                         SEQUENCE LISTING

<110>  Intervet International BV
 
<120>  A vaccine for protection against streptococcus suis of various 
       serotypes

<130>  25273 25274 25279

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1141
<212>  PRT
<213>  Streptococcus suis

<400>  1

Met Asn Ile Gln Glu Arg Phe Ser Leu Arg Lys Ser Ala Val Gly Leu 
1               5                   10                  15      


Val Ser Val Ser Leu Leu Cys Ala Ile Tyr Thr Ser Thr Val Ala Ala 
            20                  25                  30          


Asp Thr Val Val Thr Gly Val Asn Glu Ile Ile Glu Glu Ser Gln Val 
        35                  40                  45              


Lys Asp Glu Val Ser Ile Glu Ser Glu Lys Asn Glu Ser Leu Asp Gly 
    50                  55                  60                  


Ser Asn Ile Glu Ile Val Glu Glu Ile Ala Asp Asn Ile Pro Ser Pro 
65                  70                  75                  80  


Val Ile Ala Glu Gly Glu Val Ala Val Glu Met Lys Val Asp Arg Gly 
                85                  90                  95      


Thr Glu Asn Val Val Ser Arg Asn Asp Thr Glu Val Thr Thr Ser Glu 
            100                 105                 110         


Gln Asn Gln Ile Glu Val Thr Glu Thr Lys Glu Ile Leu Asn Gln Thr 
        115                 120                 125             


Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg Gln Ile Ile Trp Ala His 
    130                 135                 140                 


Gly Ile Thr Pro Pro Ala Met Glu Gln Ser Gly Gly Phe Val Lys Glu 
145                 150                 155                 160 


Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala Pro Phe Glu Ala Gly Lys 
                165                 170                 175     


Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn Ala Ser Phe Ile Asp Leu 
            180                 185                 190         


Asn Leu Cys Phe Ala Ala Val Ser Ser Asn Met Val His Trp Trp Leu 
        195                 200                 205             


Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr Leu Lys Glu Lys Lys Gly 
    210                 215                 220                 


Thr Val Asn Val Glu Glu Asn Tyr Ala Ile Thr Asp Leu Arg Arg Tyr 
225                 230                 235                 240 


Ile Asn Ser Phe Gln Asn Gln Gln Asn Ser Arg Val Phe Asp Met Phe 
                245                 250                 255     


Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly Phe Val Ser Asp Ala Leu 
            260                 265                 270         


Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro Lys Ala Gln Gly Gly Val 
        275                 280                 285             


Asn Leu Glu Asp Ser Gln Leu Val Pro Asp Ser Arg Gly Gly Phe Phe 
    290                 295                 300                 


Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr Asn Arg Ile Phe Ser Gly 
305                 310                 315                 320 


Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg Thr Val Leu Glu Ser Lys 
                325                 330                 335     


Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu Gly Tyr Ala Thr His Ile 
            340                 345                 350         


Val Thr Val Trp Gly Ala Glu Tyr Asp Asn Gln Gly Lys Ile Lys Ala 
        355                 360                 365             


Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln Glu Gln Ile Gly Leu Lys 
    370                 375                 380                 


Arg Met Gly Ile Thr Arg Asp Ala Ser Gly Asn Pro Arg Leu Asn Asn 
385                 390                 395                 400 


His Met Lys Asn Asn Ser Ala Gly Ala Leu Leu Asp Tyr Val His Thr 
                405                 410                 415     


Ile Arg Leu Gly Gln Asp Leu Trp Glu Glu Tyr Phe Asn Pro Leu Ala 
            420                 425                 430         


Lys Ala Lys Glu Thr Ala Ser Gln Thr Leu Ala Asp Thr Lys Lys Ala 
        435                 440                 445             


Leu Asp Leu Ser Ile Gln Gly Gln Ser Glu Leu Pro Glu Ser Met Arg 
    450                 455                 460                 


Leu Ile Tyr Leu Glu Lys Leu Asn Asn Leu Tyr Asn Gln Gly Ile Leu 
465                 470                 475                 480 


Ser Ile Gln Lys Ala Glu Ser Ser Glu Met Leu Ser Gly Ala Leu Glu 
                485                 490                 495     


Asn Gly Leu Asn Ser Leu Lys Ser Leu Asp Phe Pro Ile Ser Glu Val 
            500                 505                 510         


Gly Asn Ala Leu Ala Pro Asp Leu Pro Val Gly Asp Arg Ser Thr Val 
        515                 520                 525             


Ser Asp Val Asp Ser Leu Ser Ser Gln Glu Thr Ser Ser Thr Asn Leu 
    530                 535                 540                 


Glu Ala Asp Thr Glu Asn Ala Gly Ile Ile Ala Asp Gly Thr Asn Gln 
545                 550                 555                 560 


Leu His Phe Pro Val Glu Ala Gln Thr Thr Ser Ser Val Glu Ala Glu 
                565                 570                 575     


Gly Asp Asn Val Phe Glu Gln Glu Ala Asp Thr Leu Pro Ile Ile Ile 
            580                 585                 590         


Glu Asn Lys Asp Glu Phe Gly Ser Glu Leu Ser Arg Asn Met Gln Thr 
        595                 600                 605             


Ser Glu Thr Asp Ser Leu Val Val Ala Val Glu Glu Asp Val Lys Asn 
    610                 615                 620                 


Asp Glu Val Ala Gln Val Glu Glu Leu Leu Glu Ser Glu Lys Val Glu 
625                 630                 635                 640 


Asn Gln Ser Ser Glu Leu Leu Ser Asp Thr Leu Ile Val Glu Ser Ala 
                645                 650                 655     


Asn Asp Lys Glu Glu Asp Arg Val Glu Ala Val Val Ser Glu Gln Pro 
            660                 665                 670         


Asp Ser Ile Pro His Gln Asn Val Glu Ile Ser Leu Val Glu Pro Thr 
        675                 680                 685             


Asn Val Glu Thr Glu Thr Val Val Thr Pro Ile Asn Asp Ala Ala Thr 
    690                 695                 700                 


Pro His Gly Ser Pro Thr Tyr Ile Asp Asn Ser Val Thr Glu Ser Val 
705                 710                 715                 720 


Ala Thr Pro Leu Glu Lys Asp Ser Ile Gln Ala Gly Glu Thr Glu Ile 
                725                 730                 735     


Ala Glu Pro Thr Ser Ser Glu Ser Thr Asn Val Glu Thr Glu Thr Val 
            740                 745                 750         


Val Thr Pro Val Asn Asp Val Ala Thr Pro His Gly Ser Pro Thr Tyr 
        755                 760                 765             


Ile Asp Asn Ser Val Thr Glu Ser Val Ala Thr Pro Leu Glu Lys Asp 
    770                 775                 780                 


Ser Ile Gln Ala Gly Glu Thr Glu Ile Ala Glu Pro Thr Ser Ser Glu 
785                 790                 795                 800 


Ser Thr Asn Val Glu Thr Glu Thr Val Val Thr Pro Val Asn Asp Val 
                805                 810                 815     


Ala Thr Pro His Gly Ser Pro Thr Tyr Ile Asp Asn Ser Val Thr Glu 
            820                 825                 830         


Ser Val Ala Thr Pro Leu Glu Lys Asp Ser Ile Gln Ala Gly Glu Thr 
        835                 840                 845             


Glu Ile Ala Glu Pro Thr Ser Ser Glu Ser Thr Ser Val Glu Ala Glu 
    850                 855                 860                 


Leu Val Asp Asn Ser Glu Ile His Ala Ala Thr Ser Ser Val Thr Pro 
865                 870                 875                 880 


Cys Gly Ser Ser Ala Tyr Ala Asp Gly Ser Thr Thr Glu Ser Val Ala 
                885                 890                 895     


Thr Pro Leu Glu Lys Asp Ser Ile Gln Thr Gly Asn Thr Glu Ile Ala 
            900                 905                 910         


Glu Pro Thr Ser Ser Lys Ser Thr Asn Val Glu Ala Ala Ser Val Asp 
        915                 920                 925             


Asn Ser Glu Ile His Ala Asp Ala Ser Leu Thr Ala Val Ser Ser Val 
    930                 935                 940                 


Asn Leu Asp Asn Pro Val Ile Glu Pro Val Ala Ile Ser Leu Ile Gly 
945                 950                 955                 960 


Ser Lys Arg Asp Thr Asn Ala Glu Val Glu Val Ser Ser Leu Ser Lys 
                965                 970                 975     


Arg Glu Val Arg Lys Thr Asn Thr Asp Gly Leu Ile Ser Val Gln Ser 
            980                 985                 990         


Lys Val Ile Lys Lys Glu Leu Leu  Glu Ser Ser Leu Ala  Glu Ala Gly 
        995                 1000                 1005             


Ser Pro  Leu Leu Glu Ala Thr  Ile Ala Gln Ser Ser  Asn Ser Asn 
    1010                 1015                 1020             


Ser Thr  Glu Ile Gly Met Ser  Tyr Gln Asn Thr Val  Leu Leu Glu 
    1025                 1030                 1035             


Ser Asn  Asn Thr Glu Arg Gln  Val Ser Lys Ala Glu  Ile Val Met 
    1040                 1045                 1050             


Glu His  Lys Glu Thr Glu Leu  Val Glu Thr Val Ser  Ser Ala Ser 
    1055                 1060                 1065             


Glu Pro  Val Val Leu Val Glu  Asn Ile Ser Gln Thr  Ser Asn Asn 
    1070                 1075                 1080             


Thr Ile  Glu Ser Gly Lys Asn  Met Gly Val Gln Ser  Gln Ala Gly 
    1085                 1090                 1095             


Ala Lys  Gln Ile Leu Gly Val  Glu Gln Ser Ser Lys  Val Ser Thr 
    1100                 1105                 1110             


Pro Thr  Ser Arg Gln Ile Met  Gly Val Gly Leu Leu  Thr Leu Val 
    1115                 1120                 1125             


Leu Gly  Ser Ala Leu Gly Leu  Leu Lys Lys Arg Arg  Lys 
    1130                 1135                 1140     


<210>  2
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified IgM protease of Streptococcus suis serotype 7, without 
       signal sequence and 25 aa tail, but with His-tag

<400>  2

Met Asp Thr Val Val Thr Gly Val Asn Glu Ile Ile Glu Glu Ser Gln 
1               5                   10                  15      


Val Lys Asp Glu Val Ser Ile Glu Ser Glu Lys Asn Glu Ser Leu Asp 
            20                  25                  30          


Gly Ser Asn Ile Glu Ile Val Glu Glu Ile Ala Asp Asn Ile Pro Ser 
        35                  40                  45              


Pro Val Ile Ala Glu Gly Glu Val Ala Val Glu Met Lys Val Asp Arg 
    50                  55                  60                  


Gly Thr Glu Asn Val Val Ser Arg Asn Asp Thr Glu Val Thr Thr Ser 
65                  70                  75                  80  


Glu Gln Asn Gln Ile Glu Val Thr Glu Thr Lys Glu Ile Leu Asn Gln 
                85                  90                  95      


Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg Gln Ile Ile Trp Ala 
            100                 105                 110         


His Gly Ile Thr Pro Pro Ala Met Glu Gln Ser Gly Gly Phe Val Lys 
        115                 120                 125             


Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala Pro Phe Lys Ala Gly 
    130                 135                 140                 


Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn Ala Ser Phe Ile Asp 
145                 150                 155                 160 


Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn Met Val His Trp Trp 
                165                 170                 175     


Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr Leu Lys Glu Lys Lys 
            180                 185                 190         


Gly Thr Val Asn Val Gly Glu Asn Tyr Ala Ile Thr Asp Leu Arg Arg 
        195                 200                 205             


Tyr Ile Asp Ser Phe Gln Asp Gln Gln Asn Ser Arg Val Phe Asp Met 
    210                 215                 220                 


Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly Phe Val Ser Asp Ala 
225                 230                 235                 240 


Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro Lys Val Gln Gly Gly 
                245                 250                 255     


Val Asn Leu Glu Asp Ser Gln Leu Val Pro Asp Ser Arg Gly Gly Phe 
            260                 265                 270         


Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr Asn Arg Ile Phe Ser 
        275                 280                 285             


Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg Thr Val Leu Glu Ser 
    290                 295                 300                 


Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu Gly Tyr Ala Thr His 
305                 310                 315                 320 


Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn Gln Gly Lys Ile Arg 
                325                 330                 335     


Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln Glu Gln Ile Gly Leu 
            340                 345                 350         


Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly Asn Pro Arg Leu Asn 
        355                 360                 365             


Asn His Val Lys Asn Asn Ser Ala Gly Ala Leu Leu Asp Tyr Val His 
    370                 375                 380                 


Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu Glu Tyr Phe Asn Pro Phe 
385                 390                 395                 400 


Ala Lys Ala Lys Glu Ile Ala Ser Gln Ile Leu Ala Asp Arg Lys Lys 
                405                 410                 415     


Ala Leu Val Leu Ser Ile Gln Gly Gln Ser Glu Leu Pro Glu Ser Met 
            420                 425                 430         


Arg Leu Ile Tyr Leu Glu Lys Leu Asn Asn Leu Tyr Asn Gln Gly Ile 
        435                 440                 445             


Leu Ser Ile Gln Lys Thr Glu Ser Ser Glu Met Leu Ser Gly Ala Leu 
    450                 455                 460                 


Glu Asn Gly Leu Asn Ser Leu Lys Ser Leu Asp Phe Pro Ile Ser Glu 
465                 470                 475                 480 


Val Gly Asn Ala Leu Ala Pro Asp Leu Ser Val Gly Asp Arg Ser Thr 
                485                 490                 495     


Val Ser Asp Val Asp Ser Leu Ser Ser Gln Glu Thr Ser Ser Thr Asn 
            500                 505                 510         


Leu Glu Ala Asp Thr Glu Asn Ala Gly Ile Ile Ala Asp Gly Thr Asn 
        515                 520                 525             


Gln Leu His Phe Pro Val Glu Ala Gln Thr Thr Ser Ser Val Glu Ala 
    530                 535                 540                 


Glu Gly Asp Asn Val Phe Glu Gln Glu Ala Asp Thr Leu Pro Ile Ile 
545                 550                 555                 560 


Ile Glu Asn Lys Asp Glu Phe Gly Ser Glu Leu Ser Gly Asn Met Gln 
                565                 570                 575     


Thr Ser Glu Thr Asp Ser Leu Val Val Ala Val Glu Glu Asp Val Lys 
            580                 585                 590         


Asn Asp Glu Val Asp Gln Val Glu Lys Leu Leu Glu Ser Glu Lys Val 
        595                 600                 605             


Glu Asn Gln Ser Ser Glu Leu Leu Ser Asp Thr Leu Ile Val Glu Gly 
    610                 615                 620                 


Ala Asn Asp Lys Glu Glu Asp Arg Val Glu Ala Val Val Ser Glu Gln 
625                 630                 635                 640 


Pro Asp Ser Ile Pro His Gln Asn Val Glu Ile Ser Pro Val Glu Pro 
                645                 650                 655     


Met Asn Val Glu Thr Glu Ser Val Val Thr Pro Ile Asn Asp Ala Ala 
            660                 665                 670         


Thr Pro His Gly Phe Pro Met Tyr Ile Asp Asn Ser Val Thr Glu Ser 
        675                 680                 685             


Val Ala Thr Pro Leu Glu Lys Asp Ser Ile Gln Ala Gly Glu Thr Glu 
    690                 695                 700                 


Ile Ala Glu Pro Thr Ser Ser Glu Ser Thr Ser Val Glu Ala Glu Leu 
705                 710                 715                 720 


Val Asp Asn Ser Glu Ile His Ser Ala Thr Ser Ser Val Thr Pro Arg 
                725                 730                 735     


Gly Ser Ser Ala Tyr Ala Asp Ser Ser Thr Thr Glu Ser Val Ala Thr 
            740                 745                 750         


Leu Leu Glu Lys Asp Ser Ile Gln Ala Gly Glu Thr Glu Ile Ala Glu 
        755                 760                 765             


Pro Thr Ser Ser Lys Ser Thr Asn Val Glu Ala Ala Ser Val Asp Asn 
    770                 775                 780                 


Ser Glu Ile His Ala Asp Thr Ser Leu Thr Ala Val Ser Ser Val Asn 
785                 790                 795                 800 


Leu Asp Asn Pro Val Ile Glu Pro Val Ala Ile Pro Leu Ile Gly Ser 
                805                 810                 815     


Lys Arg Asp Thr Asn Ala Glu Val Glu Val Ser Ser Leu Ser Lys Arg 
            820                 825                 830         


Glu Val Arg Lys Pro Asn Thr Glu Gly Leu Ile Ser Val Gln Ser Lys 
        835                 840                 845             


Val Ile Lys Lys Glu Leu Leu Glu Ser Ser Leu Val Glu Ala Gly Ser 
    850                 855                 860                 


Pro Leu Leu Glu Ala Thr Ile Ala Gln Ser Ser Asn Ser Asn Ser Thr 
865                 870                 875                 880 


Glu Ile Gly Met Ser Tyr Gln Asn Thr Val Leu Leu Glu Ser Asn Asn 
                885                 890                 895     


Thr Glu Arg Gln Val Ser Lys Ala Glu Ile Val Ile Glu His Lys Glu 
            900                 905                 910         


Thr Glu Leu Val Glu Thr Val Ser Ser Ala Ser Glu Pro Val Val Leu 
        915                 920                 925             


Val Glu Asn Ile Ser Gln Thr Ser Asn Asn Thr Ile Glu Ser Gly Lys 
    930                 935                 940                 


Asn Met Gly Val Gln Ser Gln Ala Gly Ala Lys Gln Ile Leu Gly Ile 
945                 950                 955                 960 


Glu Gln Ser Ser Lys Val Ser Thr Pro Thr His His His His His His 
                965                 970                 975     


His His His His 
            980 


<210>  3
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified IgM protease of Streptococcus suis serotype 1, without 
       signal sequence and 25 aa tail, but with His-tag

<400>  3

Met Asp Thr Val Thr Thr Arg Glu Asn Leu Thr Ile Glu Glu Leu Gln 
1               5                   10                  15      


Glu Lys Glu Glu Ala Ser Thr Glu Ser Glu Lys Leu Gly Ser Leu Asp 
            20                  25                  30          


Asp Ser Ser Ser Glu Ile Val Glu Lys Val Val Asp Asn Ile Pro Ser 
        35                  40                  45              


Ser Ile Gly Ala Glu Arg Asp Gly Ala Val Glu Met Lys Val Asp Arg 
    50                  55                  60                  


Gly Thr Glu Asn Val Val Ser Arg Asn Asp Thr Glu Val Thr Thr Ser 
65                  70                  75                  80  


Glu Gln Asn Gln Ile Glu Val Thr Glu Thr Lys Glu Ile Leu Asn Gln 
                85                  90                  95      


Thr Ser Tyr Gln Thr Glu Ser Gly Glu Gln Arg Gln Ile Val Trp Ala 
            100                 105                 110         


Tyr Gly Ile Thr Pro Pro Val Met Glu Gln Lys Gly Gly Phe Val Lys 
        115                 120                 125             


Glu Lys Tyr Gly Asp Tyr Leu Asn Tyr Thr Ala Pro Phe Glu Ala Gly 
    130                 135                 140                 


Lys Gly Tyr Tyr Asp Thr Asn Lys Ser Leu Asn Ala Ser Phe Ile Asp 
145                 150                 155                 160 


Leu Asn Leu Cys Phe Ala Ala Val Ser Ser Asn Met Val His Trp Trp 
                165                 170                 175     


Leu Glu Gln Asn Ser Ser Tyr Val Glu Arg Tyr Leu Lys Glu Lys Lys 
            180                 185                 190         


Gly Ile Val Asn Val Glu Glu Asn Tyr Ala Ile Thr Asp Ile Arg Arg 
        195                 200                 205             


Tyr Ile Asn Ser Phe Gln Asn Gln Gln Asn Ser Arg Val Phe Asp Met 
    210                 215                 220                 


Phe Lys Thr Tyr Tyr Gly Tyr Arg Thr Asn Gly Phe Val Ser Asp Ala 
225                 230                 235                 240 


Leu Val Asp Leu Phe Ile Asn Gly Tyr Lys Pro Lys Ala Gln Gly Gly 
                245                 250                 255     


Val Asn Leu Glu Asp Ser His Leu Val Pro Asp Ser Arg Gly Gly Phe 
            260                 265                 270         


Phe Tyr Asp Val Phe Lys Glu Lys Lys Leu Thr Asn Arg Ile Phe Ser 
        275                 280                 285             


Gly Ser Tyr Glu Arg Phe Gly Glu Asp Val Arg Thr Val Leu Glu Ser 
    290                 295                 300                 


Lys Gly Leu Leu Gly Leu Thr Tyr Arg Thr Leu Gly Tyr Ala Thr His 
305                 310                 315                 320 


Ile Val Thr Val Trp Gly Ala Glu Tyr Asp Asn Gln Gly Lys Ile Arg 
                325                 330                 335     


Ala Val Tyr Ile Thr Asp Ser Asp Asp Gln Gln Glu Gln Ile Gly Leu 
            340                 345                 350         


Lys Arg Met Gly Ile Thr Arg Asp Ala Ser Gly Asn Pro Arg Leu Asn 
        355                 360                 365             


Asn His Val Lys Asn Asn Ser Ala Gly Ala Leu Leu Asp Tyr Val His 
    370                 375                 380                 


Thr Ile Arg Leu Gly Gln Asp Leu Trp Glu Glu Tyr Phe Asn Pro Leu 
385                 390                 395                 400 


Ala Lys Ser Lys Glu Ile Ala Ser Gln Thr Leu Ala Asp Thr Lys Lys 
                405                 410                 415     


Ala Leu Asp Leu Ser Ile Gln Gly Gln Ser Glu Leu Pro Glu Ser Met 
            420                 425                 430         


Arg Leu Ile Tyr Leu Glu Lys Leu Asn Asn Leu Tyr Asn Gln Gly Ile 
        435                 440                 445             


Leu Ser Ile Gln Lys Ala Glu Ser Ser Glu Met Leu Ser Gly Ala Leu 
    450                 455                 460                 


Glu Asn Gly Leu Asn Ser Leu Lys Ser Leu Asp Phe Pro Ile Ser Glu 
465                 470                 475                 480 


Val Gly Asn Ala Leu Ala Pro Asp Leu Pro Val Gly Asp Arg Ser Thr 
                485                 490                 495     


Val Ser Asp Val Asp Ser Leu Ser Ser Gln Glu Thr Ser Ser Thr Asn 
            500                 505                 510         


Leu Glu Val Asp Thr Glu Asn Ala Gly Leu Ile Ala Asp Gly Ala Asp 
        515                 520                 525             


Gln Leu His Phe Pro Val Glu Val Gln Thr Thr Ser Phe Val Glu Ala 
    530                 535                 540                 


Glu Gly Asp Asn Val Phe Glu Gln Glu Ala Asp Thr Leu Pro Ile Ile 
545                 550                 555                 560 


Ile Glu Asn Lys Asp Glu Phe Gly Ser Glu Leu Ser Arg Asn Met Gln 
                565                 570                 575     


Thr Ser Glu Thr Asp Ser Leu Val Val Ala Val Glu Glu Asp Val Lys 
            580                 585                 590         


Asn Asp Glu Val Ala Gln Val Glu Glu Leu Leu Glu Leu Glu Lys Val 
        595                 600                 605             


Glu Asn Gln Ser Ser Glu Leu Leu Ser Asp Thr Leu Ile Val Glu Gly 
    610                 615                 620                 


Ala Asn Asp Lys Glu Glu Asp Arg Val Glu Ala Val Val Ser Glu Gln 
625                 630                 635                 640 


Pro Asp Ser Ile Pro His Gln Asn Val Glu Ile Ser Leu Val Glu Pro 
                645                 650                 655     


Thr Asn Val Glu Thr Glu Ser Val Val Thr Pro Ile Asn Asp Val Ala 
            660                 665                 670         


Thr Pro His Gly Ser Pro Thr Tyr Ile Asp Asn Ser Val Thr Glu Ser 
        675                 680                 685             


Val Ala Thr Pro Leu Glu Lys Asp Ser Ile Gln Ala Gly Glu Thr Glu 
    690                 695                 700                 


Asn Ala Glu Pro Thr Ser Ser Glu Ser Thr Ser Val Glu Ala Glu Leu 
705                 710                 715                 720 


Val Asp Asn Ser Glu Ile His Ala Ala Thr Ser Ser Val Thr Pro Cys 
                725                 730                 735     


Gly Ser Ser Ala Tyr Ala Asp Ser Ser Ala Thr Glu Ser Val Ala Thr 
            740                 745                 750         


Pro Leu Glu Lys Asp Ser Ile Gln Thr Gly Asn Thr Glu Ile Ala Glu 
        755                 760                 765             


Pro Thr Ser Ser Lys Ser Thr Asn Val Glu Ala Ala Ser Val Asp Asn 
    770                 775                 780                 


Ser Glu Ile His Ala Asp Ala Ser Leu Thr Ala Val Ser Ser Val Asn 
785                 790                 795                 800 


Leu Asp Asn Pro Val Ile Glu Pro Val Ala Ile Ser Leu Ile Gly Ser 
                805                 810                 815     


Lys Arg Asp Thr Asn Ala Glu Val Glu Val Ser Ser Leu Ser Lys Arg 
            820                 825                 830         


Glu Val Arg Lys Pro Asn Thr Asp Gly Leu Ile Ser Val Gln Ser Lys 
        835                 840                 845             


Val Ile Lys Lys Glu Leu Leu Glu Ser Ser Leu Val Glu Ala Gly Ser 
    850                 855                 860                 


Pro Leu Leu Glu Ala Thr Ile Ala Gln Ser Ser Asn Ser Asn Ser Thr 
865                 870                 875                 880 


Glu Ile Gly Met Ser Tyr Gln Asn Thr Val Leu Leu Glu Ser Asn Asn 
                885                 890                 895     


Thr Glu Arg Gln Val Ser Lys Ala Glu Ile Val Met Glu His Lys Glu 
            900                 905                 910         


Thr Glu Leu Val Glu Thr Val Ser Ser Ala Ser Glu Pro Val Val Leu 
        915                 920                 925             


Val Glu Asn Ile Ser Gln Thr Ser Asn Asn Thr Ile Glu Ser Gly Lys 
    930                 935                 940                 


Asn Met Gly Val Gln Ser Gln Ala Gly Ala Lys Gln Ile Leu Gly Val 
945                 950                 955                 960 


Glu Gln Ser Ser Lys Val Ser Thr Pro Thr His His His His His His 
                965                 970                 975     


His His His His 
            980 


