                         SEQUENCE LISTING

<110>  ݷƼ޹˾
       ϵͳҽѧо
       йҽѧѧԺƤҽԺ(йҽѧѧԺƤо)
 
<120>  BPԿԭĵԴ塢Ʊ;

<130>  6A59-2103407IB

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VL FR1

<400>  1

Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser 
            20                  25  


<210>  2
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VH FR1

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VL CDR1

<400>  3

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VH CDR1

<400>  4

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VL FR2

<400>  5

Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VH FR2

<400>  6

Ile Ser Trp Val Arg Gln Ala Pro Gly Leu Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  7
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VL CDR2

<400>  7

Arg Asn Asn 
1       3    


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VH CDR2

<400>  8

Ile Ser Gly Tyr Asn Gly Asn Thr 
1               5               


<210>  9
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VL FR3

<400>  9

Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
1               5                   10                  15      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  10
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VH FR3

<400>  10

His Tyr Ala Gln Lys Leu Gln Asp Arg Val Thr Met Thr Thr Asp Thr 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Met Arg Ser Leu Gly Ser Asp Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VL CDR3

<400>  11

Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VH CDR3

<400>  12

Ala Arg Asp Tyr Leu Pro Gly Tyr Cys Ser Ser Thr Ser Cys Pro His 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VL FR4

<400>  13

Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
1               5                   10  


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VH FR4

<400>  14

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence of VH

<400>  15
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cctctggtta cacctttacc aactatggta tcagctgggt gcgacaggcc      120

cctggactag ggcttgagtg gatgggatgg atcagcggtt acaatggtaa cacacactat      180

gcacagaagc tccaggacag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagatga ggagcctggg atctgacgac acggccgtgt attactgtgc gagagattac      300

ctgcccggat attgtagtag taccagctgc cctcactttg actactgggg ccagggcacc      360

ctggtcaccg tctcgagtgc tagcaccaag ggaccttctg tgttccctct ggctccttct      420

tctaagtcca cttccggtgg tacagcagct ctgggttgtc tggtgaagga ttacttccca      480

gaaccagtga ctgtgtcctg gaactccgga gctctgactt ctggagtgca tactttccca      540

gcagtgctgc aatctagcgg actgtactct ctgtcttccg tggtgactgt gccttcttct      600

tccctgggga ctcaaactta catctgcaac gtgaaccaca agccctccaa caccaaggtg      660

gacaagaagg tggagccaaa gagctgcgat aagacccaca cctgtccacc ttgtccagct      720

ccagaactgc tgggtgggcc ttctgtgttt ctgttcccac ctaagccaaa ggataccctg      780

atgatctcta ggaccccaga agtgacctgt gtggtcgtcg atgtgtctca tgaagaccct      840

gaagtgaagt tcaactggta cgtggacggg gtggaagtgc ataacgcaaa gaccaagccc      900

agggaagagc aatacaactc cacctacagg gtggtctccg tcctgacagt cctgcatcag      960

gattggctga acggcaagga gtacaagtgc aaggtctcca ataaagccct gcctgcccct     1020

atcgagaaaa ccattagcaa agccaaaggc cagcccaggg agccccaggt ctatacactg     1080

ccccccagca gggaggagat gacaaaaaat caggtcagcc tgacatgcct ggtcaaaggc     1140

ttttatccca gcgacattgc cgtcgagtgg gagtccaatg gccagcccga gaataattat     1200

aaaacaacac cccccgtcct ggacagcgac ggcagctttt ttctgtatag caaactgaca     1260

gtcgataaaa gcaggtggca gcagggcaat gtcttttcct gcagcgtcat gcacgaggcc     1320

ctgcacaatc actatactca gaaaagcctg agcctgtccc ccgggaaatg a              1371


<210>  16
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VH

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Leu Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Asn Gly Asn Thr His Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Met Arg Ser Leu Gly Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Leu Pro Gly Tyr Cys Ser Ser Thr Ser Cys Pro His 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  17
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence of VL

<400>  17
cagcctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagcg ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggttgggtg      300

ttcggcggag ggaccaaggt caccgtccta cgtacggtgg ctgcaccttc tgtgttcatc      360

ttccctccat ctgatgagca gctgaagtct ggaaccgcat ctgtcgtctg tctgctgaac      420

aacttttacc ccagggaggc taaggtccaa tggaaggtgg acaacgccct gcagtctggt      480

aatagccagg aaagcgtgac cgaacaggat tccaaggact ccacctactc cctgtcctcc      540

acactgacac tgagcaaagc cgactatgaa aagcacaaag tgtatgcctg cgaggtcact      600

catcagggcc tgtccagccc cgtgactaaa agctttaata ggggggagtg ctga            654


<210>  18
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of VL

<400>  18

Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  19
acaggtgccc actcccaggt gcag                                              24


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  20
aaggtgtcca gtgtgargtg cag                                               23


<210>  21
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  21
cccagatggg tcctgtccca ggtgcag                                           27


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  22
caaggagtct gttccgaggt gcag                                              24


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  23
atgaggstcc cygctcagct gctgg                                             25


<210>  24
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  24
ctcttcctcc tgctactctg gctcccag                                          28


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  25
atttctctgt tgctctggat ctctg                                             25


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  26
ggtcctgggc ccagtctgtg ctg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  27
ggtcctgggc ccagtctgcc ctg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  28
gctctgtgac ctcctatgag ctg                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  29
ggtctctctc scagcytgtg ctg                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  30
gttcttgggc caattttatg ctg                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  31
ggtccaattc ycaggctgtg gtg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  32
gagtggattc tcagactgtg gtg                                               23


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  33
tgctgtcctt gctgtcctgc t                                                 21


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  34
caccagtgtg gccttgttgg cttg                                              24


<210>  35
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of BP180

<400>  35

Gly Ser Glu Glu Val Arg Lys Leu Lys Ala Arg Val Asp Glu Leu Glu 
1               5                   10                  15      


Arg Ile Arg Arg Ser Ile Leu Pro Tyr Gly Asp Ser Met Asp Arg Ile 
            20                  25                  30          


Glu Lys Asp Arg Leu Gln Gly Met Ala Pro Ala Ala Gly Ala Asp Leu 
        35                  40                  45              


Asp Lys Ile Gly Leu His Ser Asp Ser Gln Glu Glu Leu Trp Met Phe 
    50                  55                  60                  


Val Arg Lys Lys Leu Met Met Glu Gln Glu Asn Gly Asn Leu Arg 
65                  70                  75                  


<210>  36
<211>  246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence of BP180

<400>  36
ggatccgagg aggtgaggaa gctgaaggcg cgtgtggatg agctggagag gatcaggagg       60

agcatactgc cctatgggga cagcatggat agaatagaaa aggaccgcct ccagggcatg      120

gcacccgcgg cgggagcaga cctggacaaa attgggctgc acagtgacag ccaggaggag      180

ctctggatgt tcgtgaggaa gaagctaatg atggaacagg aaaatggaaa tctccgatga      240

ctcgag                                                                 246


