                         SEQUENCE LISTING

<110>  ҩҵ޹˾
 
<120>  һʶHLA-A*02:01/E629-38TCRӦ

<130>  P21407659CF

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E63  CDR1

<400>  1

Thr Ser Asp Gln Ser Tyr Gly 
1               5           


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E63  CDR2

<400>  2

Gln Gly Ser Tyr Asp Glu Gln Asn 
1               5               


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E63  CDR3

<400>  3

Ala Met Arg Glu Asn Thr Gly Thr Ala Ser Lys Leu Thr 
1               5                   10              


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E63  CDR1

<400>  4

Ser Gly His Asp Asn 
1               5   


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E63  CDR2

<400>  5

Phe Val Lys Glu Ser Lys 
1               5       


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E63  CDR3

<400>  6

Ala Ser Ser Ala Trp Gly His Gln Asn Ser Pro Leu His 
1               5                   10              


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E65  CDR1

<400>  7

Thr Ser Ile Asn Asn 
1               5   


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E65  CDR2

<400>  8

Ile Arg Ser Asn Glu Arg Glu 
1               5           


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E65  CDR3

<400>  9

Ala Thr Asp Ala Phe Gly Asn Gln Phe Tyr 
1               5                   10  


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E65  CDR1

<400>  10

Met Asp His Glu Asn 
1               5   


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E65  CDR2

<400>  11

Ser Tyr Asp Val Lys Met 
1               5       


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E65  CDR3

<400>  12

Ala Ser Ser Leu Trp Gly Arg Val Val Glu Lys Leu Phe 
1               5                   10              


<210>  13
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCRĺ㶨

<400>  13

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
1               5                   10                  15      


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
            20                  25                  30          


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
    50                  55                  60                  


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
65                  70                  75                  80  


Ile Pro Glu Asp Thr Phe Phe Pro Ser 
                85                  


<210>  14
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCRĺ㶨

<400>  14

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala 
    


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E67  CDR3

<400>  15

Ala Met Arg Glu Ala Arg Arg Ser Gln Phe Tyr 
1               5                   10      


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E67  CDR1

<400>  16

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E67  CDR2

<400>  17

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E67  CDR3

<400>  18

Ser Ala Ala Leu Gly Ser Tyr Glu Gln Tyr 
1               5                   10  


<210>  19
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E63  ɱ

<400>  19

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Gln Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Glu 
                85                  90                  95      


Asn Thr Gly Thr Ala Ser Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu 
            100                 105                 110         


Gln Val Thr Leu Asp 
        115         


<210>  20
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E63  ɱ

<400>  20

Glu Ala Gly Val Thr Gln Phe Pro Ser His Ser Val Ile Glu Lys Gly 
1               5                   10                  15      


Gln Thr Val Thr Leu Arg Cys Asp Pro Ile Ser Gly His Asp Asn Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Arg Val Met Gly Lys Glu Ile Lys Phe Leu Leu His 
        35                  40                  45              


Phe Val Lys Glu Ser Lys Gln Asp Glu Ser Gly Met Pro Asn Asn Arg 
    50                  55                  60                  


Phe Leu Ala Glu Arg Thr Gly Gly Thr Tyr Ser Thr Leu Lys Val Gln 
65                  70                  75                  80  


Pro Ala Glu Leu Glu Asp Ser Gly Val Tyr Phe Cys Ala Ser Ser Ala 
                85                  90                  95      


Trp Gly His Gln Asn Ser Pro Leu His Phe Gly Asn Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Thr 
        115 


<210>  21
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E65  ɱ

<400>  21

Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly 
1               5                   10                  15      


Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu 
            20                  25                  30          


Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu 
        35                  40                  45              


Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr 
    50                  55                  60                  


Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg 
65                  70                  75                  80  


Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Ala Phe Gly Asn 
                85                  90                  95      


Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro Asn 
            100                 105                 110     


<210>  22
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E65  ɱ

<400>  22

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Leu Trp 
                85                  90                  95      


Gly Arg Val Val Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Leu 
        


<210>  23
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E67 ɱ

<400>  23

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Gln Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Glu 
                85                  90                  95      


Ala Arg Arg Ser Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val 
            100                 105                 110         


Ile Pro Asn 
        115 


<210>  24
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E67  ɱ

<400>  24

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Ala Leu Gly Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Thr 
        


<210>  25
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCRĺ㶨

<400>  25

Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala 
    


<210>  26
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16-E6ȫ

<400>  26

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn 
            100                 105                 110         


Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        115                 120                 125             


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
    130                 135                 140                 


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155             


<210>  27
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR ĺ㶨УԴ

<400>  27

Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
1               5                   10                  15      


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
            20                  25                  30          


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
    50                  55                  60                  


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
65                  70                  75                  80  


Ala Thr 
        


<210>  28
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR ĺ㶨УԴ

<400>  28

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125 


