                         SEQUENCE LISTING

<110>  BIO-Y
       Universittsklinikum Hamburg-Eppendorf
 
<120>  YKL-40 antibody and uses thereof

<130>  P6173PC00

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


<210>  2
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  2

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Thr 
    50                  55                  60                  


Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gln Tyr Asp 
            100                 105                 110         


Thr Gly Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  3
<211>  164
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  3

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Gly Asp 
    50                  55                  60                  


Glu Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Asn Ser Leu 
                85                  90                  95      


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Thr Ser Asp Ser 
            100                 105                 110         


Tyr Trp Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
    130                 135                 140                 


Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser 
145                 150                 155                 160 


Phe Thr Asn Val 
                


<210>  4
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  4

Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu Glu 
1               5                   10                  15      


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            20                  25                  30          


Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Asn Ala Pro 
    50                  55                  60                  


Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
                85                  90                  95      


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gln Trp Asp Asp 
            100                 105                 110         


Gly Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
    130                 135                 140                 


Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser 
145                 150                 155                 160 


Phe Thr Asn Val Trp 
                165 


<210>  5
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  5

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
    50                  55                  60                  


Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Thr Asp Tyr 
            100                 105                 110         


Leu Arg Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  6
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  6

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Asn Asn 
    50                  55                  60                  


Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Thr Tyr Asp 
            100                 105                 110         


Trp Asn Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  7
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  7

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ala 
    50                  55                  60                  


Glu Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gln Tyr Gly 
            100                 105                 110         


Ala Tyr His Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  8
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  8

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Asn Tyr 
    50                  55                  60                  


Asn Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Thr Pro Asn 
            100                 105                 110         


Leu Asn Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  9
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  9

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Asp 
    50                  55                  60                  


Glu Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Ser Gly Asp 
            100                 105                 110         


Trp Trp Tyr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  10
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  10

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
    50                  55                  60                  


Glu Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Val Asp Pro 
            100                 105                 110         


Leu Asp Thr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  11
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  11

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Gln Ser 
    50                  55                  60                  


Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Ser Ser Gln 
            100                 105                 110         


Asn Gly Tyr Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  12
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  12

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Asn Asn 
    50                  55                  60                  


Glu Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Thr Ser Tyr 
            100                 105                 110         


Tyr Gly Phe Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  13
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  13

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Tyr Ala 
    50                  55                  60                  


Pro Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn Thr Tyr 
            100                 105                 110         


Asp Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
    130                 135                 140                 


Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser Phe 
145                 150                 155                 160 


Thr Asn Val Trp Lys 
                165 


<210>  14
<211>  192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  14

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ala Ser 
    50                  55                  60                  


Asp Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Ser Gly Tyr 
            100                 105                 110         


Ala Gly Thr Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr Ala 
                165                 170                 175     


Asn Tyr Glu Gly Cys Leu Trp Asn Ala Thr Gly Val Val Val Cys Thr 
            180                 185                 190         


<210>  15
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  15

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Gly Ala 
    50                  55                  60                  


Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Ser Thr Asp 
            100                 105                 110         


Ala Arg Trp Gln Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  16
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  16

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Asn Ala 
    50                  55                  60                  


Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gln Tyr Asp 
            100                 105                 110         


Asp Glu Phe Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  17
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  17

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Gly Asn 
    50                  55                  60                  


Tyr Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Val Ser Asp 
            100                 105                 110         


Ser Gly Phe Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  18
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  18

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Tyr Gly 
    50                  55                  60                  


Pro Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Ser Asp Trp 
            100                 105                 110         


Asp Gly Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  19
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human single domain antibody

<400>  19

Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala Glu Val Gln Leu Leu 
1               5                   10                  15      


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            20                  25                  30          


Cys Ala Ala Ser Gly Phe Arg Asp Ser Asp Glu Asp Met Gly Trp Val 
        35                  40                  45              


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Asp Ala 
    50                  55                  60                  


Glu Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gln Asp Gly 
            100                 105                 110         


Ala Tyr Tyr Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
    130                 135                 140                 


Gly Ala Ala Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn 
145                 150                 155                 160 


Ser Phe Thr Asn Val 
                165 


<210>  20
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  20

Phe Arg Asp Ser Asp Glu Asp Met Gly 
1               5                   


<210>  21
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  21

Ser Ile Gly Asp Glu Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  22

Thr Ser Asp Ser Tyr Trp Ser Phe Asp Tyr 
1               5                   10  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  23

Ser Ile Asn Ala Pro Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  24

Gln Trp Asp Asp Gly Tyr Ala Phe Asp Tyr 
1               5                   10  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  25

Ser Ile Ser Gly Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  26

Thr Asp Tyr Leu Arg Ser Ser Phe Asp Tyr 
1               5                   10  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  27

Ser Ile Asn Asn Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  28

Thr Tyr Asp Trp Asn Tyr Ser Phe Asp Tyr 
1               5                   10  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  29

Ser Ile Ser Ala Glu Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  30

Gln Tyr Gly Ala Tyr His Asp Phe Asp Tyr 
1               5                   10  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  31

Ser Ile Asn Tyr Asn Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  32
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  32

Thr Pro Asn Leu Asn Ser Ser Phe Asp Tyr 
1               5                   10  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  33

Ser Ile Ser Asp Glu Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  34

Ser Gly Asp Trp Trp Tyr Gly Phe Asp Tyr 
1               5                   10  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  35

Ser Ile Ser Gly Glu Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  36

Val Asp Pro Leu Asp Thr Tyr Phe Asp Tyr 
1               5                   10  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  37

Ser Ile Gln Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  38

Ser Ser Gln Asn Gly Tyr Val Phe Asp Tyr 
1               5                   10  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  39

Ser Ile Asn Asn Glu Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  40
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  40

Thr Ser Tyr Tyr Gly Phe Asp Phe Asp Tyr 
1               5                   10  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  41

Ser Ile Tyr Ala Pro Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  42

Asn Thr Tyr Asp Ala Phe Asp Tyr 
1               5               


<210>  43
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  43

Ser Ile Ala Ser Asp Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  44

Ser Gly Tyr Ala Gly Thr Val Phe Asp Tyr 
1               5                   10  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  45

Ser Ile Gly Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  46
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  46

Ser Thr Asp Ala Arg Trp Gln Phe Asp Tyr 
1               5                   10  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  47

Ser Ile Asn Ala Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  48
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  48

Gln Tyr Asp Asp Glu Phe Ala Phe Asp Tyr 
1               5                   10  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  49

Ser Ile Gly Asn Tyr Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  50
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  50

Val Ser Asp Ser Gly Phe Ser Phe Asp Tyr 
1               5                   10  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  51

Ser Ile Tyr Gly Pro Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  52
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  52

Ser Asp Trp Asp Gly Tyr Ser Phe Asp Tyr 
1               5                   10  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  53

Ser Ile Asp Ala Glu Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  54
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  54

Gln Asp Gly Ala Tyr Tyr Thr Phe Asp Tyr 
1               5                   10  


<210>  55
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is Q, S, N, D, G, E or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is S, G, N, A, D or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is S, E, N, Y, G, D or P

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is D, G, S or N

<400>  55

Ser Ile Xaa Xaa Xaa Xaa Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  56
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  56

Ser Ile Ser Thr Ser Asp Gly Ser Thr Tyr Tyr 
1               5                   10      


<210>  57
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR sequence

<400>  57

Gln Tyr Asp Thr Gly Tyr Ser Phe Asp Tyr 
1               5                   10  


<210>  58
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  58

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  59
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  59

Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210>  60
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR2 General Formula 2


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is Q, S, N, D, G, E or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is S, T, G, N, A, D or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is S, E, N, Y, G, D or P

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is D, G, S or N

<400>  60

Ser Ile Xaa Xaa Xaa Xaa Gly Ser Thr Tyr Tyr 
1               5                   10      


<210>  61
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 general formula


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Q, T, S or V

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is Y, S, W, D, P, G or T

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is D, Y, P, Q, Y, W or G

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is T, S, D, L, W, N or A

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is G, Y, G, R, N, W, D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is Y, W, S, T, F or D

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is S, A, G, Y, V, D, Q or T

<400>  61

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Asp Tyr 
1               5                   10  


<210>  62
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR2 general formula 3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is Q, S, N, D, G, E or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is S, T, G, N, D or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is S, N, Y or G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is D or N

<400>  62

Ser Ile Xaa Xaa Xaa Xaa Gly Ser Thr Tyr Tyr 
1               5                   10      


