﻿                         序列表

<110>  浙江省肿瘤医院
       中国科学院基础医学与肿瘤研究所（筹）

<120>  抗体偶联近红外II区荧光探针、构建方法和应用

<160>  8

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1078
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu Ala Leu Thr Trp His 
1               5                   10                  15      
Thr Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
            20                  25                  30          
Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
        35                  40                  45              
Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
    50                  55                  60                  
Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
65                  70                  75                  80  
Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu Thr Leu Gly Tyr Arg 
                85                  90                  95      
Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
            100                 105                 110         
Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
        115                 120                 125             
Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
    130                 135                 140                 
Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
145                 150                 155                 160 
Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                165                 170                 175     
Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
            180                 185                 190         
Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
        195                 200                 205             
Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
    210                 215                 220                 
Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
225                 230                 235                 240 
Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln His Val Val 
                245                 250                 255     
Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
            260                 265                 270         
Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
        275                 280                 285             
Thr Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
    290                 295                 300                 
Ile Ala Met Pro Gln Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
305                 310                 315                 320 
Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Lys Lys 
                325                 330                 335     
Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
            340                 345                 350         
Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
        355                 360                 365             
Pro Val Asp Thr Phe Leu Arg Gly His Glu Glu Ser Gly Asp Arg Phe 
    370                 375                 380                 
Ser Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
385                 390                 395                 400 
Ile Ser Ser Val Glu Thr Pro Tyr Ile Asp Tyr Thr His Leu Arg Ile 
                405                 410                 415     
Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
            420                 425                 430         
Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
        435                 440                 445             
Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
    450                 455                 460                 
Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
465                 470                 475                 480 
Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                485                 490                 495     
Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
            500                 505                 510         
Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
        515                 520                 525             
Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
    530                 535                 540                 
Asp Cys Leu Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr 
545                 550                 555                 560 
Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu 
                565                 570                 575     
Thr Asp Ala Ser Ala Cys Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn 
            580                 585                 590         
Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp 
        595                 600                 605             
Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile 
    610                 615                 620                 
Phe Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr 
625                 630                 635                 640 
Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                645                 650                 655     
Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
            660                 665                 670         
Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
        675                 680                 685             
Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu 
    690                 695                 700                 
Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly 
705                 710                 715                 720 
Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile 
                725                 730                 735     
Val Ile Cys Val Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg 
            740                 745                 750         
Asn Gln Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly 
        755                 760                 765             
Ser Leu Met Ala Leu Gly Phe Leu Ile Gly Tyr Thr Cys Leu Leu Ala 
    770                 775                 780                 
Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
785                 790                 795                 800 
Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile 
                805                 810                 815     
Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe 
            820                 825                 830         
Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
        835                 840                 845             
Leu Ala Cys Ile Phe Phe Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro 
    850                 855                 860                 
Ser Arg Asn Thr Ile Glu Glu Val Arg Cys Ser Thr Ala Ala His Ala 
865                 870                 875                 880 
Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Ser Asn Val Ser Arg 
                885                 890                 895     
Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Thr Pro Ser Ser 
            900                 905                 910         
Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Pro Phe Pro Gln Pro Glu 
        915                 920                 925             
Arg Gln Lys Gln Gln Gln Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln 
    930                 935                 940                 
Gln Gln Pro Leu Thr Leu Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro 
945                 950                 955                 960 
Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe Ser 
                965                 970                 975     
Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn Ser 
            980                 985                 990         
Thr His Gln Asn Ser Leu Glu Ala  Gln Lys Ser Ser Asp  Thr Leu Thr 
        995                 1000                 1005             
Arg His  Glu Pro Leu Leu Pro  Leu Gln Cys Gly Glu  Thr Asp Leu Asp 
    1010                 1015                 1020                 
Leu  Thr Val Gln Glu Thr  Gly Leu Gln Gly Pro  Val Gly Gly Asp Gln  
1025                 1030                 1035                 1040 
Arg Pro Glu Val Glu  Asp Pro Glu Glu Leu  Ser Pro Ala Leu Val  Val 
                1045                 1050                 1055     
Ser Ser Ser Gln  Ser Phe Val Ile Ser  Gly Gly Gly Ser Thr  Val Thr 
            1060                 1065                 1070         
Glu Asn Val  Val Asn Ser 
        1075             

<210>  2
<211>  1079
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Met Ala Ser Tyr Ser Cys Cys Leu Ala Leu Leu Ala Leu Ala Trp His 
1               5                   10                  15      
Ser Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
            20                  25                  30          
Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
        35                  40                  45              
Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
    50                  55                  60                  
Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
65                  70                  75                  80  
Ile Asn Ser Ser Pro Ser Leu Leu Pro Asn Met Thr Leu Gly Tyr Arg 
                85                  90                  95      
Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
            100                 105                 110         
Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
        115                 120                 125             
Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
    130                 135                 140                 
Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
145                 150                 155                 160 
Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                165                 170                 175     
Lys Asn Gln Tyr Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
            180                 185                 190         
Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
        195                 200                 205             
Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
    210                 215                 220                 
Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
225                 230                 235                 240 
Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln Gln Val Val 
                245                 250                 255     
Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
            260                 265                 270         
Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
        275                 280                 285             
Thr Gly Arg Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
    290                 295                 300                 
Ile Ala Met Pro Glu Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
305                 310                 315                 320 
Gly Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Gln Lys 
                325                 330                 335     
Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
            340                 345                 350         
Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
        355                 360                 365             
Pro Val Asp Thr Phe Val Arg Ser His Glu Glu Gly Gly Asn Arg Leu 
    370                 375                 380                 
Leu Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
385                 390                 395                 400 
Ile Asn Ser Val Glu Thr Pro Tyr Met Asp Tyr Glu His Leu Arg Ile 
                405                 410                 415     
Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
            420                 425                 430         
Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
        435                 440                 445             
Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
    450                 455                 460                 
Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
465                 470                 475                 480 
Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                485                 490                 495     
Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
            500                 505                 510         
Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
        515                 520                 525             
Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
    530                 535                 540                 
Asp Cys Gln Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr 
545                 550                 555                 560 
Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Gly Glu 
                565                 570                 575     
Thr Asp Ala Ser Ala Cys Asp Lys Cys Pro Asp Asp Phe Trp Ser Asn 
            580                 585                 590         
Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ala Trp 
        595                 600                 605             
Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile 
    610                 615                 620                 
Phe Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr 
625                 630                 635                 640 
Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                645                 650                 655     
Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
            660                 665                 670         
Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
        675                 680                 685             
Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu 
    690                 695                 700                 
Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly 
705                 710                 715                 720 
Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile 
                725                 730                 735     
Leu Ile Cys Ile Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg 
            740                 745                 750         
Asn His Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly 
        755                 760                 765             
Ser Leu Met Ala Leu Gly Ser Leu Ile Gly Tyr Thr Cys Leu Leu Ala 
    770                 775                 780                 
Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
785                 790                 795                 800 
Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile 
                805                 810                 815     
Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe 
            820                 825                 830         
Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
        835                 840                 845             
Leu Ala Cys Ile Phe Phe Asn Lys Val Tyr Ile Ile Leu Phe Lys Pro 
    850                 855                 860                 
Ser Arg Asn Thr Ile Glu Glu Val Arg Ser Ser Thr Ala Ala His Ala 
865                 870                 875                 880 
Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Pro Asn Ile Ser Arg 
                885                 890                 895     
Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Ile Pro Ser Ser 
            900                 905                 910         
Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Arg Phe Pro Gln Pro Glu 
        915                 920                 925             
Arg Gln Lys Gln Gln Gln Pro Leu Ser Leu Thr Gln Gln Glu Gln Gln 
    930                 935                 940                 
Gln Gln Pro Leu Thr Leu His Pro Gln Gln Gln Gln Gln Pro Gln Gln 
945                 950                 955                 960 
Pro Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe 
                965                 970                 975     
Ser Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn 
            980                 985                 990         
Ser Met Arg Gln Asn Ser Leu Glu  Ala Gln Arg Ser Asn  Asp Thr Leu 
        995                 1000                 1005             
Gly Arg  His Gln Ala Leu Leu  Pro Leu Gln Cys Ala  Asp Ala Asp Ser 
    1010                 1015                 1020                 
Glu  Met Thr Ile Gln Glu  Thr Gly Leu Gln Gly  Pro Met Val Gly Asp  
1025                 1030                 1035                 1040 
His Gln Pro Glu Met  Glu Ser Ser Asp Glu  Met Ser Pro Ala Leu  Val 
                1045                 1050                 1055     
Met Ser Thr Ser  Arg Ser Phe Val Ile  Ser Gly Gly Gly Ser  Ser Val 
            1060                 1065                 1070         
Thr Glu Asn  Val Leu His Ser 
        1075                 

<210>  3
<211>  1079
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Met Ala Trp Phe Gly Tyr Cys Leu Ala Leu Leu Ala Leu Thr Trp His 
1               5                   10                  15      
Ser Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
            20                  25                  30          
Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
        35                  40                  45              
Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
    50                  55                  60                  
Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
65                  70                  75                  80  
Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Met Thr Leu Gly Tyr Arg 
                85                  90                  95      
Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
            100                 105                 110         
Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
        115                 120                 125             
Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
    130                 135                 140                 
Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
145                 150                 155                 160 
Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                165                 170                 175     
Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
            180                 185                 190         
Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
        195                 200                 205             
Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
    210                 215                 220                 
Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
225                 230                 235                 240 
Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln Gln Val Val 
                245                 250                 255     
Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
            260                 265                 270         
Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
        275                 280                 285             
Thr Gly Arg Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
    290                 295                 300                 
Ile Ala Met Pro Glu Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
305                 310                 315                 320 
Gly Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Gln Lys 
                325                 330                 335     
Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
            340                 345                 350         
Glu Glu Thr Phe Asn Cys His Leu Gln Asp Gly Ala Lys Gly Pro Leu 
        355                 360                 365             
Pro Val Asp Thr Phe Val Arg Ser His Glu Glu Gly Gly Asn Arg Leu 
    370                 375                 380                 
Leu Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
385                 390                 395                 400 
Ile Asn Ser Val Glu Thr Pro Tyr Met Asp Tyr Glu His Leu Arg Ile 
                405                 410                 415     
Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
            420                 425                 430         
Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
        435                 440                 445             
Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
    450                 455                 460                 
Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
465                 470                 475                 480 
Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                485                 490                 495     
Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
            500                 505                 510         
Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Gly Lys Ile 
        515                 520                 525             
Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
    530                 535                 540                 
Asp Cys Gln Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr 
545                 550                 555                 560 
Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Gly Glu 
                565                 570                 575     
Thr Asp Ala Ser Ala Cys Asp Lys Cys Pro Asp Asp Phe Trp Ser Asn 
            580                 585                 590         
Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ala Trp 
        595                 600                 605             
Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile 
    610                 615                 620                 
Phe Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr 
625                 630                 635                 640 
Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                645                 650                 655     
Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
            660                 665                 670         
Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
        675                 680                 685             
Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu 
    690                 695                 700                 
Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly 
705                 710                 715                 720 
Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile 
                725                 730                 735     
Val Ile Cys Ile Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg 
            740                 745                 750         
Asn His Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly 
        755                 760                 765             
Ser Leu Met Ala Leu Gly Ser Leu Ile Gly Tyr Thr Cys Leu Leu Ala 
    770                 775                 780                 
Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
785                 790                 795                 800 
Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile 
                805                 810                 815     
Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe 
            820                 825                 830         
Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
        835                 840                 845             
Leu Ala Cys Ile Phe Phe Asn Lys Val Tyr Ile Ile Leu Phe Lys Pro 
    850                 855                 860                 
Ser Arg Asn Thr Ile Glu Glu Val Arg Ser Ser Thr Ala Ala His Ala 
865                 870                 875                 880 
Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Pro Asn Ile Ser Arg 
                885                 890                 895     
Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Ile Pro Ser Ser 
            900                 905                 910         
Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Arg Phe Pro Gln Pro Glu 
        915                 920                 925             
Arg Gln Lys Gln Gln Gln Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln 
    930                 935                 940                 
Gln Gln Pro Leu Thr Leu Gln Pro Gln Gln Gln Gln Gln Pro Gln Gln 
945                 950                 955                 960 
Pro Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe 
                965                 970                 975     
Ser Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn 
            980                 985                 990         
Ser Met Arg Gln Asn Ser Leu Glu  Ala Gln Lys Ser Asn  Asp Thr Leu 
        995                 1000                 1005             
Asn Arg  His Gln Ala Leu Leu  Pro Leu Gln Cys Ala  Glu Ala Asp Ser 
    1010                 1015                 1020                 
Glu  Met Thr Ile Gln Glu  Thr Gly Leu Gln Gly  Pro Met Val Gly Asp  
1025                 1030                 1035                 1040 
His Gln Pro Glu Ile  Glu Ser Pro Asp Glu  Met Ser Pro Ala Leu  Val 
                1045                 1050                 1055     
Met Ser Thr Ser  Arg Ser Phe Val Ile  Ser Gly Gly Gly Ser  Ser Val 
            1060                 1065                 1070         
Thr Glu Asn  Ile Leu His Ser 
        1075                 

<210>  4
<211>  13
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
1               5                   10              

<210>  5
<211>  14
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu Lys 
1               5                   10                  

<210>  6
<211>  154
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Ser Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His 
1               5                   10                  15      
Leu Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe 
            20                  25                  30          
Asp Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His 
        35                  40                  45              
Leu Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr 
    50                  55                  60                  
Asn Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys 
65                  70                  75                  80  
Ile Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser 
                85                  90                  95      
Arg Asp Cys Leu Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro 
            100                 105                 110         
Thr Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Asp 
        115                 120                 125             
Glu Thr Asp Ala Ser Ala Cys Asn Lys Cys Pro Asp Asp Phe Trp Ser 
    130                 135                 140                 
Asn Glu Asn His Thr Ser Cys Ile Ala Lys 
145                 150                 

<210>  7
<211>  14
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile Cys 
1               5                   10                  

<210>  8
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu Lys Cys 
1               5                   10                  15  

