б
<110>йѧԺŴ뷢ѧо
<120>poly(A)βͷAڴٽmRNAеӦ
<160>  8     
<170>PatentIn version 3.5
<210>  1
<211>  2538
<212>  DNA
<213>  ߳棨Caenorhabditis Elegans
<400>  1
atgaatgaagacagcagattatcatcatcacaacaaccgtcaacgtcgacacctcgttca       60
tcgattccttcgactatgaattcggatgaaccaaatacgtgtcgccgtcttagtcagtcc      120
caggaacagccatcaacgtccagaacttgcaaaagtgaaactccagagtttggatatagt      180
gattcattgccgttcgccccatggcgaaggaaacggtacggactgaatattcaaggactg      240
cacgaggaaattgtcgatatgtatcattggataaaaccgaacgagatagagtcgcgactt      300
cgaacgaaggtctttgagaaggtccgcgattctgtgttacggcgatggaaacagaaaaca      360
ataaaaatctcaatgtttggaagtcttagaacgaatctcttcttacctacttcggatatt      420
gacgttctcgttgaatgcgatgattgggttggaacacctggagattggcttgctgaaaca      480
gcacgtggacttgaagcggacaatattgcggagtcggtgatggtctatggaggagcattt      540
gtgcctattgtgaaaatggtggatagagatactcgattgagcattgatatttcattcaat      600
acagttcaaggagtacgagcagcttcatacattgcaaaggtgaaagaagagtttccatta      660
atagaaccacttgttctcctgctcaaacaattccttcattaccgtaatctcaatcaaaca      720
ttcaccggaggtctatcctcctatggactcgtccttttgctcgttaactttttccagctt      780
tacgccctaaacatgcgaagtcgaacaatttacgaccgaggagtcaatctaggacactta      840
ttgcttcgtttcctcgagctgtattctttagagttcaactttgaagaaatgggaatatca      900
cctggacaatgttgctatattccaaagtcggctagcggagcaagatacggtcacaagcag      960
gctcaaccagggaatctagcattggaagatccattacttactgcaaatgatgtcggtaga     1020
tctacatacaacttttcttcaatagccaatgcctttgggcaagcttttcaaatattactt     1080
gttgccgtcacattacgcgagcgaaaagggaaaaatcatgtggctatgagagcttacaaa     1140
ggatctcttctccatctcattatgccattcacatcaaaagagctcacatatcgtaactgg     1200
ttaatgagtggtgtgttatcaatgcctggccaagaagcaccggcatcgtatgacttaaat     1260
caattgcataacactttggtttctccgatggtcgatctttcacgatacgcttggcttaga     1320
aaagcaccagcgaaggcagaaaagcgggattctcgacctctgacgattgtaaatccagca     1380
gatgatcgtcaaactcttgcccaacagttgaagaagcagattctggaacaaactgaagca     1440
aagaaatcgttagaaaaaatgccggcttgtgatgacaacaaaaaagaagaggaattggtt     1500
gcaacaagagaaactgatgttgaattggaagcagaagatactgaatcagaaggtcatcat     1560
aatggtgaaaatgatttgattcttactggaccacctctaccaacgtctacacaatccgtc     1620
aatacatctgccacagtatctactgcagcgagtatttcggagcgagaagacactgattca     1680
ccaggactgtcttcgtcaatgggaaatcaatcttcagaagaagatgaggataacggaatt     1740
aataatcgaaacaattctgctgttcctgttcaattcaagaaacccttcaatgaagttgtt     1800
gcccagccagcaagagaatcgaagagaacgcagacaaccagtgaagacaagatgcaagat     1860
caattccatttcaatggatactcatatcctccaccctcacgatatgcagcaggtaccgcg     1920
gcaccatcacacaaacatcgtaatgcgcacccgcaacggcagcgtccttcaattcgtaat     1980
ctttcacaaggctctgatgggtcagatgaatacaatgttgaatcatggaacaacaatata     2040
agacaaggaagaagagcctcgtcgaattcaccaagtccatccagacagcagacgaatact     2100
agaaattgtggacccactaataatattccctacgattcatttcgctcacaaaacaagaat     2160
tcgacgttagatggttcgaataattcatcagaagagccaataacaatgtatgccgatgtt     2220
gttaaaaagaagtcttcgattacaacatcaaccaatacttccactgcagatgtcaacgtc     2280
accaatggaaatccaatacccgcaaatggaataattccacaatctatggccgtggtcaac     2340
gttggaagaggatcctatagaaatgctcttacaacttcccccatgacgcctccatcagca     2400
catacttcaatgcagaagcaacatcatttgcgtaaagataacgaatgtggtttcgacaac     2460
aactcagccacttcttctactgatttaagccatcatcaaccacaattggttccaccggtg     2520
aatcgtctgcagcgatag                                                   2538
<210>  2
<211>  845
<212>  PRT
<213>  ߳棨Caenorhabditis Elegans
<400>  2
Met Asn Glu Asp Ser Arg Leu Ser SerSer Gln Gln Pro Ser Thr Ser 
1               5                   10                  15      
Thr Pro Arg Ser Ser Ile Pro Ser Thr Met Asn Ser Asp Glu Pro Asn
            20                  25                  30          
Thr Cys Arg Arg Leu Ser Gln Ser Gln Glu Gln Pro Ser Thr Ser Arg 
        35                  40                  45              
Thr Cys Lys Ser Glu Thr Pro Glu PheGly Tyr Ser Asp Ser Leu Pro 
    50                  55                  60                  
Phe Ala Pro Trp Arg Arg Lys Arg Tyr Gly Leu Asn Ile Gln Gly Leu 
65                  70                  75                  80  
His Glu Glu Ile Val Asp Met Tyr His Trp Ile Lys Pro Asn Glu Ile 
                85                  90                  95      
Glu Ser Arg Leu Arg Thr Lys Val Phe Glu Lys Val Arg Asp Ser Val 
            100                 105                 110         
Leu Arg ArgTrp Lys Gln Lys Thr Ile Lys Ile Ser Met PheGly Ser 
        115                 120                 125             
Leu Arg ThrAsn Leu Phe Leu Pro Thr Ser Asp Ile Asp Val Leu Val 
    130                 135                 140                 
Glu Cys Asp AspTrp Val GlyThr Pro Gly Asp Trp Leu Ala Glu Thr
145                 150                 155                 160 
Ala Arg Gly Leu Glu Ala Asp Asn Ile Ala Glu Ser Val Met Val Tyr 
                165                 170                 175     
GlyGly Ala Phe Val Pro Ile Val Lys Met Val Asp Arg Asp Thr Arg 
            180                 185                 190         
Leu Ser Ile Asp Ile Ser PheAsnThr Val Gln Gly Val Arg Ala Ala
        195                 200                 205             
Ser Tyr Ile Ala Lys Val Lys Glu GluPhe Pro Leu Ile Glu Pro Leu 
    210                 215                 220                 
Val Leu LeuLeu Lys Gln Phe Leu His Tyr Arg Asn Leu Asn Gln Thr
225                 230                 235                 240 
PheThrGlyGly Leu Ser Ser Tyr Gly Leu Val Leu LeuLeu Val Asn
                245                 250                 255     
PhePhe Gln Leu Tyr Ala Leu Asn Met Arg Ser Arg Thr Ile Tyr Asp 
            260                 265                 270         
Arg Gly Val Asn Leu Gly His Leu LeuLeu Arg Phe Leu Glu Leu Tyr 
        275                 280                 285             
Ser Leu Glu PheAsnPhe Glu Glu Met Gly Ile Ser Pro Gly Gln Cys 
    290                 295                 300                 
Cys Tyr Ile Pro Lys Ser Ala Ser Gly Ala Arg Tyr Gly His Lys Gln 
305                 310                 315                 320 
Ala Gln Pro GlyAsn Leu Ala Leu Glu Asp Pro Leu LeuThr Ala Asn
                325                 330                 335     
Asp Val Gly Arg Ser Thr Tyr AsnPhe Ser Ser Ile Ala Asn Ala Phe
            340                 345                 350         
Gly Gln Ala Phe Gln Ile Leu Leu Val Ala Val Thr Leu Arg Glu Arg 
        355                 360                 365             
Lys Gly Lys Asn His Val Ala Met Arg Ala Tyr Lys Gly Ser Leu Leu
    370                 375                 380                 
His Leu Ile Met Pro PheThr Ser Lys Glu Leu Thr Tyr Arg AsnTrp
385                 390                 395                 400 
Leu Met Ser Gly Val Leu Ser Met Pro Gly Gln Glu Ala Pro Ala Ser 
                405                 410                 415     
Tyr Asp Leu Asn Gln Leu His AsnThr Leu Val Ser Pro Met Val Asp 
            420                 425                 430         
Leu Ser Arg Tyr Ala Trp Leu Arg Lys Ala Pro Ala Lys Ala Glu Lys 
        435                 440                 445             
Arg Asp Ser Arg Pro Leu Thr Ile Val Asn Pro Ala Asp Asp Arg Gln 
    450                 455                 460                 
Thr Leu Ala Gln Gln Leu Lys Lys Gln Ile Leu Glu Gln Thr Glu Ala 
465                 470                 475                 480 
Lys Lys Ser Leu Glu Lys Met Pro Ala Cys Asp AspAsn Lys Lys Glu 
                485                 490                 495     
Glu Glu Leu Val Ala Thr Arg Glu Thr Asp Val Glu Leu Glu Ala Glu 
            500                 505                 510         
Asp Thr Glu Ser Glu Gly His HisAsnGly Glu Asn Asp Leu Ile Leu 
        515                 520                 525             
ThrGly Pro Pro Leu Pro Thr Ser Thr Gln Ser Val AsnThr Ser Ala 
    530                 535                 540                 
Thr Val Ser Thr Ala Ala Ser Ile Ser Glu Arg Glu Asp Thr Asp Ser 
545                 550                 555                 560 
Pro Gly Leu Ser SerSer Met GlyAsn Gln Ser Ser Glu Glu Asp Glu 
                565                 570                 575     
Asp AsnGly Ile AsnAsn Arg AsnAsn Ser Ala Val Pro Val Gln Phe
            580                 585                 590         
Lys Lys Pro PheAsn Glu Val Val Ala Gln Pro Ala Arg Glu Ser Lys 
        595                 600                 605             
Arg Thr Gln ThrThr Ser Glu Asp Lys Met Gln Asp Gln Phe His Phe
    610                 615                 620                 
AsnGly Tyr Ser Tyr Pro ProPro Ser Arg Tyr Ala AlaGlyThr Ala 
625                 630                 635                 640 
Ala Pro Ser His Lys His Arg Asn Ala His Pro Gln Arg Gln Arg Pro 
                645                 650                 655     
Ser Ile Arg Asn Leu Ser Gln Gly Ser Asp Gly Ser Asp Glu Tyr Asn
            660                 665                 670         
Val Glu Ser TrpAsnAsnAsn Ile Arg Gln Gly Arg Arg Ala Ser Ser
        675                 680                 685             
Asn Ser Pro Ser Pro Ser Arg Gln GlnThrAsnThr Arg Asn Cys Gly
    690                 695                 700                 
Pro ThrAsnAsn Ile Pro Tyr Asp Ser Phe Arg Ser Gln Asn Lys Asn
705                 710                 715                 720 
Ser Thr Leu Asp Gly Ser AsnAsn Ser Ser Glu Glu Pro Ile Thr Met 
                725                 730                 735     
Tyr Ala Asp Val Val Lys LysLys Ser Ser Ile ThrThr Ser ThrAsn
            740                 745                 750         
Thr Ser Thr Ala Asp Val Asn Val ThrAsnGlyAsn Pro Ile Pro Ala 
        755                 760                 765             
AsnGly Ile Ile Pro Gln Ser Met Ala Val ValAsn Val Gly Arg Gly
    770                 775                 780                 
Ser Tyr Arg Asn Ala Leu ThrThr Ser Pro Met Thr Pro Pro Ser Ala 
785                 790                 795                 800 
His Thr Ser Met Gln Lys Gln His His Leu Arg Lys Asp Asn Glu Cys 
                805                 810                 815     
GlyPhe Asp AsnAsn Ser Ala Thr Ser SerThr Asp Leu Ser His His
            820                 825                 830         
Gln Pro Gln Leu Val Pro Pro Val Asn Arg Leu Gln Arg 
        835                 840                 845 
<210>  3
<211>  98
<212>  RNA
<213>  ˹УArtificial sequence
<400>  3
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa       60
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa                               98
<210>  4
<211>  98
<212>  RNA
<213>  ˹УArtificial sequence
<400>  4
aaaaaaaaaaaaaaaaaaaacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaauaaaaaaa       60
aaaaaaaacaaaaaaaaaaaaaaaaaaaaaaagaaaaa                               98
<210>  5
<211>  98
<212>  RNA
<213>  ˹УArtificial sequence
<400>  5
aaaaaaaaaaaacaaaaaaaaaaaaaaaaaaaagaaaaaaaaaaaaaaaaaaaaaaaaac       60
ccaaaaaaaaaaaaaaaaaaaaaaaaaaaaggaaaaaa                               98
<210>  6
<211>  98
<212>  RNA
<213>  ˹УArtificial sequence
<400>  6
aaaaaaaaaaaaacaaaaaaaaaaaaaaaaaaaggaaaaaaaaaaaaaaaaaaaaaaaaa       60
aaaagaaaaaaaaaaaaaaaaaaaaaaaaaccaaaaaa                               98
<210>  7
<211>  717
<212>  RNA
<213>  ˹УArtificial sequence
<400>  7
auggugagcaagggcgaggagcuguucaccgggguggugcccauccuggucgagcuggac       60
ggcgacguaaacggccacaaguucagcguguccggcgagggcgagggcgaugccaccuac      120
ggcaagcugacccugaaguucaucugcaccaccggcaagcugcccgugcccuggcccacc      180
cucgugaccacccugaccuacggcgugcagugcuucagccgcuaccccgaccacaugaag      240
cagcacgacuucuucaaguccgccaugcccgaaggcuacguccaggagcgcaccaucuuc      300
uucaaggacgacggcaacuacaagacccgcgccgaggugaaguucgagggcgacacccug      360
gugaaccgcaucgagcugaagggcaucgacuucaaggaggacggcaacauccuggggcac      420
aagcuggaguacaacuacaacagccacaacgucuauaucauggccgacaagcagaagaac      480
ggcaucaaggugaacuucaagauccgccacaacaucgaggacggcagcgugcagcucgcc      540
gaccacuaccagcagaacacccccaucggcgacggccccgugcugcugcccgacaaccac      600
uaccugagcacccaguccgcccugagcaaagaccccaacgagaagcgcgaucacaugguc      660
cugcuggaguucgugaccgccgccgggaucacucucggcauggacgagcuguacaag         717
<210>  8
<211>  708
<212>  RNA
<213>  ˹УArtificial sequence
<400>  8
auggugagcaagggcgaggaggauaacauggccaucaucaaggaguucaugcgcuucaag       60
gugcacauggagggcuccgugaacggccacgaguucgagaucgagggcgagggcgagggc      120
cgccccuacgagggcacccagaccgccaagcugaaggugaccaaggguggcccccugccc      180
uucgccugggacauccuguccccucaguucauguacggcuccaaggccuacgugaagcac      240
cccgccgacauccccgacuacuugaagcuguccuuccccgagggcuucaagugggagcgc      300
gugaugaacuucgaggacggcggcguggugaccgugacccaggacuccucccugcaggac      360
ggcgaguucaucuacaaggugaagcugcgcggcaccaacuuccccuccgacggccccgua      420
augcagaagaagaccaugggcugggaggccuccuccgagcggauguaccccgaggacggc      480
gcccugaagggcgagaucaagcagaggcugaagcugaaggacggcggccacuacgacgcu      540
gaggucaagaccaccuacaaggccaagaagcccgugcagcugcccggcgccuacaacguc      600
aacaucaaguuggacaucaccucccacaacgaggacuacaccaucguggaacaguacgaa      660
cgcgccgagggccgccacuccaccggcggcauggacgagcuguacaag                   708
