                         SEQUENCE LISTING

<110>  ϾƼ޹˾
 
<120>  SIRT1-7еӦ

<130>  IP210676

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  63
<212>  DNA
<213>  ˹

<220>
<223>  ǰ

<400>  1
atggctctgc ctgtgaccgc tctgctgctg cctctggctc tgctgctgca cgccgcaaga       60

cct                                                                     63


<210>  2
<211>  726
<212>  DNA
<213>  ˹

<220>
<223>  GPC3 scFvĺ

<400>  2
gatgtcgtga tgacccagtc cccactgtcc ctgccagtga caccaggaga gcctgcatcc       60

atctcttgcc ggagctccca gtctctggtg cacagcaacg gcaataccta cctgcactgg      120

tatctgcaga agccaggcca gagcccccag ctgctgatct acaaggtgtc caaccggttc      180

tctggagtgc cagaccggtt cagcggctcc ggctctggca ccgatttcac actgaagatc      240

agcagggtgg aggcagagga cgtgggcgtg tactattgct cccagaatac ccacgtgccc      300

cctacatttg gccagggcac caagctggag atcaagggag gaggaggcag cggcggagga      360

ggctccggcg gcggcggctc tcaggtgcag ctggtgcagt ccggagcaga ggtgaagaag      420

cctggagcca gcgtgaaggt gtcctgtaag gcctctggct acaccttcac agattatgag      480

atgcactggg tgcggcaggc acctggacag ggactggagt ggatgggcgc cctggaccca      540

aagaccggcg atacagccta ctctcagaag tttaagggca gggtgaccct gacagccgac      600

gagagcacct ccacagccta tatggagctg tctagcctgc gcagcgagga taccgccgtg      660

tactattgca cccgcttcta cagttacact tattgggggc agggcactct ggtcacagtc      720

tcttca                                                                 726


<210>  3
<211>  726
<212>  DNA
<213>  ˹

<220>
<223>  CD19 scFvĺ

<400>  3
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  4
<211>  738
<212>  DNA
<213>  ˹

<220>
<223>  BCMA scFvĺ

<400>  4
gacatcgtgc tgacccagag ccccgcttct ttagctgtgt ctttaggaga gagggccacc       60

atcaattgtc gtgcctccga gtccgtgtcc gtgattggcg cccatttaat ccactggtac      120

cagcagaaac ccggccagcc ccccaagctg ctgatctatt tagccagcaa tctggagacc      180

ggcgtgcccg ccagatttag cggaagcggc tccggcaccg attttacttt aaccatttcc      240

tctttacaag ctgaggacgc cgccatctac tactgtttac agagcagaat ctttcctcgt      300

accttcggcc aaggtaccaa gctggaaatc aagggatcca ccagcggctc cggaaagccc      360

ggttccggag agggcagcac aaagggccaa gttcagctcg tgcagagcgg ctccgagctg      420

aagaagcccg gcgcttccgt gaaggtgagc tgcaaggcca gcggatacac cttcaccgac      480

tactccatca actgggttcg tcaagctccc ggtcaaggtc tggagtggat gggctggatc      540

aacaccgaaa ccagagagcc cgcctatgcc tacgacttca gaggtcgttt cgtgttctct      600

ttagacacaa gcgtgagcac cgcctattta cagatcagct ctttaaaggc cgaggatacc      660

gccgtgtact actgcgctcg tgactacagc tacgccatgg actactgggg ccaaggtaca      720

ctggtgaccg tgtccagc                                                    738


<210>  5
<211>  777
<212>  DNA
<213>  ˹

<220>
<223>  MSLN scFvĺ

<400>  5
caggtgcagc tgcaacagag cggccctggc ctggtgacac cttcccagac cctcagcctc       60

acctgcgcca tctccggcga ttccgtgtcc agcaatagcg ccacctggaa ctggatcaga      120

cagagcccta gcagaggcct ggagtggctg ggcaggacct attataggag caagtggtac      180

aacgactacg ccgtgtccgt caagtccaga atgagcatca accccgacac cagcaagaat      240

cagttcagcc tgcagctgaa cagcgtgacc cccgaggaca cagccgtgta ttactgcgcc      300

aggggcatga tgacctacta ctacggcatg gacgtgtggg gccaaggcac cacagtgacc      360

gtgagcagcg gcattctggg cagcggagga ggcggatccg gcggcggagg cagcggagga      420

ggaggcagcc agcctgtgct gacccagtcc agctccctgt ccgcttcccc tggagcctcc      480

gcttccctga cctgcaccct gaggtccggc atcaatgtgg gcccctacag gatctactgg      540

tatcagcaga agcctggcag ccccccccag tacctgctga actacaagag cgacagcgac      600

aagcagcagg gcagcggagt gcctagcaga ttcagcggat ccaaggacgc ctccgccaat      660

gctggcgtgc tgctgatctc cggcctgaga agcgaggacg aagccgacta ctactgcatg      720

atctggcaca gcagcgctgc cgtgtttgga ggcggcaccc aactgacagt cctgtcc         777


<210>  6
<211>  723
<212>  DNA
<213>  ˹

<220>
<223>  HER2 scFvĺ

<400>  6
caggtccagc tgcagcagag cggacccgag ctcaagaagc ccggcgagac cgtgaagatc       60

agctgtaagg ccagcggcta cccctttacc aactatggaa tgaactgggt gaagcaagct      120

cccggccagg gcctgaagtg gatgggctgg atcaacacaa gcaccggaga aagcaccttc      180

gctgacgact tcaagggcag atttgacttc tccctcgaga cctccgccaa caccgcctac      240

ctgcagatca acaatctgaa gtccgaggac agcgctacct acttctgcgc cagatgggag      300

gtgtaccatg gctacgtccc ttattggggc caaggcacca ccgtgaccgt gagcagcgga      360

ggaggcggtt ctggaggcgg cggcagcggc ggcggcggca gcgacattca gctgacccag      420

tcccacaagt tcctgagcac ctccgtgggc gacagggtga gcattacctg caaggccagc      480

caggacgtgt acaatgccgt ggcctggtac cagcagaagc ctggacagag ccccaagctg      540

ctgatctaca gcgcttcctc caggtacacc ggcgtccctt ccagatttac cggctccggc      600

tccggccccg acttcacctt caccatcagc tccgtgcagg ccgaagacct ggccgtgtac      660

ttctgccaac agcacttcag gacccccttc acctttggca gcggaaccaa gctggagatc      720

aaa                                                                    723


<210>  7
<211>  138
<212>  DNA
<213>  ˹

<220>
<223>  CD8ĺ

<400>  7
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatc                                                    138


<210>  8
<211>  69
<212>  DNA
<213>  ˹

<220>
<223>  CD8Ĥĺ

<400>  8
tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc       60

ctttactgc                                                               69


<210>  9
<211>  123
<212>  DNA
<213>  ˹

<220>
<223>  CD28ڹ̼ṹĺ

<400>  9
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  10
<211>  126
<212>  DNA
<213>  ˹

<220>
<223>  4-1BBĹ̼ṹ41BBڽṹĺ

<400>  10
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  11
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  CD3ƵźŴṹCD3zetaڽṹĺ

<400>  11
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210>  12
<211>  54
<212>  DNA
<213>  ˹

<220>
<223>  T2Aĺ

<400>  12
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct             54


<210>  13
<211>  57
<212>  DNA
<213>  ˹

<220>
<223>  P2Aĺ

<400>  13
gccaccaatt ttagcctgct gaaacaggcc ggagacgtgg aggaaaaccc cggcccc          57


<210>  14
<211>  578
<212>  DNA
<213>  ˹

<220>
<223>  IRESĺ

<400>  14
tccctccccc ccccctaacg ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt       60

tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg cccggaaacc      120

tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca aaggaatgca      180

aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa gacaaacaac      240

gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg      300

ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt gccacgttgt      360

gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca acaaggggct      420

gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc ggtgcacatg      480

ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc acggggacgt      540

ggttttcctt tgaaaaacac gatgataata tggccaca                              578


<210>  15
<211>  1106
<212>  DNA
<213>  ˹

<220>
<223>  S1ĺ

<400>  15
acggtccata tacttttgtt cagcaacatc ttatgattgg cacagatcct cgaacaattc       60

ttaaagattt attgccggaa acaatacctc cacctgagtt ggatgatatg acactgtggc      120

agattgttat taatatcctt tcagaaccac caaaaaggaa aaaaagaaaa gatattaata      180

caattgaaga tgctgtgaaa ttactgcaag agtgcaaaaa aattatagtt ctaactggag      240

ctggggtgtc tgtttcatgt ggaatacctg acttcaggtc aagggatggt atttatgctc      300

gccttgctgt agacttccca gatcttccag atcctcaagc gatgtttgat attgaatatt      360

tcagaaaaga tccaagacca ttcttcaagt ttgcaaagga aatatatcct ggacaattcc      420

agccatctct ctgtcacaaa ttcatagcct tgtcagataa ggaaggaaaa ctacttcgca      480

actataccca gaacatagac acgctggaac aggttgcggg aatccaaagg ataattcagt      540

gtcatggttc ctttgcaaca gcatcttgcc tgatttgtaa atacaaagtt gactgtgaag      600

ctgtacgagg agatattttt aatcaggtag ttcctcgatg tcctaggtgc ccagctgatg      660

aaccgcttgc tatcatgaaa ccagagattg tgttttttgg tgaaaattta ccagaacagt      720

ttcatagagc catgaagtat gacaaagatg aagttgacct cctcattgtt attgggtctt      780

ccctcaaagt aagaccagta gcactaattc caagttccat accccatgaa gtgcctcaga      840

tattaattaa tagagaacct ttgcctcatc tgcattttga tgtagagctt cttggagact      900

gtgatgtcat aattaatgaa ttgtgtcata ggttaggtgg tgaatatgcc aaactttgct      960

gtaaccctgt aaagctttca gaaattactg aaaaacctcc acgaggcgga ggatcaggcg     1020

gaggctccca gtatctgttt ttgccaccaa atcgttacat tttccatggc gctgaggtat     1080

attcagactc tgaagatgac gtctga                                          1106


<210>  16
<211>  1167
<212>  DNA
<213>  ˹

<220>
<223>  S2ĺ

<400>  16
atggcagagc cagacccctc tcaccctctg gagacccagg cagggaaggt gcaggaggct       60

caggactcag attcagactc tgagggagga gccgctggtg gagaagcaga catggacttc      120

ctgcggaact tattctccca gacgctcagc ctgggcagcc agaaggagcg tctgctggac      180

gagctgacct tggaaggggt ggcccggtac atgcagagcg aacgctgtcg cagagtcatc      240

tgtttggtgg gagctggaat ctccacatcc gcaggcatcc ccgactttcg ctctccatcc      300

accggcctct atgacaacct agagaagtac catcttccct acccagaggc catctttgag      360

atcagctatt tcaagaaaca tccggaaccc ttcttcgccc tcgccaagga actctatcct      420

gggcagttca agccaaccat ctgtcactac ttcatgcgcc tgctgaagga caaggggcta      480

ctcctgcgct gctacacgca gaacatagat accctggagc gaatagccgg gctggaacag      540

gaggacttgg tggaggcgca cggcaccttc tacacatcac actgcgtcag cgccagctgc      600

cggcacgaat acccgctaag ctggatgaaa gagaagatct tctctgaggt gacgcccaag      660

tgtgaagact gtcagagcct ggtgaagcct gatatcgtct tttttggtga gagcctccca      720

gcgcgtttct tctcctgtat gcagtcagac ttcctgaagg tggacctcct cctggtcatg      780

ggtacctcct tgcaggtgca gccctttgcc tccctcatca gcaaggcacc cctctccacc      840

cctcgcctgc tcatcaacaa ggagaaagct ggccagtcgg accctttcct ggggatgatt      900

atgggcctcg gaggaggcat ggactttgac tccaagaagg cctacaggga cgtggcctgg      960

ctgggtgaat gcgaccaggg ctgcctggcc cttgctgagc tccttggatg gaagaaggag     1020

ctggaggacc ttgtccggag ggagcacgcc agcatagatg cccagtcggg ggcgggggtc     1080

cccaacccca gcacttcagc ttcccccaag aagtccccgc cacctgccaa ggacgaggcc     1140

aggacaacag agagggagaa accccag                                         1167


<210>  17
<211>  771
<212>  DNA
<213>  ˹

<220>
<223>  S3ĺ

<400>  17
atggtggggg ccggcatcag cacacccagt ggcattccag acttcagatc gccggggagt       60

ggcctgtaca gcaacctcca gcagtacgat ctcccgtacc ccgaggccat ttttgaactc      120

ccattcttct ttcacaaccc caagcccttt ttcactttgg ccaaggagct gtaccctgga      180

aactacaagc ccaacgtcac tcactacttt ctccggctgc ttcatgacaa ggggctgctt      240

ctgcggctct acacgcagaa catcgatggg cttgagagag tgtcgggcat ccctgcctca      300

aagctggttg aagctcatgg aacctttgcc tctgccacct gcacagtctg ccaaagaccc      360

ttcccagggg aggacattcg ggctgacgtg atggcagaca gggttccccg ctgcccggtc      420

tgcaccggcg ttgtgaagcc cgacattgtg ttctttgggg agccgctgcc ccagaggttc      480

ttgctgcatg tggttgattt ccccatggca gatctgctgc tcatccttgg gacctccctg      540

gaggtggagc cttttgccag cttgaccgag gccgtgcgga gctcagttcc ccgactgctc      600

atcaaccggg acttggtggg gcccttggct tggcatcctc gcagcaggga cgtggcccag      660

ctgggggacg tggttcacgg cgtggaaagc ctagtggagc ttctgggctg gacagaagag      720

atgcgggacc ttgtgcagcg ggaaactggg aagcttgatg gaccagacaa a               771


<210>  18
<211>  945
<212>  DNA
<213>  ˹

<220>
<223>  S4ĺ

<400>  18
atgaagatga gctttgcgtt gactttcagg tcagcaaaag gccgttggat cgcaaacccc       60

agccagccgt gctcgaaagc ctccattggg ttatttgtgc cagcaagtcc tcctctggac      120

cctgagaagg tcaaagagtt acagcgcttc atcacccttt ccaagagact ccttgtgatg      180

actggggcag gaatctccac cgaatcgggg ataccagact acaggtcaga aaaagtgggg      240

ctttatgccc gcactgaccg caggcccatc cagcatggtg attttgtccg gagtgcccca      300

atccgccagc ggtactgggc gagaaacttc gtaggctggc ctcaattctc ctcccaccag      360

cctaaccctg cacactgggc tttgagcacc tgggagaaac tcggaaagct gtactggttg      420

gtgacccaaa atgtggatgc tttgcacacc aaggcgggga gtcggcgcct gacagagctc      480

cacggatgca tggacagggt cctgtgcttg gattgtgggg aacagactcc ccggggggtg      540

ctgcaagagc gtttccaagt cctgaacccc acctggagtg ctgaggccca tggcctggct      600

cctgatggtg acgtctttct ctcagaggag caagtccgga gctttcaggt cccaacctgc      660

gttcaatgtg gaggccatct gaaaccagat gtcgttttct tcggggacac agtgaaccct      720

gacaaggttg attttgtgca caagcgtgta aaagaagccg actccctctt ggtggtggga      780

tcatccttgc aggtatactc tggttacagg tttatcctca ctgcctggga gaagaagctc      840

ccgattgcaa tactgaacat tgggcccaca cggtcggatg acttggcgtg tctgaaactg      900

aattctcgtt gtggagagtt gctgcctttg atagacccat gctga                      945


<210>  19
<211>  933
<212>  DNA
<213>  ˹

<220>
<223>  S5ĺ

<400>  19
atgcgacctc tccagattgt cccaagtcga ttgatttccc agctatattg tggcctgaag       60

cctccagcgt ccacacgaaa ccagatttgc ctgaaaatgg ctcggccaag ttcaagtatg      120

gcagattttc gaaagttttt tgcaaaagca aagcacatag tcatcatctc aggagctggt      180

gttagtgcag aaagtggtgt tccgaccttc agaggagctg gaggttattg gagaaaatgg      240

caagcccagg acctggcgac tcccctggcc tttgcccaca acccgtcccg ggtgtgggag      300

ttctaccact accggcggga ggtcatgggg agcaaggagc ccaacgccgg gcaccgcgcc      360

atagccgagt gtgagacccg gctgggcaag cagggccggc gagtcgtggt catcacccag      420

aacatcgatg agctgcaccg caaggctggc accaagaacc ttctggagat ccatggtagc      480

ttatttaaaa ctcgatgtac ctcttgtgga gttgtggctg agaattacaa gagtccaatt      540

tgtccagctt tatcaggaaa aggtgctcca gaacctggaa ctcaagatgc cagcatccca      600

gttgagaaac ttccccggtg tgaagaggca ggctgcgggg gcttgctgcg acctcacgtc      660

gtgtggtttg gagaaaacct ggatcctgcc attctggagg aggttgacag agagctcgcc      720

cactgtgatt tatgtctagt ggtgggcact tcctctgtgg tgtacccagc agccatgttt      780

gccccccagg tggctgccag gggcgtgcca gtggctgaat ttaacacgga gaccacccca      840

gctacgaaca gattcaggtt tcatttccag ggaccctgtg gaacgactct tcctgaagcc      900

cttgcctgtc atgaaaatga aactgtttct taa                                   933


<210>  20
<211>  1065
<212>  DNA
<213>  ˹

<220>
<223>  S6ĺ

<400>  20
atgtcggtga attacgcggc ggggctgtcg ccgtacgcgg acaagggcaa gtgcggcctc       60

ccggagatct tcgacccccc ggaggagctg gagcggaagg tgtgggaact ggcgaggctg      120

gtctggcagt cttccagtgt ggtgttccac acgggtgccg gcatcagcac tgcctctggc      180

atccccgact tcaggggtcc ccacggagtc tggaccatgg aggagcgagg tctggccccc      240

aagttcgaca ccacctttga gagcgcgcgg cccacgcaga cccacatggc gctggtgcag      300

ctggagcgcg tgggcctcct ccgcttcctg gtcagccaga acgtggacgg gctccatgtg      360

cgctcaggct tccccaggga caaactggca gagctccacg ggaacatgtt tgtggaagaa      420

tgtgccaagt gtaagacgca gtacgtccga gacacagtcg tgggcaccat gggcctgaag      480

gccacgggcc ggctctgcac cgtggctaag gcaagggggc tgcgagcctg caggggagag      540

ctgagggaca ccatcctaga ctgggaggac tccctgcccg accgggacct ggcactcgcc      600

gatgaggcca gcaggaacgc cgacctgtcc atcacgctgg gtacatcgct gcagatccgg      660

cccagcggga acctgccgct ggctaccaag cgccggggag gccgcctggt catcgtcaac      720

ctgcagccca ccaagcacga ccgccatgct gacctccgca tccatggcta cgttgacgag      780

gtcatgaccc ggctcatgaa gcacctgggg ctggagatcc ccgcctggga cggcccccgt      840

gtgctggaga gggcgctgcc acccctgccc cgcccgccca cccccaagct ggagcccaag      900

gaggaatctc ccacccggat caacggctct atccccgccg gccccaagca ggagccctgc      960

gcccagcaca acggctcaga gcccgccagc cccaaacggg agcggcccac cagccctgcc     1020

ccccacagac cccccaaaag ggtgaaggcc aaggcggtcc ccagc                     1065


<210>  21
<211>  1203
<212>  DNA
<213>  ˹

<220>
<223>  S7ĺ

<400>  21
atggcagccg ggggtctgag ccgctccgag cgcaaagcgg cggagcgggt ccggaggttg       60

cgggaggagc agcagaggga gcgcctccgc caggtgtcgc gcatcctgag gaaggcggcg      120

gcggagcgca gcgccgagga gggccggctg ctggccgaga gcgcggacct ggtaacggag      180

ctgcagggcc ggagccggcg gcgcgagggc ctgaagcggc ggcaggagga ggtgtgcgac      240

gacccggagg agctgcgggg gaaggtccgg gagctggcca gcgccgtccg gaacgccaaa      300

tacttggtcg tctacacagg cgcgggaatc agcacggcag cgtctatccc agactaccgg      360

ggccctaatg gagtgtggac actgcttcag aaagggagaa gcgttagtgc tgccgacctg      420

agcgaggccg agccaaccct cacccacatg agcatcaccc gtctgcatga gcagaagctg      480

gtgcagcatg tggtgtctca gaactgtgac gggctccacc tgaggagtgg gctgccgcgc      540

acggccatct ccgagctcca cgggaacatg tacattgaag tctgtacctc ctgcgttccc      600

aacagggagt acgtgcgggt gttcgatgtg acggagcgca ctgccctcca cagacaccag      660

acaggccgga cctgccacaa gtgtgggacc cagctgcggg acaccattgt gcactttggg      720

gagaggggga cgttggggca gcctttgaac tgggaagcgg cgaccgaggc tgccagcaga      780

gcagacacca tcctgtgtct agggtccagc ctgaaggttc taaagaagta cccacgcctc      840

tggtgcatga ccaagccccc tagccggcgg ccgaagcttt acatcgtgaa cctgcagtgg      900

accccgaagg atgactgggc tgccctgaag ctacatggga agtgtgatga cgtcatgcgg      960

ctcctcatgg ccgagctggg cttggagatc cccgcctata gcaggtggca ggatcccatt     1020

ttctcactgg cgactcccct gcgtgctggt gaagaaggca gccacagtcg gaagtcgctg     1080

tgcagaagca gagaggaggc cccgcctggg gaccggggtg caccgcttag ctcggccccc     1140

atcctagggg gctggtttgg caggggctgc acaaaacgca caaaaaggaa gaaagtgacg     1200

taa                                                                   1203


<210>  22
<211>  1002
<212>  DNA
<213>  ˹

<220>
<223>  S1Aĺ

<400>  22
ggtccatata cttttgttca gcaacatctt atgattggca cagatcctcg aacaattctt       60

aaagatttat tgccggaaac aatacctcca cctgagttgg atgatatgac actgtggcag      120

attgttatta atatcctttc agaaccacca aaaaggaaaa aaagaaaaga tattaataca      180

attgaagatg ctgtgaaatt actgcaagag tgcaaaaaaa ttatagttct aactggagct      240

ggggtgtctg tttcatgtgg aatacctgac ttcaggtcaa gggatggtat ttatgctcgc      300

cttgctgtag acttcccaga tcttccagat cctcaagcga tgtttgatat tgaatatttc      360

agaaaagatc caagaccatt cttcaagttt gcaaaggaaa tatatcctgg acaattccag      420

ccatctctct gtcacaaatt catagccttg tcagataagg aaggaaaact acttcgcaac      480

tatacccaga acatagacac gctggaacag gttgcgggaa tccaaaggat aattcagtgt      540

catggttcct ttgcaacagc atcttgcctg atttgtaaat acaaagttga ctgtgaagct      600

gtacgaggag atatttttaa tcaggtagtt cctcgatgtc ctaggtgccc agctgatgaa      660

ccgcttgcta tcatgaaacc agagattgtg ttttttggtg aaaatttacc agaacagttt      720

catagagcca tgaagtatga caaagatgaa gttgacctcc tcattgttat tgggtcttcc      780

ctcaaagtaa gaccagtagc actaattcca agttccatac cccatgaagt gcctcagata      840

ttaattaata gagaaccttt gcctcatctg cattttgatg tagagcttct tggagactgt      900

gatgtcataa ttaatgaatt gtgtcatagg ttaggtggtg aatatgccaa actttgctgt      960

aaccctgtaa agctttcaga aattactgaa aaacctccac ga                        1002


<210>  23
<211>  1101
<212>  DNA
<213>  ˹

<220>
<223>  S1Bĺ

<400>  23
ggtccatata cttttgttca gcaacatctt atgattggca cagatcctcg aacaattctt       60

aaagatttat tgccggaaac aatacctcca cctgagttgg atgatatgac actgtggcag      120

attgttatta atatcctttc agaaccacca aaaagggcgg cggcggcaga tattaataca      180

attgaagatg ctgtgaaatt actgcaagag tgcaaaaaaa ttatagttct aactggagct      240

ggggtgtctg tttcatgtgg aatacctgac ttcaggtcaa gggatggtat ttatgctcgc      300

cttgctgtag acttcccaga tcttccagat cctcaagcga tgtttgatat tgaatatttc      360

agaaaagatc caagaccatt cttcaagttt gcaaaggaaa tatatcctgg acaattccag      420

ccatctctct gtcacaaatt catagccttg tcagataagg aaggaaaact acttcgcaac      480

tatacccaga acatagacac gctggaacag gttgcgggaa tccaaaggat aattcagtgt      540

catggttcct ttgcaacagc atcttgcctg atttgtaaat acaaagttga ctgtgaagct      600

gtacgaggag atatttttaa tcaggtagtt cctcgatgtc ctaggtgccc agctgatgaa      660

ccgcttgcta tcatgaaacc agagattgtg ttttttggtg aaaatttacc agaacagttt      720

catagagcca tgaagtatga caaagatgaa gttgacctcc tcattgttat tgggtcttcc      780

ctcaaagtaa gaccagtagc actaattcca agttccatac cccatgaagt gcctcagata      840

ttaattaata gagaaccttt gcctcatctg cattttgatg tagagcttct tggagactgt      900

gatgtcataa ttaatgaatt gtgtcatagg ttaggtggtg aatatgccaa actttgctgt      960

aaccctgtaa agctttcaga aattactgaa aaacctccac gaggcggagg atcaggcgga     1020

ggctcccagt atctgttttt gccaccaaat cgttacattt tccatggcgc tgaggtatat     1080

tcagactctg aagatgacgt c                                               1101


<210>  24
<211>  1002
<212>  DNA
<213>  ˹

<220>
<223>  S1B1ĺ

<400>  24
ggtccatata cttttgttca gcaacatctt atgattggca cagatcctcg aacaattctt       60

aaagatttat tgccggaaac aatacctcca cctgagttgg atgatatgac actgtggcag      120

attgttatta atatcctttc agaaccacca aaaagggcgg cggcggcaga tattaataca      180

attgaagatg ctgtgaaatt actgcaagag tgcaaaaaaa ttatagttct aactggagct      240

ggggtgtctg tttcatgtgg aatacctgac ttcaggtcaa gggatggtat ttatgctcgc      300

cttgctgtag acttcccaga tcttccagat cctcaagcga tgtttgatat tgaatatttc      360

agaaaagatc caagaccatt cttcaagttt gcaaaggaaa tatatcctgg acaattccag      420

ccatctctct gtcacaaatt catagccttg tcagataagg aaggaaaact acttcgcaac      480

tatacccaga acatagacac gctggaacag gttgcgggaa tccaaaggat aattcagtgt      540

catggttcct ttgcaacagc atcttgcctg atttgtaaat acaaagttga ctgtgaagct      600

gtacgaggag atatttttaa tcaggtagtt cctcgatgtc ctaggtgccc agctgatgaa      660

ccgcttgcta tcatgaaacc agagattgtg ttttttggtg aaaatttacc agaacagttt      720

catagagcca tgaagtatga caaagatgaa gttgacctcc tcattgttat tgggtcttcc      780

ctcaaagtaa gaccagtagc actaattcca agttccatac cccatgaagt gcctcagata      840

ttaattaata gagaaccttt gcctcatctg cattttgatg tagagcttct tggagactgt      900

gatgtcataa ttaatgaatt gtgtcatagg ttaggtggtg aatatgccaa actttgctgt      960

aaccctgtaa agctttcaga aattactgaa aaacctccac ga                        1002


<210>  25
<211>  1101
<212>  DNA
<213>  ˹

<220>
<223>  S1Cĺ

<400>  25
ggtccatata cttttgttca gcaacatctt atgattggca cagatcctcg aacaattctt       60

aaagatttat tgccggaaac aatacctcca cctgagttgg atgatatgac actgtggcag      120

attgttatta atatcctttc agaaccacca aaaaggaaaa aaagaaaaga tattaataca      180

attgaagatg ctgtgaaatt actgcaagag tgcaaaaaaa ttatagttct aactggagct      240

ggggtgtctg tttcatgtgg aatacctgac ttcaggtcaa gggatggtat ttatgctcgc      300

cttgctgtag acttcccaga tcttccagat cctcaagcga tgtttgatat tgaatatttc      360

agaaaagatc caagaccatt cttcaagttt gcaaaggaaa tatatcctgg acaattccag      420

ccatctctct gtcacaaatt catagccttg tcagataagg aaggaaaact acttcgcaac      480

tatacccaga acatagacac gctggaacag gttgcgggaa tccaaaggat aattcagtgt      540

catggttcct ttgcaacagc atcttgcctg atttgtaaat acaaagttga ctgtgaagct      600

gtacgaggag atatttttaa tcaggtagtt cctcgatgtc ctaggtgccc agctgatgaa      660

ccgcttgcta tcatgaaacc agagattgtg ttttttggtg aaaatttacc agaacagttt      720

catagagcca tgaagtatga caaagatgaa gccgacgcgg cggcggcggc ggggtcttcc      780

ctcaaagtaa gaccagtagc actaattcca agttccatac cccatgaagt gcctcagata      840

ttaattaata gagaaccttt gcctcatctg cattttgatg tagagcttct tggagactgt      900

gatgtcataa ttaatgaatt gtgtcatagg ttaggtggtg aatatgccaa actttgctgt      960

aaccctgtaa agctttcaga aattactgaa aaacctccac gaggcggagg atcaggcgga     1020

ggctcccagt atctgttttt gccaccaaat cgttacattt tccatggcgc tgaggtatat     1080

tcagactctg aagatgacgt c                                               1101


<210>  26
<211>  1002
<212>  DNA
<213>  ˹

<220>
<223>  S1C1ĺ

<400>  26
ggtccatata cttttgttca gcaacatctt atgattggca cagatcctcg aacaattctt       60

aaagatttat tgccggaaac aatacctcca cctgagttgg atgatatgac actgtggcag      120

attgttatta atatcctttc agaaccacca aaaaggaaaa aaagaaaaga tattaataca      180

attgaagatg ctgtgaaatt actgcaagag tgcaaaaaaa ttatagttct aactggagct      240

ggggtgtctg tttcatgtgg aatacctgac ttcaggtcaa gggatggtat ttatgctcgc      300

cttgctgtag acttcccaga tcttccagat cctcaagcga tgtttgatat tgaatatttc      360

agaaaagatc caagaccatt cttcaagttt gcaaaggaaa tatatcctgg acaattccag      420

ccatctctct gtcacaaatt catagccttg tcagataagg aaggaaaact acttcgcaac      480

tatacccaga acatagacac gctggaacag gttgcgggaa tccaaaggat aattcagtgt      540

catggttcct ttgcaacagc atcttgcctg atttgtaaat acaaagttga ctgtgaagct      600

gtacgaggag atatttttaa tcaggtagtt cctcgatgtc ctaggtgccc agctgatgaa      660

ccgcttgcta tcatgaaacc agagattgtg ttttttggtg aaaatttacc agaacagttt      720

catagagcca tgaagtatga caaagatgaa gccgacgcgg cggcggcggc ggggtcttcc      780

ctcaaagtaa gaccagtagc actaattcca agttccatac cccatgaagt gcctcagata      840

ttaattaata gagaaccttt gcctcatctg cattttgatg tagagcttct tggagactgt      900

gatgtcataa ttaatgaatt gtgtcatagg ttaggtggtg aatatgccaa actttgctgt      960

aaccctgtaa agctttcaga aattactgaa aaacctccac ga                        1002


<210>  27
<211>  1266
<212>  DNA
<213>  ˹

<220>
<223>  S1Dĺ

<400>  27
atggcggacg aggcggccct cgcccttcag cccggcggct ccccctcggc ggcgggggcc       60

gacagggagg ccgcgtcgtc ccccgccggg gagccgctcc gcaagaggcc gcggagagat      120

ggcggcggag gatcaggagg cggcggaagc ggaggcggag gctccggtcc atatactttt      180

gttcagcaac atcttatgat tggcacagat cctcgaacaa ttcttaaaga tttattgccg      240

gaaacaatac ctccacctga gttggatgat atgacactgt ggcagattgt tattaatatc      300

ctttcagaac caccaaaaag gaaaaaaaga aaagatatta atacaattga agatgctgtg      360

aaattactgc aagagtgcaa aaaaattata gttctaactg gagctggggt gtctgtttca      420

tgtggaatac ctgacttcag gtcaagggat ggtatttatg ctcgccttgc tgtagacttc      480

ccagatcttc cagatcctca agcgatgttt gatattgaat atttcagaaa agatccaaga      540

ccattcttca agtttgcaaa ggaaatatat cctggacaat tccagccatc tctctgtcac      600

aaattcatag ccttgtcaga taaggaagga aaactacttc gcaactatac ccagaacata      660

gacacgctgg aacaggttgc gggaatccaa aggataattc agtgtcatgg ttcctttgca      720

acagcatctt gcctgatttg taaatacaaa gttgactgtg aagctgtacg aggagatatt      780

tttaatcagg tagttcctcg atgtcctagg tgcccagctg atgaaccgct tgctatcatg      840

aaaccagaga ttgtgttttt tggtgaaaat ttaccagaac agtttcatag agccatgaag      900

tatgacaaag atgaagttga cctcctcatt gttattgggt cttccctcaa agtaagacca      960

gtagcactaa ttccaagttc cataccccat gaagtgcctc agatattaat taatagagaa     1020

cctttgcctc atctgcattt tgatgtagag cttcttggag actgtgatgt cataattaat     1080

gaattgtgtc ataggttagg tggtgaatat gccaaacttt gctgtaaccc tgtaaagctt     1140

tcagaaatta ctgaaaaacc tccacgaggc ggaggatcag gcggaggctc ccagtatctg     1200

tttttgccac caaatcgtta cattttccat ggcgctgagg tatattcaga ctctgaagat     1260

gacgtc                                                                1266


<210>  28
<211>  1167
<212>  DNA
<213>  ˹

<220>
<223>  S1D1ĺ

<400>  28
atggcggacg aggcggccct cgcccttcag cccggcggct ccccctcggc ggcgggggcc       60

gacagggagg ccgcgtcgtc ccccgccggg gagccgctcc gcaagaggcc gcggagagat      120

ggcggcggag gatcaggagg cggcggaagc ggaggcggag gctccggtcc atatactttt      180

gttcagcaac atcttatgat tggcacagat cctcgaacaa ttcttaaaga tttattgccg      240

gaaacaatac ctccacctga gttggatgat atgacactgt ggcagattgt tattaatatc      300

ctttcagaac caccaaaaag gaaaaaaaga aaagatatta atacaattga agatgctgtg      360

aaattactgc aagagtgcaa aaaaattata gttctaactg gagctggggt gtctgtttca      420

tgtggaatac ctgacttcag gtcaagggat ggtatttatg ctcgccttgc tgtagacttc      480

ccagatcttc cagatcctca agcgatgttt gatattgaat atttcagaaa agatccaaga      540

ccattcttca agtttgcaaa ggaaatatat cctggacaat tccagccatc tctctgtcac      600

aaattcatag ccttgtcaga taaggaagga aaactacttc gcaactatac ccagaacata      660

gacacgctgg aacaggttgc gggaatccaa aggataattc agtgtcatgg ttcctttgca      720

acagcatctt gcctgatttg taaatacaaa gttgactgtg aagctgtacg aggagatatt      780

tttaatcagg tagttcctcg atgtcctagg tgcccagctg atgaaccgct tgctatcatg      840

aaaccagaga ttgtgttttt tggtgaaaat ttaccagaac agtttcatag agccatgaag      900

tatgacaaag atgaagttga cctcctcatt gttattgggt cttccctcaa agtaagacca      960

gtagcactaa ttccaagttc cataccccat gaagtgcctc agatattaat taatagagaa     1020

cctttgcctc atctgcattt tgatgtagag cttcttggag actgtgatgt cataattaat     1080

gaattgtgtc ataggttagg tggtgaatat gccaaacttt gctgtaaccc tgtaaagctt     1140

tcagaaatta ctgaaaaacc tccacga                                         1167


<210>  29
<211>  1266
<212>  DNA
<213>  ˹

<220>
<223>  S1Eĺ

<400>  29
atggcggacg aggcggccct cgcccttcag cccggcggct ccccctcggc ggcgggggcc       60

gacagggagg ccgcgtcgtc ccccgccggg gagccgctcc gcaagaggcc gcggagagat      120

ggcggcggag gatcaggagg cggcggaagc ggaggcggag gctccggtcc atatactttt      180

gttcagcaac atcttatgat tggcacagat cctcgaacaa ttcttaaaga tttattgccg      240

gaaacaatac ctccacctga gttggatgat atgacactgt ggcagattgt tattaatatc      300

ctttcagaac caccaaaaag gaaaaaaaga aaagatatta atacaattga agatgctgtg      360

aaattactgc aagagtgcaa aaaaattata gttctaactg gagctggggt gtctgtttca      420

tgtggaatac ctgacttcag gtcaagggat ggtatttatg ctcgccttgc tgtagacttc      480

ccagatcttc cagatcctca agcgatgttt gatattgaat atttcagaaa agatccaaga      540

ccattcttca agtttgcaaa ggaaatatat cctggacaat tccagccatc tctctgtcac      600

aaattcatag ccttgtcaga taaggaagga aaactacttc gcaactatac ccagaacata      660

gacacgctgg aacaggttgc gggaatccaa aggataattc agtgtcatgg ttcctttgca      720

acagcatctt gcctgatttg taaatacaaa gttgactgtg aagctgtacg aggagatatt      780

tttaatcagg tagttcctcg atgtcctagg tgcccagctg atgaaccgct tgctatcatg      840

aaaccagaga ttgtgttttt tggtgaaaat ttaccagaac agtttcatag agccatgaag      900

tatgacaaag atgaagccga cgcggcggcg gcggcggggt cttccctcaa agtaagacca      960

gtagcactaa ttccaagttc cataccccat gaagtgcctc agatattaat taatagagaa     1020

cctttgcctc atctgcattt tgatgtagag cttcttggag actgtgatgt cataattaat     1080

gaattgtgtc ataggttagg tggtgaatat gccaaacttt gctgtaaccc tgtaaagctt     1140

tcagaaatta ctgaaaaacc tccacgaggc ggaggatcag gcggaggctc ccagtatctg     1200

tttttgccac caaatcgtta cattttccat ggcgctgagg tatattcaga ctctgaagat     1260

gacgtc                                                                1266


<210>  30
<211>  1167
<212>  DNA
<213>  ˹

<220>
<223>  S1E1ĺ

<400>  30
atggcggacg aggcggccct cgcccttcag cccggcggct ccccctcggc ggcgggggcc       60

gacagggagg ccgcgtcgtc ccccgccggg gagccgctcc gcaagaggcc gcggagagat      120

ggcggcggag gatcaggagg cggcggaagc ggaggcggag gctccggtcc atatactttt      180

gttcagcaac atcttatgat tggcacagat cctcgaacaa ttcttaaaga tttattgccg      240

gaaacaatac ctccacctga gttggatgat atgacactgt ggcagattgt tattaatatc      300

ctttcagaac caccaaaaag gaaaaaaaga aaagatatta atacaattga agatgctgtg      360

aaattactgc aagagtgcaa aaaaattata gttctaactg gagctggggt gtctgtttca      420

tgtggaatac ctgacttcag gtcaagggat ggtatttatg ctcgccttgc tgtagacttc      480

ccagatcttc cagatcctca agcgatgttt gatattgaat atttcagaaa agatccaaga      540

ccattcttca agtttgcaaa ggaaatatat cctggacaat tccagccatc tctctgtcac      600

aaattcatag ccttgtcaga taaggaagga aaactacttc gcaactatac ccagaacata      660

gacacgctgg aacaggttgc gggaatccaa aggataattc agtgtcatgg ttcctttgca      720

acagcatctt gcctgatttg taaatacaaa gttgactgtg aagctgtacg aggagatatt      780

tttaatcagg tagttcctcg atgtcctagg tgcccagctg atgaaccgct tgctatcatg      840

aaaccagaga ttgtgttttt tggtgaaaat ttaccagaac agtttcatag agccatgaag      900

tatgacaaag atgaagccga cgcggcggcg gcggcggggt cttccctcaa agtaagacca      960

gtagcactaa ttccaagttc cataccccat gaagtgcctc agatattaat taatagagaa     1020

cctttgcctc atctgcattt tgatgtagag cttcttggag actgtgatgt cataattaat     1080

gaattgtgtc ataggttagg tggtgaatat gccaaacttt gctgtaaccc tgtaaagctt     1140

tcagaaatta ctgaaaaacc tccacga                                         1167


<210>  31
<211>  720
<212>  DNA
<213>  ˹

<220>
<223>  C8ĺ

<400>  31
atggaggaga gtgtcgtacg gccctcagtg tttgtggtgg atggacagac cgacatccca       60

ttcacgaggc tgggacgaag ccaccggaga cagtcgtgca gtgtggcccg ggtgggtctg      120

ggtctcttgc tgttgctgat gggggccggg ctggccgtcc aaggctggtt cctcctgcag      180

ctgcactggc gtctaggaga gatggtcacc cgcctgcctg acggacctgc aggctcctgg      240

gagcagctga tacaagagcg aaggtctcac gaggtcaacc cagcagcgca tctcacaggg      300

gccaactcca gcttgaccgg cagcgggggg ccgctgttat gggagactca gctgggcctg      360

gccttcctga ggggcctcag ctaccacgat ggggcccttg tggtcaccaa agctggctac      420

tactacatct actccaaggt gcagctgggc ggtgtgggct gcccgctggg cctggccagc      480

accatcaccc acggcctcta caagcgcaca ccccgctacc ccgaggagct ggagctgttg      540

gtcagccagc agtcaccctg cggacgggcc accagcagct cccgggtctg gtgggacagc      600

agcttcctgg gtggtgtggt acacctggag gctggggaga aggtggtcgt ccgtgtgctg      660

gatgaacgcc tggttcgact gcgtgatggt acccggtctt acttcggggc tttcatggtg      720


<210>  32
<211>  708
<212>  DNA
<213>  ˹

<220>
<223>  C8Aĺ

<400>  32
atggaggaga gtgtcgtacg gccctcagtg tttgtggtgg atggacagac cgacatccca       60

ttcacgaggc tgggacgaag ccaccggaga cagtcgtgca gtgtggcccg ggtgggtctg      120

ggtctcttgc tgttgctgat gggggccggg ctggccgtcc aaggctggtt cctcctgcag      180

ctgcactggc gtctaggaga gatggtcacc cgcctgcctg acggacctgc aggctcctgg      240

caagagcgaa ggtctcacga ggtcaaccca gcagcgcatc tcacaggggc caactccagc      300

ttgaccggca gcggggggcc gctgttatgg gagactcagc tgggcctggc cttcctgagg      360

ggcctcagct accacgatgg ggcccttgtg gtcaccaaag ctggctacta ctacatctac      420

tccaaggtgc agctgggcgg tgtgggctgc ccgctgggcc tggccagcac catcacccac      480

ggcctctaca agcgcacacc ccgctacccc gaggagctgg agctgttggt cagccagcag      540

tcaccctgcg gacgggccac cagcagctcc cgggtctggt gggacagcag cttcctgggt      600

ggtgtggtac acctggaggc tggggagaag gtggtcgtcc gtgtgctgga tgaacgcctg      660

gttcgactgc gtgatggtac ccggtcttac ttcggggctt tcatggtg                   708


<210>  33
<211>  468
<212>  DNA
<213>  ˹

<220>
<223>  C8Bĺ

<400>  33
caagagcgaa ggtctcacga ggtcaaccca gcagcgcatc tcacaggggc caactccagc       60

ttgaccggca gcggggggcc gctgttatgg gagactcagc tgggcctggc cttcctgagg      120

ggcctcagct accacgatgg ggcccttgtg gtcaccaaag ctggctacta ctacatctac      180

tccaaggtgc agctgggcgg tgtgggctgc ccgctgggcc tggccagcac catcacccac      240

ggcctctaca agcgcacacc ccgctacccc gaggagctgg agctgttggt cagccagcag      300

tcaccctgcg gacgggccac cagcagctcc cgggtctggt gggacagcag cttcctgggt      360

ggtgtggtac acctggaggc tggggagaag gtggtcgtcc gtgtgctgga tgaacgcctg      420

gttcgactgc gtgatggtac ccggtcttac ttcggggctt tcatggtg                   468


<210>  34
<211>  242
<212>  PRT
<213>  ˹

<220>
<223>  GPC3 scFvİ

<400>  34

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  35
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  GPC3 scFvɱ

<400>  35

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  36
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  GPC3 scFvɱCDR1

<400>  36

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  37
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  GPC3 scFvɱCDR2

<400>  37

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  GPC3 scFvɱCDR3

<400>  38

Ser Gln Asn Thr His Val Pro Pro Thr 
1               5                   


<210>  39
<211>  115
<212>  PRT
<213>  ˹

<220>
<223>  GPC3 scFvɱ

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  40
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  GPC3 scFvɱCDR1

<400>  40

Asp Tyr Glu Met His 
1               5   


<210>  41
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  GPC3 scFvɱCDR2

<400>  41

Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  GPC3 scFvɱCDR3

<400>  42

Phe Tyr Ser Tyr Thr Tyr Trp 
1               5           


<210>  43
<211>  242
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFvİ

<400>  43

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  44
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFvɱ

<400>  44

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  45
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFvɱCDR1

<400>  45

Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
1               5                   10      


<210>  46
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFvɱCDR2

<400>  46

His Thr Ser Arg Leu His Ser 
1               5           


<210>  47
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFvɱCDR3

<400>  47

Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  48
<211>  120
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFvɱ

<400>  48

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  49
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFvCDR1

<400>  49

Leu Pro Asp Tyr Gly Val Ser 
1               5           


<210>  50
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFvɱCDR2

<400>  50

Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  51
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  CD19 scFvɱCDR3

<400>  51

His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp 
1               5                   10              


<210>  52
<211>  246
<212>  PRT
<213>  ˹

<220>
<223>  BCMA scFv

<400>  52

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Ser Val Ile 
            20                  25                  30          


Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
145                 150                 155                 160 


Tyr Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  53
<211>  111
<212>  PRT
<213>  ˹

<220>
<223>  BCMA scFvɱ

<400>  53

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Ser Val Ile 
            20                  25                  30          


Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  54
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  BCMA scFvɱCDR1

<400>  54

Arg Ala Ser Glu Ser Val Ser Val Ile Gly Ala His Leu Ile His 
1               5                   10                  15  


<210>  55
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  BCMA scFvɱCDR2

<400>  55

Leu Ala Ser Asn Leu Glu Thr 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  BCMA scFvɱCDR3

<400>  56

Leu Gln Ser Arg Ile Phe Pro Arg Thr 
1               5                   


<210>  57
<211>  117
<212>  PRT
<213>  ˹

<220>
<223>  BCMA scFvɱ

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  58
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  BCMA scFvɱCDR1

<400>  58

Asp Tyr Ser Ile Asn 
1               5   


<210>  59
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  BCMA scFvɱCDR2

<400>  59

Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  BCMA scFvɱCDR3

<400>  60

Asp Tyr Ser Tyr Ala Met Asp Tyr Trp 
1               5                   


<210>  61
<211>  259
<212>  PRT
<213>  ˹

<220>
<223>  MSLN scFv

<400>  61

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     


Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         


Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 


Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 


Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     


Val Leu Ser 
            


<210>  62
<211>  116
<212>  PRT
<213>  ˹

<220>
<223>  MSLN scFvɱ

<400>  62

Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu 
            100                 105                 110         


Thr Val Leu Ser 
        115     


<210>  63
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  MSLN scFvɱCDR1

<400>  63

Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr 
1               5                   10                  


<210>  64
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  MSLN scFvɱCDR2

<400>  64

Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser 
1               5                   10      


<210>  65
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  MSLN scFvɱCDR3

<400>  65

Met Ile Trp His Ser Ser Ala Ala Val 
1               5                   


<210>  66
<211>  123
<212>  PRT
<213>  ˹

<220>
<223>  MSLN scFvɱ

<400>  66

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  67
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  MSLN scFvɱCDR1

<400>  67

Ser Asn Ser Ala Thr Trp Asn 
1               5           


<210>  68
<211>  18
<212>  PRT
<213>  ˹

<220>
<223>  MSLN scFvɱCDR2

<400>  68

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
1               5                   10                  15      


Lys Ser 
        


<210>  69
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  MSLN scFvɱCDR3

<400>  69

Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10          


<210>  70
<211>  241
<212>  PRT
<213>  ˹

<220>
<223>  HER2 scFv

<400>  70

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser His Lys Phe 
    130                 135                 140                 


Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
145                 150                 155                 160 


Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
    210                 215                 220                 


His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  71
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  HER2 scFvɱ

<400>  71

Asp Ile Gln Leu Thr Gln Ser His Lys Phe Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Pro Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Phe Arg Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  72
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  HER2 scFvɱCDR1

<400>  72

Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala 
1               5                   10      


<210>  73
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  HER2 scFvɱCDR2

<400>  73

Ser Ala Ser Ser Arg Tyr Thr 
1               5           


<210>  74
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  HER2 scFvɱCDR3

<400>  74

Gln Gln His Phe Arg Thr Pro Phe Thr 
1               5                   


<210>  75
<211>  119
<212>  PRT
<213>  ˹

<220>
<223>  HER2 scFvɱ

<400>  75

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  76
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  HER2 scFvɱCDR1

<400>  76

Asn Tyr Gly Met Asn 
1               5   


<210>  77
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  HER2 scFvɱCDR2

<400>  77

Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  HER2 scFvɱCDR3

<400>  78

Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp 
1               5                   10      


<210>  79
<211>  46
<212>  PRT
<213>  ˹

<220>
<223>  CD8

<400>  79

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  80
<211>  23
<212>  PRT
<213>  ˹

<220>
<223>  CD8Ĥİ

<400>  80

Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
1               5                   10                  15      


Leu Val Ile Thr Leu Tyr Cys 
            20              


<210>  81
<211>  41
<212>  PRT
<213>  ˹

<220>
<223>  CD28̼ṹİ

<400>  81

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  82
<211>  42
<212>  PRT
<213>  ˹

<220>
<223>  4-1BBĹ̼ṹİ

<400>  82

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  83
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  CD3ƵźŴṹİ

<400>  83

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  84
<211>  18
<212>  PRT
<213>  ˹

<220>
<223>  T2Aİ

<400>  84

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  85
<211>  19
<212>  PRT
<213>  ˹

<220>
<223>  P2Aİ

<400>  85

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  86
<211>  367
<212>  PRT
<213>  ˹

<220>
<223>  S1İ

<400>  86

Gly Pro Tyr Thr Phe Val Gln Gln His Leu Met Ile Gly Thr Asp Pro 
1               5                   10                  15      


Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu Thr Ile Pro Pro Pro Glu 
            20                  25                  30          


Leu Asp Asp Met Thr Leu Trp Gln Ile Val Ile Asn Ile Leu Ser Glu 
        35                  40                  45              


Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile Asn Thr Ile Glu Asp Ala 
    50                  55                  60                  


Val Lys Leu Leu Gln Glu Cys Lys Lys Ile Ile Val Leu Thr Gly Ala 
65                  70                  75                  80  


Gly Val Ser Val Ser Cys Gly Ile Pro Asp Phe Arg Ser Arg Asp Gly 
                85                  90                  95      


Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro Asp Leu Pro Asp Pro Gln 
            100                 105                 110         


Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe 
        115                 120                 125             


Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys 
    130                 135                 140                 


His Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn 
145                 150                 155                 160 


Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg 
                165                 170                 175     


Ile Ile Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys 
            180                 185                 190         


Lys Tyr Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln 
        195                 200                 205             


Val Val Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile 
    210                 215                 220                 


Met Lys Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe 
225                 230                 235                 240 


His Arg Ala Met Lys Tyr Asp Lys Asp Glu Val Asp Leu Leu Ile Val 
                245                 250                 255     


Ile Gly Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser 
            260                 265                 270         


Ile Pro His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro 
        275                 280                 285             


His Leu His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile 
    290                 295                 300                 


Asn Glu Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys 
305                 310                 315                 320 


Asn Pro Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr 
            340                 345                 350         


Ile Phe His Gly Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val 
        355                 360                 365         


<210>  87
<211>  389
<212>  PRT
<213>  ˹

<220>
<223>  S2İ

<400>  87

Met Ala Glu Pro Asp Pro Ser His Pro Leu Glu Thr Gln Ala Gly Lys 
1               5                   10                  15      


Val Gln Glu Ala Gln Asp Ser Asp Ser Asp Ser Glu Gly Gly Ala Ala 
            20                  25                  30          


Gly Gly Glu Ala Asp Met Asp Phe Leu Arg Asn Leu Phe Ser Gln Thr 
        35                  40                  45              


Leu Ser Leu Gly Ser Gln Lys Glu Arg Leu Leu Asp Glu Leu Thr Leu 
    50                  55                  60                  


Glu Gly Val Ala Arg Tyr Met Gln Ser Glu Arg Cys Arg Arg Val Ile 
65                  70                  75                  80  


Cys Leu Val Gly Ala Gly Ile Ser Thr Ser Ala Gly Ile Pro Asp Phe 
                85                  90                  95      


Arg Ser Pro Ser Thr Gly Leu Tyr Asp Asn Leu Glu Lys Tyr His Leu 
            100                 105                 110         


Pro Tyr Pro Glu Ala Ile Phe Glu Ile Ser Tyr Phe Lys Lys His Pro 
        115                 120                 125             


Glu Pro Phe Phe Ala Leu Ala Lys Glu Leu Tyr Pro Gly Gln Phe Lys 
    130                 135                 140                 


Pro Thr Ile Cys His Tyr Phe Met Arg Leu Leu Lys Asp Lys Gly Leu 
145                 150                 155                 160 


Leu Leu Arg Cys Tyr Thr Gln Asn Ile Asp Thr Leu Glu Arg Ile Ala 
                165                 170                 175     


Gly Leu Glu Gln Glu Asp Leu Val Glu Ala His Gly Thr Phe Tyr Thr 
            180                 185                 190         


Ser His Cys Val Ser Ala Ser Cys Arg His Glu Tyr Pro Leu Ser Trp 
        195                 200                 205             


Met Lys Glu Lys Ile Phe Ser Glu Val Thr Pro Lys Cys Glu Asp Cys 
    210                 215                 220                 


Gln Ser Leu Val Lys Pro Asp Ile Val Phe Phe Gly Glu Ser Leu Pro 
225                 230                 235                 240 


Ala Arg Phe Phe Ser Cys Met Gln Ser Asp Phe Leu Lys Val Asp Leu 
                245                 250                 255     


Leu Leu Val Met Gly Thr Ser Leu Gln Val Gln Pro Phe Ala Ser Leu 
            260                 265                 270         


Ile Ser Lys Ala Pro Leu Ser Thr Pro Arg Leu Leu Ile Asn Lys Glu 
        275                 280                 285             


Lys Ala Gly Gln Ser Asp Pro Phe Leu Gly Met Ile Met Gly Leu Gly 
    290                 295                 300                 


Gly Gly Met Asp Phe Asp Ser Lys Lys Ala Tyr Arg Asp Val Ala Trp 
305                 310                 315                 320 


Leu Gly Glu Cys Asp Gln Gly Cys Leu Ala Leu Ala Glu Leu Leu Gly 
                325                 330                 335     


Trp Lys Lys Glu Leu Glu Asp Leu Val Arg Arg Glu His Ala Ser Ile 
            340                 345                 350         


Asp Ala Gln Ser Gly Ala Gly Val Pro Asn Pro Ser Thr Ser Ala Ser 
        355                 360                 365             


Pro Lys Lys Ser Pro Pro Pro Ala Lys Asp Glu Ala Arg Thr Thr Glu 
    370                 375                 380                 


Arg Glu Lys Pro Gln 
385                 


<210>  88
<211>  257
<212>  PRT
<213>  ˹

<220>
<223>  S3İ

<400>  88

Met Val Gly Ala Gly Ile Ser Thr Pro Ser Gly Ile Pro Asp Phe Arg 
1               5                   10                  15      


Ser Pro Gly Ser Gly Leu Tyr Ser Asn Leu Gln Gln Tyr Asp Leu Pro 
            20                  25                  30          


Tyr Pro Glu Ala Ile Phe Glu Leu Pro Phe Phe Phe His Asn Pro Lys 
        35                  40                  45              


Pro Phe Phe Thr Leu Ala Lys Glu Leu Tyr Pro Gly Asn Tyr Lys Pro 
    50                  55                  60                  


Asn Val Thr His Tyr Phe Leu Arg Leu Leu His Asp Lys Gly Leu Leu 
65                  70                  75                  80  


Leu Arg Leu Tyr Thr Gln Asn Ile Asp Gly Leu Glu Arg Val Ser Gly 
                85                  90                  95      


Ile Pro Ala Ser Lys Leu Val Glu Ala His Gly Thr Phe Ala Ser Ala 
            100                 105                 110         


Thr Cys Thr Val Cys Gln Arg Pro Phe Pro Gly Glu Asp Ile Arg Ala 
        115                 120                 125             


Asp Val Met Ala Asp Arg Val Pro Arg Cys Pro Val Cys Thr Gly Val 
    130                 135                 140                 


Val Lys Pro Asp Ile Val Phe Phe Gly Glu Pro Leu Pro Gln Arg Phe 
145                 150                 155                 160 


Leu Leu His Val Val Asp Phe Pro Met Ala Asp Leu Leu Leu Ile Leu 
                165                 170                 175     


Gly Thr Ser Leu Glu Val Glu Pro Phe Ala Ser Leu Thr Glu Ala Val 
            180                 185                 190         


Arg Ser Ser Val Pro Arg Leu Leu Ile Asn Arg Asp Leu Val Gly Pro 
        195                 200                 205             


Leu Ala Trp His Pro Arg Ser Arg Asp Val Ala Gln Leu Gly Asp Val 
    210                 215                 220                 


Val His Gly Val Glu Ser Leu Val Glu Leu Leu Gly Trp Thr Glu Glu 
225                 230                 235                 240 


Met Arg Asp Leu Val Gln Arg Glu Thr Gly Lys Leu Asp Gly Pro Asp 
                245                 250                 255     


Lys 
    


<210>  89
<211>  314
<212>  PRT
<213>  ˹

<220>
<223>  S4İ

<400>  89

Met Lys Met Ser Phe Ala Leu Thr Phe Arg Ser Ala Lys Gly Arg Trp 
1               5                   10                  15      


Ile Ala Asn Pro Ser Gln Pro Cys Ser Lys Ala Ser Ile Gly Leu Phe 
            20                  25                  30          


Val Pro Ala Ser Pro Pro Leu Asp Pro Glu Lys Val Lys Glu Leu Gln 
        35                  40                  45              


Arg Phe Ile Thr Leu Ser Lys Arg Leu Leu Val Met Thr Gly Ala Gly 
    50                  55                  60                  


Ile Ser Thr Glu Ser Gly Ile Pro Asp Tyr Arg Ser Glu Lys Val Gly 
65                  70                  75                  80  


Leu Tyr Ala Arg Thr Asp Arg Arg Pro Ile Gln His Gly Asp Phe Val 
                85                  90                  95      


Arg Ser Ala Pro Ile Arg Gln Arg Tyr Trp Ala Arg Asn Phe Val Gly 
            100                 105                 110         


Trp Pro Gln Phe Ser Ser His Gln Pro Asn Pro Ala His Trp Ala Leu 
        115                 120                 125             


Ser Thr Trp Glu Lys Leu Gly Lys Leu Tyr Trp Leu Val Thr Gln Asn 
    130                 135                 140                 


Val Asp Ala Leu His Thr Lys Ala Gly Ser Arg Arg Leu Thr Glu Leu 
145                 150                 155                 160 


His Gly Cys Met Asp Arg Val Leu Cys Leu Asp Cys Gly Glu Gln Thr 
                165                 170                 175     


Pro Arg Gly Val Leu Gln Glu Arg Phe Gln Val Leu Asn Pro Thr Trp 
            180                 185                 190         


Ser Ala Glu Ala His Gly Leu Ala Pro Asp Gly Asp Val Phe Leu Ser 
        195                 200                 205             


Glu Glu Gln Val Arg Ser Phe Gln Val Pro Thr Cys Val Gln Cys Gly 
    210                 215                 220                 


Gly His Leu Lys Pro Asp Val Val Phe Phe Gly Asp Thr Val Asn Pro 
225                 230                 235                 240 


Asp Lys Val Asp Phe Val His Lys Arg Val Lys Glu Ala Asp Ser Leu 
                245                 250                 255     


Leu Val Val Gly Ser Ser Leu Gln Val Tyr Ser Gly Tyr Arg Phe Ile 
            260                 265                 270         


Leu Thr Ala Trp Glu Lys Lys Leu Pro Ile Ala Ile Leu Asn Ile Gly 
        275                 280                 285             


Pro Thr Arg Ser Asp Asp Leu Ala Cys Leu Lys Leu Asn Ser Arg Cys 
    290                 295                 300                 


Gly Glu Leu Leu Pro Leu Ile Asp Pro Cys 
305                 310                 


<210>  90
<211>  310
<212>  PRT
<213>  ˹

<220>
<223>  S5İ

<400>  90

Met Arg Pro Leu Gln Ile Val Pro Ser Arg Leu Ile Ser Gln Leu Tyr 
1               5                   10                  15      


Cys Gly Leu Lys Pro Pro Ala Ser Thr Arg Asn Gln Ile Cys Leu Lys 
            20                  25                  30          


Met Ala Arg Pro Ser Ser Ser Met Ala Asp Phe Arg Lys Phe Phe Ala 
        35                  40                  45              


Lys Ala Lys His Ile Val Ile Ile Ser Gly Ala Gly Val Ser Ala Glu 
    50                  55                  60                  


Ser Gly Val Pro Thr Phe Arg Gly Ala Gly Gly Tyr Trp Arg Lys Trp 
65                  70                  75                  80  


Gln Ala Gln Asp Leu Ala Thr Pro Leu Ala Phe Ala His Asn Pro Ser 
                85                  90                  95      


Arg Val Trp Glu Phe Tyr His Tyr Arg Arg Glu Val Met Gly Ser Lys 
            100                 105                 110         


Glu Pro Asn Ala Gly His Arg Ala Ile Ala Glu Cys Glu Thr Arg Leu 
        115                 120                 125             


Gly Lys Gln Gly Arg Arg Val Val Val Ile Thr Gln Asn Ile Asp Glu 
    130                 135                 140                 


Leu His Arg Lys Ala Gly Thr Lys Asn Leu Leu Glu Ile His Gly Ser 
145                 150                 155                 160 


Leu Phe Lys Thr Arg Cys Thr Ser Cys Gly Val Val Ala Glu Asn Tyr 
                165                 170                 175     


Lys Ser Pro Ile Cys Pro Ala Leu Ser Gly Lys Gly Ala Pro Glu Pro 
            180                 185                 190         


Gly Thr Gln Asp Ala Ser Ile Pro Val Glu Lys Leu Pro Arg Cys Glu 
        195                 200                 205             


Glu Ala Gly Cys Gly Gly Leu Leu Arg Pro His Val Val Trp Phe Gly 
    210                 215                 220                 


Glu Asn Leu Asp Pro Ala Ile Leu Glu Glu Val Asp Arg Glu Leu Ala 
225                 230                 235                 240 


His Cys Asp Leu Cys Leu Val Val Gly Thr Ser Ser Val Val Tyr Pro 
                245                 250                 255     


Ala Ala Met Phe Ala Pro Gln Val Ala Ala Arg Gly Val Pro Val Ala 
            260                 265                 270         


Glu Phe Asn Thr Glu Thr Thr Pro Ala Thr Asn Arg Phe Arg Phe His 
        275                 280                 285             


Phe Gln Gly Pro Cys Gly Thr Thr Leu Pro Glu Ala Leu Ala Cys His 
    290                 295                 300                 


Glu Asn Glu Thr Val Ser 
305                 310 


<210>  91
<211>  355
<212>  PRT
<213>  ˹

<220>
<223>  S6İ

<400>  91

Met Ser Val Asn Tyr Ala Ala Gly Leu Ser Pro Tyr Ala Asp Lys Gly 
1               5                   10                  15      


Lys Cys Gly Leu Pro Glu Ile Phe Asp Pro Pro Glu Glu Leu Glu Arg 
            20                  25                  30          


Lys Val Trp Glu Leu Ala Arg Leu Val Trp Gln Ser Ser Ser Val Val 
        35                  40                  45              


Phe His Thr Gly Ala Gly Ile Ser Thr Ala Ser Gly Ile Pro Asp Phe 
    50                  55                  60                  


Arg Gly Pro His Gly Val Trp Thr Met Glu Glu Arg Gly Leu Ala Pro 
65                  70                  75                  80  


Lys Phe Asp Thr Thr Phe Glu Ser Ala Arg Pro Thr Gln Thr His Met 
                85                  90                  95      


Ala Leu Val Gln Leu Glu Arg Val Gly Leu Leu Arg Phe Leu Val Ser 
            100                 105                 110         


Gln Asn Val Asp Gly Leu His Val Arg Ser Gly Phe Pro Arg Asp Lys 
        115                 120                 125             


Leu Ala Glu Leu His Gly Asn Met Phe Val Glu Glu Cys Ala Lys Cys 
    130                 135                 140                 


Lys Thr Gln Tyr Val Arg Asp Thr Val Val Gly Thr Met Gly Leu Lys 
145                 150                 155                 160 


Ala Thr Gly Arg Leu Cys Thr Val Ala Lys Ala Arg Gly Leu Arg Ala 
                165                 170                 175     


Cys Arg Gly Glu Leu Arg Asp Thr Ile Leu Asp Trp Glu Asp Ser Leu 
            180                 185                 190         


Pro Asp Arg Asp Leu Ala Leu Ala Asp Glu Ala Ser Arg Asn Ala Asp 
        195                 200                 205             


Leu Ser Ile Thr Leu Gly Thr Ser Leu Gln Ile Arg Pro Ser Gly Asn 
    210                 215                 220                 


Leu Pro Leu Ala Thr Lys Arg Arg Gly Gly Arg Leu Val Ile Val Asn 
225                 230                 235                 240 


Leu Gln Pro Thr Lys His Asp Arg His Ala Asp Leu Arg Ile His Gly 
                245                 250                 255     


Tyr Val Asp Glu Val Met Thr Arg Leu Met Lys His Leu Gly Leu Glu 
            260                 265                 270         


Ile Pro Ala Trp Asp Gly Pro Arg Val Leu Glu Arg Ala Leu Pro Pro 
        275                 280                 285             


Leu Pro Arg Pro Pro Thr Pro Lys Leu Glu Pro Lys Glu Glu Ser Pro 
    290                 295                 300                 


Thr Arg Ile Asn Gly Ser Ile Pro Ala Gly Pro Lys Gln Glu Pro Cys 
305                 310                 315                 320 


Ala Gln His Asn Gly Ser Glu Pro Ala Ser Pro Lys Arg Glu Arg Pro 
                325                 330                 335     


Thr Ser Pro Ala Pro His Arg Pro Pro Lys Arg Val Lys Ala Lys Ala 
            340                 345                 350         


Val Pro Ser 
        355 


<210>  92
<211>  400
<212>  PRT
<213>  ˹

<220>
<223>  S7İ

<400>  92

Met Ala Ala Gly Gly Leu Ser Arg Ser Glu Arg Lys Ala Ala Glu Arg 
1               5                   10                  15      


Val Arg Arg Leu Arg Glu Glu Gln Gln Arg Glu Arg Leu Arg Gln Val 
            20                  25                  30          


Ser Arg Ile Leu Arg Lys Ala Ala Ala Glu Arg Ser Ala Glu Glu Gly 
        35                  40                  45              


Arg Leu Leu Ala Glu Ser Ala Asp Leu Val Thr Glu Leu Gln Gly Arg 
    50                  55                  60                  


Ser Arg Arg Arg Glu Gly Leu Lys Arg Arg Gln Glu Glu Val Cys Asp 
65                  70                  75                  80  


Asp Pro Glu Glu Leu Arg Gly Lys Val Arg Glu Leu Ala Ser Ala Val 
                85                  90                  95      


Arg Asn Ala Lys Tyr Leu Val Val Tyr Thr Gly Ala Gly Ile Ser Thr 
            100                 105                 110         


Ala Ala Ser Ile Pro Asp Tyr Arg Gly Pro Asn Gly Val Trp Thr Leu 
        115                 120                 125             


Leu Gln Lys Gly Arg Ser Val Ser Ala Ala Asp Leu Ser Glu Ala Glu 
    130                 135                 140                 


Pro Thr Leu Thr His Met Ser Ile Thr Arg Leu His Glu Gln Lys Leu 
145                 150                 155                 160 


Val Gln His Val Val Ser Gln Asn Cys Asp Gly Leu His Leu Arg Ser 
                165                 170                 175     


Gly Leu Pro Arg Thr Ala Ile Ser Glu Leu His Gly Asn Met Tyr Ile 
            180                 185                 190         


Glu Val Cys Thr Ser Cys Val Pro Asn Arg Glu Tyr Val Arg Val Phe 
        195                 200                 205             


Asp Val Thr Glu Arg Thr Ala Leu His Arg His Gln Thr Gly Arg Thr 
    210                 215                 220                 


Cys His Lys Cys Gly Thr Gln Leu Arg Asp Thr Ile Val His Phe Gly 
225                 230                 235                 240 


Glu Arg Gly Thr Leu Gly Gln Pro Leu Asn Trp Glu Ala Ala Thr Glu 
                245                 250                 255     


Ala Ala Ser Arg Ala Asp Thr Ile Leu Cys Leu Gly Ser Ser Leu Lys 
            260                 265                 270         


Val Leu Lys Lys Tyr Pro Arg Leu Trp Cys Met Thr Lys Pro Pro Ser 
        275                 280                 285             


Arg Arg Pro Lys Leu Tyr Ile Val Asn Leu Gln Trp Thr Pro Lys Asp 
    290                 295                 300                 


Asp Trp Ala Ala Leu Lys Leu His Gly Lys Cys Asp Asp Val Met Arg 
305                 310                 315                 320 


Leu Leu Met Ala Glu Leu Gly Leu Glu Ile Pro Ala Tyr Ser Arg Trp 
                325                 330                 335     


Gln Asp Pro Ile Phe Ser Leu Ala Thr Pro Leu Arg Ala Gly Glu Glu 
            340                 345                 350         


Gly Ser His Ser Arg Lys Ser Leu Cys Arg Ser Arg Glu Glu Ala Pro 
        355                 360                 365             


Pro Gly Asp Arg Gly Ala Pro Leu Ser Ser Ala Pro Ile Leu Gly Gly 
    370                 375                 380                 


Trp Phe Gly Arg Gly Cys Thr Lys Arg Thr Lys Arg Lys Lys Val Thr 
385                 390                 395                 400 


<210>  93
<211>  334
<212>  PRT
<213>  ˹

<220>
<223>  S1Aİ

<400>  93

Gly Pro Tyr Thr Phe Val Gln Gln His Leu Met Ile Gly Thr Asp Pro 
1               5                   10                  15      


Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu Thr Ile Pro Pro Pro Glu 
            20                  25                  30          


Leu Asp Asp Met Thr Leu Trp Gln Ile Val Ile Asn Ile Leu Ser Glu 
        35                  40                  45              


Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile Asn Thr Ile Glu Asp Ala 
    50                  55                  60                  


Val Lys Leu Leu Gln Glu Cys Lys Lys Ile Ile Val Leu Thr Gly Ala 
65                  70                  75                  80  


Gly Val Ser Val Ser Cys Gly Ile Pro Asp Phe Arg Ser Arg Asp Gly 
                85                  90                  95      


Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro Asp Leu Pro Asp Pro Gln 
            100                 105                 110         


Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe 
        115                 120                 125             


Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys 
    130                 135                 140                 


His Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn 
145                 150                 155                 160 


Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg 
                165                 170                 175     


Ile Ile Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys 
            180                 185                 190         


Lys Tyr Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln 
        195                 200                 205             


Val Val Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile 
    210                 215                 220                 


Met Lys Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe 
225                 230                 235                 240 


His Arg Ala Met Lys Tyr Asp Lys Asp Glu Val Asp Leu Leu Ile Val 
                245                 250                 255     


Ile Gly Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser 
            260                 265                 270         


Ile Pro His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro 
        275                 280                 285             


His Leu His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile 
    290                 295                 300                 


Asn Glu Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys 
305                 310                 315                 320 


Asn Pro Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg 
                325                 330                 


<210>  94
<211>  367
<212>  PRT
<213>  ˹

<220>
<223>  S1Bİ

<400>  94

Gly Pro Tyr Thr Phe Val Gln Gln His Leu Met Ile Gly Thr Asp Pro 
1               5                   10                  15      


Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu Thr Ile Pro Pro Pro Glu 
            20                  25                  30          


Leu Asp Asp Met Thr Leu Trp Gln Ile Val Ile Asn Ile Leu Ser Glu 
        35                  40                  45              


Pro Pro Lys Arg Ala Ala Ala Ala Asp Ile Asn Thr Ile Glu Asp Ala 
    50                  55                  60                  


Val Lys Leu Leu Gln Glu Cys Lys Lys Ile Ile Val Leu Thr Gly Ala 
65                  70                  75                  80  


Gly Val Ser Val Ser Cys Gly Ile Pro Asp Phe Arg Ser Arg Asp Gly 
                85                  90                  95      


Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro Asp Leu Pro Asp Pro Gln 
            100                 105                 110         


Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe 
        115                 120                 125             


Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys 
    130                 135                 140                 


His Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn 
145                 150                 155                 160 


Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg 
                165                 170                 175     


Ile Ile Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys 
            180                 185                 190         


Lys Tyr Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln 
        195                 200                 205             


Val Val Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile 
    210                 215                 220                 


Met Lys Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe 
225                 230                 235                 240 


His Arg Ala Met Lys Tyr Asp Lys Asp Glu Val Asp Leu Leu Ile Val 
                245                 250                 255     


Ile Gly Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser 
            260                 265                 270         


Ile Pro His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro 
        275                 280                 285             


His Leu His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile 
    290                 295                 300                 


Asn Glu Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys 
305                 310                 315                 320 


Asn Pro Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr 
            340                 345                 350         


Ile Phe His Gly Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val 
        355                 360                 365         


<210>  95
<211>  334
<212>  PRT
<213>  ˹

<220>
<223>  S1B1İ

<400>  95

Gly Pro Tyr Thr Phe Val Gln Gln His Leu Met Ile Gly Thr Asp Pro 
1               5                   10                  15      


Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu Thr Ile Pro Pro Pro Glu 
            20                  25                  30          


Leu Asp Asp Met Thr Leu Trp Gln Ile Val Ile Asn Ile Leu Ser Glu 
        35                  40                  45              


Pro Pro Lys Arg Ala Ala Ala Ala Asp Ile Asn Thr Ile Glu Asp Ala 
    50                  55                  60                  


Val Lys Leu Leu Gln Glu Cys Lys Lys Ile Ile Val Leu Thr Gly Ala 
65                  70                  75                  80  


Gly Val Ser Val Ser Cys Gly Ile Pro Asp Phe Arg Ser Arg Asp Gly 
                85                  90                  95      


Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro Asp Leu Pro Asp Pro Gln 
            100                 105                 110         


Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe 
        115                 120                 125             


Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys 
    130                 135                 140                 


His Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn 
145                 150                 155                 160 


Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg 
                165                 170                 175     


Ile Ile Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys 
            180                 185                 190         


Lys Tyr Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln 
        195                 200                 205             


Val Val Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile 
    210                 215                 220                 


Met Lys Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe 
225                 230                 235                 240 


His Arg Ala Met Lys Tyr Asp Lys Asp Glu Val Asp Leu Leu Ile Val 
                245                 250                 255     


Ile Gly Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser 
            260                 265                 270         


Ile Pro His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro 
        275                 280                 285             


His Leu His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile 
    290                 295                 300                 


Asn Glu Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys 
305                 310                 315                 320 


Asn Pro Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg 
                325                 330                 


<210>  96
<211>  367
<212>  PRT
<213>  ˹

<220>
<223>  S1Cİ

<400>  96

Gly Pro Tyr Thr Phe Val Gln Gln His Leu Met Ile Gly Thr Asp Pro 
1               5                   10                  15      


Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu Thr Ile Pro Pro Pro Glu 
            20                  25                  30          


Leu Asp Asp Met Thr Leu Trp Gln Ile Val Ile Asn Ile Leu Ser Glu 
        35                  40                  45              


Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile Asn Thr Ile Glu Asp Ala 
    50                  55                  60                  


Val Lys Leu Leu Gln Glu Cys Lys Lys Ile Ile Val Leu Thr Gly Ala 
65                  70                  75                  80  


Gly Val Ser Val Ser Cys Gly Ile Pro Asp Phe Arg Ser Arg Asp Gly 
                85                  90                  95      


Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro Asp Leu Pro Asp Pro Gln 
            100                 105                 110         


Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe 
        115                 120                 125             


Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys 
    130                 135                 140                 


His Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn 
145                 150                 155                 160 


Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg 
                165                 170                 175     


Ile Ile Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys 
            180                 185                 190         


Lys Tyr Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln 
        195                 200                 205             


Val Val Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile 
    210                 215                 220                 


Met Lys Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe 
225                 230                 235                 240 


His Arg Ala Met Lys Tyr Asp Lys Asp Glu Ala Asp Ala Ala Ala Ala 
                245                 250                 255     


Ala Gly Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser 
            260                 265                 270         


Ile Pro His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro 
        275                 280                 285             


His Leu His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile 
    290                 295                 300                 


Asn Glu Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys 
305                 310                 315                 320 


Asn Pro Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Ser Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr 
            340                 345                 350         


Ile Phe His Gly Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val 
        355                 360                 365         


<210>  97
<211>  334
<212>  PRT
<213>  ˹

<220>
<223>  S1C1İ

<400>  97

Gly Pro Tyr Thr Phe Val Gln Gln His Leu Met Ile Gly Thr Asp Pro 
1               5                   10                  15      


Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu Thr Ile Pro Pro Pro Glu 
            20                  25                  30          


Leu Asp Asp Met Thr Leu Trp Gln Ile Val Ile Asn Ile Leu Ser Glu 
        35                  40                  45              


Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile Asn Thr Ile Glu Asp Ala 
    50                  55                  60                  


Val Lys Leu Leu Gln Glu Cys Lys Lys Ile Ile Val Leu Thr Gly Ala 
65                  70                  75                  80  


Gly Val Ser Val Ser Cys Gly Ile Pro Asp Phe Arg Ser Arg Asp Gly 
                85                  90                  95      


Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro Asp Leu Pro Asp Pro Gln 
            100                 105                 110         


Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe 
        115                 120                 125             


Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys 
    130                 135                 140                 


His Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn 
145                 150                 155                 160 


Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg 
                165                 170                 175     


Ile Ile Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys 
            180                 185                 190         


Lys Tyr Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln 
        195                 200                 205             


Val Val Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile 
    210                 215                 220                 


Met Lys Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe 
225                 230                 235                 240 


His Arg Ala Met Lys Tyr Asp Lys Asp Glu Ala Asp Ala Ala Ala Ala 
                245                 250                 255     


Ala Gly Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser 
            260                 265                 270         


Ile Pro His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro 
        275                 280                 285             


His Leu His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile 
    290                 295                 300                 


Asn Glu Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys 
305                 310                 315                 320 


Asn Pro Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg 
                325                 330                 


<210>  98
<211>  422
<212>  PRT
<213>  ˹

<220>
<223>  S1Dİ

<400>  98

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Pro Tyr Thr Phe Val Gln Gln His 
    50                  55                  60                  


Leu Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro 
65                  70                  75                  80  


Glu Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile 
                85                  90                  95      


Val Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp 
            100                 105                 110         


Ile Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys 
        115                 120                 125             


Ile Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro 
    130                 135                 140                 


Asp Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe 
145                 150                 155                 160 


Pro Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg 
                165                 170                 175     


Lys Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly 
            180                 185                 190         


Gln Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys 
        195                 200                 205             


Glu Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu 
    210                 215                 220                 


Gln Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala 
225                 230                 235                 240 


Thr Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val 
                245                 250                 255     


Arg Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro 
            260                 265                 270         


Ala Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly 
        275                 280                 285             


Glu Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp 
    290                 295                 300                 


Glu Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro 
305                 310                 315                 320 


Val Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu 
                325                 330                 335     


Ile Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu 
            340                 345                 350         


Gly Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly 
        355                 360                 365             


Glu Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr 
    370                 375                 380                 


Glu Lys Pro Pro Arg Gly Gly Gly Ser Gly Gly Gly Ser Gln Tyr Leu 
385                 390                 395                 400 


Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu Val Tyr Ser 
                405                 410                 415     


Asp Ser Glu Asp Asp Val 
            420         


<210>  99
<211>  389
<212>  PRT
<213>  ˹

<220>
<223>  S1D1İ

<400>  99

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Pro Tyr Thr Phe Val Gln Gln His 
    50                  55                  60                  


Leu Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro 
65                  70                  75                  80  


Glu Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile 
                85                  90                  95      


Val Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp 
            100                 105                 110         


Ile Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys 
        115                 120                 125             


Ile Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro 
    130                 135                 140                 


Asp Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe 
145                 150                 155                 160 


Pro Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg 
                165                 170                 175     


Lys Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly 
            180                 185                 190         


Gln Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys 
        195                 200                 205             


Glu Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu 
    210                 215                 220                 


Gln Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala 
225                 230                 235                 240 


Thr Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val 
                245                 250                 255     


Arg Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro 
            260                 265                 270         


Ala Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly 
        275                 280                 285             


Glu Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp 
    290                 295                 300                 


Glu Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro 
305                 310                 315                 320 


Val Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu 
                325                 330                 335     


Ile Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu 
            340                 345                 350         


Gly Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly 
        355                 360                 365             


Glu Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr 
    370                 375                 380                 


Glu Lys Pro Pro Arg 
385                 


<210>  100
<211>  422
<212>  PRT
<213>  ˹

<220>
<223>  S1Eİ

<400>  100

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Pro Tyr Thr Phe Val Gln Gln His 
    50                  55                  60                  


Leu Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro 
65                  70                  75                  80  


Glu Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile 
                85                  90                  95      


Val Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp 
            100                 105                 110         


Ile Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys 
        115                 120                 125             


Ile Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro 
    130                 135                 140                 


Asp Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe 
145                 150                 155                 160 


Pro Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg 
                165                 170                 175     


Lys Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly 
            180                 185                 190         


Gln Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys 
        195                 200                 205             


Glu Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu 
    210                 215                 220                 


Gln Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala 
225                 230                 235                 240 


Thr Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val 
                245                 250                 255     


Arg Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro 
            260                 265                 270         


Ala Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly 
        275                 280                 285             


Glu Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp 
    290                 295                 300                 


Glu Ala Asp Ala Ala Ala Ala Ala Gly Ser Ser Leu Lys Val Arg Pro 
305                 310                 315                 320 


Val Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu 
                325                 330                 335     


Ile Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu 
            340                 345                 350         


Gly Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly 
        355                 360                 365             


Glu Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr 
    370                 375                 380                 


Glu Lys Pro Pro Arg Gly Gly Gly Ser Gly Gly Gly Ser Gln Tyr Leu 
385                 390                 395                 400 


Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu Val Tyr Ser 
                405                 410                 415     


Asp Ser Glu Asp Asp Val 
            420         


<210>  101
<211>  389
<212>  PRT
<213>  ˹

<220>
<223>  S1E1İ

<400>  101

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Pro Tyr Thr Phe Val Gln Gln His 
    50                  55                  60                  


Leu Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro 
65                  70                  75                  80  


Glu Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile 
                85                  90                  95      


Val Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp 
            100                 105                 110         


Ile Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys 
        115                 120                 125             


Ile Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro 
    130                 135                 140                 


Asp Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe 
145                 150                 155                 160 


Pro Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg 
                165                 170                 175     


Lys Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly 
            180                 185                 190         


Gln Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys 
        195                 200                 205             


Glu Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu 
    210                 215                 220                 


Gln Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala 
225                 230                 235                 240 


Thr Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val 
                245                 250                 255     


Arg Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro 
            260                 265                 270         


Ala Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly 
        275                 280                 285             


Glu Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp 
    290                 295                 300                 


Glu Ala Asp Ala Ala Ala Ala Ala Gly Ser Ser Leu Lys Val Arg Pro 
305                 310                 315                 320 


Val Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu 
                325                 330                 335     


Ile Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu 
            340                 345                 350         


Gly Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly 
        355                 360                 365             


Glu Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr 
    370                 375                 380                 


Glu Lys Pro Pro Arg 
385                 


<210>  102
<211>  240
<212>  PRT
<213>  ˹

<220>
<223>  C8İ

<400>  102

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  103
<211>  236
<212>  PRT
<213>  ˹

<220>
<223>  C8Aİ

<400>  103

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly 
                85                  90                  95      


Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
            100                 105                 110         


Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
        115                 120                 125             


Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
    130                 135                 140                 


Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
145                 150                 155                 160 


Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
                165                 170                 175     


Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
            180                 185                 190         


Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
        195                 200                 205             


Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
    210                 215                 220                 


Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235     


<210>  104
<211>  156
<212>  PRT
<213>  ˹

<220>
<223>  C8Bİ

<400>  104

Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly 
1               5                   10                  15      


Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 
            20                  25                  30          


Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 
        35                  40                  45              


Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 
    50                  55                  60                  


Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 
65                  70                  75                  80  


Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 
                85                  90                  95      


Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 
            100                 105                 110         


Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
        115                 120                 125             


Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 
    130                 135                 140                 


Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
145                 150                 155     


<210>  105
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  SIRT1׺˶λź

<400>  105

Pro Leu Arg Lys Arg Pro Arg Arg 
1               5               


<210>  106
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  SIRT1׺˶λź

<400>  106

Pro Pro Lys Arg Lys Lys Arg Lys 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  SIRT1׺˶λźͻ

<400>  107

Pro Leu Arg Lys Arg Pro Ala Ala 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  SIRT1׺˶λźͻ

<400>  108

Pro Pro Lys Arg Ala Ala Ala Ala 
1               5               


<210>  109
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  SIRT1׺˳ź

<400>  109

Leu Leu Leu Thr Asp Gly Leu Leu 
1               5               


<210>  110
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  SIRT1׺˳ź

<400>  110

Val Asp Leu Leu Ile Val Ile 
1               5           


<210>  111
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  SIRT1׺˳źͻ

<400>  111

Ala Ala Ala Thr Asp Gly Ala Ala 
1               5               


<210>  112
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  SIRT1׺˳źͻ

<400>  112

Ala Asp Ala Ala Ala Ala Ala 
1               5           


