                         SEQUENCE LISTING

<110>  ڻҩз޹˾
 
<120>  һIL17弰ƱӦ

<130>  P21403427C

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF4 CDR1

<400>  1

Gly Arg Thr Asp Gly Thr Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF5 CDR1

<400>  2

Gly Ser Thr Ile Gly Thr Tyr Ala 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF6 CDR1

<400>  3

Gly Asp Thr Leu Asn Ile Phe Ala 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF1 CDR1

<400>  4

Gly Arg Ser Phe Ser Asp Tyr Ile 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF10 CDR1

<400>  5

Gly Ser Ile Ser Ser Ile Asn Ala 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF2 CDR1

<400>  6

Gly Arg Ser Phe Ser Ser Tyr Ile 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A8 CDR1

<400>  7

Gly Ser Ile Phe Asn Ala His Ala 
1               5               


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A33 CDR1

<400>  8

Gly Ile Ser Thr Ser Phe Phe Ser Ser Gly Ala 
1               5                   10      


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A5 CDR1

<400>  9

Gly Arg Thr Phe Ser Ser Tyr Asp 
1               5               


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A19 CDR1

<400>  10

Gly Ile Ser Arg Ser Phe Phe Asp Ser Thr Ala 
1               5                   10      


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A20 CDR1

<400>  11

Arg Thr Phe Phe Gly Thr His Ala 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A21 CDR1

<400>  12

Glu Asn Ala Phe Val Leu Tyr Ala 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A23 CDR1

<400>  13

Gly Arg Thr Phe Ser Ser His Asp 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A27 CDR1

<400>  14

Thr Ile Leu Phe Ser Ile His Ser 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A28 CDR1

<400>  15

Gly Arg Thr Phe Ser Gly Tyr Asp 
1               5               


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A10 CDR1

<400>  16

Glu Glu Ile Ser Ile Ser Ile Tyr Ser 
1               5                   


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26 CDR1

<400>  17

Glu Ile Val Ile Ser Ile Tyr Ser 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A29 CDR1

<400>  18

Gly Val Met Phe Gly Leu Tyr Ser 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A45 CDR1

<400>  19

Gly Ile His Ile Ser Ile Tyr Ser 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A46 CDR1

<400>  20

Gly Leu Asp Ile Ser Ile Tyr Ser 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59 CDR1

<400>  21

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A53 CDR1

<400>  22

Gly Leu Val Phe Ser Leu Tyr Thr 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A43 CDR1

<400>  23

Gly Asn Ile Phe Asn Ile His Gly 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A39 CDR1

<400>  24

Gly Phe Ala Leu Gly Pro Tyr Ala 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF4 CDR2

<400>  25

Leu Arg Trp Ser Asp Tyr Ile Thr 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF5 CDR2

<400>  26

Val Ser Trp Ser Gly Asp Ile Ala 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF6 CDR2

<400>  27

Ile Arg Trp Asp Asp Gly Ile Thr 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF1 CDR2

<400>  28

Ile Thr Arg Thr Thr Gly Ile Thr 
1               5               


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF10 CDR2

<400>  29

Arg Ser Ser Ser Gly Tyr Thr 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A8 CDR2

<400>  30

Ile Thr Ser Gly Gly Ser Thr 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A33 CDR2

<400>  31

Ile Thr Pro Asp Gly Ile Thr 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A5 CDR2

<400>  32

Ile Arg Ser Gly Gly Ser Thr 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A19 CDR2

<400>  33

Ile Thr Pro Gly Asp Ile Thr 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A20 CDR2

<400>  34

Ile Thr Ser Asp Gly Ser Thr 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A21 CDR2

<400>  35

Ile Thr Arg Gly Gly Asp Ile 
1               5           


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A23 CDR2

<400>  36

Ile Ser Trp Ser Gly Gly Ser Thr 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A28 CDR2

<400>  37

Ile Arg Trp Ser Gly Gly Thr Thr 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A30 CDR2

<400>  38

Ile Ser Trp Ser Gly Gly Arg Ser 
1               5               


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A10 CDR2

<400>  39

Met Thr Thr Arg Gly Ile Thr 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26 CDR2

<400>  40

Met Thr Thr Arg Gly Thr Thr 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A29 CDR2

<400>  41

Ile Thr Arg Thr Gly Thr Thr 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A45 CDR2

<400>  42

Met Ser Arg Leu Gly Thr Thr 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A46 CDR2

<400>  43

Met Ser Arg Arg Gly Thr Thr 
1               5           


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59 CDR2

<400>  44

Ile Ser Ser His Asp Gly Ser Thr 
1               5               


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A53 CDR2

<400>  45

Ile Phe Asp Asp Gly Ser Pro 
1               5           


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A43 CDR2

<400>  46

Thr Ser Gly Gly Ser Thr 
1               5       


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A39 CDR2

<400>  47

Ile Lys Pro Asp Gly Ser Thr 
1               5           


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF4 CDR3

<400>  48

Thr Gln Ser Glu Val Pro Gly Thr Trp Thr Tyr 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF5 CDR3

<400>  49

Thr Gln Ser Val Val Pro Gly Ser Trp Thr Tyr 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF6 CDR3

<400>  50

Ala Thr Gly Pro Thr Pro Gly Ser Trp Ile Tyr 
1               5                   10      


<210>  51
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF1 CDR3

<400>  51

Ala Ala Ser Ser Met Gly Tyr Phe Thr Tyr Ser Ala Ala Arg Val Gln 
1               5                   10                  15      


Ala Lys Tyr Asp Tyr 
            20      


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF10 CDR3

<400>  52

Asn Ala Asp Gly Pro Ser Thr Trp Ile Ala Gly Gly Tyr 
1               5                   10              


<210>  53
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF2 CDR3

<400>  53

Ala Ala Ser Ser Met Gly Tyr Phe Thr Tyr Ser Ala Ala Arg Val Gln 
1               5                   10                  15      


Met Lys Tyr Asp Tyr 
            20      


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A8 CDR3

<400>  54

Asn Ala Asp His Thr Tyr Tyr Ser Asp Ser Ala Leu Lys Asp Phe 
1               5                   10                  15  


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A33 CDR3

<400>  55

Ser Val Gly Gly Thr 
1               5   


<210>  56
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A5 CDR3

<400>  56

Asn Ser Val Leu Glu Tyr Gly His Asn Trp Tyr Ala Ala Asp Gly Ser 
1               5                   10                  15      


Phe Gly Pro 
            


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A20 CDR3

<400>  57

Asn Ala Asp Gly Arg Trp Tyr Glu Leu Asp Tyr 
1               5                   10      


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A21 CDR3

<400>  58

Asn Ala Gly Ser Leu Gly Gly Tyr 
1               5               


<210>  59
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A23 CDR3

<400>  59

Asn Ser Val Leu Glu Tyr Gly Ser Asn Trp Tyr Ala Ala Asp Gly Ser 
1               5                   10                  15      


Phe Gly Ala 
            


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A27 CDR3

<400>  60

Asn Ala Asp Ser Thr Tyr Tyr Asp Asp Phe Leu Pro 
1               5                   10          


<210>  61
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A28 CDR3

<400>  61

Asn Ser Val Leu Glu Tyr Gly Ser Ser Trp Phe Ala Ala Asp Gly Ser 
1               5                   10                  15      


Phe Gly Pro 
            


<210>  62
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A30 CDR3

<400>  62

Asn Ser Val Leu Glu Tyr Gly Ser Ser Trp Tyr Ala Ala Asp Gly Ser 
1               5                   10                  15      


Phe Gly Pro 
            


<210>  63
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A36 CDR3

<400>  63

Asn Ser Val Leu Glu Tyr Gly Ser Ser Trp Phe Ala Ala Asp Gly Ser 
1               5                   10                  15      


Phe Gly Ser 
            


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A10 CDR3

<400>  64

Asn Leu Gly Arg Ser Gly Gly Tyr 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26 CDR3

<400>  65

Asn Leu Gly Gln Ser Gly Gly Leu 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A29 CDR3

<400>  66

Asn Ala Gly Gln Thr Gly Gly Tyr 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A45 CDR3

<400>  67

Asn Leu Gly Gln Ser Gly Glu Leu 
1               5               


<210>  68
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59 CDR3

<400>  68

Ala Arg Gly Thr Ile Leu Leu Phe Lys Ile Cys Val Pro Asp Ala Asn 
1               5                   10                  15      


Glu Tyr Asp Tyr 
            20  


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A53 CDR3

<400>  69

Asn Ala Tyr Arg Pro Phe Pro Ser 
1               5               


<210>  70
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A43 CDR3

<400>  70

Asn Ala Asp Asn Arg Tyr Tyr Glu Val Thr Glu Tyr Asn Tyr 
1               5                   10                  


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A39 CDR3

<400>  71

Asn Ala Gly Gly Ser Gly Gly Ile 
1               5               


<210>  72
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF4 VHH

<400>  72

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Asp Gly Thr Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Leu Leu Arg Trp Ser Asp Tyr Ile Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Ser Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Gln Ser Glu Val Pro Gly Thr Trp Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  73
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF5 VHH

<400>  73

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Gly Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Val Ser Trp Ser Gly Asp Ile Ala Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gln Ser Val Val Pro Gly Ser Trp Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  74
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF6 VHH

<400>  74

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Leu Asn Ile Phe 
            20                  25                  30          


Ala Met Gly Trp Leu Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Leu Ile Arg Trp Asp Asp Gly Ile Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Gly Pro Thr Pro Gly Ser Trp Ile Tyr Tyr Gly Gln Gly Ala 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  75
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF7 VHH

<400>  75

Pro Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Leu Asn Ile Phe 
            20                  25                  30          


Ala Met Gly Trp Leu Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Leu Ile Arg Trp Asp Asp Gly Ile Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Gly Pro Thr Pro Gly Ser Trp Ile Tyr Tyr Gly Gln Gly Ala 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  76
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF1 VHH

<400>  76

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Arg Ser Phe Ser Asp Tyr 
            20                  25                  30          


Ile Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Thr Thr Gly Ile Thr Ala Tyr Glu Asp Ala Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ser Met Gly Tyr Phe Thr Tyr Ser Ala Ala Arg Val Gln 
            100                 105                 110         


Ala Lys Tyr Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  77
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF3 VHH

<400>  77

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Arg Ser Phe Ser Asp Tyr 
            20                  25                  30          


Ile Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Thr Thr Gly Ile Thr Ala Tyr Glu Asp Ala Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ser Met Gly Tyr Phe Thr Tyr Ser Ala Ala Arg Val Gln 
            100                 105                 110         


Ala Lys Tyr Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  78
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF10 VHH

<400>  78

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Gly Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Ala Arg Ser Ser Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Ala Asp Gly Pro Ser Thr Trp Ile Ala Gly Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  79
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AF2 VHH

<400>  79

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Arg Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Thr Thr Gly Ile Thr Ala Tyr Glu Asp Ala Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ser Met Gly Tyr Phe Thr Tyr Ser Ala Ala Arg Val Gln 
            100                 105                 110         


Met Lys Tyr Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  80
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A8 VHH

<400>  80

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ala His 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp His Thr Tyr Tyr Ser Asp Ser Ala Leu Lys Asp Phe Trp Gly 
            100                 105                 110         


Arg Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  81
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A33 VHH

<400>  81

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ser Thr Ser Phe Phe 
            20                  25                  30          


Ser Ser Gly Ala Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Trp Val Ala Ala Ile Thr Pro Asp Gly Ile Thr Asp Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ile Lys Ser 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


His Cys Ser Val Gly Gly Thr Leu Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  82
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A5 VHH

<400>  82

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Ser Gly Gly Ser Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ser Val Leu Glu Tyr Gly His Asn Trp Tyr Ala Ala Asp Gly Ser Phe 
            100                 105                 110         


Gly Pro Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  83
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A19 VHH

<400>  83

His Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ser Arg Ser Phe Phe 
            20                  25                  30          


Asp Ser Thr Ala Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Trp Val Ala Glu Ile Thr Pro Gly Asp Ile Thr Asn Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Leu Gln Ser 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


His Cys Ser Val Gly Gly Thr Leu Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  84
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A20 VHH

<400>  84

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Phe Phe Gly Thr His 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Arg Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Asp Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp Gly Arg Trp Tyr Glu Leu Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  85
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A21 VHH

<400>  85

Glu Val Gln Leu Gln Ala Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Asn Ala Phe Val Leu Tyr 
            20                  25                  30          


Ala Ala His Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Arg Gly Gly Asp Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Arg Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Gly Ser Leu Gly Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  86
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A23 VHH

<400>  86

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser His 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Tyr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Val Leu Glu Tyr Gly Ser Asn Trp Tyr Ala Ala Asp Gly Ser 
            100                 105                 110         


Phe Gly Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  87
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A27 VHH

<400>  87

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Thr Ile Leu Phe Ser Ile His 
            20                  25                  30          


Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Asp Gly Ser Thr Asn Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp Ser Thr Tyr Tyr Asp Asp Phe Leu Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  88
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A28 VHH

<400>  88

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Arg Thr Phe Ser Gly Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Arg Trp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Val Leu Glu Tyr Gly Ser Ser Trp Phe Ala Ala Asp Gly Ser 
            100                 105                 110         


Phe Gly Pro Trp Gly Gln Gly Thr His Val Thr Ile Ser Ser 
        115                 120                 125     


<210>  89
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A30 VHH

<400>  89

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Arg Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Val Leu Glu Tyr Gly Ser Ser Trp Tyr Ala Ala Asp Gly Ser 
            100                 105                 110         


Phe Gly Pro Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  90
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A34 VHH

<400>  90

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Thr Ile Leu Phe Ser Ile His 
            20                  25                  30          


Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Asp Gly Ser Thr Asn Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp Ser Thr Tyr Tyr Asp Asp Phe Leu Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  91
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A36 VHH

<400>  91

Gln Val Lys Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Gly Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Val Leu Glu Tyr Gly Ser Ser Trp Phe Ala Ala Asp Gly Ser 
            100                 105                 110         


Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  92
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A10 VHH

<400>  92

Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Val Ser Ser Glu Glu Ile Ser Ile Ser Ile Tyr 
            20                  25                  30          


Ser Val Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Met Thr Thr Arg Gly Ile Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Gln Pro Asp Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Leu Gly Arg Ser Gly Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  93
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26 VHH

<400>  93

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Ile Val Ile Ser Ile Tyr 
            20                  25                  30          


Ser Val Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Met Thr Thr Arg Gly Thr Thr Asn Tyr Ala Glu Ser Val Arg 
    50                  55                  60                  


Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Lys Ser Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Gln Pro Gly Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Gly Gln Ser Gly Gly Leu Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  94
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A29 VHH

<400>  94

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Tyr Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Met Phe Gly Leu Tyr 
            20                  25                  30          


Ser Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Arg Thr Gly Thr Thr Lys Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Lys Met Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Pro Glu Asp Thr Gly Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Gly Gln Thr Gly Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  95
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A45 VHH

<400>  95

Gln Val Gln Leu Glu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Ile His Ile Ser Ile Tyr 
            20                  25                  30          


Ser Gly Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Ala Leu Val 
        35                  40                  45              


Ala Tyr Met Ser Arg Leu Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Asp Arg Phe Ile Ile Ser Thr Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Ser Asp Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Gly Gln Ser Gly Glu Leu Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  96
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A46 VHH

<400>  96

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Asp Ile Ser Ile Tyr 
            20                  25                  30          


Ser Val Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Ala Leu Val 
        35                  40                  45              


Ala Tyr Met Ser Arg Arg Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Asp Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Ser Asp Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Gly Gln Ser Gly Glu Leu Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  97
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59 VHH

<400>  97

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser His Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Ile Leu Leu Phe Lys Ile Cys Val Pro Asp Ala Asn 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  98
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A53 VHH

<400>  98

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Leu Val Phe Ser Leu Tyr 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Thr Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Phe Asp Asp Gly Ser Pro Thr Tyr Val Asp Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Tyr Arg Pro Phe Pro Ser Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  99
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A43 VHH

<400>  99

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Asn Ile Phe Asn Ile His 
            20                  25                  30          


Gly Leu Gly Trp Tyr Arg Gln Ala Pro Glu Met Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp Asn Arg Tyr Tyr Glu Val Thr Glu Tyr Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  100
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A39 VHH

<400>  100

Glu Val Gln Leu Gln Ala Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Gly Pro Tyr 
            20                  25                  30          


Ala Met Lys Trp Tyr Arg Gln Val Pro Gly Arg Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Asn Ile Lys Pro Asp Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Arg Asp Asn Val Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Gly Gly Ser Gly Gly Ile Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  101
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAF022

<400>  101

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Gly Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Val Ser Trp Ser Gly Asp Ile Ala Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gln Ser Val Val Pro Gly Ser Trp Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Lys Leu Glu 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Ser Ile Phe Asn Ala His Ala Met Gly Trp Tyr 
        275                 280                 285             


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ser Ile Thr Ser 
    290                 295                 300                 


Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
                325                 330                 335     


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Asp His Thr Tyr 
            340                 345                 350         


Tyr Ser Asp Ser Ala Leu Lys Asp Phe Trp Gly Arg Gly Thr Gln Val 
        355                 360                 365             


Thr Val Ser Ser 
    370         


<210>  102
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAF025

<400>  102

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Gly Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Val Ser Trp Ser Gly Asp Ile Ala Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gln Ser Val Val Pro Gly Ser Trp Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser His Val Gln Leu Val 
                245                 250                 255     


Asp Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Ile Ser Arg Ser Phe Phe Asp Ser Thr Ala Thr 
        275                 280                 285             


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val Ala Glu 
    290                 295                 300                 


Ile Thr Pro Gly Asp Ile Thr Asn Tyr Val Asp Ser Val Lys Gly Arg 
305                 310                 315                 320 


Phe Thr Ile Ser Arg Asp Asn Ala Leu Gln Ser Met Tyr Leu Gln Met 
                325                 330                 335     


Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr His Cys Ser Val Gly 
            340                 345                 350         


Gly Thr Leu Gly His Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 365 


<210>  103
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAF041

<400>  103

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Gly Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Val Ser Trp Ser Gly Asp Ile Ala Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gln Ser Val Val Pro Gly Ser Trp Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Lys Leu Glu 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            260                 265                 270         


Cys Ala Val Ser Gly Asn Ile Phe Asn Ile His Gly Leu Gly Trp Tyr 
        275                 280                 285             


Arg Gln Ala Pro Glu Met Gln Arg Glu Leu Val Ala Ala Ile Thr Ser 
    290                 295                 300                 


Gly Gly Ser Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu Gln Met Asn Lys Leu 
                325                 330                 335     


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Asp Asn Arg Tyr 
            340                 345                 350         


Tyr Glu Val Thr Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        355                 360                 365             


Val Ser Ser 
    370     


<210>  104
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PA002

<400>  104

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Ala His 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp His Thr Tyr Tyr Ser Asp Ser Ala Leu Lys Asp Phe Trp Gly 
            100                 105                 110         


Arg Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
            180                 185                 190         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
        195                 200                 205             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp Val 
                245                 250                 255     


Gln Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu 
            260                 265                 270         


Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Gly Thr Tyr Ala Met 
        275                 280                 285             


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val 
    290                 295                 300                 


Val Ser Trp Ser Gly Asp Ile Ala Ser Tyr Ala Asp Ser Val Lys Gly 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Met Val Tyr Leu Gln 
                325                 330                 335     


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Gln 
            340                 345                 350         


Ser Val Val Pro Gly Ser Trp Thr Tyr Trp Gly Gln Gly Thr Gln Val 
        355                 360                 365             


Thr Val Ser Ser 
    370         


<210>  105
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PA026

<400>  105

His Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ser Arg Ser Phe Phe 
            20                  25                  30          


Asp Ser Thr Ala Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              


Glu Trp Val Ala Glu Ile Thr Pro Gly Asp Ile Thr Asn Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Leu Gln Ser 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


His Cys Ser Val Gly Gly Thr Leu Gly His Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
                165                 170                 175     


Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser 
    210                 215                 220                 


Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Asp Val Gln Leu Gln Ala Ser Gly Gly 
                245                 250                 255     


Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Ser Thr Ile Gly Thr Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Glu Arg Glu Phe Val Ala Val Val Ser Trp Ser Gly Asp Ile 
    290                 295                 300                 


Ala Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
305                 310                 315                 320 


Asp Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
                325                 330                 335     


Asp Thr Ala Val Tyr Tyr Cys Thr Gln Ser Val Val Pro Gly Ser Trp 
            340                 345                 350         


Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 365 


<210>  106
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PA154

<400>  106

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Asn Ile Phe Asn Ile His 
            20                  25                  30          


Gly Leu Gly Trp Tyr Arg Gln Ala Pro Glu Met Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp Asn Arg Tyr Tyr Glu Val Thr Glu Tyr Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
145                 150                 155                 160 


Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp Val Gln 
                245                 250                 255     


Leu Gln Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Gly Thr Tyr Ala Met Gly 
        275                 280                 285             


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Val 
    290                 295                 300                 


Ser Trp Ser Gly Asp Ile Ala Ser Tyr Ala Asp Ser Val Lys Gly Arg 
305                 310                 315                 320 


Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Met Val Tyr Leu Gln Met 
                325                 330                 335     


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Gln Ser 
            340                 345                 350         


Val Val Pro Gly Ser Trp Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        355                 360                 365             


Val Ser Ser 
    370     


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ͷ

<400>  107

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  108
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-HSA

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


