﻿                         序列表

<110>  凯莱英医药集团（天津）股份有限公司

<120>  转氨酶突变体及其应用

<130>  PN167388KLY

<160>  2

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  484
<212>  PRT
<213>  Arthrobacter citreus

<400>  1
Met Gly Leu Thr Val Gln Lys Ile Asn Trp Glu Gln Val Lys Glu Trp 
1               5                   10                  15      
Asp Arg Lys Tyr Leu Met Arg Thr Phe Ser Thr Gln Asn Glu Tyr Gln 
            20                  25                  30          
Pro Val Pro Ile Glu Ser Thr Glu Gly Asp Tyr Leu Ile Thr Pro Gly 
        35                  40                  45              
Gly Thr Arg Leu Leu Asp Phe Phe Asn Gln Leu Tyr Cys Val Asn Leu 
    50                  55                  60                  
Gly Gln Lys Asn Gln Lys Val Asn Ala Ala Ile Lys Glu Ala Leu Asp 
65                  70                  75                  80  
Arg Tyr Gly Phe Val Trp Asp Thr Tyr Ala Thr Asp Tyr Lys Ala Lys 
                85                  90                  95      
Ala Ala Lys Ile Ile Ile Glu Asp Ile Leu Gly Asp Glu Asp Trp Pro 
            100                 105                 110         
Gly Lys Val Arg Phe Val Ser Thr Gly Ser Glu Ala Val Glu Thr Ala 
        115                 120                 125             
Leu Asn Ile Ala Arg Leu Tyr Thr Asn Arg Pro Leu Val Val Thr Arg 
    130                 135                 140                 
Glu His Asp Tyr His Gly Trp Thr Gly Gly Ala Ala Thr Val Thr Arg 
145                 150                 155                 160 
Leu Arg Ser Phe Arg Ser Gly Leu Val Gly Glu Asn Ser Glu Ser Phe 
                165                 170                 175     
Ser Ala Gln Ile Pro Gly Ser Ser Cys Ser Ser Ala Val Leu Met Ala 
            180                 185                 190         
Pro Ser Ser Asn Thr Phe Gln Asp Ser Asn Gly Asn Tyr Leu Lys Asp 
        195                 200                 205             
Glu Asn Gly Glu Leu Leu Ser Val Lys Tyr Thr Arg Arg Met Ile Glu 
    210                 215                 220                 
Asn Tyr Gly Pro Glu Gln Val Ala Ala Val Ile Thr Glu Val Ser Gln 
225                 230                 235                 240 
Gly Val Gly Ser Thr Met Pro Pro Tyr Glu Tyr Val Pro Gln Ile Arg 
                245                 250                 255     
Lys Met Thr Lys Glu Leu Gly Val Leu Trp Ile Ser Asp Glu Val Leu 
            260                 265                 270         
Thr Gly Phe Gly Arg Thr Gly Lys Trp Phe Gly Tyr Gln His Tyr Gly 
        275                 280                 285             
Val Gln Pro Asp Ile Ile Thr Met Gly Lys Gly Leu Ser Ser Ser Ser 
    290                 295                 300                 
Leu Pro Ala Gly Ala Val Val Val Ser Lys Glu Ile Ala Ala Phe Met 
305                 310                 315                 320 
Asp Lys His Arg Trp Glu Ser Val Ser Thr Tyr Ala Gly His Pro Val 
                325                 330                 335     
Ala Met Ala Ala Val Cys Ala Asn Leu Glu Val Met Met Glu Glu Asn 
            340                 345                 350         
Leu Val Glu Gln Ala Lys Asn Ser Gly Glu Tyr Ile Arg Ser Lys Leu 
        355                 360                 365             
Glu Leu Leu Gln Glu Lys His Lys Ser Ile Gly Asn Phe Asp Gly Tyr 
    370                 375                 380                 
Gly Leu Leu Trp Ile Val Asp Ile Val Asn Ala Lys Thr Lys Thr Pro 
385                 390                 395                 400 
Tyr Val Lys Leu Asp Arg Asn Phe Arg His Gly Met Asn Pro Asn Gln 
                405                 410                 415     
Ile Pro Thr Gln Ile Ile Met Glu Lys Ala Leu Glu Lys Gly Val Leu 
            420                 425                 430         
Ile Gly Gly Ala Met Pro Asn Thr Met Arg Ile Gly Ala Ser Leu Asn 
        435                 440                 445             
Val Ser Arg Gly Asp Ile Asp Lys Ala Met Asp Ala Leu Asp Tyr Ala 
    450                 455                 460                 
Leu Asp Tyr Leu Glu Ser Gly Glu Trp Gln Gln Ser Leu Glu His His 
465                 470                 475                 480 
His His His His 
                

<210>  2
<211>  1455
<212>  DNA
<213>  Arthrobacter citreus

<400>  2
atgggcctga ccgtacagaa gatcaactgg gaacaagtaa aggagtggga ccgcaagtac        60
ctgatgcgca ctttttccac tcagaacgaa taccagccgg taccgattga atctacggaa       120
ggtgattatc tgatcacccc gggtggcacc cgtctgctgg acttcttcaa ccaactgtat       180
tgcgttaacc tgggccagaa aaaccagaaa gtcaacgccg cgattaaaga ggcactggac       240
cgctacggct tcgtatggga cacttatgct accgactaca aggcgaaagc cgcgaaaatc       300
attatcgagg atattctggg tgacgaggat tggcctggta aagttcgttt tgttagcact       360
ggctccgaag ccgtggaaac cgcgctgaat atcgcgcgtc tgtataccaa tcgtccgctg       420
gttgtgaccc gtgaacacga ctatcacggt tggaccggcg gcgctgcaac cgtcactcgt       480
ctgcgtagct tccgttctgg tctggtgggt gaaaactccg aaagcttctc tgctcagatc       540
ccgggttctt cttgtagctc tgcagtcctg atggccccgt cttccaacac cttccaggac       600
tctaacggca actacctgaa agacgaaaac ggtgaactgc tgtccgttaa atacacccgt       660
cgcatgattg aaaactacgg cccggagcag gtagccgcag tgattacgga agttagccag       720
ggtgttggtt ctacgatgcc gccatacgaa tatgttccac agatccgtaa aatgactaaa       780
gagctgggcg ttctgtggat ctccgacgag gtcctgaccg gttttggtcg taccggtaaa       840
tggttcggtt accagcatta tggcgttcaa ccagatatca ttactatggg caagggcctg       900
tcttcttcct ctctgccggc gggcgcagta gttgtgtcca aagaaatcgc tgcgtttatg       960
gacaaacacc gctgggaatc tgtttccacc tacgcgggtc acccggtggc gatggcagct      1020
gtgtgcgcta acctggaagt gatgatggaa gaaaacctgg tggaacaagc taaaaatagc      1080
ggcgaataca tccgtagcaa actggaactg ctgcaggaaa agcataaaag catcggcaac      1140
ttcgacggtt acggtctgct gtggattgtt gatatcgtga atgcgaaaac taaaaccccg      1200
tatgtcaaac tggatcgcaa cttccgccac ggcatgaacc cgaaccagat cccgacgcag      1260
attatcatgg aaaaagctct ggaaaaaggc gttctgatcg gtggtgcaat gcctaacact      1320
atgcgtatcg gcgcatctct gaacgtatct cgtggtgata tcgataaagc tatggatgct      1380
ctggattacg cgctggatta cctggagtcc ggtgaatggc agcagagcct cgagcaccac      1440
caccaccacc actga                                                       1455

