                         SEQUENCE LISTING

<110>  Centro de Investigacin y de Estudios Avanzados del I.P.N.
 
<120>  Sistema gentico para la biosntesis de leupeptina y su uso en 
       sistemas heterlogos de produccin

<130>  Cinvestav50

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  22443
<212>  DNA
<213>  Streptomyces roseus


<220>
<221>  misc_feature
<222>  (1)..(22443)
<223>  BGC (biosynthetic gene cluster) o clster de genes biosintticos 
       codificante para leupeptina

<400>  1
atgtacttcc tccagcagct ggaggagggc aggccgacct accacatgcc cgtcttctac       60

ggcctcgaag gcccggtgga cgagaccgcg ctccgcgcct gcgcccaggg cctggtcgac      120

cggcacgagg cgctgcgcac ccgcttcgtc ctgcgggacg gcgagctgtg gcagcacatc      180

gacaccgagg ccgctctcgt ctggtcctcc gccgtcgcgc acggagccgg ggacgtcgag      240

gagtggatgg ccgccgaaca ccaccggccc ttcgacctgg ggtccggacc gctcttccgg      300

gcggccctgc tgcacacccc cgagggcgcg gtcctcgcgc tcgccatgca ccacatcgtc      360

gccgacggct ggtccgtcgg gatcctcgtc cgcgagctcc tcaccgcgta cgcccactac      420

ggcgacgggc ccgacggcgg ccctgacggc accgaccgcc ggcgcccggc cgggttcgtg      480

gccccggagg cccccgagta ccagtacgcc gacttctccg actggcagga ggaatggctc      540

cgcggccccg ccgcccagcg ccagctcgcc tactgggaga agcagctgga gggcgaactg      600

cccgacgcgc ccctgccccg cgacggccgg cccgcggcag gcgcggcccg cggcgcggcg      660

gcgctgcact ccttcgaggt gccggccccg gtgctcgccc gcatggaacg cctgtgccgt      720

gacacccaca gcacccccta cacgctgatg ctggcggcct tccagatcgt gctgggccgc      780

tacacgggca ccgacgacgt actcgtcggg acgccggtgg cgggacgggg ccgcaaggag      840

ttccaggaca ccgtcggcct gttcgtcaac acgctggtga tccgcgccga cctctccgac      900

gatcccgcct tccgggtcca cctggaacgc gtacgggaca ccgtgctcga cgcccaggac      960

caccaggacc tgcccttcga acgcgtcgtc gaccgcctcg ccgccggacg caccggcgag     1020

gacgccggcc ccttccaggt catgttcggc ctgcacgacg aggacggcat gaccgacggc     1080

ctgcccggcc cgaaggccac gctgctcgaa ggaccggcag gaaccgccaa gttcgacctg     1140

accttcgacg tcgtacggac cggcggcgcg ctgacctgcc ggctggaata ccgggcggac     1200

ctgttcgacg ccgccaccgt ccgacagttc ggccggcact tcgcccgcct cctggacgcc     1260

gccaccgaga accccgaact gcccctcagc caactgccga tgctgtcggc cggcgagcgg     1320

accggcatcg gctcgcagct ccccgaccgc gccgccctcc cgcacatccc gggcgcaccg     1380

gcctgcgtcc acgagatctt cgccggacac gccgcccgca ctcccgacgc cgtcgccctc     1440

gtccacgagg gcacctccct cacctaccgc gagctcgaca cccgcgccaa ccggctcgca     1500

caccggctgc gcgccctcgg cgtgggcccc gacaccctcg tcggactgtg cctgccccgc     1560

tccgccgacc tcgtcgtcgc tctgctcggc atcctcaagg ccggcggcgc ctacctgccc     1620

ctcgaccccg acaacccgcc cgagcggctg cgccacatcg tccaggacgc ccgcctggag     1680

cacgtcgtcg gcaccaccgg cacccgggcc ctgtgggacg ccccgggcct gcacaccgtc     1740

gacctgctcg ccgacgcccc gctcctggcc gcccaaccgg acaccgcccc cgccaccggt     1800

gtgaccccgg accatctggc ctacgtcatc tacacctccg ggtccaccgg cctccccaag     1860

ggcaccttgg tgccccatgc caacgtcaca cggctgttct ccgccaccga ccactggttc     1920

ggcttcggcc ccgacgacgt gtggaccctc ttccactcca tcgccttcga cttctccgtc     1980

tgggagctgt ggggagccct cgcccacggc ggccgcctcg tcgtggtccc gtacgggacc     2040

agccgctcgc ccgaggagtt ccaccggctg ctgcgcgccg aacgggtcac cgtcctcaac     2100

cagaccccct ccgccttcta ccagctggcc cgggccgacg aggaacacca ccgcacggcc     2160

ggaccggccg accctggcct cgccctgcgc cacgtcgtct tcggcgggga agccctcgac     2220

gtcgccgccc tcgccggatg gttcgcccgc cacggcgaca ccgcaccccg cctggtcaac     2280

atgtacggca tcaccgagac gaccgtgcac gtcacctacc ggccgctgac cgcccgcgac     2340

gccgaggagg gccgcggcag cgtcatcggc gtgcccatcc cggacctgcg tctgcacctg     2400

ctcgacgcgc gcggccggac cgtcccgcgc ggcgccgtcg gggagctgta cgtcgccgga     2460

gcgggcctgg cgcgcggcta cctgcgccgg cccgaactca ccgccgagcg ctttcccacc     2520

ggacccgccg aaggtgtcgc cgacgcaccc gccgggccct cggccggtga gcggctctac     2580

cgcaccggag acctggcgcg ggccctgccc gacggggacc tggagtacct cggccgcatc     2640

gaccaccagg tcaaactgcg cggcttccgg atcgaactgg gcgaggtcga ggccgccctg     2700

gccgcccacc ccctcgtcga cgccgcggtc gcgctcgtcg cacccgatcc cgcggggaac     2760

gacgtcctgg tcggctacct ggccgtgacc ggggccgagg acggggcggg gcccaccgtc     2820

gaggagatgc gcgagcacct cgcgcggcgg ctgccgggct acatgatccc cggcgcgttc     2880

gtcaccctgc ccgccttccc gctgaccgcc aacggcaaga ccgaccggcg ccggctgccc     2940

gcccccggct cggccggccg cacccccacc gccgagtacg aggcaccccg cgggccggtc     3000

gagaccgcgc tcaccgaggt cttcgcccag gtcctcgggc acgaacgggt cggcgccctg     3060

gacaactggt tcgccctcgg cggggactcc atccgctccc tccaggtgct cgcccggatc     3120

cgcgaacgag gcctcgacct caccgtcgcc gacctcatga gctccccgac ggtccgcgcc     3180

ctcgccccgt acgtcaccgc ccgggaccgg gccgcggccg ctgccgaaac cccgtacgag     3240

cccttcgcac tgctgacccc cgcggaccgc gccgccctgc ccgaggggct ggaggacgcc     3300

tacccgatga cccggctcca ggccggcatg ctctaccaca gcgacctgcc gtcggccggc     3360

ggacgcgtct accacaacgt ggcctcctac ctgatcgaag cgcccttctc cgaggacgcc     3420

tggcggacca ccgtcgaggt cctcgcgacc cggcacgaga tgctgcgcac ctccttcgac     3480

ccgcacggat tcaccgagcc cctccaactc gtccaccgcg gcgcccgccc ggagctcacc     3540

ttcgaggacc tgcacggcct cgacaccgag gcccagcgca ccgccgtcgc cgcccgctac     3600

gccgccgagc gcgaccggcc cttcgactgg gaccggcccc cgctgatccg gttccacgtc     3660

caacgcctct ccgacacccg cctccagctg ttcgtcgccg agcaccacgc cgtcctcgac     3720

ggctggagcg aacgctcgct cctcaccgaa ctcgcctcct gctacaccga ggcgctcgcc     3780

gcccggaccc ccgcggacgg cccctccccg caggccggcc cccgctcccg gttcgccacc     3840

ttcgtcgccc tcgaacgggc cgccctggcc gaccccgggc agcgcgcctt ctggaccggc     3900

aaggccgccg acgcccccgc gaccaagctg gcccgcccgg cggcgaccgg cggacccgcc     3960

cggatgtcct ggtacctcgc gcccctgccc ggggaactgc acgaccggct caccaccctg     4020

gccgccgcat gcggcgtacc gctgcgcacc gtcctgctcg ccgcccacct gaggaccatg     4080

gccctgctgg gcggcggcga cgctgtcacc accggagtgg tccacaacgg ccgcgccgag     4140

gagaccgacg gggacaaggt cgtcggcgtc ttcctgaaca ccctgccgct gagcctcacc     4200

gtcaccgggc tcagctggcg cggcctcgtc gggcacgtcg ccgccgcgga ggcggaactg     4260

cacgcgcacc gccgcttccc gctcgccgag atccagcgcc tgtccggggg tggcccgctc     4320

ttcgagacgt tcttcaacta cacccacttc cacgtggagc aggacgggcc ggccgacggc     4380

gcgttcaccg tgctggagga gaccggagag gccggcaccg acttcgcctt cggcgcggag     4440

ttctcccgca gccccgacgg cgccctgctc gaactcggcc tgcgcttcga cgcggcccag     4500

ttctccgagg agcagatggc gagcgcgcac gcctcctaca gggccgccct gtgcgatctg     4560

gccgaagccc ccgatcgcga ctgcacggcc gccgacctgc tgcccgaggc cgaacaccgc     4620

cgctacgccg actggaaccg gaccgccgtc gactacccgc ggccgcacgt cctgaccagg     4680

ctgatcgacg agcagcgcga ccggaccccg gacgcacccg ccgtccgctt cgagggcgcc     4740

gagctgacct accgcgccct cgacgccgag gccgagcggc tgtgcgcggc actgcgggaa     4800

cgcggcgccg gccccggcac gttcgtgggc ctgctgctgg aacgctccct ggccctgccc     4860

gtcgtactcc tcgccgtcct caagtccggc gccgcctacg tcccgctgga cccggagcac     4920

ccggagccgc gcgtacggtc gttgctcgcc gagtctggca tcggcctggt ggtcgccgag     4980

ggcgcgtggg ccgagcggct ggcggactcc ggggtcaccg tcctgcggcc ggaggaggcc     5040

gcgacgggca ccgcgggtcc tgcgcgggcg cccgaaccgt ccgatccggc atacatgatc     5100

ttcacctcgg gatccaccgg caagcccaag ggggtcgtgg tctcgcaccg cgccatcgcc     5160

aacaggctgc tgtggatgca ggacgcatac gggctgaccc cgggggagcg ggtgctgcac     5220

aagacgccgt acaccttcga cgtctccgtg tgggagctgt tctggcccct gctgaccggc     5280

gccaccctgg tcctcgcccg tcccggcggc cagcgcgacc ccggctacct cgccggactg     5340

atccgggccg aaggtgtcac cacggtgcac ttcgtcccgt cgatgctcag cgtcttcctc     5400

gacgacccgg cagccctggc cggcgcggcc ggcctcaccc gcgtcgtctg cagcggcgag     5460

gccctgccgc acgagctcca gcgcaggttc ttcgagcggc tgcccggcgt cgagctgcac     5520

aacctctacg ggcccaccga ggcggccgtc gacgtcacct actggcagtg ccggccggac     5580

ggcggcgaca ccgtgcccat cggccggccc atcgccaaca tgcgcaccca cgtcctggac     5640

cgccgcctgg ccgaggcccc cctcggcgtc accggtgagc tcttcctcga aggcgtcggc     5700

ctcgccgacg gctaccacgg acgacccgag ctgacggccg agcggttcat cgagcacacc     5760

ggcccggacg gcaccctccg gcgcctctac cggaccggcg acctcgcccg gcaccgcccc     5820

gacggagccc tggagtacgc gggccgcacc gaccaccagc tcaagatccg cggattccgc     5880

gtcgagcccg gggagatcga ggccgtcctc gccgaacacc ccggcgtccg cgactgcgcg     5940

gtcctgcccc gcggcgaacg cctcgtcggc tacttcgtcc ccgagccggc cgccccggag     6000

accgcctcgg cgcccgcctc cccgcccgaa ccgggcgaac tggcccgcca cgcgcgggag     6060

cggctgcccg agtacatggt cccctccgcc tgggtgtgcc tgacggccct cccgctgacc     6120

gccaacggca agctggaccg tgccgcgctg cctgatccgg accccgccga cctgcgggga     6180

ggcgtcgagc cgaccccgcc ccgcgacgca ctcgaaaccc gcctcgccgg gatctgggag     6240

cagctcctgg tggccggccc ggtcggcgtc cacgacgact tcttcgattc cggcggccac     6300

tccatcgacg ccctgcgcct gatcggccgg atcaaccagg ccttcggcga gcgcctcggc     6360

gtctcggccg tcctggagca cccgaccgtg gcgcggcagg ccgagctgct gcgcggccgc     6420

caggtcgagg cggccccgga cacggtggtg cgcctgcgga ccgagggcgg cctcgacccg     6480

ctcgtcctgc tccacccgat cggcggcaac gtcctgtgct accgcgccct ggccgccgaa     6540

ctgggcgccg accgaccggt gttcgggctg accgcgcccg gaccgaccga ccccgaagtc     6600

accgccggga ccgcgcccgc agccatatcc gacgccgcgc ccgacgccac cgtcgaggag     6660

ctggccgccg cccacctcaa ggccctgcgc cggatccgcc ccaccggccc ctaccacctg     6720

gccggctggt ccttcggcgg actcctcgcc tacgagatgg cggcccaact gcgcgccgcc     6780

ggacaggagg tggcgaccct cgccctgctg gacaccggct acccggagcc cggccacgtc     6840

cccgacgacg agaacgagct gctggagtgg ttccacgagg acctggcccg ctccgcgggg     6900

ttcgacccca ccgaccagaa cctgtccgtg ctgcgcagcg ccctgctgag cgtcgccgac     6960

acccccgccc ggctcgccgt cctggccgag caggtggaac gcgagggctt cgcccccggc     7020

ctggacccgc gcgacctcgc ccggcactac acggccttcc gcaccgggct ccgcgccgcc     7080

gccgcctacc ggccccccgc cccgccctgc cccgtcctgt tcctccagag cacgaccggg     7140

gcccgggaga gcgccgccga ccgatgggcg gcccgggtcg gggcgggcct gacccgccac     7200

gacgccgcca ccgaccacta cgggctgatg cggccgccgc acagcagcgc ggccgccgcc     7260

ctgctgcgca ccgccctcgc cgaggccgac ccccgctgac cgggcccccc ggcccgcccg     7320

gggcgcccgt agggggtgtc ccgccgatcg gaacggctcg ccccgaccga cgagacaccc     7380

cccccggccc ttccaccccg ccccagccct tcgcgcgccg tgcgccgacg aggcgtgccc     7440

cggcatgccc ccgcgccccg caccagaaca ggaaacggaa cacaccacgt gacgagtgac     7500

accccggggc ccgcccccga gctgagcggc cggatccgcg gcggtcccgc cgaactcctc     7560

cacgacgaag tgctcgcccc gcagttcggg ttcgagtccc gccacctgct acgccactac     7620

gtcgccatcg agaagaccct ggccgccgaa tacgtccgca tggacctgat caccgaggag     7680

gaggcccacc ggatcgccgc cctgctggac gccgtcgggc ccgacaccct cagcgcgcag     7740

cccggcgcca acatgtcgga catcgccttc gccctcgaac ggcacgtcga ggccggcctg     7800

cccgccccgg tcacgcactg gcacgcggac cgcagccgca acgacctcca ggcctgcgcc     7860

caggtgatgt acggccgcga ccagctcgcc cgcttcgcga gcgccctcct cgaactcggc     7920

tcaatcgtgg ttgagttggc tcagcagacc tgcgacctgc ccatgccggg gtacacccac     7980

ttccaggccg cccagatcat cacccccggc ttccacctcg ccgcgctctc cgaacacctg     8040

ctgcacaccc acgcccggct gctgaacgcc tacgacggga tcgacgcctg cccgctcggc     8100

gccggcgcca tggccggaca ggaactgccc tgggaccgcg accggatggc ccggctgctc     8160

ggcttctccc ggccgcagcc ccacgccctg accgccgtgg cctcgcgccg ctggagcgcc     8220

gaactgaccg cggaactcag cctgctgggc accgcgctga gccgcttcac caccgacctc     8280

ctcacctggg gtggcagcga gtacgggttc atcgaactgc ccgacgaact gtccggcatc     8340

tcctccgcca tgccgcagaa gaagaactac ccggtcctgg agcgcatccg ggggcgcacc     8400

gcccacctga cggccttcca cttcgacgtg ctcctgggcc agcgcaacac ccccttctgc     8460

aatctcgtcg aggtgtccaa ggaggccggc acccacctgc tgaacgcctt cgactccgcc     8520

cacggcaccg tccgcctcct caccgaggta ctgcgccggc tgaccttccg cgccgaccgc     8580

atgcgccagg tgtgcgagcg cgagttcctc ggcggcttca gcctcgccaa cgccctctgc     8640

ctcaccgaag gggtgccctg gcgcaccgcc caggtcgtcg ccgggaagta cgtcgtgctc     8700

gccgcgacgg cgggcgccgc ccccgccccc ggcgaacccg ccctgctggc cgaggcggcc     8760

gccggacacg gcatcaccct cgccgacccc gcccgactcc tggacgaggc cttcgacgtc     8820

gaccggggcc tggagcgcat ggtgtccgcc gggtcggccc gccccgacgc cgtccgcgcg     8880

gtcctgcgcg accagcagga gacgtacgaa cagctgcgcg ccgactggca ggcgcgcgcc     8940

gacgcgctcc gcgcgggcgc cgaggagggc gagcgcgccc tgtacggaac gccggccgac     9000

aagacccaag aggaggacgg cgatggcacc cgcacccgcg tacagcacgc ccactgacac     9060

cgccgagggg acgacagccg tccccgtcgg ccccggctcc ggcagcgcct tcggcacctt     9120

cggcgaactg ctccagggcg ccctgcccca cccgcagggg gacttcctgg tcacctttcc     9180

cctcgcccgc tgggccaccg ccgtgttcca cccggagccc ggccgccgcg aggtccgggt     9240

gcgcccggcg cacaaggcca agtcccgccg cgtcgccgag gccgtcctgg ccgccctcgg     9300

cacggccggc ggcggcctgc tggaggtcgc cggggacctg cccgagggca agggcctcgc     9360

cagttcctcc gccgacctgg tcgccaccgt acgggccgtc ggggccgccc acgggcgcgc     9420

cttcaccccc gacgagacgg agggcttcct gcgcggcatc gaaccggccg acggggtcat     9480

gtacgacgag atcgtcgcct tccaccaccg ggaggtgcgc ctcggccgcc gcctcggcgt     9540

gctgccgccc ctcaccgtcg tcgcccacga cgagggcggc caggtcgaca cggtcgcgca     9600

caaccggggc gcccgggcca tcgacgccgc agaccgggag gagtacgccc gcctgctgga     9660

ccggctcacc gacgccgtgg cccgcggcga cctcgccgag gtcggcgccg tcgccacccg     9720

cagcgccgag atgaacgccc gccgccgccg gcgcgccgga ttcgccgaac tgcacgccct     9780

gtgtcgcgag gtcgacgggc tgggcctggt cctcgcccac agcggaacca tgctcggtgt     9840

cctcctggag gcgaacgacc ccgccctcgc cggcaagacc gagcacatcc gggccggctg     9900

cgcggcgctc ggcggcgagg tgtccgtaca ccgctccctc ggcgccgacg acagctggag     9960

cccgcaggct ccacccgccc accccaccga gctggagatc tgagcatgct gttcgacacc    10020

gtgaccgacg cgatcggcgg gaccccgctg gtccggctgc gcctgggcga ggcccggggc    10080

gtggaggtct acgccaagct ggaactgcag aacctgttcg ccatgaagga ccgcgtcgcc    10140

cgcaacatcc tgctggaggc ccggcggctg ggcaccctga agcccggcga ccccgtcatc    10200

gagagctcct cggggaccat ggcgctcggc gtcgccctcg tcggccgctc gctcggccac    10260

gaggtgcaca tcgtcaccga cccgcggatc gaccccgtca ccctcgccaa actccgcgcc    10320

ctgggctgcc gggtgcacat cgtcgaggcg atgaccagcc acggctggca gagcgcccgc    10380

ctggagcggc tcgcggagct cctcgacgaa ctgcccggcg ccttctggcc gcagcagtac    10440

accaaccccg acaaccccgg cgcctaccgt cccctcgccg gcgaactcct ggcggacctc    10500

ggccggttcg acaccctcgt cggagccgtc ggcagcggcg gctccctgtg cggcaccgcc    10560

cgggcgctgc gcgagcggct gcccgccctg cacgtcgtcg gcgtcgactg cgtgggcagc    10620

gccctcttcg gacagcccga cgtaccgcag cggctgcaga gcgggctggg caacagcctg    10680

ctgcccaaga acctggaccg caccctcgtc gacgaggtgc actggctcaa cgaccacgag    10740

gccttcgccg cgacctggga cctcgcccgc gagcagcaga tcttcggcgg caacacctcg    10800

ggctccgtct accgggtcct caccggcctc gccgacggcg ccgaacccgg cacccggatc    10860

gtcggcatcc tccccgaccg cggcgaccgc tacgccgaca ccgtctacaa cgacgagcac    10920

tgggacgcga accggctgcg cgaggtgccc accgccaccg cgccggccgc cctcggaccc    10980

gacgggaccg cgcgcacctg gtccaccgtc gcctacagcc cgcccgccgg gatcggccgg    11040

cacctgctgt tcgtcgagtc caacaccacc ggcaccggca tgctcgcgct ggcgcgggcg    11100

cgcgaactgg gcaccgtccc cgtcctgctg accggcgacc ccgaccgcta ccggggactc    11160

gcggagagcg gcgccgaagt ggtgcgctgc gacaccaact ccgacgccgc cctgcgcgcc    11220

gccgtacagg agcggttccg ccgcgaggag atcgccgggg tcaccaccac gagcgacttc    11280

tacgtaccgg ccgccgcccg gatcgcccag tggctcggcc tgcccggcaa cgcgcccgag    11340

gcagtggcgg tctgccgcga caagtccgcc ctgcgcgaga gactgcgggc cgcgggcgtc    11400

cgccagcccc gttactccct cgtccgcgag ccggccggag ccgcggccgc cgtcgcccgc    11460

accggactgc cgtgcgtggt caagccggcc gacgactcgg gctccaccaa cgtcctgctc    11520

tgcgccgacg aggccgaggc ccgcgcccag atccagcgga tcctcgcgat cgacaccaac    11580

gtgcggggca tgcccaccgc ccgcaccgtc ctcgtcgagg agtacctgga cgggccggag    11640

tacagcgtcg agatgttcgg cctggacggg caggccgtgt gcgtcggcat caccgccaag    11700

tccgtgaccg ccggcccgca cttcgtcgag caccgccacc tcttccccgc ccccctgccc    11760

gccgccaccg cccagctgat caccgacacg gtgaccgcgg ccctggacgc ggccgggatc    11820

cggctgggcg ccacccacac cgaggtcaaa ctgaccgccg acgggcccgc cctcgtcgag    11880

atcaacccgc gcccggccgg cggcatgatc cccgaactga tccggctcgc caccggcgtc    11940

gacctcctcg acgcgcagct gcgcgccgcc ctcggcctgc ccccgcacct gaaggcggag    12000

gaagccggcc acgccgggat ccagttcttg ctcgccgaca ccgacggcac cctcacggcc    12060

gtccacggcg cggaggccgc ggcggtcgtg gagggggtcg aatcggtgct ggtcaccgcc    12120

gcccccggca cccccgtacg caggccccgc agcgcctccg accggctcgg gcacgtgatc    12180

gcccgccacg cggaacccga cggcgtgcac accgccctcg acgccgcgcg cgccctcgtc    12240

cacctcgaca tccaggccgc gccgcgctcc tgaccctccg ccccacccgt cccgacgacg    12300

cgccgtacga cccgtacggc cgcacccgac ccgaaaggtg aaccgccatg agcaacccct    12360

tcgagaacga caacgcctcc tacgtcgtgg tccgcaacga cgagctccag cactccctgt    12420

ggcccgcgac caaccccgtc ccggccggct ggaccgtggt gcacggcccc gacggccgcc    12480

aggcctgcct ggaccacgtc gagcgggtct ggaccgacat gcgccccgcc tccctggtgg    12540

ccgccctcac cggggacgcg ccccgtggct gagcccgtcc accgcaccga gcacccggcc    12600

ggacccgacc ccgtacggac cctgcgcacc ctcttcgccg aggtcctcgg ccgcgccgag    12660

gtcgacgcgg accacagctt caccgggctg ggtggcgaca gcatccaggc gatccaggtc    12720

gtcagccgtg cccgcgcggc gggcctggcc gtcagcaccc gcgacgtgct ccgcgcggag    12780

agcgtcaccg cgctcgccgc caccgcccgg ggccgggtcg gcgaggacgc cggcccggcc    12840

acgcccccgc gccgtctggg cccggtggca cccaccccca tcatgggctg gctcgccgaa    12900

ctcggcggtc ccgtcgacac gtacaaccag tcgctcgtcc tgcgcacccc gccgggcttc    12960

ggggcggccg ccgccgtacg caccgtccat gccctcctgg acacccacga gatgctccgc    13020

ctgcggctgc ccgacggtat cggggccacc ggcgccgaac cggtcgtacc gcccgccggc    13080

tccgtcgccg cgacggacct gctggagcac gtggacgccc gcgggagggc cgaggcggaa    13140

ctgcccgccc tgacccggga gcggatgcgc gccgcgcggc gcctgctcgc gccgcgggac    13200

ggccacatgc tgcgcgccgt gttcctggac cggggagccg gacggcaggg acggctcgcg    13260

ctcgtcatcc accacctcgt ggtcgacggc gtctcctgga ggatcctcca ggacgatgtg    13320

cgcacctgtt ggacggcgct caccgagggc cgcgagcccg tcctggaacc ggcggcgacc    13380

cccttcgcgc actgggccga cctgctgcgc gcggaggcga cctcaggccg ccggaccgcc    13440

gaagccgacc gctgggcagc cgccctgcgt gaggcccccc agcccctggc cggggtccgc    13500

ccgcccggcg gcctcgaccc ggagtgcgcg gagaacaccc tcaccctgac cctcgggccg    13560

gacgtggcgg gccccctgct cacgaccgcg cccggcctcg tcaacggcac ggtcaacgac    13620

gtgctgctga ccgccctggc cctcgccgtg ctcggccggc gcagtgccga cggggcggac    13680

ggggcggacg aggagggcgc cgtcctcatc gacgtcgagg gccacggccg ggaggacgtc    13740

gccgagggca ccgacctgtc ccgcaccgtc ggctggttca ccacggtgtt ccccgtacgc    13800

ctcgccctcg gccgcccgga cctcgacgag gcccgccggg gcggacccgc ggtcggcgcc    13860

gccctgcggc tggtcaagga ggaactgcgc gccgtacccg acaagggcat cggcttcggg    13920

ctgctgcgcc acctcaactc ccgtaccggg cccgatctcg cggcacgcgg catcccccag    13980

atcggcttca actacctcgg ccggttcccg atgggcggcg acgccccctg ggacgccgcg    14040

cccggccacg acttcgccct cgacgacgcc gacgaaggcc tcccgatggc ccacgccgtg    14100

gaggtcaacg cggccgccca cgagggcccg gacgggctca ccctcagcgc cacctggacc    14160

tgggcgggca acgcccttcc cgggccgtgg gtccacgacc tcgcgcggga gtggttcacc    14220

atgctgcgcg ccgtcgtcac ccacgccggc cgccccgacg ccggcgggct gaccccctcc    14280

gacgtcccgc tcgcccaggt cagccaggcc gacctcgaca ccttcgaatc ccagctcgga    14340

gccctgctgt gatccctctg tcccacgccc agcagcggct gtggttccac gcccgggacg    14400

gcgccgacgg cgcgctctac cacattcccg tcggactgcg gctggacggc gccctcgacc    14460

gcccggccct gcgcgccgcc ctcgcggacg tgagcgggcg ccacgaggcc ctgcgcaccg    14520

tcttccccga ggtggcgggc cgcccccacc agcgggtcct ggaccccgcg gacgccgccc    14580

cggtcctcac cgtcaccgac tgcccgcccg ccgaccgcgc ccggcgggcc gagcaagcct    14640

cgtcccggcc cttcgacctc cgcgtcgaac caccgctgcg cgtggagctg ttcaccgacg    14700

gcgccgagga ccactacctg ctgctggtcc tgcaccacat cgcgggcgac ggccactccg    14760

tgaacatcct cgtccgcgac ctcgccgccg cctacaccgc ccggtgcggc ggccgggcgc    14820

ccgactggcc cgaactgccc gtccagtacc cggactacgc actgtggcag cgcgaactcc    14880

tcggccccgc ccaggacccc gcctccctgc acggccgcct gctcacccac tgggccaccg    14940

tcctcgacgg cctgcccgag gaactggccc tgcccggcgc ccggccccgg ccggccgtgg    15000

ccggccaccg gggcgcactg gtggaggccc ggaccggcgc cgaagcacac gccggactgg    15060

ccgcgctggc ccgaggcgcc cgcgccaccc ccttcatggc cgtccaggcc gccttcgccg    15120

ccctgctcac ccgcctgggt gccggcaccg acctgccgct gggctgcccc gtcgacggcc    15180

gggacgacga ggccctcacc gacctcgtgg gcctcttcgt caacaccctg atcgtgcgag    15240

ccgacacctc gggcgacccc accttcacgg aggtgctggg ccgcgtgcgc accgcggccc    15300

tggagacgta cgcccaccag gaactgccct tcgaatcgct ggtcgaacgc ctcaacccgg    15360

cccgctcgcc cgcccgccac ccgcttttcc aggtcgccgt ctccgcccag cgcggcgagc    15420

cgcggcgccc cgcgttcgcg ggcctgcggg ccgaggtgga ggcggtgcgc accgacaccg    15480

ccaagttcga cctcaccctg gaggtggagg agctccacga cccggccacc gggcaacccc    15540

tgggcctggt cctcgggctg gagtacgcga gcgacctgtt cgacgggacc acggcccgcc    15600

gcctgctgga ccgcctcgtc cacctcatcg acgccgtcgt ccgcgagccc ggcgtcccgc    15660

tctccgcact cgacgtcctg ctgcccgggg agcgcgccga cctgctggag cactggcagg    15720

gcgcgcccgt cacccccgac gcccgaaccg tccacggcgt cttcgaggag cgcgcctgcg    15780

cccacccgga ccgccccgcg gttctctgcg ccggccggga gaccacgtac ggcgaactcg    15840

acgcccgggc cgaatggatc gccggacggc tgcgcgccct cggcgtccga ccgggcgagt    15900

ccgtcgccgt actgatggac cgctccgccg acctcgtcgc cgcctgcctg ggcatcctca    15960

aggcgggcgg cgcctacctg ccgctggacg cgcgggcccc acgcgcccgt accgaggccg    16020

tgctcaccgc ggccggggcc gccgtcctcg tcaccgacgc cccggagggg gaacccgtac    16080

cggcgggtcc gcgccacgta ctgcgtccgg acggacggcc cgccgcggcg gccgggacgg    16140

ccggcaccgg gggaccgggc gggcacgccg acgcgctcgc ctacctgatg tacacctccg    16200

gctccaccgg cacccccaag ggcgtggccg tctcccaccg cgaggtcgtc gccctcgcca    16260

ccgaccggcg ctggcgcggc ggcgcgcacg agcgggtgct gttccgctcc ccgcacgcct    16320

tcgacgcctc cacctacgaa ctgtgggtgc cgctcctgaa cggcggcctg gtcgtcgtcg    16380

cgccgcccgg cgaactcgac gtggacgcgc tggcccggct gatgtccgag gaggaggtca    16440

ccgggacctt cctcaccgcc accctcttca acgtcctcgc cgaccgctgc ctgcccgcgc    16500

tcgcagcgct gcgcgaggtg atgaccggag gcgaggccgc ctcgccgtcc atggtccgcc    16560

gggtccgcga ggcctgcccc gccaccaccg tcaccaacgc ctacggcccc accgagacca    16620

ccaccttcgc ggcgaccttc gccgtcggcc cgggccagga gccccccgcc gggcaggtcc    16680

cgatcggccg ccccctcgac ggaacccggc tgtacgtcct ggacgagcgg ctggccctcg    16740

tggcgcccgg cgtcatcggc gagctctaca tcgcgggcgc cggactcgca cagggctacc    16800

tcgggcgggc cgggctgacc gccgaacgct tcgtcgcctg cccgtacggc ccccagggca    16860

gccggatgta ccgcaccggc gacctggccc gctggagcgc cgacggccag gtcgagtacc    16920

tcggccgcgc cgaccggcag gtcaagatcc gcggactgcg catcgaaccc gccgagatcg    16980

agcacgtcct ggccggccac ccggcggtgg gccaggccgc cgtcaccgtc gtggacacgg    17040

ccgccggtcc cgcgctcgcg ggctacgccg tccccgccga gggcacgccc gcacccgacc    17100

cgcgggaact gcgcgagcac ctgcgggccc ggctgcccga ctacatggtc cccgccaccc    17160

tcaccttgct cgacgccttc cccgtcaccg caaacggcaa gacggacctt gccgccctgc    17220

ccgtgcccgc cccggcgacc gccggcaccg cgggcgcccg acaggagccg cgcaccgacg    17280

acgagcgcgc cctgtgcgcc atctgggaaa aggtcctggg cgtctcgcac atcggcgtgc    17340

acgacagctt cttcgacctc ggcgggcact ccctgctcgc cacccagctg ctcgccgagg    17400

tccgggaccg cttcggcggt gccatcgcga tccgccagtt cttcaccggc cccaccgtcg    17460

ccgaactggc cgccgccctg cccgccgccg cggccgccgg tgccggcgcc gaggacccgc    17520

cgatcgtccg ccgggcccgc cgcacccaga ccgcctgacc accgaaggac caccaccgtg    17580

aaccacccgc agtccacccc tgccgcaccc gccgccgccc cggccgcccg ctccctggtc    17640

gaggacgtcc tgcccctgtc cccgctccag gacgggatcc tcttccacgc cctcttcgac    17700

gaggaagaac gcgacgtcta cgtggcccag ctgctcctcg acctcgacgg ccccctcgac    17760

gcggaccggc tgcgcgccgc cgccgacacc gtcctggaga ggcacgccaa cctccgcgcc    17820

ggcttcctgc gacgcgccac cggcgaaccc gcccaagtcg tccagcgcgg ggtccgggcc    17880

ccctggcagg aggtggacct gtccgggctc ggcgagagcg agcgcaccgc agccgtcgac    17940

accctcctcg ccgaggaccg ggccacccgc ttcgacctcg cccggccgcc gctgctgcgc    18000

ttcaccctcg tccgcaccgg cccgctctcc caccgactgc tgctcaccta ccaccacatc    18060

gtgatggacg gctggtcctg gccggtcctg gtccgcgagc tcctcgccct gcacgccgcg    18120

gacgacgccc ccctggggcc cgtcaccccc tactccgcct tcctgagccg gctccacagc    18180

cgtgacacgg ccgccgccca ggacgcctgg acccgcgcgc tggacggcct gcccggcgga    18240

acccgtaccg cgcccgtgtc accgccgccc ggctcggtgc tgccccaccg cgtggagacg    18300

tacctccccg agtccctcac cgaacggctc ggcgccctcg cccgcggcca ccggatcacc    18360

tccggaaccc tgctccaagg cgcgtgggca gttctgctcg gccgccagat ccgctccgag    18420

gacgtggtct tcggcgccgt cgtcagcggc cgcgaccccg aactgcccgg cgtcgccgac    18480

atcgtgggcc tgtgcatcaa caccgtgccg gtccgcgtgc gcatcgaccc ggccgagtcc    18540

ctcgtcgcgc tgttcgagcg gctccaggac gagcaggcgc gcctgatcga ccaccaccac    18600

ctggggctgg tcgagatcca gcggctcgcg ggagcgggcg agctcttcga ctcctgcgtc    18660

gccttccaga actacccgat cgacgcggcc ggcctcgccg cactgggcgc gggcgggctc    18720

caggtcaccg cagtggaccc gcacgacgcc gcccattacc cgctctcatt gaccgccatc    18780

cccggcgacc ggctgcggct gcagatcgac taccggccgg acgtcttcga acgcgacacc    18840

gcccaggccc tgatcgaacg cctcgcccgt ctcctggaag ccgtcgccgc ggacccctcg    18900

tgcccggtgg gcaccgtgga cctgctctca cccgccgaac gccaccgggt cctggtcgaa    18960

tggaacgaca cggcccgcga cgaggagtac gcggaggtcg tcgagcgggt ccgccggcag    19020

gccgggcgcc gccccgacgc cgtcgccacc accgacgaca ccggccgcga actgagctac    19080

acggacctcg tggcccgcgc cgacgccctc gccctggccc tgctcgccga cggggtgcgc    19140

cccggcgacc tggtcgccgt actcagcgag cccaccgccc gcgtccccgt cgcgatgctc    19200

ggcatcctcg gggccggtgc ggcctacgtc cccctcgacc ccgagggccc cgtcacccgt    19260

accgccgacc tcctggcgag cggcgggatc gcccgcctgc tggccgcccc cgaacagcgg    19320

gcgcgtgccg aggagatcgc cgccgcggtc cccggcgggc tgcccgtcct ggtgatcgac    19380

gacgcggccg ccgcggcccc gggcgagcgc ccggcgccgg ccggggggcc cgacgccctc    19440

gcctacgtct gcttcacctc gggctccacc ggcaagccca agggcgccat ggtccaccgc    19500

cggggcatga acaaccacct cctggccaag gtggaggacc tcggtctcgg cgacggcgac    19560

cgcgtggtga tgaacgcccc gctgaccttc gacatctccg tgtggcaggt cctcgccccg    19620

ctgatcaccg gcggacaggt gcacctggtc acccgggaca ccgcccggga cccggccgcg    19680

ctgttcgacg acgccgcgcg cagggggatc accgtactgg agaccgtgcc gtccttcgtc    19740

cgcgccgccg tcgacctgtg ggacaccggc gtgctgccgc cggccctgcc cgagctgcgc    19800

tggttcatcg tcaacggcga ggtgctgccg cccgaactgt gcacccgctg gtacgcgcgc    19860

cacccgcagg ccgcgatcgt caacgcctac ggcctcaccg agtgctccga cgacaacacg    19920

cacgccttca tcggccccga cgtacacgcc cagctggaac acggccggct gcccgtcgga    19980

cgcccgctgc gcaacaactc cctctacctg ctggacgccg cgctcgcccc cgtaccgccc    20040

ggcgtgccag gcgaactctt catcggcggc accggcgtgg gccccggata cctgcgcgac    20100

ccgcgccgct ccagcgagcg ctacgtcccc gacccgttct ccgccgtgcc cggcagccgc    20160

atgtaccgca ccggcgatct cgcgcggatg cgcgccgacg gccagctcga cttcctcggc    20220

cgccaggacc accaggtcaa ggtccgcggc aaccgcatcg aactgggcga ggtggagacc    20280

gcgctgcgcg ccgtaccggg cgtcggcgag gccgtcgtcg ccgtagaccg ggaccacgcg    20340

ggccagcagc ggctcgtcgg ctacttcacc ggtacgccca ccgccgagga ggtccgcacg    20400

gaactgggcc gcagcctccc caactacatg gttccctcgc tgttcctgca cctgccgcag    20460

ttcccgctca ccgtcaacgg caagctcgac cgcaaggccc tccccgaccc gggcaccgtg    20520

caccgccccg ccggacggct gcccgccacc cccgccgaga agacggtctg cgagatcttc    20580

gcctccgtcc tcggcctcca ggaggcgggg atggacgacg acttcttcgc ccacggcggc    20640

cactcgctcc tcgccacccg gttgaccggc cgcatcggca ccgaactcgg tgtacggctg    20700

ggcatccgcg acctcttcga aacgcccacc cccgcgggca tcgccgcccg cctcgccgag    20760

gccaccgccg cccccgcccg ccccgcgctg cgcccccgct cccgcgacca ggcctgatca    20820

cccctgacca ggcgcggtca cgcccgaccg ggcgtgaccg cgccgcgaag agccccgacc    20880

gcacccccag gagacaccac caccatgagc ccgaccgaga ccacccccgt gcccctgcgc    20940

atcgcgcacc gggccgggct gacccccgag gccaccgcgg tccgcgctcc cgagggcgag    21000

ctgacgtacc gccagttcga ccgccgggcg cgcgcggtgg ccgaggagct gcgcgcggcc    21060

ggcgccgggc cggaggacac cgtgctcctg ggggtgcgcc gcggcgtcca ctgggcggtg    21120

gggctgctgg gcatctggta cgccggcgcg gcccccctcc tggtggacct cgacgccccc    21180

gacgagcggc tgcgcaccct gctgggggcc gccggcaccc ggcacgcggt cgcccccgac    21240

acccacgccg ccgcgatgct gcaacgccgc accgggaggg agctgttctg ggcgtccacc    21300

acgaccgcgg cgcccacctc ggcggccccg cccgccgacg tcgcaccggg gtccctcgcc    21360

tacgtgctct tcacctccgg atccaccggg cagcccaagc ccgtggcggt cggccacgcc    21420

ggactcgccg cacaggtcgc caccctggcc ggacgctacg ggctgaccga ccaggacgcg    21480

gtcctgcagt tcgccgcccc cgccttcgac gtcagcctgg aggaggccct gcccacctgg    21540

tgcacgggcg gcgcggccgt cttcgtcaag gacaacgtcc tctcgcccgc cgaactggag    21600

ccgttcctgg ccgcggagcg gatcagcgtc gtcaacctgc ccaccccgta ctggtcgcag    21660

tgggccaagg atctggagcg cgccccccgg ccgctgccgt ccgcactgcg ccgcgtggtg    21720

atcggcagcg acgcgggccg caccgcggac ctcgcgcgct ggacgacggc cggccacccc    21780

ccggtgatca gctgctacgg cctcaccgag tccacgatca ccgccacctc ctacgagccg    21840

gtaccggccg aactcgccgc cttcaccggc gaggagctga tcccgctcgg cgaacccctg    21900

gccggcgtgc gggcgtacgt cctcgacgag gaactgcgcg aggcaccccc cggcgccgcc    21960

ggcgagctgt accttgcggg ttcctgcctg gcccgcggct accacggccg cccgggcctg    22020

acctccgaac ggttcgtcgc cgaccccttc gccgacgccc cgggcggccg catgtaccgc    22080

acgggcgacc gggtcacccg cgcccccggc ggcccgctcg tcttcctcgg gcgcgccgac    22140

gaccaggtca agatccgcgg ccaccgcgtc gaactcaagg aggtggaggc ggccgtggcc    22200

gcccaccccg acgtcgtcga cgtggtcgtg cgcgccgtcg cggcgaccgg cggaccgcag    22260

ctcgccgcct gggccgccgt cacggtcggc agtcccctca ccccggaggg actgcgccgt    22320

caccttctgg ccagaatgcc cgggtacctc gtaccggccg cggtgacact gatggagcgg    22380

ctgccccgta ccccgggcgg caagctcgac cccagggcgc tccccgcgcc cgccctccga    22440

tga                                                                  22443


<210>  2
<211>  21
<212>  DNA
<213>  Sinttico


<220>
<221>  misc_feature
<223>  Oligo delantero LeupA_F para amplificar el Fragmento A1 de 640 pb
       correspondiente al primer dominio de adenilacin de Streptomyces 
       roseus ATCC 31245

<400>  2
cggcaccacc ggcacccggg c                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Sinttico


<220>
<221>  misc_feature
<223>  Oligo reverso LeupA_R1 para amplificar el Fragmento A1 de 640 pb 
       correspondiente al primer dominio de adenilacin de Streptomyces 
       roseus ATCC 31245

<400>  3
acgcaggtcc gggatgggca c                                                 21


