctggtg       420
accgtgagca gcggcggcgg cggcagcggc ggcggcggca gcggcggcgg cggcagccag       480
agcgccctga cccagccccc cagcgccagc ggcagccccg gccagagcgt gaccatcagc       540
tgcaccggca ccagcagcga cgtgggcggc tacaactacg tgagctggta ccagcagcac       600
cccggcaagg cccccaagct gatgatctac gaggtgagca agcgccccag cggcgtgccc       660
gaccgcttca gcggcagcaa gagcggcaac accgccagcc tgaccgtgag cggcctgcag       720
gccgaggacg aggccgacta ctactgcagc agctacgccg gcagcaacaa ctacgtgttc       780
ggcaccggca ccaaggtgac cgtgctgacc accacccccg ccccccgccc ccccaccccc       840
gcccccacca tcgccagcca gcccctgagc ctgcgccccg aggcctgccg ccccgccgcc       900
ggcggcgccg tgcacacccg cggcctggac ttcgcctgcg acatctacat ctgggccccc       960
ctggccggca cctgcggcgt gctgctgctg agcctggtga tcaccctgta ctgcaagcgc      1020
ggccgcaaga agctgctgta catcttcaag cagcccttca tgcgccccgt gcagaccacc      1080
caggaggagg acggctgcag ctgccgcttc cccgaggagg agggcggctg cgagctgcgc      1140
gtgaagttca gccgcagcgc cgacgccccc gcctaccagc agggccagaa ccagctgtac      1200
aacgagctga acctgggccg ccgcgaggag tacgacgtgc tggacaagcg ccgcggccgc      1260
gaccccgaga tgggcggcaa gccccgccgc cagaaccccc aggagggcct gtacaacgag      1320
ctgcagaagg acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcgccgc      1380
cgcggccagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa ggacacctac      1440
gacgccctgc acatgcaggc cctgcccccc cgc                                   1473

