                         SEQUENCE LISTING

<110>  Evaxion Biotech A/S
 
<120>  STAPHYLOCOCCAL PROTEIN VARIANTS AND TRUNCATES

<130>  23287PCT00

<160>  89    

<170>  PatentIn version 3.5

<210>  1
<211>  319
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  SIGNAL
<222>  (1)..(26)

<220>
<221>  mat_peptide
<222>  (27)..(319)

<400>  1

Met Lys Thr Arg Ile Val Ser Ser Val Thr Thr Thr Leu Leu Leu Gly 
    -25                 -20                 -15                 


Ser Ile Leu Met Asn Pro Val Ala Asn Ala Ala Asp Ser Asp Ile Asn 
-10                 -5              -1  1               5       


Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser Asn Thr Thr Val Lys Thr 
            10                  15                  20          


Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn Gly Met His Lys Lys Val 
        25                  30                  35              


Phe Tyr Ser Phe Ile Asp Asp Lys Asn His Asn Lys Lys Leu Leu Val 
    40                  45                  50                  


Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln Tyr Arg Val Tyr Ser Glu 
55                  60                  65                  70  


Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp Pro Ser Ala Phe Lys Val 
                75                  80                  85      


Gln Leu Gln Leu Pro Asp Asn Glu Val Ala Gln Ile Ser Asp Tyr Tyr 
            90                  95                  100         


Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr Met Ser Thr Leu Thr Tyr 
        105                 110                 115             


Gly Phe Asn Gly Asn Val Thr Gly Asp Asp Thr Gly Lys Ile Gly Gly 
    120                 125                 130                 


Leu Ile Gly Ala Asn Val Ser Ile Gly His Thr Leu Lys Tyr Val Gln 
135                 140                 145                 150 


Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro Thr Asp Lys Lys Val Gly 
                155                 160                 165     


Trp Lys Val Ile Phe Asn Asn Met Val Asn Gln Asn Trp Gly Pro Tyr 
            170                 175                 180         


Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly Asn Gln Leu Phe Met Lys 
        185                 190                 195             


Thr Arg Asn Gly Ser Met Lys Ala Ala Asp Asn Phe Leu Asp Pro Asn 
    200                 205                 210                 


Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe Ser Pro Asp Phe Ala Thr 
215                 220                 225                 230 


Val Ile Thr Met Asp Arg Lys Ala Ser Lys Gln Gln Thr Asn Ile Asp 
                235                 240                 245     


Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr Gln Leu His Trp Thr Ser 
            250                 255                 260         


Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp Lys Trp Ile Asp Arg Ser 
        265                 270                 275             


Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys Glu Glu Met Thr Asn 
    280                 285                 290             


<210>  2
<211>  293
<212>  PRT
<213>  Staphylococcus aureus

<400>  2

Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                  15      


Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                  25                  30          


Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                  40                  45              


Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                  55                  60                  


Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                  70                  75                  80  


Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                  90                  95      


Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                 105                 110         


Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                 120                 125             


Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                 135                 140                 


Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                 150                 155                 160 


Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                 170                 175     


Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                 185                 190         


Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                 200                 205             


Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                 215                 220                 


Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                 230                 235                 240 


Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                 250                 255     


Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                 265                 270         


Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                 280                 285             


Glu Glu Met Thr Asn 
    290             


<210>  3
<211>  281
<212>  PRT
<213>  Staphylococcus aureus

<400>  3

Asp Ile Gly Ser Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr 
1               5                   10                  15      


Asp Lys Glu Asn Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp 
            20                  25                  30          


Asp Lys Asn His Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr 
        35                  40                  45              


Ile Ala Gly Gln Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser 
    50                  55                  60                  


Gly Leu Ala Trp Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp 
65                  70                  75                  80  


Asn Glu Val Ala Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp 
                85                  90                  95      


Thr Lys Glu Tyr Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val 
            100                 105                 110         


Thr Gly Asp Asp Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val 
        115                 120                 125             


Ser Ile Gly His Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile 
    130                 135                 140                 


Leu Glu Ser Pro Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn 
145                 150                 155                 160 


Asn Met Val Asn Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn 
                165                 170                 175     


Pro Val Tyr Gly Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met 
            180                 185                 190         


Lys Ala Ala Asp Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu 
        195                 200                 205             


Ser Ser Gly Phe Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg 
    210                 215                 220                 


Lys Ala Ser Lys Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val 
225                 230                 235                 240 


Arg Asp Asp Tyr Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr 
                245                 250                 255     


Asn Thr Lys Asp Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile 
            260                 265                 270         


Asp Trp Glu Lys Glu Glu Met Thr Asn 
        275                 280     


<210>  4
<211>  293
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (1)..(12)

<400>  4

Ser Glu Thr Glu Val Ser Val Arg Ser Ala Ser Ser Asp Ile Gly Ser 
1               5                   10                  15      


Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                  25                  30          


Gly Met His Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                  40                  45              


Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                  55                  60                  


Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                  70                  75                  80  


Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                  90                  95      


Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                 105                 110         


Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                 120                 125             


Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                 135                 140                 


Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                 150                 155                 160 


Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                 170                 175     


Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                 185                 190         


Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                 200                 205             


Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                 215                 220                 


Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                 230                 235                 240 


Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                 250                 255     


Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                 265                 270         


Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                 280                 285             


Glu Glu Met Thr Asn 
    290             


<210>  5
<211>  293
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (35)..(35)

<400>  5

Ala Asp Ser Asp Ile Asn Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser 
1               5                   10                  15      


Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                  25                  30          


Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                  40                  45              


Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                  55                  60                  


Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                  70                  75                  80  


Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                  90                  95      


Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                 105                 110         


Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                 120                 125             


Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                 135                 140                 


Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                 150                 155                 160 


Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                 170                 175     


Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                 185                 190         


Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                 200                 205             


Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                 215                 220                 


Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                 230                 235                 240 


Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                 250                 255     


Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                 265                 270         


Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                 280                 285             


Glu Glu Met Thr Asn 
    290             


<210>  6
<211>  281
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  H23L substitution

<400>  6

Asp Ile Gly Ser Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr 
1               5                   10                  15      


Asp Lys Glu Asn Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp 
            20                  25                  30          


Asp Lys Asn His Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr 
        35                  40                  45              


Ile Ala Gly Gln Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser 
    50                  55                  60                  


Gly Leu Ala Trp Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp 
65                  70                  75                  80  


Asn Glu Val Ala Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp 
                85                  90                  95      


Thr Lys Glu Tyr Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val 
            100                 105                 110         


Thr Gly Asp Asp Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val 
        115                 120                 125             


Ser Ile Gly His Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile 
    130                 135                 140                 


Leu Glu Ser Pro Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn 
145                 150                 155                 160 


Asn Met Val Asn Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn 
                165                 170                 175     


Pro Val Tyr Gly Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met 
            180                 185                 190         


Lys Ala Ala Asp Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu 
        195                 200                 205             


Ser Ser Gly Phe Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg 
    210                 215                 220                 


Lys Ala Ser Lys Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val 
225                 230                 235                 240 


Arg Asp Asp Tyr Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr 
                245                 250                 255     


Asn Thr Lys Asp Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile 
            260                 265                 270         


Asp Trp Glu Lys Glu Glu Met Thr Asn 
        275                 280     


<210>  7
<211>  293
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (1)..(12)

<220>
<221>  VARIANT
<222>  (35)..(35)

<400>  7

Ser Glu Thr Glu Val Ser Val Arg Ser Ala Ser Ser Asp Ile Gly Ser 
1               5                   10                  15      


Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn 
            20                  25                  30          


Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn His 
        35                  40                  45              


Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln 
    50                  55                  60                  


Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp 
65                  70                  75                  80  


Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val Ala 
                85                  90                  95      


Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr 
            100                 105                 110         


Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp 
        115                 120                 125             


Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His 
    130                 135                 140                 


Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro 
145                 150                 155                 160 


Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val Asn 
                165                 170                 175     


Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly 
            180                 185                 190         


Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala Asp 
        195                 200                 205             


Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe 
    210                 215                 220                 


Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser Lys 
225                 230                 235                 240 


Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr 
                245                 250                 255     


Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp 
            260                 265                 270         


Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys 
        275                 280                 285             


Glu Glu Met Thr Asn 
    290             


<210>  8
<211>  960
<212>  DNA
<213>  Staphylococcus aureus

<400>  8
atgaaaacac gtatagtcag ctcagtaaca acaacactat tgctaggttc catattaatg       60

aatcctgtcg ctaatgccgc agattctgat attaatatta aaaccggtac tacagatatt      120

ggaagcaata ctacagtaaa aacaggtgat ttagtcactt atgataaaga aaatggcatg      180

cacaaaaaag tattttatag ttttatcgat gataaaaatc ataataaaaa actgctagtt      240

attagaacga aaggtaccat tgctggtcaa tatagagttt atagcgaaga aggtgctaac      300

aaaagtggtt tagcctggcc ttcagccttt aaggtacagt tgcaactacc tgataatgaa      360

gtagctcaaa tatctgatta ctatccaaga aattcgattg atacaaaaga gtatatgagt      420

actttaactt atggattcaa cggtaatgtt actggtgatg atacaggaaa aattggcggc      480

cttattggtg caaatgtttc gattggtcat acactgaaat atgttcaacc tgatttcaaa      540

acaattttag agagcccaac tgataaaaaa gtaggctgga aagtgatatt taacaatatg      600

gtgaatcaaa attggggacc atatgataga gattcttgga acccggtata tggcaatcaa      660

cttttcatga aaactagaaa tggctctatg aaagcagcag ataacttcct tgatcctaac      720

aaagcaagtt ctctattatc ttcagggttt tcaccagact tcgctacagt tattactatg      780

gatagaaaag catccaaaca acaaacaaat atagatgtaa tatacgaacg agttcgtgat      840

gactaccaat tgcactggac ttcaacaaat tggaaaggta ccaatactaa agataaatgg      900

atagatcgtt cttcagaaag atataaaatc gattgggaaa aagaagaaat gacaaattaa      960


<210>  9
<211>  879
<212>  DNA
<213>  Staphylococcus aureus

<400>  9
gcagattctg atattaatat taaaaccggt actacagata ttggaagcaa tactacagta       60

aaaacaggtg atttagtcac ttatgataaa gaaaatggca tgcacaaaaa agtattttat      120

agttttatcg atgataaaaa tcataataaa aaactgctag ttattagaac gaaaggtacc      180

attgctggtc aatatagagt ttatagcgaa gaaggtgcta acaaaagtgg tttagcctgg      240

ccttcagcct ttaaggtaca gttgcaacta cctgataatg aagtagctca aatatctgat      300

tactatccaa gaaattcgat tgatacaaaa gagtatatga gtactttaac ttatggattc      360

aacggtaatg ttactggtga tgatacagga aaaattggcg gccttattgg tgcaaatgtt      420

tcgattggtc atacactgaa atatgttcaa cctgatttca aaacaatttt agagagccca      480

actgataaaa aagtaggctg gaaagtgata tttaacaata tggtgaatca aaattgggga      540

ccatatgata gagattcttg gaacccggta tatggcaatc aacttttcat gaaaactaga      600

aatggctcta tgaaagcagc agataacttc cttgatccta acaaagcaag ttctctatta      660

tcttcagggt tttcaccaga cttcgctaca gttattacta tggatagaaa agcatccaaa      720

caacaaacaa atatagatgt aatatacgaa cgagttcgtg atgactacca attgcactgg      780

acttcaacaa attggaaagg taccaatact aaagataaat ggatagatcg ttcttcagaa      840

agatataaaa tcgattggga aaaagaagaa atgacaaat                             879


<210>  10
<211>  843
<212>  DNA
<213>  Staphylococcus aureus

<400>  10
gatattggaa gcaatactac agtaaaaaca ggtgatttag tcacttatga taaagaaaat       60

ggcatgcaca aaaaagtatt ttatagtttt atcgatgata aaaatcataa taaaaaactg      120

ctagttatta gaacgaaagg taccattgct ggtcaatata gagtttatag cgaagaaggt      180

gctaacaaaa gtggtttagc ctggccttca gcctttaagg tacagttgca actacctgat      240

aatgaagtag ctcaaatatc tgattactat ccaagaaatt cgattgatac aaaagagtat      300

atgagtactt taacttatgg attcaacggt aatgttactg gtgatgatac aggaaaaatt      360

ggcggcctta ttggtgcaaa tgtttcgatt ggtcatacac tgaaatatgt tcaacctgat      420

ttcaaaacaa ttttagagag cccaactgat aaaaaagtag gctggaaagt gatatttaac      480

aatatggtga atcaaaattg gggaccatat gatagagatt cttggaaccc ggtatatggc      540

aatcaacttt tcatgaaaac tagaaatggc tctatgaaag cagcagataa cttccttgat      600

cctaacaaag caagttctct attatcttca gggttttcac cagacttcgc tacagttatt      660

actatggata gaaaagcatc caaacaacaa acaaatatag atgtaatata cgaacgagtt      720

cgtgatgact accaattgca ctggacttca acaaattgga aaggtaccaa tactaaagat      780

aaatggatag atcgttcttc agaaagatat aaaatcgatt gggaaaaaga agaaatgaca      840

aat                                                                    843


<210>  11
<211>  879
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  mutation
<222>  (1)..(36)

<400>  11
agcgaaaccg aagtgagcgt gcgcagcgcg agcagcgata ttggaagcaa tactacagta       60

aaaacaggtg atttagtcac ttatgataaa gaaaatggca tgcacaaaaa agtattttat      120

agttttatcg atgataaaaa tcataataaa aaactgctag ttattagaac gaaaggtacc      180

attgctggtc aatatagagt ttatagcgaa gaaggtgcta acaaaagtgg tttagcctgg      240

ccttcagcct ttaaggtaca gttgcaacta cctgataatg aagtagctca aatatctgat      300

tactatccaa gaaattcgat tgatacaaaa gagtatatga gtactttaac ttatggattc      360

aacggtaatg ttactggtga tgatacagga aaaattggcg gccttattgg tgcaaatgtt      420

tcgattggtc atacactgaa atatgttcaa cctgatttca aaacaatttt agagagccca      480

actgataaaa aagtaggctg gaaagtgata tttaacaata tggtgaatca aaattgggga      540

ccatatgata gagattcttg gaacccggta tatggcaatc aacttttcat gaaaactaga      600

aatggctcta tgaaagcagc agataacttc cttgatccta acaaagcaag ttctctatta      660

tcttcagggt tttcaccaga cttcgctaca gttattacta tggatagaaa agcatccaaa      720

caacaaacaa atatagatgt aatatacgaa cgagttcgtg atgactacca attgcactgg      780

acttcaacaa attggaaagg taccaatact aaagataaat ggatagatcg ttcttcagaa      840

agatataaaa tcgattggga aaaagaagaa atgacaaat                             879


<210>  12
<211>  879
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  mutation
<222>  (103)..(105)

<400>  12
gcagattctg atattaatat taaaaccggt actacagata ttggaagcaa tactacagta       60

aaaacaggtg atttagtcac ttatgataaa gaaaatggca tgttaaaaaa agtattttat      120

agttttatcg atgataaaaa tcataataaa aaactgctag ttattagaac gaaaggtacc      180

attgctggtc aatatagagt ttatagcgaa gaaggtgcta acaaaagtgg tttagcctgg      240

ccttcagcct ttaaggtaca gttgcaacta cctgataatg aagtagctca aatatctgat      300

tactatccaa gaaattcgat tgatacaaaa gagtatatga gtactttaac ttatggattc      360

aacggtaatg ttactggtga tgatacagga aaaattggcg gccttattgg tgcaaatgtt      420

tcgattggtc atacactgaa atatgttcaa cctgatttca aaacaatttt agagagccca      480

actgataaaa aagtaggctg gaaagtgata tttaacaata tggtgaatca aaattgggga      540

ccatatgata gagattcttg gaacccggta tatggcaatc aacttttcat gaaaactaga      600

aatggctcta tgaaagcagc agataacttc cttgatccta acaaagcaag ttctctatta      660

tcttcagggt tttcaccaga cttcgctaca gttattacta tggatagaaa agcatccaaa      720

caacaaacaa atatagatgt aatatacgaa cgagttcgtg atgactacca attgcactgg      780

acttcaacaa attggaaagg taccaatact aaagataaat ggatagatcg ttcttcagaa      840

agatataaaa tcgattggga aaaagaagaa atgacaaat                             879


<210>  13
<211>  843
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  mutation
<222>  (67)..(69)

<400>  13
gatattggaa gcaatactac agtaaaaaca ggtgatttag tcacttatga taaagaaaat       60

ggcatgttaa aaaaagtatt ttatagtttt atcgatgata aaaatcataa taaaaaactg      120

ctagttatta gaacgaaagg taccattgct ggtcaatata gagtttatag cgaagaaggt      180

gctaacaaaa gtggtttagc ctggccttca gcctttaagg tacagttgca actacctgat      240

aatgaagtag ctcaaatatc tgattactat ccaagaaatt cgattgatac aaaagagtat      300

atgagtactt taacttatgg attcaacggt aatgttactg gtgatgatac aggaaaaatt      360

ggcggcctta ttggtgcaaa tgtttcgatt ggtcatacac tgaaatatgt tcaacctgat      420

ttcaaaacaa ttttagagag cccaactgat aaaaaagtag gctggaaagt gatatttaac      480

aatatggtga atcaaaattg gggaccatat gatagagatt cttggaaccc ggtatatggc      540

aatcaacttt tcatgaaaac tagaaatggc tctatgaaag cagcagataa cttccttgat      600

cctaacaaag caagttctct attatcttca gggttttcac cagacttcgc tacagttatt      660

actatggata gaaaagcatc caaacaacaa acaaatatag atgtaatata cgaacgagtt      720

cgtgatgact accaattgca ctggacttca acaaattgga aaggtaccaa tactaaagat      780

aaatggatag atcgttcttc agaaagatat aaaatcgatt gggaaaaaga agaaatgaca      840

aat                                                                    843


<210>  14
<211>  879
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  mutation
<222>  (1)..(36)

<220>
<221>  mutation
<222>  (103)..(105)

<400>  14
agcgaaaccg aagtgagcgt gcgcagcgcg agcagcgata ttggaagcaa tactacagta       60

aaaacaggtg atttagtcac ttatgataaa gaaaatggca tgttaaaaaa agtattttat      120

agttttatcg atgataaaaa tcataataaa aaactgctag ttattagaac gaaaggtacc      180

attgctggtc aatatagagt ttatagcgaa gaaggtgcta acaaaagtgg tttagcctgg      240

ccttcagcct ttaaggtaca gttgcaacta cctgataatg aagtagctca aatatctgat      300

tactatccaa gaaattcgat tgatacaaaa gagtatatga gtactttaac ttatggattc      360

aacggtaatg ttactggtga tgatacagga aaaattggcg gccttattgg tgcaaatgtt      420

tcgattggtc atacactgaa atatgttcaa cctgatttca aaacaatttt agagagccca      480

actgataaaa aagtaggctg gaaagtgata tttaacaata tggtgaatca aaattgggga      540

ccatatgata gagattcttg gaacccggta tatggcaatc aacttttcat gaaaactaga      600

aatggctcta tgaaagcagc agataacttc cttgatccta acaaagcaag ttctctatta      660

tcttcagggt tttcaccaga cttcgctaca gttattacta tggatagaaa agcatccaaa      720

caacaaacaa atatagatgt aatatacgaa cgagttcgtg atgactacca attgcactgg      780

acttcaacaa attggaaagg taccaatact aaagataaat ggatagatcg ttcttcagaa      840

agatataaaa tcgattggga aaaagaagaa atgacaaat                             879


<210>  15
<211>  520
<212>  PRT
<213>  Staphylococcus aureus

<400>  15

Met Met Thr Leu Gln Ile His Thr Gly Gly Ile Asn Leu Lys Lys Lys 
1               5                   10                  15      


Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile Ala Ser Val Thr 
            20                  25                  30          


Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro Ala Ala Asn Ala 
        35                  40                  45              


Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn 
    50                  55                  60                  


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
65                  70                  75                  80  


Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
                85                  90                  95      


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
            100                 105                 110         


Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
        115                 120                 125             


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp 
    130                 135                 140                 


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
145                 150                 155                 160 


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn 
                165                 170                 175     


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
            180                 185                 190         


Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 
        195                 200                 205             


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
    210                 215                 220                 


Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu 
225                 230                 235                 240 


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
                245                 250                 255     


Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
            260                 265                 270         


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
        275                 280                 285             


Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
    290                 295                 300                 


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
305                 310                 315                 320 


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
                325                 330                 335     


Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn 
            340                 345                 350         


Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn 
        355                 360                 365             


Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys 
    370                 375                 380                 


Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys 
385                 390                 395                 400 


Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn 
                405                 410                 415     


Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly 
            420                 425                 430         


Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys 
        435                 440                 445             


Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly 
    450                 455                 460                 


Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala 
465                 470                 475                 480 


Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile 
                485                 490                 495     


Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu 
            500                 505                 510         


Leu Ala Gly Arg Arg Arg Glu Leu 
        515                 520 


<210>  16
<211>  291
<212>  PRT
<213>  Staphylococcus aureus

<400>  16

Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp 
                85                  90                  95      


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
225                 230                 235                 240 


Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  17
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (3)..(3)

<220>
<221>  VARIANT
<222>  (8)..(8)

<220>
<221>  VARIANT
<222>  (35)..(35)

<220>
<221>  VARIANT
<222>  (41)..(41)

<220>
<221>  VARIANT
<222>  (64)..(64)

<220>
<221>  VARIANT
<222>  (69)..(69)

<220>
<221>  VARIANT
<222>  (96)..(96)

<220>
<221>  VARIANT
<222>  (102)..(102)

<220>
<221>  VARIANT
<222>  (122)..(122)

<220>
<221>  VARIANT
<222>  (127)..(127)

<220>
<221>  VARIANT
<222>  (154)..(154)

<220>
<221>  VARIANT
<222>  (160)..(160)

<220>
<221>  VARIANT
<222>  (180)..(180)

<220>
<221>  VARIANT
<222>  (185)..(185)

<220>
<221>  VARIANT
<222>  (212)..(212)

<220>
<221>  VARIANT
<222>  (218)..(218)

<220>
<221>  VARIANT
<222>  (238)..(238)

<220>
<221>  VARIANT
<222>  (243)..(243)

<220>
<221>  VARIANT
<222>  (270)..(270)

<220>
<221>  VARIANT
<222>  (276)..(276)

<400>  17

Ala Gln Val Asp Glu Ala Gln Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Ala Pro Ser Gln Ser Ala Lys Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Val 
    50                  55                  60                  


Asn Lys Asp Gln Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala 
                85                  90                  95      


Pro Ser Gln Ser Thr Lys Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Val Asn Lys Glu Gln Lys Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser Gln Ser Ala Lys 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Asp Ala Pro Ser Gln Ser Ala Lys Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Val Asn Lys 
225                 230                 235                 240 


Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser 
            260                 265                 270         


Val Ser Lys Lys Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  18
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (3)..(3)

<220>
<221>  VARIANT
<222>  (8)..(8)

<220>
<221>  VARIANT
<222>  (35)..(35)

<220>
<221>  VARIANT
<222>  (37)..(38)

<220>
<221>  VARIANT
<222>  (64)..(64)

<220>
<221>  VARIANT
<222>  (69)..(69)

<220>
<221>  VARIANT
<222>  (96)..(96)

<220>
<221>  VARIANT
<222>  (98)..(99)

<220>
<221>  VARIANT
<222>  (122)..(122)

<220>
<221>  VARIANT
<222>  (127)..(127)

<220>
<221>  VARIANT
<222>  (154)..(154)

<220>
<221>  VARIANT
<222>  (156)..(157)

<220>
<221>  VARIANT
<222>  (180)..(180)

<220>
<221>  VARIANT
<222>  (185)..(185)

<220>
<221>  VARIANT
<222>  (212)..(212)

<220>
<221>  VARIANT
<222>  (214)..(215)

<220>
<221>  VARIANT
<222>  (238)..(238)

<220>
<221>  VARIANT
<222>  (243)..(243)

<220>
<221>  VARIANT
<222>  (270)..(270)

<220>
<221>  VARIANT
<222>  (272)..(273)

<400>  18

Ala Gln Val Asp Glu Ala Gln Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Ala Pro Ala Lys Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Val 
    50                  55                  60                  


Asn Lys Asp Gln Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala 
                85                  90                  95      


Pro Ala Lys Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Val Asn Lys Glu Gln Lys Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ala Lys Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Asp Ala Pro Ala Lys Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Val Asn Lys 
225                 230                 235                 240 


Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ala 
            260                 265                 270         


Lys Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  19
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (3)..(3)

<220>
<221>  VARIANT
<222>  (8)..(8)

<220>
<221>  VARIANT
<222>  (34)..(34)

<220>
<221>  VARIANT
<222>  (37)..(37)

<220>
<221>  VARIANT
<222>  (64)..(64)

<220>
<221>  VARIANT
<222>  (69)..(69)

<220>
<221>  VARIANT
<222>  (95)..(95)

<220>
<221>  VARIANT
<222>  (98)..(98)

<220>
<221>  VARIANT
<222>  (122)..(122)

<220>
<221>  VARIANT
<222>  (127)..(127)

<220>
<221>  VARIANT
<222>  (153)..(153)

<220>
<221>  VARIANT
<222>  (156)..(156)

<220>
<221>  VARIANT
<222>  (180)..(180)

<220>
<221>  VARIANT
<222>  (185)..(185)

<220>
<221>  VARIANT
<222>  (211)..(211)

<220>
<221>  VARIANT
<222>  (214)..(214)

<220>
<221>  VARIANT
<222>  (238)..(238)

<220>
<221>  VARIANT
<222>  (243)..(243)

<220>
<221>  VARIANT
<222>  (269)..(269)

<220>
<221>  VARIANT
<222>  (272)..(272)

<400>  19

Ala Gln Val Asp Glu Ala Gln Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Arg Asp Pro Arg Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Val 
    50                  55                  60                  


Asn Lys Asp Gln Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Arg Asp 
                85                  90                  95      


Pro Arg Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Val Asn Lys Glu Gln Lys Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Arg Asp Pro Arg Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Arg Asp Pro Arg Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Val Asn Lys 
225                 230                 235                 240 


Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Arg Asp Pro Arg 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  20
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (3)..(3)

<220>
<221>  VARIANT
<222>  (8)..(8)

<220>
<221>  VARIANT
<222>  (35)..(35)

<220>
<221>  VARIANT
<222>  (37)..(37)

<220>
<221>  VARIANT
<222>  (64)..(64)

<220>
<221>  VARIANT
<222>  (69)..(69)

<220>
<221>  VARIANT
<222>  (96)..(96)

<220>
<221>  VARIANT
<222>  (98)..(98)

<220>
<221>  VARIANT
<222>  (122)..(122)

<220>
<221>  VARIANT
<222>  (127)..(127)

<220>
<221>  VARIANT
<222>  (154)..(154)

<220>
<221>  VARIANT
<222>  (156)..(156)

<220>
<221>  VARIANT
<222>  (180)..(180)

<220>
<221>  VARIANT
<222>  (185)..(185)

<220>
<221>  VARIANT
<222>  (212)..(212)

<220>
<221>  VARIANT
<222>  (214)..(214)

<220>
<221>  VARIANT
<222>  (238)..(238)

<220>
<221>  VARIANT
<222>  (243)..(243)

<220>
<221>  VARIANT
<222>  (270)..(270)

<220>
<221>  VARIANT
<222>  (272)..(272)

<400>  20

Ala Gln Val Asp Glu Ala Gln Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Arg Pro Arg Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Val 
    50                  55                  60                  


Asn Lys Asp Gln Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Arg 
                85                  90                  95      


Pro Arg Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Val Asn Lys Glu Gln Lys Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Asp Arg Pro Arg Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Asp Arg Pro Arg Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Val Asn Lys 
225                 230                 235                 240 


Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Arg Pro Arg 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  21
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (8)..(9)

<220>
<221>  VARIANT
<222>  (35)..(35)

<220>
<221>  VARIANT
<222>  (41)..(41)

<220>
<221>  VARIANT
<222>  (69)..(70)

<220>
<221>  VARIANT
<222>  (96)..(96)

<220>
<221>  VARIANT
<222>  (102)..(102)

<220>
<221>  VARIANT
<222>  (127)..(128)

<220>
<221>  VARIANT
<222>  (154)..(154)

<220>
<221>  VARIANT
<222>  (160)..(160)

<220>
<221>  VARIANT
<222>  (185)..(186)

<220>
<221>  VARIANT
<222>  (212)..(212)

<220>
<221>  VARIANT
<222>  (218)..(218)

<220>
<221>  VARIANT
<222>  (243)..(244)

<220>
<221>  VARIANT
<222>  (270)..(270)

<220>
<221>  VARIANT
<222>  (276)..(276)

<400>  21

Ala Gln His Asp Glu Ala Gln Lys Lys Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Ala Pro Ser Gln Ser Ala Lys Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp Gln Lys Lys Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala 
                85                  90                  95      


Pro Ser Gln Ser Thr Lys Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Gln Lys Lys 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser Gln Ser Ala Lys 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Phe Asn Lys Glu Gln Lys Lys Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Asp Ala Pro Ser Gln Ser Ala Lys Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
225                 230                 235                 240 


Glu Gln Lys Lys Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser 
            260                 265                 270         


Val Ser Lys Lys Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  22
<211>  1563
<212>  DNA
<213>  Staphylococcus aureus

<400>  22
atgatgactt tacaaataca tacagggggt attaatttga aaaagaaaaa catttattca       60

attcgtaaac taggtgtagg tattgcatct gtaactttag gtacattact tatatctggt      120

ggcgtaacac ctgctgcaaa tgctgcgcaa cacgatgaag ctcaacaaaa tgctttttat      180

caagtcttaa atatgcctaa cttaaatgct gatcaacgca atggttttat ccaaagcctt      240

aaagatgatc caagccaaag tgctaacgtt ttaggtgaag ctcaaaaact taatgactct      300

caagctccaa aagctgatgc gcaacaaaat aacttcaaca aagatcaaca aagcgccttc      360

tatgaaatct tgaacatgcc taacttaaac gaagcgcaac gtaacggctt cattcaaagt      420

cttaaagacg acccaagcca aagcactaac gttttaggtg aagctaaaaa attaaacgaa      480

tctcaagcac cgaaagctga taacaatttc aacaaagaac aacaaaatgc tttctatgaa      540

atcttgaata tgcctaactt aaacgaagaa caacgcaatg gtttcatcca aagcttaaaa      600

gatgacccaa gccaaagtgc taacctattg tcagaagcta aaaagttaaa tgaatctcaa      660

gcaccgaaag cggataacaa attcaacaaa gaacaacaaa atgctttcta tgaaatctta      720

catttaccta acttaaacga agaacaacgc aatggtttca tccaaagcct aaaagatgac      780

ccaagccaaa gcgctaacct tttagcagaa gctaaaaagc taaatgatgc tcaagcacca      840

aaagctgaca acaaattcaa caaagaacaa caaaatgctt tctatgaaat tttacattta      900

cctaacttaa ctgaagaaca acgtaacggc ttcatccaaa gccttaaaga cgatccttca      960

gtgagcaaag aaattttagc agaagctaaa aagctaaacg atgctcaagc accaaaagag     1020

gaagacaata acaagcctgg caaagaagac aataacaagc ctggcaaaga agacaacaac     1080

aagcctggta aagaagacaa caacaagcct ggcaaagaag acggcaacaa gcctggtaaa     1140

gaagacaaca aaaaacctgg taaagaagat ggcaacaagc ctggtaaaga agacaacaaa     1200

aaacctggta aagaagacgg caacaagcct ggcaaagaag atggcaacaa acctggtaaa     1260

gaagatggta acggagtaca tgtcgttaaa cctggtgata cagtaaatga cattgcaaaa     1320

gcaaacggca ctactgctga caaaattgct gcagataaca aattagctga taaaaacatg     1380

atcaaacctg gtcaagaact tgttgttgat aagaagcaac cagcaaacca tgcagatgct     1440

aacaaagctc aagcattacc agaaactggt gaagaaaatc cattcatcgg tacaactgta     1500

tttggtggat tatcattagc cttaggtgca gcgttattag ctggacgtcg tcgcgaacta     1560

taa                                                                   1563


<210>  23
<211>  873
<212>  DNA
<213>  Staphylococcus aureus

<400>  23
gcgcaacacg atgaagctca acaaaatgct ttttatcaag tcttaaatat gcctaactta       60

aatgctgatc aacgcaatgg ttttatccaa agccttaaag atgatccaag ccaaagtgct      120

aacgttttag gtgaagctca aaaacttaat gactctcaag ctccaaaagc tgatgcgcaa      180

caaaataact tcaacaaaga tcaacaaagc gccttctatg aaatcttgaa catgcctaac      240

ttaaacgaag cgcaacgtaa cggcttcatt caaagtctta aagacgaccc aagccaaagc      300

actaacgttt taggtgaagc taaaaaatta aacgaatctc aagcaccgaa agctgataac      360

aatttcaaca aagaacaaca aaatgctttc tatgaaatct tgaatatgcc taacttaaac      420

gaagaacaac gcaatggttt catccaaagc ttaaaagatg acccaagcca aagtgctaac      480

ctattgtcag aagctaaaaa gttaaatgaa tctcaagcac cgaaagcgga taacaaattc      540

aacaaagaac aacaaaatgc tttctatgaa atcttacatt tacctaactt aaacgaagaa      600

caacgcaatg gtttcatcca aagcctaaaa gatgacccaa gccaaagcgc taacctttta      660

gcagaagcta aaaagctaaa tgatgctcaa gcaccaaaag ctgacaacaa attcaacaaa      720

gaacaacaaa atgctttcta tgaaatttta catttaccta acttaactga agaacaacgt      780

aacggcttca tccaaagcct taaagacgat ccttcagtga gcaaagaaat tttagcagaa      840

gctaaaaagc taaacgatgc tcaagcacca aaa                                   873


<210>  24
<211>  873
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  24
gcgcaagtgg atgaagctca aaaaaatgct ttttatcaag tcttaaatat gcctaactta       60

aatgctgatc aacgcaatgg ttttatccaa agccttaaag atgctccaag ccaaagtgct      120

aaagttttag gtgaagctca aaaacttaat gactctcaag ctccaaaagc tgatgcgcaa      180

caaaataacg tgaacaaaga tcaaaaaagc gccttctatg aaatcttgaa catgcctaac      240

ttaaacgaag cgcaacgtaa cggcttcatt caaagtctta aagacgctcc aagccaaagc      300

actaaagttt taggtgaagc taaaaaatta aacgaatctc aagcaccgaa agctgataac      360

aatgtgaaca aagaacaaaa aaatgctttc tatgaaatct tgaatatgcc taacttaaac      420

gaagaacaac gcaatggttt catccaaagc ttaaaagatg ctccaagcca aagtgctaaa      480

ctattgtcag aagctaaaaa gttaaatgaa tctcaagcac cgaaagcgga taacaaagtg      540

aacaaagaac aaaaaaatgc tttctatgaa atcttacatt tacctaactt aaacgaagaa      600

caacgcaatg gtttcatcca aagcctaaaa gatgctccaa gccaaagcgc taaactttta      660

gcagaagcta aaaagctaaa tgatgctcaa gcaccaaaag ctgacaacaa agtgaacaaa      720

gaacaaaaaa atgctttcta tgaaatttta catttaccta acttaactga agaacaacgt      780

aacggcttca tccaaagcct taaagacgct ccttcagtga gcaaaaaaat tttagcagaa      840

gctaaaaagc taaacgatgc tcaagcacca aaa                                   873


<210>  25
<211>  873
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  25
gcgcaagtgg atgaagctca aaaaaatgct ttttatcaag tcttaaatat gcctaactta       60

aatgctgatc aacgcaatgg ttttatccaa agccttaaag atgcaccagc aaaaagtgct      120

aacgttttag gtgaagctca aaaacttaat gactctcaag ctccaaaagc tgatgcgcaa      180

caaaataacg tgaacaaaga tcaaaaaagc gccttctatg aaatcttgaa catgcctaac      240

ttaaacgaag cgcaacgtaa cggcttcatt caaagtctta aagacgcacc agcaaaaagc      300

actaacgttt taggtgaagc taaaaaatta aacgaatctc aagcaccgaa agctgataac      360

aatgtgaaca aagaacaaaa aaatgctttc tatgaaatct tgaatatgcc taacttaaac      420

gaagaacaac gcaatggttt catccaaagc ttaaaagatg caccagcaaa aagtgctaac      480

ctattgtcag aagctaaaaa gttaaatgaa tctcaagcac cgaaagcgga taacaaagtg      540

aacaaagaac aaaaaaatgc tttctatgaa atcttacatt tacctaactt aaacgaagaa      600

caacgcaatg gtttcatcca aagcctaaaa gatgcaccag caaaaagcgc taacctttta      660

gcagaagcta aaaagctaaa tgatgctcaa gcaccaaaag ctgacaacaa agtgaacaaa      720

gaacaaaaaa atgctttcta tgaaatttta catttaccta acttaactga agaacaacgt      780

aacggcttca tccaaagcct taaagacgca cctgcaaaaa gcaaagaaat tttagcagaa      840

gctaaaaagc taaacgatgc tcaagcacca aaa                                   873


<210>  26
<211>  873
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  26
gcgcaagtgg atgaagctca aaaaaatgct ttttatcaag tcttaaatat gcctaactta       60

aatgctgatc aacgcaatgg ttttatccaa agccttaaaa gggatccaag gcaaagtgct      120

aacgttttag gtgaagctca aaaacttaat gactctcaag ctccaaaagc tgatgcgcaa      180

caaaataacg tgaacaaaga tcaaaaaagc gccttctatg aaatcttgaa catgcctaac      240

ttaaacgaag cgcaacgtaa cggcttcatt caaagtctta aaagggaccc aaggcaaagc      300

actaacgttt taggtgaagc taaaaaatta aacgaatctc aagcaccgaa agctgataac      360

aatgtgaaca aagaacaaaa aaatgctttc tatgaaatct tgaatatgcc taacttaaac      420

gaagaacaac gcaatggttt catccaaagc ttaaaaaggg acccaaggca aagtgctaac      480

ctattgtcag aagctaaaaa gttaaatgaa tctcaagcac cgaaagcgga taacaaagtg      540

aacaaagaac aaaaaaatgc tttctatgaa atcttacatt tacctaactt aaacgaagaa      600

caacgcaatg gtttcatcca aagcctaaaa agggacccaa ggcaaagcgc taacctttta      660

gcagaagcta aaaagctaaa tgatgctcaa gcaccaaaag ctgacaacaa agtgaacaaa      720

gaacaaaaaa atgctttcta tgaaatttta catttaccta acttaactga agaacaacgt      780

aacggcttca tccaaagcct taaaagggat cctagggtga gcaaagaaat tttagcagaa      840

gctaaaaagc taaacgatgc tcaagcacca aaa                                   873


<210>  27
<211>  873
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  27
gcgcaagtgg atgaagctca aaaaaatgct ttttatcaag tcttaaatat gcctaactta       60

aatgctgatc aacgcaatgg ttttatccaa agccttaaag ataggccaag gcaaagtgct      120

aacgttttag gtgaagctca aaaacttaat gactctcaag ctccaaaagc tgatgcgcaa      180

caaaataacg tgaacaaaga tcaaaaaagc gccttctatg aaatcttgaa catgcctaac      240

ttaaacgaag cgcaacgtaa cggcttcatt caaagtctta aagacaggcc aaggcaaagc      300

actaacgttt taggtgaagc taaaaaatta aacgaatctc aagcaccgaa agctgataac      360

aatgtgaaca aagaacaaaa aaatgctttc tatgaaatct tgaatatgcc taacttaaac      420

gaagaacaac gcaatggttt catccaaagc ttaaaagata ggccaaggca aagtgctaac      480

ctattgtcag aagctaaaaa gttaaatgaa tctcaagcac cgaaagcgga taacaaagtg      540

aacaaagaac aaaaaaatgc tttctatgaa atcttacatt tacctaactt aaacgaagaa      600

caacgcaatg gtttcatcca aagcctaaaa gataggccaa ggcaaagcgc taacctttta      660

gcagaagcta aaaagctaaa tgatgctcaa gcaccaaaag ctgacaacaa agtgaacaaa      720

gaacaaaaaa atgctttcta tgaaatttta catttaccta acttaactga agaacaacgt      780

aacggcttca tccaaagcct taaagacagg cctagggtga gcaaagaaat tttagcagaa      840

gctaaaaagc taaacgatgc tcaagcacca aaa                                   873


<210>  28
<211>  873
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  28
gcgcaacacg atgaagctca aaaaaaagct ttttatcaag tcttaaatat gcctaactta       60

aatgctgatc aacgcaatgg ttttatccaa agccttaaag atgctccaag ccaaagtgct      120

aaagttttag gtgaagctca aaaacttaat gactctcaag ctccaaaagc tgatgcgcaa      180

caaaataact tcaacaaaga tcaaaaaaaa gccttctatg aaatcttgaa catgcctaac      240

ttaaacgaag cgcaacgtaa cggcttcatt caaagtctta aagacgctcc aagccaaagc      300

actaaagttt taggtgaagc taaaaaatta aacgaatctc aagcaccgaa agctgataac      360

aatttcaaca aagaacaaaa aaaagctttc tatgaaatct tgaatatgcc taacttaaac      420

gaagaacaac gcaatggttt catccaaagc ttaaaagatg ctccaagcca aagtgctaaa      480

ctattgtcag aagctaaaaa gttaaatgaa tctcaagcac cgaaagcgga taacaaattc      540

aacaaagaac aaaaaaaagc tttctatgaa atcttacatt tacctaactt aaacgaagaa      600

caacgcaatg gtttcatcca aagcctaaaa gatgctccaa gccaaagcgc taaactttta      660

gcagaagcta aaaagctaaa tgatgctcaa gcaccaaaag ctgacaacaa attcaacaaa      720

gaacaaaaaa aagctttcta tgaaatttta catttaccta acttaactga agaacaacgt      780

aacggcttca tccaaagcct taaagacgct ccttcagtga gcaaaaaaat tttagcagaa      840

gctaaaaagc taaacgatgc tcaagcacca aaa                                   873


<210>  29
<211>  311
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  SIGNAL
<222>  (1)..(28)

<220>
<221>  mat_peptide
<222>  (29)..(311)

<400>  29

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
            -25                 -20                 -15         


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
        -10                 -5              -1  1               


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
5                   10                  15                  20  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
                25                  30                  35      


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
            40                  45                  50          


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
        55                  60                  65              


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
    70                  75                  80                  


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
85                  90                  95                  100 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
                105                 110                 115     


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
            120                 125                 130         


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
        135                 140                 145             


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
    150                 155                 160                 


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
165                 170                 175                 180 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
                185                 190                 195     


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
            200                 205                 210         


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
        215                 220                 225             


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
    230                 235                 240                 


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
245                 250                 255                 260 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
                265                 270                 275     


Ile Lys Val Lys Gly His Asn 
            280             


<210>  30
<211>  283
<212>  PRT
<213>  Staphylococcus aureus

<400>  30

Asn Thr Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg 
1               5                   10                  15      


Thr Glu Asp Val Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys 
    50                  55                  60                  


Gly Ser Gly Tyr Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr 
65                  70                  75                  80  


Asn Ile Gly Leu Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr 
                85                  90                  95      


Leu Pro Lys Asn Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly 
            100                 105                 110         


Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn 
        115                 120                 125             


Gly Ser Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr 
    130                 135                 140                 


Val Ser Glu Val Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val 
145                 150                 155                 160 


Lys Ala Asn Glu Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp 
                165                 170                 175     


Arg Tyr Leu Phe Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg 
            180                 185                 190         


Glu Tyr Phe Ala Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly 
        195                 200                 205             


Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser 
    210                 215                 220                 


Asp Thr Ser Glu Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr 
225                 230                 235                 240 


Tyr Ala Thr Leu Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His 
                245                 250                 255     


Asn Ala Phe Val Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp 
            260                 265                 270         


Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280             


<210>  31
<211>  936
<212>  DNA
<213>  Staphylococcus aureus

<400>  31
atgtttaaga aaaaaatgtt agctgcaact ttgtcagtag gactgattgc acctttagca       60

tctccgattc aagaatctag agcaaatact aatattgaaa atattggtga tggtgctgaa      120

gtaatcaaac gtacggagga tgtaagtagt aagaaatggg gcgttactca aaatgtccaa      180

ttcgactttg taaaagataa aaaatataac aaagacgctt taattgttaa aatgcaaggt      240

tttattaatt ccagaacttc attttcagat gtgaagggta gtggatatga attaactaaa      300

cgaatgattt ggccattcca atataatata ggactgacga ctaaagatcc aaatgttagc      360

ttaatcaatt accttcctaa aaacaaaata gaaactactg atgttggtca aacattagga      420

tataacattg gaggtaattt ccagtcagca ccatctatag gtggcaatgg ctcatttaat      480

tattctaaaa caattagtta tacccaaaag agttatgtca gtgaagtaga caagcaaaac      540

tcaaaatctg ttaaatgggg tgttaaagca aacgaatttg ttacgcctga tggaaaaaaa      600

tctgcgcatg atagatattt attcgtacaa agtccaaatg gtccaacagg ttcagcaaga      660

gaatattttg ctcctgataa tcaattgcca cctttagttc aaagtggctt taatccatcg      720

tttatcacta cactatcaca tgaaaaaggt tcaagtgata cgagtgaatt tgaaatttca      780

tatggtagaa acttagatat tacatatgcg actttattcc ctagaactgg tatttacgca      840

gaaagaaagc ataatgcatt tgtaaataga aactttgtag ttagatatga agttaattgg      900

aaaacacacg aaattaaagt gaaaggacat aattaa                                936


<210>  32
<211>  849
<212>  DNA
<213>  Staphylococcus aureus

<400>  32
aatactaata ttgaaaatat tggtgatggt gctgaagtaa tcaaacgtac ggaggatgta       60

agtagtaaga aatggggcgt tactcaaaat gtccaattcg actttgtaaa agataaaaaa      120

tataacaaag acgctttaat tgttaaaatg caaggtttta ttaattccag aacttcattt      180

tcagatgtga agggtagtgg atatgaatta actaaacgaa tgatttggcc attccaatat      240

aatataggac tgacgactaa agatccaaat gttagcttaa tcaattacct tcctaaaaac      300

aaaatagaaa ctactgatgt tggtcaaaca ttaggatata acattggagg taatttccag      360

tcagcaccat ctataggtgg caatggctca tttaattatt ctaaaacaat tagttatacc      420

caaaagagtt atgtcagtga agtagacaag caaaactcaa aatctgttaa atggggtgtt      480

aaagcaaacg aatttgttac gcctgatgga aaaaaatctg cgcatgatag atatttattc      540

gtacaaagtc caaatggtcc aacaggttca gcaagagaat attttgctcc tgataatcaa      600

ttgccacctt tagttcaaag tggctttaat ccatcgttta tcactacact atcacatgaa      660

aaaggttcaa gtgatacgag tgaatttgaa atttcatatg gtagaaactt agatattaca      720

tatgcgactt tattccctag aactggtatt tacgcagaaa gaaagcataa tgcatttgta      780

aatagaaact ttgtagttag atatgaagtt aattggaaaa cacacgaaat taaagtgaaa      840

ggacataat                                                              849


<210>  33
<211>  509
<212>  PRT
<213>  Staphylococcus aureus


<220>
<221>  SIGNAL
<222>  (1)..(27)

<220>
<221>  PROPEP
<222>  (28)..(209)

<220>
<221>  mat_peptide
<222>  (210)..(509)

<400>  33

Met Arg Lys Phe Ser  Arg Tyr Ala Phe Thr  Ser Met Ala Ala Leu  
                -205                 -200                 -195 


Thr Leu Leu Ser Thr  Leu Ser Pro Ala Ala  Leu Ala Ile Asp Ser  
                -190                 -185                 -180 


Lys Asn Lys Pro Ala  Asn Ser Asp Ile Lys  Phe Glu Val Thr Gln  
                -175                 -170                 -165 


Lys Ser Asp Ala Val  Lys Ala Leu Lys Glu  Leu Pro Lys Ser Glu  
                -160                 -155                 -150 


Asn Val Lys Asn Ile  Tyr Gln Asp Tyr Ala  Val Thr Asp Val Lys  
                -145                 -140                 -135 


Thr Asp Lys Lys Gly  Phe Thr His Tyr Thr  Leu Gln Pro Ser Val  
                -130                 -125                 -120 


Asp Gly Val His Ala  Pro Asp Lys Glu Val  Lys Val His Ala Asp  
                -115                 -110                 -105 


Lys Ser Gly Lys Val  Val Leu Ile Asn Gly Asp Thr Asp Ala Lys Lys 
                -100                 -95                 -90     


Val Lys Pro Thr Asn Lys Val Thr Leu Ser Lys Asp Asp Ala Ala Asp 
            -85                 -80                 -75         


Lys Ala Phe Lys Ala Val Lys Ile Asp Lys Asn Lys Ala Lys Asn Leu 
        -70                 -65                 -60             


Lys Asp Lys Val Ile Lys Glu Asn Lys Val Glu Ile Asp Gly Asp Ser 
    -55                 -50                 -45                 


Asn Lys Tyr Val Tyr Asn Val Glu Leu Ile Thr Val Thr Pro Glu Ile 
-40                 -35                 -30                 -25 


Ser His Trp Lys Val Lys Ile Asp Ala Gln Thr Gly Glu Ile Leu Glu 
                -20                 -15                 -10     


Lys Met Asn Leu Val Lys Glu Ala Ala Glu Thr Gly Lys Gly Lys Gly 
            -5              -1  1               5               


Val Leu Gly Asp Thr Lys Asp Ile Asn Ile Asn Ser Ile Asp Gly Gly 
    10                  15                  20                  


Phe Ser Leu Glu Asp Leu Thr His Gln Gly Lys Leu Ser Ala Phe Ser 
25                  30                  35                  40  


Phe Asn Asp Gln Thr Gly Gln Ala Thr Leu Ile Thr Asn Glu Asp Glu 
                45                  50                  55      


Asn Phe Val Lys Asp Glu Gln Arg Ala Gly Val Asp Ala Asn Tyr Tyr 
            60                  65                  70          


Ala Lys Gln Thr Tyr Asp Tyr Tyr Lys Asp Thr Phe Gly Arg Glu Ser 
        75                  80                  85              


Tyr Asp Asn Gln Gly Ser Pro Ile Val Ser Leu Thr His Val Asn Asn 
    90                  95                  100                 


Tyr Gly Gly Gln Asp Asn Arg Asn Asn Ala Ala Trp Ile Gly Asp Lys 
105                 110                 115                 120 


Met Ile Tyr Gly Asp Gly Asp Gly Arg Thr Phe Thr Ser Leu Ser Gly 
                125                 130                 135     


Ala Asn Asp Val Val Ala His Glu Leu Thr His Gly Val Thr Gln Glu 
            140                 145                 150         


Thr Ala Asn Leu Glu Tyr Lys Asp Gln Ser Gly Ala Leu Asn Glu Ser 
        155                 160                 165             


Phe Ser Asp Val Phe Gly Tyr Phe Val Asp Asp Glu Asp Phe Leu Met 
    170                 175                 180                 


Gly Glu Asp Val Tyr Thr Pro Gly Lys Glu Gly Asp Ala Leu Arg Ser 
185                 190                 195                 200 


Met Ser Asn Pro Glu Gln Phe Gly Gln Pro Ala His Met Lys Asp Tyr 
                205                 210                 215     


Val Phe Thr Glu Lys Asp Asn Gly Gly Val His Thr Asn Ser Gly Ile 
            220                 225                 230         


Pro Asn Lys Ala Ala Tyr Asn Val Ile Gln Ala Ile Gly Lys Ser Lys 
        235                 240                 245             


Ser Glu Gln Ile Tyr Tyr Arg Ala Leu Thr Glu Tyr Leu Thr Ser Asn 
    250                 255                 260                 


Ser Asn Phe Lys Asp Cys Lys Asp Ala Leu Tyr Gln Ala Ala Lys Asp 
265                 270                 275                 280 


Leu Tyr Asp Glu Gln Thr Ala Glu Gln Val Tyr Glu Ala Trp Asn Glu 
                285                 290                 295     


Val Gly Val Glu 
            300 


<210>  34
<211>  482
<212>  PRT
<213>  Staphylococcus aureus

<400>  34

Ile Asp Ser Lys Asn Lys Pro Ala Asn Ser Asp Ile Lys Phe Glu Val 
1               5                   10                  15      


Thr Gln Lys Ser Asp Ala Val Lys Ala Leu Lys Glu Leu Pro Lys Ser 
            20                  25                  30          


Glu Asn Val Lys Asn Ile Tyr Gln Asp Tyr Ala Val Thr Asp Val Lys 
        35                  40                  45              


Thr Asp Lys Lys Gly Phe Thr His Tyr Thr Leu Gln Pro Ser Val Asp 
    50                  55                  60                  


Gly Val His Ala Pro Asp Lys Glu Val Lys Val His Ala Asp Lys Ser 
65                  70                  75                  80  


Gly Lys Val Val Leu Ile Asn Gly Asp Thr Asp Ala Lys Lys Val Lys 
                85                  90                  95      


Pro Thr Asn Lys Val Thr Leu Ser Lys Asp Asp Ala Ala Asp Lys Ala 
            100                 105                 110         


Phe Lys Ala Val Lys Ile Asp Lys Asn Lys Ala Lys Asn Leu Lys Asp 
        115                 120                 125             


Lys Val Ile Lys Glu Asn Lys Val Glu Ile Asp Gly Asp Ser Asn Lys 
    130                 135                 140                 


Tyr Val Tyr Asn Val Glu Leu Ile Thr Val Thr Pro Glu Ile Ser His 
145                 150                 155                 160 


Trp Lys Val Lys Ile Asp Ala Gln Thr Gly Glu Ile Leu Glu Lys Met 
                165                 170                 175     


Asn Leu Val Lys Glu Ala Ala Glu Thr Gly Lys Gly Lys Gly Val Leu 
            180                 185                 190         


Gly Asp Thr Lys Asp Ile Asn Ile Asn Ser Ile Asp Gly Gly Phe Ser 
        195                 200                 205             


Leu Glu Asp Leu Thr His Gln Gly Lys Leu Ser Ala Phe Ser Phe Asn 
    210                 215                 220                 


Asp Gln Thr Gly Gln Ala Thr Leu Ile Thr Asn Glu Asp Glu Asn Phe 
225                 230                 235                 240 


Val Lys Asp Glu Gln Arg Ala Gly Val Asp Ala Asn Tyr Tyr Ala Lys 
                245                 250                 255     


Gln Thr Tyr Asp Tyr Tyr Lys Asp Thr Phe Gly Arg Glu Ser Tyr Asp 
            260                 265                 270         


Asn Gln Gly Ser Pro Ile Val Ser Leu Thr His Val Asn Asn Tyr Gly 
        275                 280                 285             


Gly Gln Asp Asn Arg Asn Asn Ala Ala Trp Ile Gly Asp Lys Met Ile 
    290                 295                 300                 


Tyr Gly Asp Gly Asp Gly Arg Thr Phe Thr Ser Leu Ser Gly Ala Asn 
305                 310                 315                 320 


Asp Val Val Ala His Glu Leu Thr His Gly Val Thr Gln Glu Thr Ala 
                325                 330                 335     


Asn Leu Glu Tyr Lys Asp Gln Ser Gly Ala Leu Asn Glu Ser Phe Ser 
            340                 345                 350         


Asp Val Phe Gly Tyr Phe Val Asp Asp Glu Asp Phe Leu Met Gly Glu 
        355                 360                 365             


Asp Val Tyr Thr Pro Gly Lys Glu Gly Asp Ala Leu Arg Ser Met Ser 
    370                 375                 380                 


Asn Pro Glu Gln Phe Gly Gln Pro Ala His Met Lys Asp Tyr Val Phe 
385                 390                 395                 400 


Thr Glu Lys Asp Asn Gly Gly Val His Thr Asn Ser Gly Ile Pro Asn 
                405                 410                 415     


Lys Ala Ala Tyr Asn Val Ile Gln Ala Ile Gly Lys Ser Lys Ser Glu 
            420                 425                 430         


Gln Ile Tyr Tyr Arg Ala Leu Thr Glu Tyr Leu Thr Ser Asn Ser Asn 
        435                 440                 445             


Phe Lys Asp Cys Lys Asp Ala Leu Tyr Gln Ala Ala Lys Asp Leu Tyr 
    450                 455                 460                 


Asp Glu Gln Thr Ala Glu Gln Val Tyr Glu Ala Trp Asn Glu Val Gly 
465                 470                 475                 480 


Val Glu 
        


<210>  35
<211>  482
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (326)..(326)

<220>
<221>  VARIANT
<222>  (452)..(452)

<400>  35

Ile Asp Ser Lys Asn Lys Pro Ala Asn Ser Asp Ile Lys Phe Glu Val 
1               5                   10                  15      


Thr Gln Lys Ser Asp Ala Val Lys Ala Leu Lys Glu Leu Pro Lys Ser 
            20                  25                  30          


Glu Asn Val Lys Asn Ile Tyr Gln Asp Tyr Ala Val Thr Asp Val Lys 
        35                  40                  45              


Thr Asp Lys Lys Gly Phe Thr His Tyr Thr Leu Gln Pro Ser Val Asp 
    50                  55                  60                  


Gly Val His Ala Pro Asp Lys Glu Val Lys Val His Ala Asp Lys Ser 
65                  70                  75                  80  


Gly Lys Val Val Leu Ile Asn Gly Asp Thr Asp Ala Lys Lys Val Lys 
                85                  90                  95      


Pro Thr Asn Lys Val Thr Leu Ser Lys Asp Asp Ala Ala Asp Lys Ala 
            100                 105                 110         


Phe Lys Ala Val Lys Ile Asp Lys Asn Lys Ala Lys Asn Leu Lys Asp 
        115                 120                 125             


Lys Val Ile Lys Glu Asn Lys Val Glu Ile Asp Gly Asp Ser Asn Lys 
    130                 135                 140                 


Tyr Val Tyr Asn Val Glu Leu Ile Thr Val Thr Pro Glu Ile Ser His 
145                 150                 155                 160 


Trp Lys Val Lys Ile Asp Ala Gln Thr Gly Glu Ile Leu Glu Lys Met 
                165                 170                 175     


Asn Leu Val Lys Glu Ala Ala Glu Thr Gly Lys Gly Lys Gly Val Leu 
            180                 185                 190         


Gly Asp Thr Lys Asp Ile Asn Ile Asn Ser Ile Asp Gly Gly Phe Ser 
        195                 200                 205             


Leu Glu Asp Leu Thr His Gln Gly Lys Leu Ser Ala Phe Ser Phe Asn 
    210                 215                 220                 


Asp Gln Thr Gly Gln Ala Thr Leu Ile Thr Asn Glu Asp Glu Asn Phe 
225                 230                 235                 240 


Val Lys Asp Glu Gln Arg Ala Gly Val Asp Ala Asn Tyr Tyr Ala Lys 
                245                 250                 255     


Gln Thr Tyr Asp Tyr Tyr Lys Asp Thr Phe Gly Arg Glu Ser Tyr Asp 
            260                 265                 270         


Asn Gln Gly Ser Pro Ile Val Ser Leu Thr His Val Asn Asn Tyr Gly 
        275                 280                 285             


Gly Gln Asp Asn Arg Asn Asn Ala Ala Trp Ile Gly Asp Lys Met Ile 
    290                 295                 300                 


Tyr Gly Asp Gly Asp Gly Arg Thr Phe Thr Ser Leu Ser Gly Ala Asn 
305                 310                 315                 320 


Asp Val Val Ala His Ala Leu Thr His Gly Val Thr Gln Glu Thr Ala 
                325                 330                 335     


Asn Leu Glu Tyr Lys Asp Gln Ser Gly Ala Leu Asn Glu Ser Phe Ser 
            340                 345                 350         


Asp Val Phe Gly Tyr Phe Val Asp Asp Glu Asp Phe Leu Met Gly Glu 
        355                 360                 365             


Asp Val Tyr Thr Pro Gly Lys Glu Gly Asp Ala Leu Arg Ser Met Ser 
    370                 375                 380                 


Asn Pro Glu Gln Phe Gly Gln Pro Ala His Met Lys Asp Tyr Val Phe 
385                 390                 395                 400 


Thr Glu Lys Asp Asn Gly Gly Val His Thr Asn Ser Gly Ile Pro Asn 
                405                 410                 415     


Lys Ala Ala Tyr Asn Val Ile Gln Ala Ile Gly Lys Ser Lys Ser Glu 
            420                 425                 430         


Gln Ile Tyr Tyr Arg Ala Leu Thr Glu Tyr Leu Thr Ser Asn Ser Asn 
        435                 440                 445             


Phe Lys Asp Ser Lys Asp Ala Leu Tyr Gln Ala Ala Lys Asp Leu Tyr 
    450                 455                 460                 


Asp Glu Gln Thr Ala Glu Gln Val Tyr Glu Ala Trp Asn Glu Val Gly 
465                 470                 475                 480 


Val Glu 
        


<210>  36
<211>  1446
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  mutation
<222>  (976)..(978)

<220>
<221>  mutation
<222>  (1354)..(1356)

<400>  36
attgattcaa aaaataaacc agctaattct gatattaaat ttgaggtgac tcaaaagagt       60

gatgcggtca aagcattaaa agaattgcct aaatccgaaa atgtaaaaaa tatttatcaa      120

gattacgctg ttactgatgt aaaaactgat aaaaaaggat ttacgcatta tacattgcaa      180

ccgagtgttg atggtgttca tgcacctgac aaagaagtga aagtacacgc agacaaatca      240

ggaaaagtcg ttttaatcaa tggggatact gatgcgaaga aagtaaagcc aacgaataaa      300

gtgacattaa gtaaagatga cgcagccgac aaagcattta aagcagttaa gattgataag      360

aataaagcga aaaatcttaa agataaagtc attaaagaaa acaaagttga aatcgatggt      420

gacagtaata aatacgttta taatgttgag ttaattacag tgacaccaga aatttcacat      480

tggaaagtta aaattgatgc tcaaactggc gaaattttag aaaaaatgaa cttagttaaa      540

gaagctgcag aaactggtaa aggaaaaggt gtacttggcg atacaaaaga tatcaatatc      600

aatagtattg acggtggatt tagcctagaa gatttaacgc atcaaggtaa attatcagca      660

tttagcttta atgatcaaac aggtcaagca acattgatta ctaatgaaga tgaaaacttc      720

gtaaaagatg agcaacgtgc tggcgtagat gcaaattatt acgctaaaca aacatatgat      780

tattacaaag acacatttgg tcgtgaatca tatgacaacc aaggtagtcc aattgtttca      840

ttaacgcatg ttaataacta cggtggtcaa gataacagaa ataatgccgc atggatcggt      900

gacaaaatga tctatggtga tggtgatggt cgcacattca caagtttatc gggtgcaaat      960

gacgtagtag cacacgcatt aacacacggt gtgacacaag agacagcgaa cttagaatat     1020

aaggaccagt caggcgctct aaatgaaagc ttttcagatg tttttggata ctttgtagat     1080

gacgaggatt tcttaatggg tgaagatgtc tacacacctg gaaaagaggg agacgcttta     1140

cgcagcatgt caaacccaga acaatttggt caaccagctc atatgaaaga ctatgtattc     1200

actgaaaaag ataatggtgg cgtacatacg aattctggaa ttccaaataa agcagcttat     1260

aacgtgattc aagcaatagg gaaatctaaa tcagaacaaa tttactaccg agcattaacg     1320

gaatacttaa caagtaattc aaacttcaaa gatagcaaag atgcattata ccaagcggct     1380

aaagatttat atgacgagca aacagctgaa caggtgtatg aagcatggaa tgaagtaggc     1440

gtggag                                                                1446


<210>  37
<211>  619
<212>  PRT
<213>  Staphylococcus aureus

<400>  37

Met Pro Lys Asn Lys Ile Leu Ile Tyr Leu Leu Ser Thr Thr Leu Val 
1               5                   10                  15      


Leu Pro Thr Leu Val Ser Pro Thr Ala Tyr Ala Asp Thr Pro Gln Lys 
            20                  25                  30          


Asp Thr Thr Ala Lys Thr Thr Ser His Asp Ser Lys Lys Ser Thr Asp 
        35                  40                  45              


Asp Glu Thr Ser Lys Asp Thr Thr Ser Lys Asp Ile Asp Lys Ala Asp 
    50                  55                  60                  


Asn Asn Asn Thr Ser Asn Gln Asp Asn Asn Asp Lys Lys Val Lys Thr 
65                  70                  75                  80  


Ile Asp Asp Ser Thr Ser Asp Ser Asn Asn Ile Ile Asp Phe Ile Tyr 
                85                  90                  95      


Lys Asn Leu Pro Gln Thr Asn Ile Asn Gln Leu Leu Thr Lys Asn Lys 
            100                 105                 110         


Tyr Asp Asp Asn Tyr Ser Leu Thr Thr Leu Ile Gln Asn Leu Phe Asn 
        115                 120                 125             


Leu Asn Ser Asp Ile Ser Asp Tyr Glu Gln Pro Arg Asn Gly Glu Lys 
    130                 135                 140                 


Ser Thr Asn Asp Ser Asn Lys Asn Ser Asp Asn Ser Ile Lys Asn Asp 
145                 150                 155                 160 


Thr Asp Thr Gln Ser Ser Lys Gln Asp Lys Ala Asp Asn Gln Lys Ala 
                165                 170                 175     


Pro Lys Ser Asn Asn Thr Lys Pro Ser Thr Ser Asn Lys Gln Pro Asn 
            180                 185                 190         


Ser Pro Lys Pro Thr Gln Pro Asn Gln Ser Asn Ser Gln Pro Ala Ser 
        195                 200                 205             


Asp Asp Lys Val Asn Gln Lys Ser Ser Ser Lys Asp Asn Gln Ser Met 
    210                 215                 220                 


Ser Asp Ser Ala Leu Asp Ser Ile Leu Asp Gln Tyr Ser Glu Asp Ala 
225                 230                 235                 240 


Lys Lys Thr Gln Lys Asp Tyr Ala Ser Gln Ser Lys Lys Asp Lys Asn 
                245                 250                 255     


Glu Lys Ser Asn Thr Lys Asn Pro Gln Leu Pro Thr Gln Asp Glu Leu 
            260                 265                 270         


Lys His Lys Ser Lys Pro Ala Gln Ser Phe Asn Asn Asp Val Asn Gln 
        275                 280                 285             


Lys Asp Thr Arg Ala Thr Ser Leu Phe Glu Thr Asp Pro Ser Ile Ser 
    290                 295                 300                 


Asn Asn Asp Asp Ser Gly Gln Phe Asn Val Val Asp Ser Lys Asp Thr 
305                 310                 315                 320 


Arg Gln Phe Val Lys Ser Ile Ala Lys Asp Ala His Arg Ile Gly Gln 
                325                 330                 335     


Asp Asn Asp Ile Tyr Ala Ser Val Met Ile Ala Gln Ala Ile Leu Glu 
            340                 345                 350         


Ser Asp Ser Gly Arg Ser Ala Leu Ala Lys Ser Pro Asn His Asn Leu 
        355                 360                 365             


Phe Gly Ile Lys Gly Ala Phe Glu Gly Asn Ser Val Pro Phe Asn Thr 
    370                 375                 380                 


Leu Glu Ala Asp Gly Asn Gln Leu Tyr Ser Ile Asn Ala Gly Phe Arg 
385                 390                 395                 400 


Lys Tyr Pro Ser Thr Lys Glu Ser Leu Lys Asp Tyr Ser Asp Leu Ile 
                405                 410                 415     


Lys Asn Gly Ile Asp Gly Asn Arg Thr Ile Tyr Lys Pro Thr Trp Lys 
            420                 425                 430         


Ser Glu Ala Asp Ser Tyr Lys Asp Ala Thr Ser His Leu Ser Lys Thr 
        435                 440                 445             


Tyr Ala Thr Asp Pro Asn Tyr Ala Lys Lys Leu Asn Ser Ile Ile Lys 
    450                 455                 460                 


His Tyr Gln Leu Thr Gln Phe Asp Asp Glu Arg Met Pro Asp Leu Asp 
465                 470                 475                 480 


Lys Tyr Glu Arg Ser Ile Lys Asp Tyr Asp Asp Ser Ser Asp Glu Phe 
                485                 490                 495     


Lys Pro Phe Arg Glu Val Ser Asp Asn Met Pro Tyr Pro His Gly Gln 
            500                 505                 510         


Cys Thr Trp Tyr Val Tyr Asn Arg Met Lys Gln Phe Gly Thr Ser Ile 
        515                 520                 525             


Ser Gly Asp Leu Gly Asp Ala His Asn Trp Asn Asn Arg Ala Gln Tyr 
    530                 535                 540                 


Arg Asp Tyr Gln Val Ser His Thr Pro Lys Arg His Ala Ala Val Val 
545                 550                 555                 560 


Phe Glu Ala Gly Gln Phe Gly Ala Asp Gln His Tyr Gly His Val Ala 
                565                 570                 575     


Phe Val Glu Lys Val Asn Ser Asp Gly Ser Ile Val Ile Ser Glu Ser 
            580                 585                 590         


Asn Val Lys Gly Leu Gly Ile Ile Ser His Arg Thr Ile Asn Ala Ala 
        595                 600                 605             


Ala Ala Glu Glu Leu Ser Tyr Ile Thr Gly Lys 
    610                 615                 


<210>  38
<211>  592
<212>  PRT
<213>  Staphylococcus aureus

<400>  38

Asp Thr Pro Gln Lys Asp Thr Thr Ala Lys Thr Thr Ser His Asp Ser 
1               5                   10                  15      


Lys Lys Ser Thr Asp Asp Glu Thr Ser Lys Asp Thr Thr Ser Lys Asp 
            20                  25                  30          


Ile Asp Lys Ala Asp Asn Asn Asn Thr Ser Asn Gln Asp Asn Asn Asp 
        35                  40                  45              


Lys Lys Val Lys Thr Ile Asp Asp Ser Thr Ser Asp Ser Asn Asn Ile 
    50                  55                  60                  


Ile Asp Phe Ile Tyr Lys Asn Leu Pro Gln Thr Asn Ile Asn Gln Leu 
65                  70                  75                  80  


Leu Thr Lys Asn Lys Tyr Asp Asp Asn Tyr Ser Leu Thr Thr Leu Ile 
                85                  90                  95      


Gln Asn Leu Phe Asn Leu Asn Ser Asp Ile Ser Asp Tyr Glu Gln Pro 
            100                 105                 110         


Arg Asn Gly Glu Lys Ser Thr Asn Asp Ser Asn Lys Asn Ser Asp Asn 
        115                 120                 125             


Ser Ile Lys Asn Asp Thr Asp Thr Gln Ser Ser Lys Gln Asp Lys Ala 
    130                 135                 140                 


Asp Asn Gln Lys Ala Pro Lys Ser Asn Asn Thr Lys Pro Ser Thr Ser 
145                 150                 155                 160 


Asn Lys Gln Pro Asn Ser Pro Lys Pro Thr Gln Pro Asn Gln Ser Asn 
                165                 170                 175     


Ser Gln Pro Ala Ser Asp Asp Lys Val Asn Gln Lys Ser Ser Ser Lys 
            180                 185                 190         


Asp Asn Gln Ser Met Ser Asp Ser Ala Leu Asp Ser Ile Leu Asp Gln 
        195                 200                 205             


Tyr Ser Glu Asp Ala Lys Lys Thr Gln Lys Asp Tyr Ala Ser Gln Ser 
    210                 215                 220                 


Lys Lys Asp Lys Asn Glu Lys Ser Asn Thr Lys Asn Pro Gln Leu Pro 
225                 230                 235                 240 


Thr Gln Asp Glu Leu Lys His Lys Ser Lys Pro Ala Gln Ser Phe Asn 
                245                 250                 255     


Asn Asp Val Asn Gln Lys Asp Thr Arg Ala Thr Ser Leu Phe Glu Thr 
            260                 265                 270         


Asp Pro Ser Ile Ser Asn Asn Asp Asp Ser Gly Gln Phe Asn Val Val 
        275                 280                 285             


Asp Ser Lys Asp Thr Arg Gln Phe Val Lys Ser Ile Ala Lys Asp Ala 
    290                 295                 300                 


His Arg Ile Gly Gln Asp Asn Asp Ile Tyr Ala Ser Val Met Ile Ala 
305                 310                 315                 320 


Gln Ala Ile Leu Glu Ser Asp Ser Gly Arg Ser Ala Leu Ala Lys Ser 
                325                 330                 335     


Pro Asn His Asn Leu Phe Gly Ile Lys Gly Ala Phe Glu Gly Asn Ser 
            340                 345                 350         


Val Pro Phe Asn Thr Leu Glu Ala Asp Gly Asn Gln Leu Tyr Ser Ile 
        355                 360                 365             


Asn Ala Gly Phe Arg Lys Tyr Pro Ser Thr Lys Glu Ser Leu Lys Asp 
    370                 375                 380                 


Tyr Ser Asp Leu Ile Lys Asn Gly Ile Asp Gly Asn Arg Thr Ile Tyr 
385                 390                 395                 400 


Lys Pro Thr Trp Lys Ser Glu Ala Asp Ser Tyr Lys Asp Ala Thr Ser 
                405                 410                 415     


His Leu Ser Lys Thr Tyr Ala Thr Asp Pro Asn Tyr Ala Lys Lys Leu 
            420                 425                 430         


Asn Ser Ile Ile Lys His Tyr Gln Leu Thr Gln Phe Asp Asp Glu Arg 
        435                 440                 445             


Met Pro Asp Leu Asp Lys Tyr Glu Arg Ser Ile Lys Asp Tyr Asp Asp 
    450                 455                 460                 


Ser Ser Asp Glu Phe Lys Pro Phe Arg Glu Val Ser Asp Asn Met Pro 
465                 470                 475                 480 


Tyr Pro His Gly Gln Cys Thr Trp Tyr Val Tyr Asn Arg Met Lys Gln 
                485                 490                 495     


Phe Gly Thr Ser Ile Ser Gly Asp Leu Gly Asp Ala His Asn Trp Asn 
            500                 505                 510         


Asn Arg Ala Gln Tyr Arg Asp Tyr Gln Val Ser His Thr Pro Lys Arg 
        515                 520                 525             


His Ala Ala Val Val Phe Glu Ala Gly Gln Phe Gly Ala Asp Gln His 
    530                 535                 540                 


Tyr Gly His Val Ala Phe Val Glu Lys Val Asn Ser Asp Gly Ser Ile 
545                 550                 555                 560 


Val Ile Ser Glu Ser Asn Val Lys Gly Leu Gly Ile Ile Ser His Arg 
                565                 570                 575     


Thr Ile Asn Ala Ala Ala Ala Glu Glu Leu Ser Tyr Ile Thr Gly Lys 
            580                 585                 590         


<210>  39
<211>  592
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (386)..(386)

<220>
<221>  VARIANT
<222>  (411)..(411)

<220>
<221>  VARIANT
<222>  (513)..(513)

<400>  39

Asp Thr Pro Gln Lys Asp Thr Thr Ala Lys Thr Thr Ser His Asp Ser 
1               5                   10                  15      


Lys Lys Ser Asn Asp Asp Glu Thr Ser Lys Asp Thr Thr Ser Lys Asp 
            20                  25                  30          


Ile Asp Lys Ala Asp Asn Asn Asn Thr Ser Asn Gln Asp Asn Asn Asp 
        35                  40                  45              


Lys Lys Phe Lys Thr Ile Asp Asp Ser Thr Ser Asp Ser Asn Asn Ile 
    50                  55                  60                  


Ile Asp Phe Ile Tyr Lys Asn Leu Pro Gln Thr Asn Ile Asn Gln Leu 
65                  70                  75                  80  


Leu Thr Lys Asn Lys Tyr Asp Asp Asn Tyr Ser Leu Thr Thr Leu Ile 
                85                  90                  95      


Gln Asn Leu Phe Asn Leu Asn Ser Asp Ile Ser Asp Tyr Glu Gln Pro 
            100                 105                 110         


Arg Asn Gly Glu Lys Ser Thr Asn Asp Ser Asn Lys Asn Ser Asp Asn 
        115                 120                 125             


Ser Ile Lys Asn Asp Thr Asp Thr Gln Ser Ser Lys Gln Asp Lys Ala 
    130                 135                 140                 


Asp Asn Gln Lys Ala Pro Lys Ser Asn Asn Thr Lys Pro Ser Thr Ser 
145                 150                 155                 160 


Asn Lys Gln Pro Asn Ser Pro Lys Pro Thr Gln Pro Asn Gln Ser Asn 
                165                 170                 175     


Ser Gln Pro Ala Ser Asp Asp Lys Ala Asn Gln Lys Ser Ser Ser Lys 
            180                 185                 190         


Asp Asn Gln Ser Met Ser Asp Ser Ala Leu Asp Ser Ile Leu Asp Gln 
        195                 200                 205             


Tyr Ser Glu Asp Ala Lys Lys Thr Gln Lys Asp Tyr Ala Ser Gln Ser 
    210                 215                 220                 


Lys Lys Asp Lys Asn Glu Lys Ser Asn Thr Lys Asn Pro Gln Leu Pro 
225                 230                 235                 240 


Thr Gln Asp Glu Leu Lys His Lys Ser Lys Pro Ala Gln Ser Phe Asn 
                245                 250                 255     


Asn Asp Val Asn Gln Lys Asp Thr Arg Ala Thr Ser Leu Phe Glu Thr 
            260                 265                 270         


Asp Pro Ser Ile Ser Asn Asn Asp Asp Ser Gly Gln Phe Asn Val Val 
        275                 280                 285             


Asp Ser Lys Asp Thr Arg Gln Phe Val Lys Ser Ile Ala Lys Asp Ala 
    290                 295                 300                 


His Arg Ile Gly Gln Asp Asn Asp Ile Tyr Ala Ser Val Met Ile Ala 
305                 310                 315                 320 


Gln Ala Ile Leu Glu Ser Asp Ser Gly Arg Ser Ala Leu Ala Lys Ser 
                325                 330                 335     


Pro Asn His Asn Leu Phe Gly Ile Lys Gly Ala Phe Glu Gly Asn Ser 
            340                 345                 350         


Val Pro Phe Asn Thr Leu Gln Ala Asp Gly Asn Lys Leu Tyr Ser Ile 
        355                 360                 365             


Asn Ala Gly Phe Arg Lys Tyr Pro Ser Thr Lys Glu Ser Leu Lys Asn 
    370                 375                 380                 


Tyr Ser Asp Leu Ile Lys Asn Gly Ile Asp Gly Asn Arg Thr Ile Tyr 
385                 390                 395                 400 


Lys Pro Thr Trp Lys Ser Glu Ala Asp Ser Tyr Lys Asp Ala Thr Ser 
                405                 410                 415     


His Leu Ser Lys Thr Tyr Ala Thr Asp Pro Asn Tyr Ala Lys Lys Leu 
            420                 425                 430         


Asn Ser Ile Ile Lys His Tyr Gln Leu Thr Gln Phe Asp Asp Glu Arg 
        435                 440                 445             


Met Pro Asp Leu Asp Lys Tyr Glu Arg Ser Ile Lys Asp Tyr Asp Asp 
    450                 455                 460                 


Ser Ser Asp Glu Phe Lys Pro Phe Arg Glu Val Ser Asp Ser Met Pro 
465                 470                 475                 480 


Tyr Pro His Gly Gln Ser Thr Trp Tyr Val Tyr Asn Arg Met Lys Gln 
                485                 490                 495     


Phe Gly Thr Ser Ile Ser Gly Asp Leu Gly Asp Ala His Asn Trp Asn 
            500                 505                 510         


Asn Arg Ala Gln Tyr Arg Asp Tyr Gln Val Ser His Thr Pro Lys Arg 
        515                 520                 525             


His Ala Ala Val Val Phe Glu Ala Gly Gln Phe Gly Ala Asp Gln His 
    530                 535                 540                 


Tyr Gly His Val Ala Phe Val Glu Lys Val Asn Ser Asp Gly Ser Ile 
545                 550                 555                 560 


Val Ile Ser Glu Ser Asn Val Lys Gly Leu Gly Ile Ile Ser His Arg 
                565                 570                 575     


Thr Ile Asn Ala Ala Ala Ala Glu Glu Leu Ser Tyr Ile Thr Gly Lys 
            580                 585                 590         


<210>  40
<211>  1860
<212>  DNA
<213>  Staphylococcus aureus

<400>  40
atgcctaaaa ataaaatttt aatttatttg ctatcaacta cgctcgtatt acctacttta       60

gtttcaccta ccgcttatgc tgacacacct caaaaagata ctacagctaa gacaacatct      120

catgattcca aaaaatctac tgatgatgaa acttctaagg atactacaag taaagatatt      180

gataaagcag acaacaataa tactagtaac caagacaata acgacaaaaa agttaaaact      240

atagacgaca gcacttcaga ctctaacaat atcattgatt ttatttataa gaatttacca      300

caaaccaata taaaccaatt gctaaccaaa aataaatacg atgataatta ctcattaaca      360

actttaatcc aaaacttatt caatttaaat tcggatattt ctgattacga acaacctcgt      420

aatggtgaaa agtcaacaaa tgattcgaat aaaaacagtg ataatagcat caaaaatgat      480

acggatacgc aatcatctaa acaagataaa gcagacaatc aaaaagcacc taaatcaaac      540

aatacaaaac caagtacatc taataagcaa ccaaattcgc caaagccaac acaaccaaat      600

caatcaaata gtcaaccagc aagtgacgat aaagtaaatc aaaaatcttc atcgaaagat      660

aatcaatcaa tgtcagattc ggctttagat tctattttgg atcaatacag tgaagatgca      720

aagaaaacac aaaaagatta cgcatctcaa tctaaaaaag acaaaaatga aaaatctaat      780

acaaagaatc cacagttacc aacacaagat gaattgaaac ataaatctaa acctgctcaa      840

tcattcaata acgatgttaa tcaaaaggat acacgtgcaa catcactatt cgaaacagat      900

cctagtatat ctaacaatga tgatagtgga caatttaacg ttgttgactc aaaagataca      960

cgtcaatttg tcaaatcaat tgctaaagat gcacaccgca ttggtcaaga taacgatatt     1020

tatgcgtctg tcatgattgc ccaagcaatc ttagaatctg actcaggtcg tagtgcttta     1080

gctaagtcac caaaccataa tttattcggt atcaaaggtg cttttgaagg gaattctgtt     1140

ccttttaaca cattagaagc tgatggtaat caattgtata gtattaatgc tggattccga     1200

aaatatccaa gcacgaaaga atcactaaaa gattactctg accttattaa aaatggtatt     1260

gatggcaatc gaacaattta taaaccaaca tggaaatcgg aagccgattc ttataaagat     1320

gcaacatcac acttatctaa aacatatgct acagatccaa actatgctaa gaaattaaac     1380

agtattatta aacactatca attaactcag tttgacgatg aacgtatgcc agatttagat     1440

aaatatgaac gttctatcaa ggattatgat gattcatcag atgaattcaa acctttccgc     1500

gaggtatctg ataatatgcc atatccacat ggccaatgta cttggtacgt atataaccgt     1560

atgaaacaat ttggtacatc tatctcaggt gatttaggtg atgcacataa ttggaataat     1620

cgagctcaat accgtgatta tcaagtaagt catacaccaa aacgtcatgc tgctgttgta     1680

tttgaggctg gacaatttgg tgcagatcaa cattacggtc atgtagcatt tgttgaaaaa     1740

gttaacagtg atggttctat cgttatttca gaatccaatg ttaaaggatt aggtatcatt     1800

tctcatagaa ctatcaatgc agctgccgct gaagaattat catatattac aggtaaataa     1860


<210>  41
<211>  1776
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mutated sequence

<400>  41
gatacacctc aaaaagatac tacagctaag acaacatctc atgattcaaa aaaatctaat       60

gacgatgaaa cttctaagga tactacaagt aaagatattg ataaagcaga caacaataat      120

acaagtaacc aagacaataa cgacaaaaaa tttaaaacta tagacgacag cacttcagac      180

tctaacaata tcattgattt tatttataag aatttaccac aaaccaatat aaaccaattg      240

ctaaccaaaa ataaatacga tgataattac tcattaacaa ctttaatcca aaacctattc      300

aatttaaatt cggatatttc tgattacgaa caacctcgta atggcgaaaa gtcaacaaat      360

gattcgaata aaaacagtga caatagcatc aaaaatgaca ctgatacgca atcatctaaa      420

caagataaag cagacaatca aaaagcacct aaatcaaaca atacaaaacc aagtacatct      480

aataagcaac caaattcgcc aaagccaaca caacctaatc aatcaaatag tcaaccagca      540

agtgacgata aagcaaatca aaaatcttca tcgaaagata atcaatcaat gtcagattcg      600

gctttagact ctattttgga tcaatacagt gaagatgcaa agaaaacaca aaaagattat      660

gcatctcaat ctaaaaaaga caaaaatgaa aaatctaata caaagaatcc acagttacca      720

acacaagatg aattgaaaca taaatctaaa cctgctcaat cattcaataa cgatgttaat      780

caaaaggata cacgtgcaac atcattattc gaaacagatc ctagtatatc taacaatgat      840

gatagcggac aatttaacgt tgttgactca aaagatacac gtcaatttgt caaatcaatt      900

gctaaagatg cacatcgcat tggtcaagat aacgatattt atgcgtctgt catgattgcc      960

caagcaatct tagaatctga ctcaggtcgt agtgctttag ctaagtcacc aaaccataat     1020

ttattcggta tcaaaggtgc ttttgaaggg aattctgttc cttttaacac attacaggct     1080

gatggtaata aattgtatag tattaatgct ggattccgaa aatatccaag cacgaaagaa     1140

tcactaaaaa actactctga ccttattaaa aatggtattg atggcaatcg aacaatttat     1200

aaaccaacat ggaaatcgga agccgattct tataaagatg caacatcaca cttatctaaa     1260

acatatgcta cagatccaaa ctatgctaag aaattaaaca gtattattaa acactatcaa     1320

ttaactcagt ttgacgatga acgcatgcca gatttagata aatatgaacg ttctatcaag     1380

gattatgatg attcatcaga tgaattcaaa cctttccgtg aggtatctga tagtatgcca     1440

tatccacatg gtcaaagcac ttggtacgta tataaccgta tgaaacaatt tggtacatct     1500

atctcaggtg atttaggtga tgcacataat tggaataatc gagctcaata ccgtgattat     1560

caagtaagtc atacaccaaa acgtcatgct gctgttgtat ttgaggctgg acaatttggt     1620

gcagatcaac attacggtca tgtagcattt gttgaaaaag ttaacagtga tggttctatc     1680

gttatttcag aatccaatgt taaaggatta ggtatcattt ctcatagaac tatcaatgca     1740

gctgccgctg aagaattatc atatattaca ggtaaa                               1776


<210>  42
<211>  390
<212>  PRT
<213>  Staphylococcus aureus

<400>  42

Lys Val Ala Lys Gln Gly Gln Tyr Lys Asn Gln Asp Pro Ile Val Leu 
1               5                   10                  15      


Val His Gly Phe Asn Gly Phe Thr Asp Asp Ile Asn Pro Ser Val Leu 
            20                  25                  30          


Ala His Tyr Trp Gly Gly Asn Lys Met Asn Ile Arg Gln Asp Leu Glu 
        35                  40                  45              


Glu Asn Gly Tyr Lys Ala Tyr Glu Ala Ser Ile Ser Ala Phe Gly Ser 
    50                  55                  60                  


Asn Tyr Asp Arg Ala Val Glu Leu Tyr Tyr Tyr Ile Lys Gly Gly Arg 
65                  70                  75                  80  


Val Asp Tyr Gly Ala Ala His Ala Ala Lys Tyr Gly His Glu Arg Tyr 
                85                  90                  95      


Gly Lys Thr Tyr Glu Gly Ile Tyr Lys Asp Trp Lys Pro Gly Gln Lys 
            100                 105                 110         


Val His Leu Val Gly His Ser Met Gly Gly Gln Thr Ile Arg Gln Leu 
        115                 120                 125             


Glu Glu Leu Leu Arg Asn Gly Ser Arg Glu Glu Ile Glu Tyr Gln Lys 
    130                 135                 140                 


Lys His Gly Gly Glu Ile Ser Pro Leu Phe Lys Gly Asn Asn Asp Asn 
145                 150                 155                 160 


Met Ile Ser Ser Ile Thr Thr Leu Gly Thr Pro His Asn Gly Thr His 
                165                 170                 175     


Ala Ser Asp Leu Ala Gly Asn Glu Ala Leu Val Arg Gln Ile Val Phe 
            180                 185                 190         


Asp Ile Gly Lys Met Phe Gly Asn Lys Asn Ser Arg Val Asp Phe Gly 
        195                 200                 205             


Leu Ala Gln Trp Gly Leu Lys Gln Lys Pro Asn Glu Ser Tyr Ile Asp 
    210                 215                 220                 


Tyr Val Lys Arg Val Lys Gln Ser Asn Leu Trp Lys Ser Lys Asp Asn 
225                 230                 235                 240 


Gly Phe Tyr Asp Leu Thr Arg Glu Gly Ala Thr Asp Leu Asn Arg Lys 
                245                 250                 255     


Thr Ser Leu Asn Pro Asn Ile Val Tyr Lys Thr Tyr Thr Gly Glu Ala 
            260                 265                 270         


Thr His Lys Ala Leu Asn Ser Asp Arg Gln Lys Ala Asp Leu Asn Met 
        275                 280                 285             


Phe Phe Pro Phe Val Ile Thr Gly Asn Leu Ile Gly Lys Ala Thr Glu 
    290                 295                 300                 


Lys Glu Trp Arg Glu Asn Asp Gly Leu Val Ser Val Ile Ser Ser Gln 
305                 310                 315                 320 


His Pro Phe Asn Gln Ala Tyr Thr Asn Ala Thr Asp Lys Ile Gln Lys 
                325                 330                 335     


Gly Ile Trp Gln Val Thr Pro Thr Lys His Asp Trp Asp His Val Asp 
            340                 345                 350         


Phe Val Gly Gln Asp Ser Ser Asp Thr Val Arg Thr Arg Glu Glu Leu 
        355                 360                 365             


Gln Asp Phe Trp His His Leu Ala Asp Asp Leu Val Lys Thr Glu Lys 
    370                 375                 380                 


Val Thr Asp Thr Lys Gln 
385                 390 


<210>  43
<211>  1170
<212>  DNA
<213>  Staphylococcus aureus

<400>  43
aaagttgcca aacaagggca gtataaaaat caagacccta tcgtgttagt gcatggtttc       60

aatggattta cagatgatat taatccttca gtgttagctc attattgggg cggtaataaa      120

atgaacattc gccaagattt agaagaaaat ggttacaaag cttatgaagc aagtataagt      180

gcttttggaa gtaactatga ccgcgcagtt gaactttatt attatatcaa aggcggtcgt      240

gtagattatg gtgcagcaca tgcagcaaaa tatggacatg aacgttatgg aaaaacatac      300

gaaggaattt acaaagactg gaaaccagga cagaaggtac acctagttgg acatagtatg      360

ggtggtcaaa cgatacgtca actagaagaa ttactgcgta atggtagtcg tgaagaaata      420

gagtatcaaa agaaacatgg tggcgaaatt tctccactat tcaaaggtaa taatgacaat      480

atgatttcat caattactac tttaggaacg ccacataatg gaacgcatgc ttcagattta      540

gctggtaatg aagctttagt gagacaaatt gtatttgata tcggtaaaat gtttggtaat      600

aaaaactcta gagtagactt cgggttggct caatggggtc taaaacagaa gccaaatgaa      660

tcatacattg attatgtcaa acgcgttaaa caatctaatt tatggaaatc aaaagataat      720

ggattttacg atctgacgcg tgagggtgca acagatttaa atcgtaaaac gtcgttgaac      780

cctaacattg tgtataaaac atacactggt gaagcaacgc acaaagcatt aaatagcgat      840

agacaaaaag cagacttaaa tatgtttttc ccatttgtga ttactggtaa cttaatcggt      900

aaagctactg aaaaagaatg gcgagaaaac gatggtttag tatccgttat ttcttctcag      960

catccattta atcaagctta tacaaatgcg acggataaaa ttcaaaaagg catttggcaa     1020

gtaacgccta caaaacatga ttgggatcat gttgattttg tcggacaaga tagttctgat     1080

acagtgcgca caagagaaga attacaagat ttttggcatc atttagcaga cgatttagtg     1140

aaaactgaaa aggtgactga tactaagcaa                                      1170


<210>  44
<211>  769
<212>  PRT
<213>  Staphylococcus aureus

<400>  44

Met Asp Ile Gly Lys Lys His Val Ile Pro Lys Ser Gln Tyr Arg Arg 
1               5                   10                  15      


Lys Arg Arg Glu Phe Phe His Asn Glu Asp Arg Glu Glu Asn Leu Asn 
            20                  25                  30          


Gln His Gln Asp Lys Gln Asn Ile Asp Asn Thr Thr Ser Lys Lys Ala 
        35                  40                  45              


Asp Lys Gln Ile His Lys Asp Ser Ile Asp Lys His Glu Arg Phe Lys 
    50                  55                  60                  


Asn Ser Leu Ser Ser His Leu Glu Gln Arg Asn Arg Asp Val Asn Glu 
65                  70                  75                  80  


Asn Lys Ala Glu Glu Ser Lys Ser Asn Gln Asp Ser Lys Ser Ala Tyr 
                85                  90                  95      


Asn Arg Asp His Tyr Leu Thr Asp Asp Val Ser Lys Lys Gln Asn Ser 
            100                 105                 110         


Leu Asp Ser Val Asp Gln Asp Thr Glu Lys Ser Lys Tyr Tyr Glu Gln 
        115                 120                 125             


Asn Ser Glu Ala Thr Leu Ser Thr Lys Ser Thr Asp Lys Val Glu Ser 
    130                 135                 140                 


Thr Glu Met Arg Lys Leu Ser Ser Asp Lys Asn Lys Val Gly His Glu 
145                 150                 155                 160 


Glu Gln His Val Leu Ser Lys Pro Ser Glu His Asp Lys Glu Thr Arg 
                165                 170                 175     


Ile Asp Ser Glu Ser Ser Arg Thr Asp Ser Asp Ser Ser Met Gln Thr 
            180                 185                 190         


Glu Lys Ile Lys Lys Asp Ser Ser Asp Gly Asn Lys Ser Ser Asn Leu 
        195                 200                 205             


Lys Ser Glu Val Ile Ser Asp Lys Ser Asn Thr Val Pro Lys Leu Ser 
    210                 215                 220                 


Glu Ser Asp Asp Glu Val Asn Asn Gln Lys Pro Leu Thr Leu Pro Glu 
225                 230                 235                 240 


Glu Gln Lys Leu Lys Arg Gln Gln Ser Gln Asn Glu Gln Thr Lys Thr 
                245                 250                 255     


Tyr Thr Tyr Gly Asp Ser Glu Gln Asn Asp Lys Ser Asn His Glu Asn 
            260                 265                 270         


Asp Leu Ser His His Ile Pro Ser Ile Ser Asp Asp Lys Asp Asn Val 
        275                 280                 285             


Met Arg Glu Asn His Ile Val Asp Asp Asn Pro Asp Asn Asp Ile Asn 
    290                 295                 300                 


Thr Pro Ser Leu Ser Lys Thr Asp Asp Asp Arg Lys Leu Asp Glu Lys 
305                 310                 315                 320 


Ile His Val Glu Asp Lys His Lys Gln Asn Ala Asp Ser Ser Glu Thr 
                325                 330                 335     


Val Gly Tyr Gln Ser Gln Ser Thr Ala Ser His Arg Ser Thr Glu Lys 
            340                 345                 350         


Arg Asn Ile Ser Ile Asn Asp His Asp Lys Leu Asn Gly Gln Lys Thr 
        355                 360                 365             


Asn Thr Lys Thr Ser Ala Asn Asn Asn Gln Lys Lys Ala Thr Ser Lys 
    370                 375                 380                 


Leu Asn Lys Gly Arg Ala Thr Asn Asn Asn Tyr Ser Asp Ile Leu Lys 
385                 390                 395                 400 


Lys Phe Trp Met Met Tyr Trp Pro Lys Leu Val Ile Leu Met Gly Ile 
                405                 410                 415     


Ile Ile Leu Ile Val Ile Leu Asn Ala Ile Phe Asn Asn Val Asn Lys 
            420                 425                 430         


Asn Asp Arg Met Asn Asp Asn Asn Asp Ala Asp Ala Gln Lys Tyr Thr 
        435                 440                 445             


Thr Thr Met Lys Asn Ala Asn Asn Thr Val Lys Ser Val Val Thr Val 
    450                 455                 460                 


Glu Asn Glu Thr Ser Lys Asp Ser Ser Leu Pro Lys Asp Lys Ala Ser 
465                 470                 475                 480 


Gln Asp Glu Val Gly Ser Gly Val Val Tyr Lys Lys Ser Gly Asp Thr 
                485                 490                 495     


Leu Tyr Ile Val Thr Asn Ala His Val Val Gly Asp Lys Glu Asn Gln 
            500                 505                 510         


Lys Ile Thr Phe Ser Asn Asn Lys Ser Val Val Gly Lys Val Leu Gly 
        515                 520                 525             


Lys Asp Lys Trp Ser Asp Leu Ala Val Val Lys Ala Thr Ser Ser Asp 
    530                 535                 540                 


Ser Ser Val Lys Glu Ile Ala Ile Gly Asp Ser Asn Asn Leu Val Leu 
545                 550                 555                 560 


Gly Glu Pro Ile Leu Val Val Gly Asn Pro Leu Gly Val Asp Phe Lys 
                565                 570                 575     


Gly Thr Val Thr Glu Gly Ile Ile Ser Gly Leu Asn Arg Asn Val Pro 
            580                 585                 590         


Ile Asp Phe Asp Lys Asp Asn Lys Tyr Asp Met Leu Met Lys Ala Phe 
        595                 600                 605             


Gln Ile Asp Ala Ser Val Asn Pro Gly Asn Ser Gly Gly Ala Val Val 
    610                 615                 620                 


Asn Arg Glu Gly Lys Leu Ile Gly Val Val Ala Ala Lys Ile Ser Met 
625                 630                 635                 640 


Pro Asn Val Glu Asn Met Ser Phe Ala Ile Pro Val Asn Glu Val Gln 
                645                 650                 655     


Lys Ile Val Lys Asp Leu Glu Thr Lys Gly Lys Ile Asp Tyr Pro Asp 
            660                 665                 670         


Val Gly Val Lys Met Lys Asn Ile Ala Ser Leu Asn Ser Phe Glu Arg 
        675                 680                 685             


Gln Ala Val Lys Leu Pro Gly Lys Val Lys Asn Gly Val Val Val Asp 
    690                 695                 700                 


Gln Val Asp Asn Asn Gly Leu Ala Asp Gln Ser Gly Leu Lys Lys Gly 
705                 710                 715                 720 


Asp Val Ile Thr Glu Leu Asp Gly Lys Leu Leu Glu Asp Asp Leu Arg 
                725                 730                 735     


Phe Arg Gln Ile Ile Phe Ser His Lys Asp Asp Leu Lys Ser Ile Thr 
            740                 745                 750         


Ala Lys Ile Tyr Arg Asp Gly Lys Glu Lys Glu Ile Asn Ile Lys Leu 
        755                 760                 765             


Lys 
    


<210>  45
<211>  342
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (192)..(192)

<400>  45

Asn Asn Val Asn Lys Asn Asp Arg Met Asn Asp Asn Asn Asp Ala Asp 
1               5                   10                  15      


Ala Gln Lys Tyr Thr Thr Thr Met Lys Asn Ala Asn Asn Thr Val Lys 
            20                  25                  30          


Ser Val Val Thr Val Glu Asn Glu Thr Ser Lys Asp Ser Ser Leu Pro 
        35                  40                  45              


Lys Asp Lys Ala Ser Gln Asp Glu Val Gly Ser Gly Val Val Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Asp Thr Leu Tyr Ile Val Thr Asn Ala His Val Val Gly 
65                  70                  75                  80  


Asp Lys Glu Asn Gln Lys Ile Thr Phe Ser Asn Asn Lys Ser Val Val 
                85                  90                  95      


Gly Lys Val Leu Gly Lys Asp Lys Trp Ser Asp Leu Ala Val Val Lys 
            100                 105                 110         


Ala Thr Ser Ser Asp Ser Ser Val Lys Glu Ile Ala Ile Gly Asp Ser 
        115                 120                 125             


Asn Asn Leu Val Leu Gly Glu Pro Ile Leu Val Val Gly Asn Pro Leu 
    130                 135                 140                 


Gly Val Asp Phe Lys Gly Thr Val Thr Glu Gly Ile Ile Ser Gly Leu 
145                 150                 155                 160 


Asn Arg Asn Val Pro Ile Asp Phe Asp Lys Asp Asn Lys Tyr Asp Met 
                165                 170                 175     


Leu Met Lys Ala Phe Gln Ile Asp Ala Ser Val Asn Pro Gly Asn Ala 
            180                 185                 190         


Gly Gly Ala Val Val Asn Arg Glu Gly Lys Leu Ile Gly Val Val Ala 
        195                 200                 205             


Ala Lys Ile Ser Met Pro Asn Val Glu Asn Met Ser Phe Ala Ile Pro 
    210                 215                 220                 


Val Asn Glu Val Gln Lys Ile Val Lys Asp Leu Glu Thr Lys Gly Lys 
225                 230                 235                 240 


Ile Asp Tyr Pro Asp Val Gly Val Lys Met Lys Asn Ile Ala Ser Leu 
                245                 250                 255     


Asn Ser Phe Glu Arg Gln Ala Val Lys Leu Pro Gly Lys Val Lys Asn 
            260                 265                 270         


Gly Val Val Val Asp Gln Val Asp Asn Asn Gly Leu Ala Asp Gln Ser 
        275                 280                 285             


Gly Leu Lys Lys Gly Asp Val Ile Thr Glu Leu Asp Gly Lys Leu Leu 
    290                 295                 300                 


Glu Asp Asp Leu Arg Phe Arg Gln Ile Ile Phe Ser His Lys Asp Asp 
305                 310                 315                 320 


Leu Lys Ser Ile Thr Ala Lys Ile Tyr Arg Asp Gly Lys Glu Lys Glu 
                325                 330                 335     


Ile Asn Ile Lys Leu Lys 
            340         


<210>  46
<211>  763
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mutated sequence


<220>
<221>  VARIANT
<222>  (192)..(192)

<220>
<221>  MISC_FEATURE
<222>  (343)..(354)
<223>  Linker

<400>  46

Asn Asn Val Asn Lys Asn Asp Arg Met Asn Asp Asn Asn Asp Ala Asp 
1               5                   10                  15      


Ala Gln Lys Tyr Thr Thr Thr Met Lys Asn Ala Asn Asn Thr Val Lys 
            20                  25                  30          


Ser Val Val Thr Val Glu Asn Glu Thr Ser Lys Asp Ser Ser Leu Pro 
        35                  40                  45              


Lys Asp Lys Ala Ser Gln Asp Glu Val Gly Ser Gly Val Val Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Asp Thr Leu Tyr Ile Val Thr Asn Ala His Val Val Gly 
65                  70                  75                  80  


Asp Lys Glu Asn Gln Lys Ile Thr Phe Ser Asn Asn Lys Ser Val Val 
                85                  90                  95      


Gly Lys Val Leu Gly Lys Asp Lys Trp Ser Asp Leu Ala Val Val Lys 
            100                 105                 110         


Ala Thr Ser Ser Asp Ser Ser Val Lys Glu Ile Ala Ile Gly Asp Ser 
        115                 120                 125             


Asn Asn Leu Val Leu Gly Glu Pro Ile Leu Val Val Gly Asn Pro Leu 
    130                 135                 140                 


Gly Val Asp Phe Lys Gly Thr Val Thr Glu Gly Ile Ile Ser Gly Leu 
145                 150                 155                 160 


Asn Arg Asn Val Pro Ile Asp Phe Asp Lys Asp Asn Lys Tyr Asp Met 
                165                 170                 175     


Leu Met Lys Ala Phe Gln Ile Asp Ala Ser Val Asn Pro Gly Asn Ala 
            180                 185                 190         


Gly Gly Ala Val Val Asn Arg Glu Gly Lys Leu Ile Gly Val Val Ala 
        195                 200                 205             


Ala Lys Ile Ser Met Pro Asn Val Glu Asn Met Ser Phe Ala Ile Pro 
    210                 215                 220                 


Val Asn Glu Val Gln Lys Ile Val Lys Asp Leu Glu Thr Lys Gly Lys 
225                 230                 235                 240 


Ile Asp Tyr Pro Asp Val Gly Val Lys Met Lys Asn Ile Ala Ser Leu 
                245                 250                 255     


Asn Ser Phe Glu Arg Gln Ala Val Lys Leu Pro Gly Lys Val Lys Asn 
            260                 265                 270         


Gly Val Val Val Asp Gln Val Asp Asn Asn Gly Leu Ala Asp Gln Ser 
        275                 280                 285             


Gly Leu Lys Lys Gly Asp Val Ile Thr Glu Leu Asp Gly Lys Leu Leu 
    290                 295                 300                 


Glu Asp Asp Leu Arg Phe Arg Gln Ile Ile Phe Ser His Lys Asp Asp 
305                 310                 315                 320 


Leu Lys Ser Ile Thr Ala Lys Ile Tyr Arg Asp Gly Lys Glu Lys Glu 
                325                 330                 335     


Ile Asn Ile Lys Leu Lys Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly 
            340                 345                 350         


Gly Ala Met Asp Ile Gly Lys Lys His Val Ile Pro Lys Ser Gln Tyr 
        355                 360                 365             


Arg Arg Lys Arg Arg Glu Phe Phe His Asn Glu Asp Arg Glu Glu Asn 
    370                 375                 380                 


Leu Asn Gln His Gln Asp Lys Gln Asn Ile Asp Asn Thr Thr Ser Lys 
385                 390                 395                 400 


Lys Ala Asp Lys Gln Ile His Lys Asp Ser Ile Asp Lys His Glu Arg 
                405                 410                 415     


Phe Lys Asn Ser Leu Ser Ser His Leu Glu Gln Arg Asn Arg Asp Val 
            420                 425                 430         


Asn Glu Asn Lys Ala Glu Glu Ser Lys Ser Asn Gln Asp Ser Lys Ser 
        435                 440                 445             


Ala Tyr Asn Arg Asp His Tyr Leu Thr Asp Asp Val Ser Lys Lys Gln 
    450                 455                 460                 


Asn Ser Leu Asp Ser Val Asp Gln Asp Thr Glu Lys Ser Lys Tyr Tyr 
465                 470                 475                 480 


Glu Gln Asn Ser Glu Ala Thr Leu Ser Thr Lys Ser Thr Asp Lys Val 
                485                 490                 495     


Glu Ser Thr Glu Met Arg Lys Leu Ser Ser Asp Lys Asn Lys Val Gly 
            500                 505                 510         


His Glu Glu Gln His Val Leu Ser Lys Pro Ser Glu His Asp Lys Glu 
        515                 520                 525             


Thr Arg Ile Asp Ser Glu Ser Ser Arg Thr Asp Ser Asp Ser Ser Met 
    530                 535                 540                 


Gln Thr Glu Lys Ile Lys Lys Asp Ser Ser Asp Gly Asn Lys Ser Ser 
545                 550                 555                 560 


Asn Leu Lys Ser Glu Val Ile Ser Asp Lys Ser Asn Thr Val Pro Lys 
                565                 570                 575     


Leu Ser Glu Ser Asp Asp Glu Val Asn Asn Gln Lys Pro Leu Thr Leu 
            580                 585                 590         


Pro Glu Glu Gln Lys Leu Lys Arg Gln Gln Ser Gln Asn Glu Gln Thr 
        595                 600                 605             


Lys Thr Tyr Thr Tyr Gly Asp Ser Glu Gln Asn Asp Lys Ser Asn His 
    610                 615                 620                 


Glu Asn Asp Leu Ser His His Ile Pro Ser Ile Ser Asp Asp Lys Asp 
625                 630                 635                 640 


Asn Val Met Arg Glu Asn His Ile Val Asp Asp Asn Pro Asp Asn Asp 
                645                 650                 655     


Ile Asn Thr Pro Ser Leu Ser Lys Thr Asp Asp Asp Arg Lys Leu Asp 
            660                 665                 670         


Glu Lys Ile His Val Glu Asp Lys His Lys Gln Asn Ala Asp Ser Ser 
        675                 680                 685             


Glu Thr Val Gly Tyr Gln Ser Gln Ser Thr Ala Ser His Arg Ser Thr 
    690                 695                 700                 


Glu Lys Arg Asn Ile Ser Ile Asn Asp His Asp Lys Leu Asn Gly Gln 
705                 710                 715                 720 


Lys Thr Asn Thr Lys Thr Ser Ala Asn Asn Asn Gln Lys Lys Ala Thr 
                725                 730                 735     


Ser Lys Leu Asn Lys Gly Arg Ala Thr Asn Asn Asn Tyr Ser Asp Ile 
            740                 745                 750         


Leu Lys Lys Phe Trp Met Met Tyr Trp Pro Lys 
        755                 760             


<210>  47
<211>  1009
<212>  PRT
<213>  Staphylococcus aureus

<400>  47

Met Lys Lys Lys Asn Trp Ile Tyr Ala Leu Ile Val Thr Leu Ile Ile 
1               5                   10                  15      


Ile Ile Ala Ile Val Ser Met Ile Phe Phe Val Gln Thr Lys Tyr Gly 
            20                  25                  30          


Asp Gln Ser Glu Lys Gly Ser Gln Ser Val Ser Asn Lys Asn Asn Lys 
        35                  40                  45              


Ile His Ile Ala Ile Val Asn Glu Asp Gln Pro Thr Thr Tyr Asn Gly 
    50                  55                  60                  


Lys Lys Val Glu Leu Gly Gln Ala Phe Ile Lys Arg Leu Ala Asn Glu 
65                  70                  75                  80  


Lys Asn Tyr Lys Phe Glu Thr Val Thr Arg Asn Val Ala Glu Ser Gly 
                85                  90                  95      


Leu Lys Asn Gly Gly Tyr Gln Val Met Ile Val Ile Pro Glu Asn Phe 
            100                 105                 110         


Ser Lys Leu Ala Met Gln Leu Asp Ala Lys Thr Pro Ser Lys Ile Ser 
        115                 120                 125             


Leu Gln Tyr Lys Thr Ala Val Gly Gln Lys Glu Glu Val Ala Lys Asn 
    130                 135                 140                 


Thr Glu Lys Val Val Ser Asn Val Leu Asn Asp Phe Asn Lys Asn Leu 
145                 150                 155                 160 


Val Glu Ile Tyr Leu Thr Ser Ile Ile Asp Asn Leu His Asn Ala Gln 
                165                 170                 175     


Lys Asn Val Gly Ala Ile Met Thr Arg Glu His Gly Val Asn Ser Lys 
            180                 185                 190         


Phe Ser Asn Tyr Leu Leu Asn Pro Ile Asn Asp Phe Pro Glu Leu Phe 
        195                 200                 205             


Thr Asp Thr Leu Val Asn Ser Ile Ser Ala Asn Lys Asp Ile Thr Lys 
    210                 215                 220                 


Trp Phe Gln Thr Tyr Asn Lys Ser Leu Leu Ser Ala Asn Ser Asp Thr 
225                 230                 235                 240 


Phe Arg Val Asn Thr Asp Tyr Asn Val Ser Thr Leu Ile Glu Lys Gln 
                245                 250                 255     


Asn Ser Leu Phe Asp Glu His Asn Thr Ala Met Asp Lys Met Leu Gln 
            260                 265                 270         


Asp Tyr Lys Ser Gln Lys Asp Ser Val Glu Leu Asp Asn Tyr Ile Asn 
        275                 280                 285             


Ala Leu Lys Gln Met Asp Ser Gln Ile Asp Gln Gln Ser Ser Met Gln 
    290                 295                 300                 


Asp Thr Gly Lys Glu Glu Tyr Lys Gln Thr Val Lys Glu Asn Leu Asp 
305                 310                 315                 320 


Lys Leu Arg Glu Ile Ile Gln Ser Gln Glu Ser Pro Phe Ser Lys Gly 
                325                 330                 335     


Met Ile Glu Asp Tyr Arg Lys Gln Leu Thr Glu Ser Leu Gln Asp Glu 
            340                 345                 350         


Leu Ala Asn Asn Lys Asp Leu Gln Asp Ala Leu Asn Ser Ile Lys Met 
        355                 360                 365             


Asn Asn Ala Gln Phe Ala Glu Asn Leu Glu Lys Gln Leu His Asp Asp 
    370                 375                 380                 


Ile Val Lys Glu Pro Asp Ser Asp Thr Thr Phe Ile Tyr Asn Met Ser 
385                 390                 395                 400 


Lys Gln Asp Phe Ile Ala Ala Gly Leu Asn Glu Asp Glu Ala Asn Lys 
                405                 410                 415     


Tyr Glu Ala Ile Val Lys Glu Ala Lys Arg Tyr Lys Asn Glu Tyr Asn 
            420                 425                 430         


Leu Lys Lys Pro Leu Ala Glu His Ile Asn Leu Thr Asp Tyr Asp Asn 
        435                 440                 445             


Gln Val Ala Gln Asp Thr Ser Ser Leu Ile Asn Asp Gly Val Lys Val 
    450                 455                 460                 


Gln Arg Thr Glu Thr Ile Lys Ser Asn Asp Ile Asn Gln Leu Thr Val 
465                 470                 475                 480 


Ala Thr Asp Pro His Phe Asn Phe Glu Gly Asp Ile Lys Ile Asn Gly 
                485                 490                 495     


Lys Lys Tyr Asp Ile Lys Asp Gln Ser Val Gln Leu Asp Thr Ser Asn 
            500                 505                 510         


Lys Glu Tyr Lys Val Glu Val Asn Gly Val Ala Lys Leu Lys Lys Asp 
        515                 520                 525             


Ala Glu Lys Asp Phe Leu Lys Asp Lys Thr Met His Leu Gln Leu Leu 
    530                 535                 540                 


Phe Gly Gln Ala Asn Arg Gln Asp Glu Pro Asn Asp Lys Lys Ala Thr 
545                 550                 555                 560 


Ser Val Val Asp Val Thr Leu Asn His Asn Leu Asp Gly Arg Leu Ser 
                565                 570                 575     


Lys Asp Ala Leu Ser Gln Gln Leu Ser Ala Leu Ser Arg Phe Asp Ala 
            580                 585                 590         


His Tyr Lys Met Tyr Thr Asp Thr Lys Gly Arg Glu Asp Lys Pro Phe 
        595                 600                 605             


Asp Asn Lys Arg Leu Ile Asp Met Met Val Asp Gln Val Ile Asn Asp 
    610                 615                 620                 


Met Glu Ser Phe Lys Asp Asp Lys Val Ala Val Leu His Gln Ile Asp 
625                 630                 635                 640 


Ser Met Glu Glu Asn Ser Asp Lys Leu Ile Asp Asp Ile Leu Asn Asn 
                645                 650                 655     


Lys Lys Asn Thr Thr Lys Asn Lys Glu Asp Ile Ser Lys Leu Ile Asp 
            660                 665                 670         


Gln Leu Glu Asn Val Lys Lys Thr Phe Ala Glu Glu Pro Gln Glu Pro 
        675                 680                 685             


Lys Ile Asp Lys Gly Lys Asn Asp Glu Phe Asn Thr Met Ser Ser Asn 
    690                 695                 700                 


Leu Asp Lys Glu Ile Ser Arg Ile Ser Glu Lys Ser Thr Gln Leu Leu 
705                 710                 715                 720 


Ser Asp Thr Gln Glu Ser Lys Thr Ile Ala Asp Ser Val Ser Gly Gln 
                725                 730                 735     


Leu Asn Gln Leu Asp Asn Asn Val Asn Lys Leu His Ala Thr Gly Arg 
            740                 745                 750         


Ala Leu Gly Val Arg Ala Asn Asp Leu Asn Arg Gln Met Ala Lys Asn 
        755                 760                 765             


Asp Lys Asp Asn Glu Leu Phe Ala Lys Glu Phe Lys Lys Val Leu Gln 
    770                 775                 780                 


Asn Ser Lys Asp Gly Asp Arg Gln Asn Gln Ala Leu Lys Ala Phe Met 
785                 790                 795                 800 


Ser Asn Pro Val Gln Lys Lys Asn Leu Glu Asn Val Leu Ala Asn Asn 
                805                 810                 815     


Gly Asn Thr Asp Val Ile Ser Pro Thr Leu Phe Val Leu Leu Met Tyr 
            820                 825                 830         


Leu Leu Ser Met Ile Thr Ala Tyr Ile Phe Tyr Ser Tyr Glu Arg Ala 
        835                 840                 845             


Lys Gly Gln Met Asn Phe Ile Lys Asp Asp Tyr Ser Ser Lys Asn Asn 
    850                 855                 860                 


Leu Trp Asn Asn Ala Ile Thr Ser Gly Val Ile Gly Ala Thr Gly Leu 
865                 870                 875                 880 


Val Glu Gly Leu Ile Val Gly Leu Ile Ala Met Asn Lys Phe His Val 
                885                 890                 895     


Leu Ala Gly Tyr Arg Ala Lys Phe Ile Leu Met Val Ile Leu Thr Met 
            900                 905                 910         


Met Val Phe Val Leu Ile Asn Thr Tyr Leu Leu Arg Gln Val Lys Ser 
        915                 920                 925             


Ile Gly Met Phe Leu Met Ile Ala Ala Leu Gly Leu Tyr Phe Val Ala 
    930                 935                 940                 


Met Asn Asn Leu Lys Ala Ala Gly Gln Gly Val Thr Asn Lys Ile Ser 
945                 950                 955                 960 


Pro Leu Ser Tyr Ile Asp Asn Met Phe Phe Asn Tyr Leu Asn Ala Glu 
                965                 970                 975     


His Pro Ile Gly Leu Ala Leu Val Ile Leu Thr Val Leu Val Ile Ile 
            980                 985                 990         


Gly Phe Val Leu Asn Met Phe Ile  Lys His Phe Lys Lys  Glu Arg Leu 
        995                 1000                 1005             


Ile 
    


<210>  48
<211>  793
<212>  PRT
<213>  Staphylococcus aureus

<400>  48

Gln Thr Lys Tyr Gly Asp Gln Ser Glu Lys Gly Ser Gln Ser Val Ser 
1               5                   10                  15      


Asn Lys Asn Asn Lys Ile His Ile Ala Ile Val Asn Glu Asp Gln Pro 
            20                  25                  30          


Thr Thr Tyr Asn Gly Lys Lys Val Glu Leu Gly Gln Ala Phe Ile Lys 
        35                  40                  45              


Arg Leu Ala Asn Glu Lys Asn Tyr Lys Phe Glu Thr Val Thr Arg Asn 
    50                  55                  60                  


Val Ala Glu Ser Gly Leu Lys Asn Gly Gly Tyr Gln Val Met Ile Val 
65                  70                  75                  80  


Ile Pro Glu Asn Phe Ser Lys Leu Ala Met Gln Leu Asp Ala Lys Thr 
                85                  90                  95      


Pro Ser Lys Ile Ser Leu Gln Tyr Lys Thr Ala Val Gly Gln Lys Glu 
            100                 105                 110         


Glu Val Ala Lys Asn Thr Glu Lys Val Val Ser Asn Val Leu Asn Asp 
        115                 120                 125             


Phe Asn Lys Asn Leu Val Glu Ile Tyr Leu Thr Ser Ile Ile Asp Asn 
    130                 135                 140                 


Leu His Asn Ala Gln Lys Asn Val Gly Ala Ile Met Thr Arg Glu His 
145                 150                 155                 160 


Gly Val Asn Ser Lys Phe Ser Asn Tyr Leu Leu Asn Pro Ile Asn Asp 
                165                 170                 175     


Phe Pro Glu Leu Phe Thr Asp Thr Leu Val Asn Ser Ile Ser Ala Asn 
            180                 185                 190         


Lys Asp Ile Thr Lys Trp Phe Gln Thr Tyr Asn Lys Ser Leu Leu Ser 
        195                 200                 205             


Ala Asn Ser Asp Thr Phe Arg Val Asn Thr Asp Tyr Asn Val Ser Thr 
    210                 215                 220                 


Leu Ile Glu Lys Gln Asn Ser Leu Phe Asp Glu His Asn Thr Ala Met 
225                 230                 235                 240 


Asp Lys Met Leu Gln Asp Tyr Lys Ser Gln Lys Asp Ser Val Glu Leu 
                245                 250                 255     


Asp Asn Tyr Ile Asn Ala Leu Lys Gln Met Asp Ser Gln Ile Asp Gln 
            260                 265                 270         


Gln Ser Ser Met Gln Asp Thr Gly Lys Glu Glu Tyr Lys Gln Thr Val 
        275                 280                 285             


Lys Glu Asn Leu Asp Lys Leu Arg Glu Ile Ile Gln Ser Gln Glu Ser 
    290                 295                 300                 


Pro Phe Ser Lys Gly Met Ile Glu Asp Tyr Arg Lys Gln Leu Thr Glu 
305                 310                 315                 320 


Ser Leu Gln Asp Glu Leu Ala Asn Asn Lys Asp Leu Gln Asp Ala Leu 
                325                 330                 335     


Asn Ser Ile Lys Met Asn Asn Ala Gln Phe Ala Glu Asn Leu Glu Lys 
            340                 345                 350         


Gln Leu His Asp Asp Ile Val Lys Glu Pro Asp Ser Asp Thr Thr Phe 
        355                 360                 365             


Ile Tyr Asn Met Ser Lys Gln Asp Phe Ile Ala Ala Gly Leu Asn Glu 
    370                 375                 380                 


Asp Glu Ala Asn Lys Tyr Glu Ala Ile Val Lys Glu Ala Lys Arg Tyr 
385                 390                 395                 400 


Lys Asn Glu Tyr Asn Leu Lys Lys Pro Leu Ala Glu His Ile Asn Leu 
                405                 410                 415     


Thr Asp Tyr Asp Asn Gln Val Ala Gln Asp Thr Ser Ser Leu Ile Asn 
            420                 425                 430         


Asp Gly Val Lys Val Gln Arg Thr Glu Thr Ile Lys Ser Asn Asp Ile 
        435                 440                 445             


Asn Gln Leu Thr Val Ala Thr Asp Pro His Phe Asn Phe Glu Gly Asp 
    450                 455                 460                 


Ile Lys Ile Asn Gly Lys Lys Tyr Asp Ile Lys Asp Gln Ser Val Gln 
465                 470                 475                 480 


Leu Asp Thr Ser Asn Lys Glu Tyr Lys Val Glu Val Asn Gly Val Ala 
                485                 490                 495     


Lys Leu Lys Lys Asp Ala Glu Lys Asp Phe Leu Lys Asp Lys Thr Met 
            500                 505                 510         


His Leu Gln Leu Leu Phe Gly Gln Ala Asn Arg Gln Asp Glu Pro Asn 
        515                 520                 525             


Asp Lys Lys Ala Thr Ser Val Val Asp Val Thr Leu Asn His Asn Leu 
    530                 535                 540                 


Asp Gly Arg Leu Ser Lys Asp Ala Leu Ser Gln Gln Leu Ser Ala Leu 
545                 550                 555                 560 


Ser Arg Phe Asp Ala His Tyr Lys Met Tyr Thr Asp Thr Lys Gly Arg 
                565                 570                 575     


Glu Asp Lys Pro Phe Asp Asn Lys Arg Leu Ile Asp Met Met Val Asp 
            580                 585                 590         


Gln Val Ile Asn Asp Met Glu Ser Phe Lys Asp Asp Lys Val Ala Val 
        595                 600                 605             


Leu His Gln Ile Asp Ser Met Glu Glu Asn Ser Asp Lys Leu Ile Asp 
    610                 615                 620                 


Asp Ile Leu Asn Asn Lys Lys Asn Thr Thr Lys Asn Lys Glu Asp Ile 
625                 630                 635                 640 


Ser Lys Leu Ile Asp Gln Leu Glu Asn Val Lys Lys Thr Phe Ala Glu 
                645                 650                 655     


Glu Pro Gln Glu Pro Lys Ile Asp Lys Gly Lys Asn Asp Glu Phe Asn 
            660                 665                 670         


Thr Met Ser Ser Asn Leu Asp Lys Glu Ile Ser Arg Ile Ser Glu Lys 
        675                 680                 685             


Ser Thr Gln Leu Leu Ser Asp Thr Gln Glu Ser Lys Thr Ile Ala Asp 
    690                 695                 700                 


Ser Val Ser Gly Gln Leu Asn Gln Leu Asp Asn Asn Val Asn Lys Leu 
705                 710                 715                 720 


His Ala Thr Gly Arg Ala Leu Gly Val Arg Ala Asn Asp Leu Asn Arg 
                725                 730                 735     


Gln Met Ala Lys Asn Asp Lys Asp Asn Glu Leu Phe Ala Lys Glu Phe 
            740                 745                 750         


Lys Lys Val Leu Gln Asn Ser Lys Asp Gly Asp Arg Gln Asn Gln Ala 
        755                 760                 765             


Leu Lys Ala Phe Met Ser Asn Pro Val Gln Lys Lys Asn Leu Glu Asn 
    770                 775                 780                 


Val Leu Ala Asn Asn Gly Asn Thr Asp 
785                 790             


<210>  49
<211>  30
<212>  PRT
<213>  Staphylococcus aureus

<400>  49

Lys Ala Ala Gly Gln Gly Val Thr Asn Lys Ile Ser Pro Leu Ser Tyr 
1               5                   10                  15      


Ile Asp Asn Met Phe Phe Asn Tyr Leu Asn Ala Glu His Pro 
            20                  25                  30  


<210>  50
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  50

Gly Ser Gly Gly Gly Ala 
1               5       


<210>  51
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  51

Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly Gly Ala 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  52

Lys Pro Glu Pro Lys Pro Ala Pro Ala Pro Lys Pro 
1               5                   10          


<210>  53
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding linker

<400>  53
ggttctggcg gaggggct                                                     18


<210>  54
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker encoding DNA

<400>  54
ggttctggcg gaggggctgg aagtggtggg ggcgcc                                 36


<210>  55
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Linker encoding DNA

<400>  55
aaacctgagc cgaaaccagc tcccgcccct aagcca                                 36


<210>  56
<211>  582
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  56

Asn Thr Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg 
1               5                   10                  15      


Thr Glu Asp Val Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys 
    50                  55                  60                  


Gly Ser Gly Tyr Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr 
65                  70                  75                  80  


Asn Ile Gly Leu Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr 
                85                  90                  95      


Leu Pro Lys Asn Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly 
            100                 105                 110         


Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn 
        115                 120                 125             


Gly Ser Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr 
    130                 135                 140                 


Val Ser Glu Val Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val 
145                 150                 155                 160 


Lys Ala Asn Glu Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp 
                165                 170                 175     


Arg Tyr Leu Phe Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg 
            180                 185                 190         


Glu Tyr Phe Ala Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly 
        195                 200                 205             


Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser 
    210                 215                 220                 


Asp Thr Ser Glu Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr 
225                 230                 235                 240 


Tyr Ala Thr Leu Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His 
                245                 250                 255     


Asn Ala Phe Val Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp 
            260                 265                 270         


Lys Thr His Glu Ile Lys Val Lys Gly His Asn Gly Ser Gly Gly Gly 
        275                 280                 285             


Ala Ser Glu Thr Glu Val Ser Val Arg Ser Ala Ser Ser Asp Ile Gly 
    290                 295                 300                 


Ser Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp Lys Glu 
305                 310                 315                 320 


Asn Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp Lys Asn 
                325                 330                 335     


His Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile Ala Gly 
            340                 345                 350         


Gln Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly Leu Ala 
        355                 360                 365             


Trp Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn Glu Val 
    370                 375                 380                 


Ala Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr Lys Glu 
385                 390                 395                 400 


Tyr Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp 
                405                 410                 415     


Asp Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly 
            420                 425                 430         


His Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu Glu Ser 
        435                 440                 445             


Pro Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn Met Val 
    450                 455                 460                 


Asn Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro Val Tyr 
465                 470                 475                 480 


Gly Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys Ala Ala 
                485                 490                 495     


Asp Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser Ser Gly 
            500                 505                 510         


Phe Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys Ala Ser 
        515                 520                 525             


Lys Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg Asp Asp 
    530                 535                 540                 


Tyr Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn Thr Lys 
545                 550                 555                 560 


Asp Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp Trp Glu 
                565                 570                 575     


Lys Glu Glu Met Thr Asn 
            580         


<210>  57
<211>  779
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protien

<400>  57

Ile Asp Ser Lys Asn Lys Pro Ala Asn Ser Asp Ile Lys Phe Glu Val 
1               5                   10                  15      


Thr Gln Lys Ser Asp Ala Val Lys Ala Leu Lys Glu Leu Pro Lys Ser 
            20                  25                  30          


Glu Asn Val Lys Asn Ile Tyr Gln Asp Tyr Ala Val Thr Asp Val Lys 
        35                  40                  45              


Thr Asp Lys Lys Gly Phe Thr His Tyr Thr Leu Gln Pro Ser Val Asp 
    50                  55                  60                  


Gly Val His Ala Pro Asp Lys Glu Val Lys Val His Ala Asp Lys Ser 
65                  70                  75                  80  


Gly Lys Val Val Leu Ile Asn Gly Asp Thr Asp Ala Lys Lys Val Lys 
                85                  90                  95      


Pro Thr Asn Lys Val Thr Leu Ser Lys Asp Asp Ala Ala Asp Lys Ala 
            100                 105                 110         


Phe Lys Ala Val Lys Ile Asp Lys Asn Lys Ala Lys Asn Leu Lys Asp 
        115                 120                 125             


Lys Val Ile Lys Glu Asn Lys Val Glu Ile Asp Gly Asp Ser Asn Lys 
    130                 135                 140                 


Tyr Val Tyr Asn Val Glu Leu Ile Thr Val Thr Pro Glu Ile Ser His 
145                 150                 155                 160 


Trp Lys Val Lys Ile Asp Ala Gln Thr Gly Glu Ile Leu Glu Lys Met 
                165                 170                 175     


Asn Leu Val Lys Glu Ala Ala Glu Thr Gly Lys Gly Lys Gly Val Leu 
            180                 185                 190         


Gly Asp Thr Lys Asp Ile Asn Ile Asn Ser Ile Asp Gly Gly Phe Ser 
        195                 200                 205             


Leu Glu Asp Leu Thr His Gln Gly Lys Leu Ser Ala Phe Ser Phe Asn 
    210                 215                 220                 


Asp Gln Thr Gly Gln Ala Thr Leu Ile Thr Asn Glu Asp Glu Asn Phe 
225                 230                 235                 240 


Val Lys Asp Glu Gln Arg Ala Gly Val Asp Ala Asn Tyr Tyr Ala Lys 
                245                 250                 255     


Gln Thr Tyr Asp Tyr Tyr Lys Asp Thr Phe Gly Arg Glu Ser Tyr Asp 
            260                 265                 270         


Asn Gln Gly Ser Pro Ile Val Ser Leu Thr His Val Asn Asn Tyr Gly 
        275                 280                 285             


Gly Gln Asp Asn Arg Asn Asn Ala Ala Trp Ile Gly Asp Lys Met Ile 
    290                 295                 300                 


Tyr Gly Asp Gly Asp Gly Arg Thr Phe Thr Ser Leu Ser Gly Ala Asn 
305                 310                 315                 320 


Asp Val Val Ala His Ala Leu Thr His Gly Val Thr Gln Glu Thr Ala 
                325                 330                 335     


Asn Leu Glu Tyr Lys Asp Gln Ser Gly Ala Leu Asn Glu Ser Phe Ser 
            340                 345                 350         


Asp Val Phe Gly Tyr Phe Val Asp Asp Glu Asp Phe Leu Met Gly Glu 
        355                 360                 365             


Asp Val Tyr Thr Pro Gly Lys Glu Gly Asp Ala Leu Arg Ser Met Ser 
    370                 375                 380                 


Asn Pro Glu Gln Phe Gly Gln Pro Ala His Met Lys Asp Tyr Val Phe 
385                 390                 395                 400 


Thr Glu Lys Asp Asn Gly Gly Val His Thr Asn Ser Gly Ile Pro Asn 
                405                 410                 415     


Lys Ala Ala Tyr Asn Val Ile Gln Ala Ile Gly Lys Ser Lys Ser Glu 
            420                 425                 430         


Gln Ile Tyr Tyr Arg Ala Leu Thr Glu Tyr Leu Thr Ser Asn Ser Asn 
        435                 440                 445             


Phe Lys Asp Ser Lys Asp Ala Leu Tyr Gln Ala Ala Lys Asp Leu Tyr 
    450                 455                 460                 


Asp Glu Gln Thr Ala Glu Gln Val Tyr Glu Ala Trp Asn Glu Val Gly 
465                 470                 475                 480 


Val Glu Gly Ser Gly Gly Gly Ala Ala Gln Val Asp Glu Ala Gln Lys 
                485                 490                 495     


Asn Ala Phe Tyr Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln 
            500                 505                 510         


Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ala Lys Ser Ala 
        515                 520                 525             


Asn Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    530                 535                 540                 


Ala Asp Ala Gln Gln Asn Asn Val Asn Lys Asp Gln Lys Ser Ala Phe 
545                 550                 555                 560 


Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly 
                565                 570                 575     


Phe Ile Gln Ser Leu Lys Asp Ala Pro Ala Lys Ser Thr Asn Val Leu 
            580                 585                 590         


Gly Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn 
        595                 600                 605             


Asn Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu Asn Met 
    610                 615                 620                 


Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
625                 630                 635                 640 


Asp Ala Pro Ala Lys Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu 
                645                 650                 655     


Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Lys Val Asn Lys Glu Gln 
            660                 665                 670         


Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu 
        675                 680                 685             


Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ala Lys Ser 
    690                 695                 700                 


Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro 
705                 710                 715                 720 


Lys Ala Asp Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu 
                725                 730                 735     


Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile 
            740                 745                 750         


Gln Ser Leu Lys Asp Ala Pro Ala Lys Ser Lys Glu Ile Leu Ala Glu 
        755                 760                 765             


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    770                 775                 


<210>  58
<211>  706
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  58

Met Asp Ile Gly Lys Lys His Val Ile Pro Lys Ser Gln Tyr Arg Arg 
1               5                   10                  15      


Lys Arg Arg Glu Phe Phe His Asn Glu Asp Arg Glu Glu Asn Leu Asn 
            20                  25                  30          


Gln His Gln Asp Lys Gln Asn Ile Asp Asn Thr Thr Ser Lys Lys Ala 
        35                  40                  45              


Asp Lys Gln Ile His Lys Asp Ser Ile Asp Lys His Glu Arg Phe Lys 
    50                  55                  60                  


Asn Ser Leu Ser Ser His Leu Glu Gln Arg Asn Arg Asp Val Asn Glu 
65                  70                  75                  80  


Asn Lys Ala Glu Glu Ser Lys Ser Asn Gln Asp Ser Lys Ser Ala Tyr 
                85                  90                  95      


Asn Arg Asp His Tyr Leu Thr Asp Asp Val Ser Lys Lys Gln Asn Ser 
            100                 105                 110         


Leu Asp Ser Val Asp Gln Asp Thr Glu Lys Ser Lys Tyr Tyr Glu Gln 
        115                 120                 125             


Asn Ser Glu Ala Thr Leu Ser Thr Lys Ser Thr Asp Lys Val Glu Ser 
    130                 135                 140                 


Thr Glu Met Arg Lys Leu Ser Ser Asp Lys Asn Lys Val Gly His Glu 
145                 150                 155                 160 


Glu Gln His Val Leu Ser Lys Pro Ser Glu His Asp Lys Glu Thr Arg 
                165                 170                 175     


Ile Asp Ser Glu Ser Ser Arg Thr Asp Ser Asp Ser Ser Met Gln Thr 
            180                 185                 190         


Glu Lys Ile Lys Lys Asp Ser Ser Asp Gly Asn Lys Ser Ser Asn Leu 
        195                 200                 205             


Lys Ser Glu Val Ile Ser Asp Lys Ser Asn Thr Val Pro Lys Leu Ser 
    210                 215                 220                 


Glu Ser Asp Asp Glu Val Asn Asn Gln Lys Pro Leu Thr Leu Pro Glu 
225                 230                 235                 240 


Glu Gln Lys Leu Lys Arg Gln Gln Ser Gln Asn Glu Gln Thr Lys Thr 
                245                 250                 255     


Tyr Thr Tyr Gly Asp Ser Glu Gln Asn Asp Lys Ser Asn His Glu Asn 
            260                 265                 270         


Asp Leu Ser His His Ile Pro Ser Ile Ser Asp Asp Lys Asp Asn Val 
        275                 280                 285             


Met Arg Glu Asn His Ile Val Asp Asp Asn Pro Asp Asn Asp Ile Asn 
    290                 295                 300                 


Thr Pro Ser Leu Ser Lys Thr Asp Asp Asp Arg Lys Leu Asp Glu Lys 
305                 310                 315                 320 


Ile His Val Glu Asp Lys His Lys Gln Asn Ala Asp Ser Ser Glu Thr 
                325                 330                 335     


Val Gly Tyr Gln Ser Gln Ser Thr Ala Ser His Arg Ser Thr Glu Lys 
            340                 345                 350         


Arg Asn Ile Ser Ile Asn Asp His Asp Lys Leu Asn Gly Gln Lys Thr 
        355                 360                 365             


Asn Thr Lys Thr Ser Ala Asn Asn Asn Gln Lys Lys Ala Thr Ser Lys 
    370                 375                 380                 


Leu Asn Lys Gly Arg Ala Thr Asn Asn Asn Tyr Ser Asp Ile Leu Lys 
385                 390                 395                 400 


Lys Phe Trp Met Met Tyr Trp Pro Lys Gly Ser Gly Gly Gly Ala Ala 
                405                 410                 415     


Gln Val Asp Glu Ala Gln Lys Asn Ala Phe Tyr Gln Val Leu Asn Met 
            420                 425                 430         


Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
        435                 440                 445             


Asp Ala Pro Ala Lys Ser Ala Asn Val Leu Gly Glu Ala Gln Lys Leu 
    450                 455                 460                 


Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Val Asn 
465                 470                 475                 480 


Lys Asp Gln Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu 
                485                 490                 495     


Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro 
            500                 505                 510         


Ala Lys Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu Ser 
        515                 520                 525             


Gln Ala Pro Lys Ala Asp Asn Asn Val Asn Lys Glu Gln Lys Asn Ala 
    530                 535                 540                 


Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg Asn 
545                 550                 555                 560 


Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ala Lys Ser Ala Asn Leu 
                565                 570                 575     


Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp 
            580                 585                 590         


Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu His 
        595                 600                 605             


Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu 
    610                 615                 620                 


Lys Asp Ala Pro Ala Lys Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys 
625                 630                 635                 640 


Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Val Asn Lys Glu 
                645                 650                 655     


Gln Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
            660                 665                 670         


Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ala Lys 
        675                 680                 685             


Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala 
    690                 695                 700                 


Pro Lys 
705     


<210>  59
<211>  988
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  59

Lys Val Ala Lys Gln Gly Gln Tyr Lys Asn Gln Asp Pro Ile Val Leu 
1               5                   10                  15      


Val His Gly Phe Asn Gly Phe Thr Asp Asp Ile Asn Pro Ser Val Leu 
            20                  25                  30          


Ala His Tyr Trp Gly Gly Asn Lys Met Asn Ile Arg Gln Asp Leu Glu 
        35                  40                  45              


Glu Asn Gly Tyr Lys Ala Tyr Glu Ala Ser Ile Ser Ala Phe Gly Ser 
    50                  55                  60                  


Asn Tyr Asp Arg Ala Val Glu Leu Tyr Tyr Tyr Ile Lys Gly Gly Arg 
65                  70                  75                  80  


Val Asp Tyr Gly Ala Ala His Ala Ala Lys Tyr Gly His Glu Arg Tyr 
                85                  90                  95      


Gly Lys Thr Tyr Glu Gly Ile Tyr Lys Asp Trp Lys Pro Gly Gln Lys 
            100                 105                 110         


Val His Leu Val Gly His Ser Met Gly Gly Gln Thr Ile Arg Gln Leu 
        115                 120                 125             


Glu Glu Leu Leu Arg Asn Gly Ser Arg Glu Glu Ile Glu Tyr Gln Lys 
    130                 135                 140                 


Lys His Gly Gly Glu Ile Ser Pro Leu Phe Lys Gly Asn Asn Asp Asn 
145                 150                 155                 160 


Met Ile Ser Ser Ile Thr Thr Leu Gly Thr Pro His Asn Gly Thr His 
                165                 170                 175     


Ala Ser Asp Leu Ala Gly Asn Glu Ala Leu Val Arg Gln Ile Val Phe 
            180                 185                 190         


Asp Ile Gly Lys Met Phe Gly Asn Lys Asn Ser Arg Val Asp Phe Gly 
        195                 200                 205             


Leu Ala Gln Trp Gly Leu Lys Gln Lys Pro Asn Glu Ser Tyr Ile Asp 
    210                 215                 220                 


Tyr Val Lys Arg Val Lys Gln Ser Asn Leu Trp Lys Ser Lys Asp Asn 
225                 230                 235                 240 


Gly Phe Tyr Asp Leu Thr Arg Glu Gly Ala Thr Asp Leu Asn Arg Lys 
                245                 250                 255     


Thr Ser Leu Asn Pro Asn Ile Val Tyr Lys Thr Tyr Thr Gly Glu Ala 
            260                 265                 270         


Thr His Lys Ala Leu Asn Ser Asp Arg Gln Lys Ala Asp Leu Asn Met 
        275                 280                 285             


Phe Phe Pro Phe Val Ile Thr Gly Asn Leu Ile Gly Lys Ala Thr Glu 
    290                 295                 300                 


Lys Glu Trp Arg Glu Asn Asp Gly Leu Val Ser Val Ile Ser Ser Gln 
305                 310                 315                 320 


His Pro Phe Asn Gln Ala Tyr Thr Asn Ala Thr Asp Lys Ile Gln Lys 
                325                 330                 335     


Gly Ile Trp Gln Val Thr Pro Thr Lys His Asp Trp Asp His Val Asp 
            340                 345                 350         


Phe Val Gly Gln Asp Ser Ser Asp Thr Val Arg Thr Arg Glu Glu Leu 
        355                 360                 365             


Gln Asp Phe Trp His His Leu Ala Asp Asp Leu Val Lys Thr Glu Lys 
    370                 375                 380                 


Val Thr Asp Thr Lys Gln Gly Ser Gly Gly Gly Ala Asp Thr Pro Gln 
385                 390                 395                 400 


Lys Asp Thr Thr Ala Lys Thr Thr Ser His Asp Ser Lys Lys Ser Asn 
                405                 410                 415     


Asp Asp Glu Thr Ser Lys Asp Thr Thr Ser Lys Asp Ile Asp Lys Ala 
            420                 425                 430         


Asp Asn Asn Asn Thr Ser Asn Gln Asp Asn Asn Asp Lys Lys Phe Lys 
        435                 440                 445             


Thr Ile Asp Asp Ser Thr Ser Asp Ser Asn Asn Ile Ile Asp Phe Ile 
    450                 455                 460                 


Tyr Lys Asn Leu Pro Gln Thr Asn Ile Asn Gln Leu Leu Thr Lys Asn 
465                 470                 475                 480 


Lys Tyr Asp Asp Asn Tyr Ser Leu Thr Thr Leu Ile Gln Asn Leu Phe 
                485                 490                 495     


Asn Leu Asn Ser Asp Ile Ser Asp Tyr Glu Gln Pro Arg Asn Gly Glu 
            500                 505                 510         


Lys Ser Thr Asn Asp Ser Asn Lys Asn Ser Asp Asn Ser Ile Lys Asn 
        515                 520                 525             


Asp Thr Asp Thr Gln Ser Ser Lys Gln Asp Lys Ala Asp Asn Gln Lys 
    530                 535                 540                 


Ala Pro Lys Ser Asn Asn Thr Lys Pro Ser Thr Ser Asn Lys Gln Pro 
545                 550                 555                 560 


Asn Ser Pro Lys Pro Thr Gln Pro Asn Gln Ser Asn Ser Gln Pro Ala 
                565                 570                 575     


Ser Asp Asp Lys Ala Asn Gln Lys Ser Ser Ser Lys Asp Asn Gln Ser 
            580                 585                 590         


Met Ser Asp Ser Ala Leu Asp Ser Ile Leu Asp Gln Tyr Ser Glu Asp 
        595                 600                 605             


Ala Lys Lys Thr Gln Lys Asp Tyr Ala Ser Gln Ser Lys Lys Asp Lys 
    610                 615                 620                 


Asn Glu Lys Ser Asn Thr Lys Asn Pro Gln Leu Pro Thr Gln Asp Glu 
625                 630                 635                 640 


Leu Lys His Lys Ser Lys Pro Ala Gln Ser Phe Asn Asn Asp Val Asn 
                645                 650                 655     


Gln Lys Asp Thr Arg Ala Thr Ser Leu Phe Glu Thr Asp Pro Ser Ile 
            660                 665                 670         


Ser Asn Asn Asp Asp Ser Gly Gln Phe Asn Val Val Asp Ser Lys Asp 
        675                 680                 685             


Thr Arg Gln Phe Val Lys Ser Ile Ala Lys Asp Ala His Arg Ile Gly 
    690                 695                 700                 


Gln Asp Asn Asp Ile Tyr Ala Ser Val Met Ile Ala Gln Ala Ile Leu 
705                 710                 715                 720 


Glu Ser Asp Ser Gly Arg Ser Ala Leu Ala Lys Ser Pro Asn His Asn 
                725                 730                 735     


Leu Phe Gly Ile Lys Gly Ala Phe Glu Gly Asn Ser Val Pro Phe Asn 
            740                 745                 750         


Thr Leu Gln Ala Asp Gly Asn Lys Leu Tyr Ser Ile Asn Ala Gly Phe 
        755                 760                 765             


Arg Lys Tyr Pro Ser Thr Lys Glu Ser Leu Lys Asn Tyr Ser Asp Leu 
    770                 775                 780                 


Ile Lys Asn Gly Ile Asp Gly Asn Arg Thr Ile Tyr Lys Pro Thr Trp 
785                 790                 795                 800 


Lys Ser Glu Ala Asp Ser Tyr Lys Asp Ala Thr Ser His Leu Ser Lys 
                805                 810                 815     


Thr Tyr Ala Thr Asp Pro Asn Tyr Ala Lys Lys Leu Asn Ser Ile Ile 
            820                 825                 830         


Lys His Tyr Gln Leu Thr Gln Phe Asp Asp Glu Arg Met Pro Asp Leu 
        835                 840                 845             


Asp Lys Tyr Glu Arg Ser Ile Lys Asp Tyr Asp Asp Ser Ser Asp Glu 
    850                 855                 860                 


Phe Lys Pro Phe Arg Glu Val Ser Asp Ser Met Pro Tyr Pro His Gly 
865                 870                 875                 880 


Gln Ser Thr Trp Tyr Val Tyr Asn Arg Met Lys Gln Phe Gly Thr Ser 
                885                 890                 895     


Ile Ser Gly Asp Leu Gly Asp Ala His Asn Trp Asn Asn Arg Ala Gln 
            900                 905                 910         


Tyr Arg Asp Tyr Gln Val Ser His Thr Pro Lys Arg His Ala Ala Val 
        915                 920                 925             


Val Phe Glu Ala Gly Gln Phe Gly Ala Asp Gln His Tyr Gly His Val 
    930                 935                 940                 


Ala Phe Val Glu Lys Val Asn Ser Asp Gly Ser Ile Val Ile Ser Glu 
945                 950                 955                 960 


Ser Asn Val Lys Gly Leu Gly Ile Ile Ser His Arg Thr Ile Asn Ala 
                965                 970                 975     


Ala Ala Ala Glu Glu Leu Ser Tyr Ile Thr Gly Lys 
            980                 985             


<210>  60
<211>  1189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  60

Gln Thr Lys Tyr Gly Asp Gln Ser Glu Lys Gly Ser Gln Ser Val Ser 
1               5                   10                  15      


Asn Lys Asn Asn Lys Ile His Ile Ala Ile Val Asn Glu Asp Gln Pro 
            20                  25                  30          


Thr Thr Tyr Asn Gly Lys Lys Val Glu Leu Gly Gln Ala Phe Ile Lys 
        35                  40                  45              


Arg Leu Ala Asn Glu Lys Asn Tyr Lys Phe Glu Thr Val Thr Arg Asn 
    50                  55                  60                  


Val Ala Glu Ser Gly Leu Lys Asn Gly Gly Tyr Gln Val Met Ile Val 
65                  70                  75                  80  


Ile Pro Glu Asn Phe Ser Lys Leu Ala Met Gln Leu Asp Ala Lys Thr 
                85                  90                  95      


Pro Ser Lys Ile Ser Leu Gln Tyr Lys Thr Ala Val Gly Gln Lys Glu 
            100                 105                 110         


Glu Val Ala Lys Asn Thr Glu Lys Val Val Ser Asn Val Leu Asn Asp 
        115                 120                 125             


Phe Asn Lys Asn Leu Val Glu Ile Tyr Leu Thr Ser Ile Ile Asp Asn 
    130                 135                 140                 


Leu His Asn Ala Gln Lys Asn Val Gly Ala Ile Met Thr Arg Glu His 
145                 150                 155                 160 


Gly Val Asn Ser Lys Phe Ser Asn Tyr Leu Leu Asn Pro Ile Asn Asp 
                165                 170                 175     


Phe Pro Glu Leu Phe Thr Asp Thr Leu Val Asn Ser Ile Ser Ala Asn 
            180                 185                 190         


Lys Asp Ile Thr Lys Trp Phe Gln Thr Tyr Asn Lys Ser Leu Leu Ser 
        195                 200                 205             


Ala Asn Ser Asp Thr Phe Arg Val Asn Thr Asp Tyr Asn Val Ser Thr 
    210                 215                 220                 


Leu Ile Glu Lys Gln Asn Ser Leu Phe Asp Glu His Asn Thr Ala Met 
225                 230                 235                 240 


Asp Lys Met Leu Gln Asp Tyr Lys Ser Gln Lys Asp Ser Val Glu Leu 
                245                 250                 255     


Asp Asn Tyr Ile Asn Ala Leu Lys Gln Met Asp Ser Gln Ile Asp Gln 
            260                 265                 270         


Gln Ser Ser Met Gln Asp Thr Gly Lys Glu Glu Tyr Lys Gln Thr Val 
        275                 280                 285             


Lys Glu Asn Leu Asp Lys Leu Arg Glu Ile Ile Gln Ser Gln Glu Ser 
    290                 295                 300                 


Pro Phe Ser Lys Gly Met Ile Glu Asp Tyr Arg Lys Gln Leu Thr Glu 
305                 310                 315                 320 


Ser Leu Gln Asp Glu Leu Ala Asn Asn Lys Asp Leu Gln Asp Ala Leu 
                325                 330                 335     


Asn Ser Ile Lys Met Asn Asn Ala Gln Phe Ala Glu Asn Leu Glu Lys 
            340                 345                 350         


Gln Leu His Asp Asp Ile Val Lys Glu Pro Asp Ser Asp Thr Thr Phe 
        355                 360                 365             


Ile Tyr Asn Met Ser Lys Gln Asp Phe Ile Ala Ala Gly Leu Asn Glu 
    370                 375                 380                 


Asp Glu Ala Asn Lys Tyr Glu Ala Ile Val Lys Glu Ala Lys Arg Tyr 
385                 390                 395                 400 


Lys Asn Glu Tyr Asn Leu Lys Lys Pro Leu Ala Glu His Ile Asn Leu 
                405                 410                 415     


Thr Asp Tyr Asp Asn Gln Val Ala Gln Asp Thr Ser Ser Leu Ile Asn 
            420                 425                 430         


Asp Gly Val Lys Val Gln Arg Thr Glu Thr Ile Lys Ser Asn Asp Ile 
        435                 440                 445             


Asn Gln Leu Thr Val Ala Thr Asp Pro His Phe Asn Phe Glu Gly Asp 
    450                 455                 460                 


Ile Lys Ile Asn Gly Lys Lys Tyr Asp Ile Lys Asp Gln Ser Val Gln 
465                 470                 475                 480 


Leu Asp Thr Ser Asn Lys Glu Tyr Lys Val Glu Val Asn Gly Val Ala 
                485                 490                 495     


Lys Leu Lys Lys Asp Ala Glu Lys Asp Phe Leu Lys Asp Lys Thr Met 
            500                 505                 510         


His Leu Gln Leu Leu Phe Gly Gln Ala Asn Arg Gln Asp Glu Pro Asn 
        515                 520                 525             


Asp Lys Lys Ala Thr Ser Val Val Asp Val Thr Leu Asn His Asn Leu 
    530                 535                 540                 


Asp Gly Arg Leu Ser Lys Asp Ala Leu Ser Gln Gln Leu Ser Ala Leu 
545                 550                 555                 560 


Ser Arg Phe Asp Ala His Tyr Lys Met Tyr Thr Asp Thr Lys Gly Arg 
                565                 570                 575     


Glu Asp Lys Pro Phe Asp Asn Lys Arg Leu Ile Asp Met Met Val Asp 
            580                 585                 590         


Gln Val Ile Asn Asp Met Glu Ser Phe Lys Asp Asp Lys Val Ala Val 
        595                 600                 605             


Leu His Gln Ile Asp Ser Met Glu Glu Asn Ser Asp Lys Leu Ile Asp 
    610                 615                 620                 


Asp Ile Leu Asn Asn Lys Lys Asn Thr Thr Lys Asn Lys Glu Asp Ile 
625                 630                 635                 640 


Ser Lys Leu Ile Asp Gln Leu Glu Asn Val Lys Lys Thr Phe Ala Glu 
                645                 650                 655     


Glu Pro Gln Glu Pro Lys Ile Asp Lys Gly Lys Asn Asp Glu Phe Asn 
            660                 665                 670         


Thr Met Ser Ser Asn Leu Asp Lys Glu Ile Ser Arg Ile Ser Glu Lys 
        675                 680                 685             


Ser Thr Gln Leu Leu Ser Asp Thr Gln Glu Ser Lys Thr Ile Ala Asp 
    690                 695                 700                 


Ser Val Ser Gly Gln Leu Asn Gln Leu Asp Asn Asn Val Asn Lys Leu 
705                 710                 715                 720 


His Ala Thr Gly Arg Ala Leu Gly Val Arg Ala Asn Asp Leu Asn Arg 
                725                 730                 735     


Gln Met Ala Lys Asn Asp Lys Asp Asn Glu Leu Phe Ala Lys Glu Phe 
            740                 745                 750         


Lys Lys Val Leu Gln Asn Ser Lys Asp Gly Asp Arg Gln Asn Gln Ala 
        755                 760                 765             


Leu Lys Ala Phe Met Ser Asn Pro Val Gln Lys Lys Asn Leu Glu Asn 
    770                 775                 780                 


Val Leu Ala Asn Asn Gly Asn Thr Asp Gly Ser Gly Gly Gly Ala Lys 
785                 790                 795                 800 


Val Ala Lys Gln Gly Gln Tyr Lys Asn Gln Asp Pro Ile Val Leu Val 
                805                 810                 815     


His Gly Phe Asn Gly Phe Thr Asp Asp Ile Asn Pro Ser Val Leu Ala 
            820                 825                 830         


His Tyr Trp Gly Gly Asn Lys Met Asn Ile Arg Gln Asp Leu Glu Glu 
        835                 840                 845             


Asn Gly Tyr Lys Ala Tyr Glu Ala Ser Ile Ser Ala Phe Gly Ser Asn 
    850                 855                 860                 


Tyr Asp Arg Ala Val Glu Leu Tyr Tyr Tyr Ile Lys Gly Gly Arg Val 
865                 870                 875                 880 


Asp Tyr Gly Ala Ala His Ala Ala Lys Tyr Gly His Glu Arg Tyr Gly 
                885                 890                 895     


Lys Thr Tyr Glu Gly Ile Tyr Lys Asp Trp Lys Pro Gly Gln Lys Val 
            900                 905                 910         


His Leu Val Gly His Ser Met Gly Gly Gln Thr Ile Arg Gln Leu Glu 
        915                 920                 925             


Glu Leu Leu Arg Asn Gly Ser Arg Glu Glu Ile Glu Tyr Gln Lys Lys 
    930                 935                 940                 


His Gly Gly Glu Ile Ser Pro Leu Phe Lys Gly Asn Asn Asp Asn Met 
945                 950                 955                 960 


Ile Ser Ser Ile Thr Thr Leu Gly Thr Pro His Asn Gly Thr His Ala 
                965                 970                 975     


Ser Asp Leu Ala Gly Asn Glu Ala Leu Val Arg Gln Ile Val Phe Asp 
            980                 985                 990         


Ile Gly Lys Met Phe Gly Asn Lys  Asn Ser Arg Val Asp  Phe Gly Leu 
        995                 1000                 1005             


Ala Gln  Trp Gly Leu Lys Gln  Lys Pro Asn Glu Ser  Tyr Ile Asp 
    1010                 1015                 1020             


Tyr Val  Lys Arg Val Lys Gln  Ser Asn Leu Trp Lys  Ser Lys Asp 
    1025                 1030                 1035             


Asn Gly  Phe Tyr Asp Leu Thr  Arg Glu Gly Ala Thr  Asp Leu Asn 
    1040                 1045                 1050             


Arg Lys  Thr Ser Leu Asn Pro  Asn Ile Val Tyr Lys  Thr Tyr Thr 
    1055                 1060                 1065             


Gly Glu  Ala Thr His Lys Ala  Leu Asn Ser Asp Arg  Gln Lys Ala 
    1070                 1075                 1080             


Asp Leu  Asn Met Phe Phe Pro  Phe Val Ile Thr Gly  Asn Leu Ile 
    1085                 1090                 1095             


Gly Lys  Ala Thr Glu Lys Glu  Trp Arg Glu Asn Asp  Gly Leu Val 
    1100                 1105                 1110             


Ser Val  Ile Ser Ser Gln His  Pro Phe Asn Gln Ala  Tyr Thr Asn 
    1115                 1120                 1125             


Ala Thr  Asp Lys Ile Gln Lys  Gly Ile Trp Gln Val  Thr Pro Thr 
    1130                 1135                 1140             


Lys His  Asp Trp Asp His Val  Asp Phe Val Gly Gln  Asp Ser Ser 
    1145                 1150                 1155             


Asp Thr  Val Arg Thr Arg Glu  Glu Leu Gln Asp Phe  Trp His His 
    1160                 1165                 1170             


Leu Ala  Asp Asp Leu Val Lys  Thr Glu Lys Val Thr  Asp Thr Lys 
    1175                 1180                 1185             


Gln 
    


<210>  61
<211>  805
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  61

Met Asp Ile Gly Lys Lys His Val Ile Pro Lys Ser Gln Tyr Arg Arg 
1               5                   10                  15      


Lys Arg Arg Glu Phe Phe His Asn Glu Asp Arg Glu Glu Asn Leu Asn 
            20                  25                  30          


Gln His Gln Asp Lys Gln Asn Ile Asp Asn Thr Thr Ser Lys Lys Ala 
        35                  40                  45              


Asp Lys Gln Ile His Lys Asp Ser Ile Asp Lys His Glu Arg Phe Lys 
    50                  55                  60                  


Asn Ser Leu Ser Ser His Leu Glu Gln Arg Asn Arg Asp Val Asn Glu 
65                  70                  75                  80  


Asn Lys Ala Glu Glu Ser Lys Ser Asn Gln Asp Ser Lys Ser Ala Tyr 
                85                  90                  95      


Asn Arg Asp His Tyr Leu Thr Asp Asp Val Ser Lys Lys Gln Asn Ser 
            100                 105                 110         


Leu Asp Ser Val Asp Gln Asp Thr Glu Lys Ser Lys Tyr Tyr Glu Gln 
        115                 120                 125             


Asn Ser Glu Ala Thr Leu Ser Thr Lys Ser Thr Asp Lys Val Glu Ser 
    130                 135                 140                 


Thr Glu Met Arg Lys Leu Ser Ser Asp Lys Asn Lys Val Gly His Glu 
145                 150                 155                 160 


Glu Gln His Val Leu Ser Lys Pro Ser Glu His Asp Lys Glu Thr Arg 
                165                 170                 175     


Ile Asp Ser Glu Ser Ser Arg Thr Asp Ser Asp Ser Ser Met Gln Thr 
            180                 185                 190         


Glu Lys Ile Lys Lys Asp Ser Ser Asp Gly Asn Lys Ser Ser Asn Leu 
        195                 200                 205             


Lys Ser Glu Val Ile Ser Asp Lys Ser Asn Thr Val Pro Lys Leu Ser 
    210                 215                 220                 


Glu Ser Asp Asp Glu Val Asn Asn Gln Lys Pro Leu Thr Leu Pro Glu 
225                 230                 235                 240 


Glu Gln Lys Leu Lys Arg Gln Gln Ser Gln Asn Glu Gln Thr Lys Thr 
                245                 250                 255     


Tyr Thr Tyr Gly Asp Ser Glu Gln Asn Asp Lys Ser Asn His Glu Asn 
            260                 265                 270         


Asp Leu Ser His His Ile Pro Ser Ile Ser Asp Asp Lys Asp Asn Val 
        275                 280                 285             


Met Arg Glu Asn His Ile Val Asp Asp Asn Pro Asp Asn Asp Ile Asn 
    290                 295                 300                 


Thr Pro Ser Leu Ser Lys Thr Asp Asp Asp Arg Lys Leu Asp Glu Lys 
305                 310                 315                 320 


Ile His Val Glu Asp Lys His Lys Gln Asn Ala Asp Ser Ser Glu Thr 
                325                 330                 335     


Val Gly Tyr Gln Ser Gln Ser Thr Ala Ser His Arg Ser Thr Glu Lys 
            340                 345                 350         


Arg Asn Ile Ser Ile Asn Asp His Asp Lys Leu Asn Gly Gln Lys Thr 
        355                 360                 365             


Asn Thr Lys Thr Ser Ala Asn Asn Asn Gln Lys Lys Ala Thr Ser Lys 
    370                 375                 380                 


Leu Asn Lys Gly Arg Ala Thr Asn Asn Asn Tyr Ser Asp Ile Leu Lys 
385                 390                 395                 400 


Lys Phe Trp Met Met Tyr Trp Pro Lys Gly Ser Gly Gly Gly Ala Lys 
                405                 410                 415     


Val Ala Lys Gln Gly Gln Tyr Lys Asn Gln Asp Pro Ile Val Leu Val 
            420                 425                 430         


His Gly Phe Asn Gly Phe Thr Asp Asp Ile Asn Pro Ser Val Leu Ala 
        435                 440                 445             


His Tyr Trp Gly Gly Asn Lys Met Asn Ile Arg Gln Asp Leu Glu Glu 
    450                 455                 460                 


Asn Gly Tyr Lys Ala Tyr Glu Ala Ser Ile Ser Ala Phe Gly Ser Asn 
465                 470                 475                 480 


Tyr Asp Arg Ala Val Glu Leu Tyr Tyr Tyr Ile Lys Gly Gly Arg Val 
                485                 490                 495     


Asp Tyr Gly Ala Ala His Ala Ala Lys Tyr Gly His Glu Arg Tyr Gly 
            500                 505                 510         


Lys Thr Tyr Glu Gly Ile Tyr Lys Asp Trp Lys Pro Gly Gln Lys Val 
        515                 520                 525             


His Leu Val Gly His Ser Met Gly Gly Gln Thr Ile Arg Gln Leu Glu 
    530                 535                 540                 


Glu Leu Leu Arg Asn Gly Ser Arg Glu Glu Ile Glu Tyr Gln Lys Lys 
545                 550                 555                 560 


His Gly Gly Glu Ile Ser Pro Leu Phe Lys Gly Asn Asn Asp Asn Met 
                565                 570                 575     


Ile Ser Ser Ile Thr Thr Leu Gly Thr Pro His Asn Gly Thr His Ala 
            580                 585                 590         


Ser Asp Leu Ala Gly Asn Glu Ala Leu Val Arg Gln Ile Val Phe Asp 
        595                 600                 605             


Ile Gly Lys Met Phe Gly Asn Lys Asn Ser Arg Val Asp Phe Gly Leu 
    610                 615                 620                 


Ala Gln Trp Gly Leu Lys Gln Lys Pro Asn Glu Ser Tyr Ile Asp Tyr 
625                 630                 635                 640 


Val Lys Arg Val Lys Gln Ser Asn Leu Trp Lys Ser Lys Asp Asn Gly 
                645                 650                 655     


Phe Tyr Asp Leu Thr Arg Glu Gly Ala Thr Asp Leu Asn Arg Lys Thr 
            660                 665                 670         


Ser Leu Asn Pro Asn Ile Val Tyr Lys Thr Tyr Thr Gly Glu Ala Thr 
        675                 680                 685             


His Lys Ala Leu Asn Ser Asp Arg Gln Lys Ala Asp Leu Asn Met Phe 
    690                 695                 700                 


Phe Pro Phe Val Ile Thr Gly Asn Leu Ile Gly Lys Ala Thr Glu Lys 
705                 710                 715                 720 


Glu Trp Arg Glu Asn Asp Gly Leu Val Ser Val Ile Ser Ser Gln His 
                725                 730                 735     


Pro Phe Asn Gln Ala Tyr Thr Asn Ala Thr Asp Lys Ile Gln Lys Gly 
            740                 745                 750         


Ile Trp Gln Val Thr Pro Thr Lys His Asp Trp Asp His Val Asp Phe 
        755                 760                 765             


Val Gly Gln Asp Ser Ser Asp Thr Val Arg Thr Arg Glu Glu Leu Gln 
    770                 775                 780                 


Asp Phe Trp His His Leu Ala Asp Asp Leu Val Lys Thr Glu Lys Val 
785                 790                 795                 800 


Thr Asp Thr Lys Gln 
                805 


<210>  62
<211>  879
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  62

Asp Thr Pro Gln Lys Asp Thr Thr Ala Lys Thr Thr Ser His Asp Ser 
1               5                   10                  15      


Lys Lys Ser Asn Asp Asp Glu Thr Ser Lys Asp Thr Thr Ser Lys Asp 
            20                  25                  30          


Ile Asp Lys Ala Asp Asn Asn Asn Thr Ser Asn Gln Asp Asn Asn Asp 
        35                  40                  45              


Lys Lys Phe Lys Thr Ile Asp Asp Ser Thr Ser Asp Ser Asn Asn Ile 
    50                  55                  60                  


Ile Asp Phe Ile Tyr Lys Asn Leu Pro Gln Thr Asn Ile Asn Gln Leu 
65                  70                  75                  80  


Leu Thr Lys Asn Lys Tyr Asp Asp Asn Tyr Ser Leu Thr Thr Leu Ile 
                85                  90                  95      


Gln Asn Leu Phe Asn Leu Asn Ser Asp Ile Ser Asp Tyr Glu Gln Pro 
            100                 105                 110         


Arg Asn Gly Glu Lys Ser Thr Asn Asp Ser Asn Lys Asn Ser Asp Asn 
        115                 120                 125             


Ser Ile Lys Asn Asp Thr Asp Thr Gln Ser Ser Lys Gln Asp Lys Ala 
    130                 135                 140                 


Asp Asn Gln Lys Ala Pro Lys Ser Asn Asn Thr Lys Pro Ser Thr Ser 
145                 150                 155                 160 


Asn Lys Gln Pro Asn Ser Pro Lys Pro Thr Gln Pro Asn Gln Ser Asn 
                165                 170                 175     


Ser Gln Pro Ala Ser Asp Asp Lys Ala Asn Gln Lys Ser Ser Ser Lys 
            180                 185                 190         


Asp Asn Gln Ser Met Ser Asp Ser Ala Leu Asp Ser Ile Leu Asp Gln 
        195                 200                 205             


Tyr Ser Glu Asp Ala Lys Lys Thr Gln Lys Asp Tyr Ala Ser Gln Ser 
    210                 215                 220                 


Lys Lys Asp Lys Asn Glu Lys Ser Asn Thr Lys Asn Pro Gln Leu Pro 
225                 230                 235                 240 


Thr Gln Asp Glu Leu Lys His Lys Ser Lys Pro Ala Gln Ser Phe Asn 
                245                 250                 255     


Asn Asp Val Asn Gln Lys Asp Thr Arg Ala Thr Ser Leu Phe Glu Thr 
            260                 265                 270         


Asp Pro Ser Ile Ser Asn Asn Asp Asp Ser Gly Gln Phe Asn Val Val 
        275                 280                 285             


Asp Ser Lys Asp Thr Arg Gln Phe Val Lys Ser Ile Ala Lys Asp Ala 
    290                 295                 300                 


His Arg Ile Gly Gln Asp Asn Asp Ile Tyr Ala Ser Val Met Ile Ala 
305                 310                 315                 320 


Gln Ala Ile Leu Glu Ser Asp Ser Gly Arg Ser Ala Leu Ala Lys Ser 
                325                 330                 335     


Pro Asn His Asn Leu Phe Gly Ile Lys Gly Ala Phe Glu Gly Asn Ser 
            340                 345                 350         


Val Pro Phe Asn Thr Leu Gln Ala Asp Gly Asn Lys Leu Tyr Ser Ile 
        355                 360                 365             


Asn Ala Gly Phe Arg Lys Tyr Pro Ser Thr Lys Glu Ser Leu Lys Asn 
    370                 375                 380                 


Tyr Ser Asp Leu Ile Lys Asn Gly Ile Asp Gly Asn Arg Thr Ile Tyr 
385                 390                 395                 400 


Lys Pro Thr Trp Lys Ser Glu Ala Asp Ser Tyr Lys Asp Ala Thr Ser 
                405                 410                 415     


His Leu Ser Lys Thr Tyr Ala Thr Asp Pro Asn Tyr Ala Lys Lys Leu 
            420                 425                 430         


Asn Ser Ile Ile Lys His Tyr Gln Leu Thr Gln Phe Asp Asp Glu Arg 
        435                 440                 445             


Met Pro Asp Leu Asp Lys Tyr Glu Arg Ser Ile Lys Asp Tyr Asp Asp 
    450                 455                 460                 


Ser Ser Asp Glu Phe Lys Pro Phe Arg Glu Val Ser Asp Ser Met Pro 
465                 470                 475                 480 


Tyr Pro His Gly Gln Ser Thr Trp Tyr Val Tyr Asn Arg Met Lys Gln 
                485                 490                 495     


Phe Gly Thr Ser Ile Ser Gly Asp Leu Gly Asp Ala His Asn Trp Asn 
            500                 505                 510         


Asn Arg Ala Gln Tyr Arg Asp Tyr Gln Val Ser His Thr Pro Lys Arg 
        515                 520                 525             


His Ala Ala Val Val Phe Glu Ala Gly Gln Phe Gly Ala Asp Gln His 
    530                 535                 540                 


Tyr Gly His Val Ala Phe Val Glu Lys Val Asn Ser Asp Gly Ser Ile 
545                 550                 555                 560 


Val Ile Ser Glu Ser Asn Val Lys Gly Leu Gly Ile Ile Ser His Arg 
                565                 570                 575     


Thr Ile Asn Ala Ala Ala Ala Glu Glu Leu Ser Tyr Ile Thr Gly Lys 
            580                 585                 590         


Gly Ser Gly Gly Gly Ala Asp Ile Gly Ser Asn Thr Thr Val Lys Thr 
        595                 600                 605             


Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn Gly Met Leu Lys Lys Val 
    610                 615                 620                 


Phe Tyr Ser Phe Ile Asp Asp Lys Asn His Asn Lys Lys Leu Leu Val 
625                 630                 635                 640 


Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln Tyr Arg Val Tyr Ser Glu 
                645                 650                 655     


Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp Pro Ser Ala Phe Lys Val 
            660                 665                 670         


Gln Leu Gln Leu Pro Asp Asn Glu Val Ala Gln Ile Ser Asp Tyr Tyr 
        675                 680                 685             


Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr Met Ser Thr Leu Thr Tyr 
    690                 695                 700                 


Gly Phe Asn Gly Asn Val Thr Gly Asp Asp Thr Gly Lys Ile Gly Gly 
705                 710                 715                 720 


Leu Ile Gly Ala Asn Val Ser Ile Gly His Thr Leu Lys Tyr Val Gln 
                725                 730                 735     


Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro Thr Asp Lys Lys Val Gly 
            740                 745                 750         


Trp Lys Val Ile Phe Asn Asn Met Val Asn Gln Asn Trp Gly Pro Tyr 
        755                 760                 765             


Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly Asn Gln Leu Phe Met Lys 
    770                 775                 780                 


Thr Arg Asn Gly Ser Met Lys Ala Ala Asp Asn Phe Leu Asp Pro Asn 
785                 790                 795                 800 


Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe Ser Pro Asp Phe Ala Thr 
                805                 810                 815     


Val Ile Thr Met Asp Arg Lys Ala Ser Lys Gln Gln Thr Asn Ile Asp 
            820                 825                 830         


Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr Gln Leu His Trp Thr Ser 
        835                 840                 845             


Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp Lys Trp Ile Asp Arg Ser 
    850                 855                 860                 


Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys Glu Glu Met Thr Asn 
865                 870                 875                 


<210>  63
<211>  771
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protien

<400>  63

Ile Asp Ser Lys Asn Lys Pro Ala Asn Ser Asp Ile Lys Phe Glu Val 
1               5                   10                  15      


Thr Gln Lys Ser Asp Ala Val Lys Ala Leu Lys Glu Leu Pro Lys Ser 
            20                  25                  30          


Glu Asn Val Lys Asn Ile Tyr Gln Asp Tyr Ala Val Thr Asp Val Lys 
        35                  40                  45              


Thr Asp Lys Lys Gly Phe Thr His Tyr Thr Leu Gln Pro Ser Val Asp 
    50                  55                  60                  


Gly Val His Ala Pro Asp Lys Glu Val Lys Val His Ala Asp Lys Ser 
65                  70                  75                  80  


Gly Lys Val Val Leu Ile Asn Gly Asp Thr Asp Ala Lys Lys Val Lys 
                85                  90                  95      


Pro Thr Asn Lys Val Thr Leu Ser Lys Asp Asp Ala Ala Asp Lys Ala 
            100                 105                 110         


Phe Lys Ala Val Lys Ile Asp Lys Asn Lys Ala Lys Asn Leu Lys Asp 
        115                 120                 125             


Lys Val Ile Lys Glu Asn Lys Val Glu Ile Asp Gly Asp Ser Asn Lys 
    130                 135                 140                 


Tyr Val Tyr Asn Val Glu Leu Ile Thr Val Thr Pro Glu Ile Ser His 
145                 150                 155                 160 


Trp Lys Val Lys Ile Asp Ala Gln Thr Gly Glu Ile Leu Glu Lys Met 
                165                 170                 175     


Asn Leu Val Lys Glu Ala Ala Glu Thr Gly Lys Gly Lys Gly Val Leu 
            180                 185                 190         


Gly Asp Thr Lys Asp Ile Asn Ile Asn Ser Ile Asp Gly Gly Phe Ser 
        195                 200                 205             


Leu Glu Asp Leu Thr His Gln Gly Lys Leu Ser Ala Phe Ser Phe Asn 
    210                 215                 220                 


Asp Gln Thr Gly Gln Ala Thr Leu Ile Thr Asn Glu Asp Glu Asn Phe 
225                 230                 235                 240 


Val Lys Asp Glu Gln Arg Ala Gly Val Asp Ala Asn Tyr Tyr Ala Lys 
                245                 250                 255     


Gln Thr Tyr Asp Tyr Tyr Lys Asp Thr Phe Gly Arg Glu Ser Tyr Asp 
            260                 265                 270         


Asn Gln Gly Ser Pro Ile Val Ser Leu Thr His Val Asn Asn Tyr Gly 
        275                 280                 285             


Gly Gln Asp Asn Arg Asn Asn Ala Ala Trp Ile Gly Asp Lys Met Ile 
    290                 295                 300                 


Tyr Gly Asp Gly Asp Gly Arg Thr Phe Thr Ser Leu Ser Gly Ala Asn 
305                 310                 315                 320 


Asp Val Val Ala His Ala Leu Thr His Gly Val Thr Gln Glu Thr Ala 
                325                 330                 335     


Asn Leu Glu Tyr Lys Asp Gln Ser Gly Ala Leu Asn Glu Ser Phe Ser 
            340                 345                 350         


Asp Val Phe Gly Tyr Phe Val Asp Asp Glu Asp Phe Leu Met Gly Glu 
        355                 360                 365             


Asp Val Tyr Thr Pro Gly Lys Glu Gly Asp Ala Leu Arg Ser Met Ser 
    370                 375                 380                 


Asn Pro Glu Gln Phe Gly Gln Pro Ala His Met Lys Asp Tyr Val Phe 
385                 390                 395                 400 


Thr Glu Lys Asp Asn Gly Gly Val His Thr Asn Ser Gly Ile Pro Asn 
                405                 410                 415     


Lys Ala Ala Tyr Asn Val Ile Gln Ala Ile Gly Lys Ser Lys Ser Glu 
            420                 425                 430         


Gln Ile Tyr Tyr Arg Ala Leu Thr Glu Tyr Leu Thr Ser Asn Ser Asn 
        435                 440                 445             


Phe Lys Asp Ser Lys Asp Ala Leu Tyr Gln Ala Ala Lys Asp Leu Tyr 
    450                 455                 460                 


Asp Glu Gln Thr Ala Glu Gln Val Tyr Glu Ala Trp Asn Glu Val Gly 
465                 470                 475                 480 


Val Glu Gly Ser Gly Gly Gly Ala Asn Thr Asn Ile Glu Asn Ile Gly 
                485                 490                 495     


Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val Ser Ser Lys Lys 
            500                 505                 510         


Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val Lys Asp Lys Lys 
        515                 520                 525             


Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly Phe Ile Asn Ser 
    530                 535                 540                 


Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr Glu Leu Thr Lys 
545                 550                 555                 560 


Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu Thr Thr Lys Asp 
                565                 570                 575     


Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Glu Thr 
            580                 585                 590         


Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln 
        595                 600                 605             


Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr Ser Lys Thr 
    610                 615                 620                 


Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val Asp Lys Gln Asn 
625                 630                 635                 640 


Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu Phe Val Thr Pro 
                645                 650                 655     


Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe Val Gln Ser Pro 
            660                 665                 670         


Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala Pro Asp Asn Gln 
        675                 680                 685             


Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr 
    690                 695                 700                 


Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu Phe Glu Ile Ser 
705                 710                 715                 720 


Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu Phe Pro Arg Thr 
                725                 730                 735     


Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val Asn Arg Asn Phe 
            740                 745                 750         


Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu Ile Lys Val Lys 
        755                 760                 765             


Gly His Asn 
    770     


<210>  64
<211>  570
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  64

Asn Thr Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg 
1               5                   10                  15      


Thr Glu Asp Val Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys 
    50                  55                  60                  


Gly Ser Gly Tyr Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr 
65                  70                  75                  80  


Asn Ile Gly Leu Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr 
                85                  90                  95      


Leu Pro Lys Asn Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly 
            100                 105                 110         


Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn 
        115                 120                 125             


Gly Ser Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr 
    130                 135                 140                 


Val Ser Glu Val Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val 
145                 150                 155                 160 


Lys Ala Asn Glu Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp 
                165                 170                 175     


Arg Tyr Leu Phe Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg 
            180                 185                 190         


Glu Tyr Phe Ala Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly 
        195                 200                 205             


Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser 
    210                 215                 220                 


Asp Thr Ser Glu Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr 
225                 230                 235                 240 


Tyr Ala Thr Leu Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His 
                245                 250                 255     


Asn Ala Phe Val Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp 
            260                 265                 270         


Lys Thr His Glu Ile Lys Val Lys Gly His Asn Gly Ser Gly Gly Gly 
        275                 280                 285             


Ala Asp Ile Gly Ser Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr 
    290                 295                 300                 


Tyr Asp Lys Glu Asn Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile 
305                 310                 315                 320 


Asp Asp Lys Asn His Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly 
                325                 330                 335     


Thr Ile Ala Gly Gln Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys 
            340                 345                 350         


Ser Gly Leu Ala Trp Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro 
        355                 360                 365             


Asp Asn Glu Val Ala Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile 
    370                 375                 380                 


Asp Thr Lys Glu Tyr Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn 
385                 390                 395                 400 


Val Thr Gly Asp Asp Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn 
                405                 410                 415     


Val Ser Ile Gly His Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr 
            420                 425                 430         


Ile Leu Glu Ser Pro Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe 
        435                 440                 445             


Asn Asn Met Val Asn Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp 
    450                 455                 460                 


Asn Pro Val Tyr Gly Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser 
465                 470                 475                 480 


Met Lys Ala Ala Asp Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu 
                485                 490                 495     


Leu Ser Ser Gly Phe Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp 
            500                 505                 510         


Arg Lys Ala Ser Lys Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg 
        515                 520                 525             


Val Arg Asp Asp Tyr Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly 
    530                 535                 540                 


Thr Asn Thr Lys Asp Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys 
545                 550                 555                 560 


Ile Asp Trp Glu Lys Glu Glu Met Thr Asn 
                565                 570 


<210>  65
<211>  779
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  65

Ile Asp Ser Lys Asn Lys Pro Ala Asn Ser Asp Ile Lys Phe Glu Val 
1               5                   10                  15      


Thr Gln Lys Ser Asp Ala Val Lys Ala Leu Lys Glu Leu Pro Lys Ser 
            20                  25                  30          


Glu Asn Val Lys Asn Ile Tyr Gln Asp Tyr Ala Val Thr Asp Val Lys 
        35                  40                  45              


Thr Asp Lys Lys Gly Phe Thr His Tyr Thr Leu Gln Pro Ser Val Asp 
    50                  55                  60                  


Gly Val His Ala Pro Asp Lys Glu Val Lys Val His Ala Asp Lys Ser 
65                  70                  75                  80  


Gly Lys Val Val Leu Ile Asn Gly Asp Thr Asp Ala Lys Lys Val Lys 
                85                  90                  95      


Pro Thr Asn Lys Val Thr Leu Ser Lys Asp Asp Ala Ala Asp Lys Ala 
            100                 105                 110         


Phe Lys Ala Val Lys Ile Asp Lys Asn Lys Ala Lys Asn Leu Lys Asp 
        115                 120                 125             


Lys Val Ile Lys Glu Asn Lys Val Glu Ile Asp Gly Asp Ser Asn Lys 
    130                 135                 140                 


Tyr Val Tyr Asn Val Glu Leu Ile Thr Val Thr Pro Glu Ile Ser His 
145                 150                 155                 160 


Trp Lys Val Lys Ile Asp Ala Gln Thr Gly Glu Ile Leu Glu Lys Met 
                165                 170                 175     


Asn Leu Val Lys Glu Ala Ala Glu Thr Gly Lys Gly Lys Gly Val Leu 
            180                 185                 190         


Gly Asp Thr Lys Asp Ile Asn Ile Asn Ser Ile Asp Gly Gly Phe Ser 
        195                 200                 205             


Leu Glu Asp Leu Thr His Gln Gly Lys Leu Ser Ala Phe Ser Phe Asn 
    210                 215                 220                 


Asp Gln Thr Gly Gln Ala Thr Leu Ile Thr Asn Glu Asp Glu Asn Phe 
225                 230                 235                 240 


Val Lys Asp Glu Gln Arg Ala Gly Val Asp Ala Asn Tyr Tyr Ala Lys 
                245                 250                 255     


Gln Thr Tyr Asp Tyr Tyr Lys Asp Thr Phe Gly Arg Glu Ser Tyr Asp 
            260                 265                 270         


Asn Gln Gly Ser Pro Ile Val Ser Leu Thr His Val Asn Asn Tyr Gly 
        275                 280                 285             


Gly Gln Asp Asn Arg Asn Asn Ala Ala Trp Ile Gly Asp Lys Met Ile 
    290                 295                 300                 


Tyr Gly Asp Gly Asp Gly Arg Thr Phe Thr Ser Leu Ser Gly Ala Asn 
305                 310                 315                 320 


Asp Val Val Ala His Ala Leu Thr His Gly Val Thr Gln Glu Thr Ala 
                325                 330                 335     


Asn Leu Glu Tyr Lys Asp Gln Ser Gly Ala Leu Asn Glu Ser Phe Ser 
            340                 345                 350         


Asp Val Phe Gly Tyr Phe Val Asp Asp Glu Asp Phe Leu Met Gly Glu 
        355                 360                 365             


Asp Val Tyr Thr Pro Gly Lys Glu Gly Asp Ala Leu Arg Ser Met Ser 
    370                 375                 380                 


Asn Pro Glu Gln Phe Gly Gln Pro Ala His Met Lys Asp Tyr Val Phe 
385                 390                 395                 400 


Thr Glu Lys Asp Asn Gly Gly Val His Thr Asn Ser Gly Ile Pro Asn 
                405                 410                 415     


Lys Ala Ala Tyr Asn Val Ile Gln Ala Ile Gly Lys Ser Lys Ser Glu 
            420                 425                 430         


Gln Ile Tyr Tyr Arg Ala Leu Thr Glu Tyr Leu Thr Ser Asn Ser Asn 
        435                 440                 445             


Phe Lys Asp Ser Lys Asp Ala Leu Tyr Gln Ala Ala Lys Asp Leu Tyr 
    450                 455                 460                 


Asp Glu Gln Thr Ala Glu Gln Val Tyr Glu Ala Trp Asn Glu Val Gly 
465                 470                 475                 480 


Val Glu Gly Ser Gly Gly Gly Ala Ala Gln Val Asp Glu Ala Gln Lys 
                485                 490                 495     


Asn Ala Phe Tyr Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln 
            500                 505                 510         


Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser Gln Ser Ala 
        515                 520                 525             


Lys Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    530                 535                 540                 


Ala Asp Ala Gln Gln Asn Asn Val Asn Lys Asp Gln Lys Ser Ala Phe 
545                 550                 555                 560 


Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly 
                565                 570                 575     


Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser Gln Ser Thr Lys Val Leu 
            580                 585                 590         


Gly Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn 
        595                 600                 605             


Asn Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu Asn Met 
    610                 615                 620                 


Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
625                 630                 635                 640 


Asp Ala Pro Ser Gln Ser Ala Lys Leu Leu Ser Glu Ala Lys Lys Leu 
                645                 650                 655     


Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Lys Val Asn Lys Glu Gln 
            660                 665                 670         


Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu 
        675                 680                 685             


Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser Gln Ser 
    690                 695                 700                 


Ala Lys Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro 
705                 710                 715                 720 


Lys Ala Asp Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu 
                725                 730                 735     


Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile 
            740                 745                 750         


Gln Ser Leu Lys Asp Ala Pro Ser Val Ser Lys Lys Ile Leu Ala Glu 
        755                 760                 765             


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    770                 775                 


<210>  66
<211>  1082
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  66

Asn Thr Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg 
1               5                   10                  15      


Thr Glu Asp Val Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys 
    50                  55                  60                  


Gly Ser Gly Tyr Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr 
65                  70                  75                  80  


Asn Ile Gly Leu Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr 
                85                  90                  95      


Leu Pro Lys Asn Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly 
            100                 105                 110         


Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn 
        115                 120                 125             


Gly Ser Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr 
    130                 135                 140                 


Val Ser Glu Val Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val 
145                 150                 155                 160 


Lys Ala Asn Glu Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp 
                165                 170                 175     


Arg Tyr Leu Phe Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg 
            180                 185                 190         


Glu Tyr Phe Ala Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly 
        195                 200                 205             


Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser 
    210                 215                 220                 


Asp Thr Ser Glu Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr 
225                 230                 235                 240 


Tyr Ala Thr Leu Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His 
                245                 250                 255     


Asn Ala Phe Val Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp 
            260                 265                 270         


Lys Thr His Glu Ile Lys Val Lys Gly His Asn Gly Ser Gly Gly Gly 
        275                 280                 285             


Ala Gln Thr Lys Tyr Gly Asp Gln Ser Glu Lys Gly Ser Gln Ser Val 
    290                 295                 300                 


Ser Asn Lys Asn Asn Lys Ile His Ile Ala Ile Val Asn Glu Asp Gln 
305                 310                 315                 320 


Pro Thr Thr Tyr Asn Gly Lys Lys Val Glu Leu Gly Gln Ala Phe Ile 
                325                 330                 335     


Lys Arg Leu Ala Asn Glu Lys Asn Tyr Lys Phe Glu Thr Val Thr Arg 
            340                 345                 350         


Asn Val Ala Glu Ser Gly Leu Lys Asn Gly Gly Tyr Gln Val Met Ile 
        355                 360                 365             


Val Ile Pro Glu Asn Phe Ser Lys Leu Ala Met Gln Leu Asp Ala Lys 
    370                 375                 380                 


Thr Pro Ser Lys Ile Ser Leu Gln Tyr Lys Thr Ala Val Gly Gln Lys 
385                 390                 395                 400 


Glu Glu Val Ala Lys Asn Thr Glu Lys Val Val Ser Asn Val Leu Asn 
                405                 410                 415     


Asp Phe Asn Lys Asn Leu Val Glu Ile Tyr Leu Thr Ser Ile Ile Asp 
            420                 425                 430         


Asn Leu His Asn Ala Gln Lys Asn Val Gly Ala Ile Met Thr Arg Glu 
        435                 440                 445             


His Gly Val Asn Ser Lys Phe Ser Asn Tyr Leu Leu Asn Pro Ile Asn 
    450                 455                 460                 


Asp Phe Pro Glu Leu Phe Thr Asp Thr Leu Val Asn Ser Ile Ser Ala 
465                 470                 475                 480 


Asn Lys Asp Ile Thr Lys Trp Phe Gln Thr Tyr Asn Lys Ser Leu Leu 
                485                 490                 495     


Ser Ala Asn Ser Asp Thr Phe Arg Val Asn Thr Asp Tyr Asn Val Ser 
            500                 505                 510         


Thr Leu Ile Glu Lys Gln Asn Ser Leu Phe Asp Glu His Asn Thr Ala 
        515                 520                 525             


Met Asp Lys Met Leu Gln Asp Tyr Lys Ser Gln Lys Asp Ser Val Glu 
    530                 535                 540                 


Leu Asp Asn Tyr Ile Asn Ala Leu Lys Gln Met Asp Ser Gln Ile Asp 
545                 550                 555                 560 


Gln Gln Ser Ser Met Gln Asp Thr Gly Lys Glu Glu Tyr Lys Gln Thr 
                565                 570                 575     


Val Lys Glu Asn Leu Asp Lys Leu Arg Glu Ile Ile Gln Ser Gln Glu 
            580                 585                 590         


Ser Pro Phe Ser Lys Gly Met Ile Glu Asp Tyr Arg Lys Gln Leu Thr 
        595                 600                 605             


Glu Ser Leu Gln Asp Glu Leu Ala Asn Asn Lys Asp Leu Gln Asp Ala 
    610                 615                 620                 


Leu Asn Ser Ile Lys Met Asn Asn Ala Gln Phe Ala Glu Asn Leu Glu 
625                 630                 635                 640 


Lys Gln Leu His Asp Asp Ile Val Lys Glu Pro Asp Ser Asp Thr Thr 
                645                 650                 655     


Phe Ile Tyr Asn Met Ser Lys Gln Asp Phe Ile Ala Ala Gly Leu Asn 
            660                 665                 670         


Glu Asp Glu Ala Asn Lys Tyr Glu Ala Ile Val Lys Glu Ala Lys Arg 
        675                 680                 685             


Tyr Lys Asn Glu Tyr Asn Leu Lys Lys Pro Leu Ala Glu His Ile Asn 
    690                 695                 700                 


Leu Thr Asp Tyr Asp Asn Gln Val Ala Gln Asp Thr Ser Ser Leu Ile 
705                 710                 715                 720 


Asn Asp Gly Val Lys Val Gln Arg Thr Glu Thr Ile Lys Ser Asn Asp 
                725                 730                 735     


Ile Asn Gln Leu Thr Val Ala Thr Asp Pro His Phe Asn Phe Glu Gly 
            740                 745                 750         


Asp Ile Lys Ile Asn Gly Lys Lys Tyr Asp Ile Lys Asp Gln Ser Val 
        755                 760                 765             


Gln Leu Asp Thr Ser Asn Lys Glu Tyr Lys Val Glu Val Asn Gly Val 
    770                 775                 780                 


Ala Lys Leu Lys Lys Asp Ala Glu Lys Asp Phe Leu Lys Asp Lys Thr 
785                 790                 795                 800 


Met His Leu Gln Leu Leu Phe Gly Gln Ala Asn Arg Gln Asp Glu Pro 
                805                 810                 815     


Asn Asp Lys Lys Ala Thr Ser Val Val Asp Val Thr Leu Asn His Asn 
            820                 825                 830         


Leu Asp Gly Arg Leu Ser Lys Asp Ala Leu Ser Gln Gln Leu Ser Ala 
        835                 840                 845             


Leu Ser Arg Phe Asp Ala His Tyr Lys Met Tyr Thr Asp Thr Lys Gly 
    850                 855                 860                 


Arg Glu Asp Lys Pro Phe Asp Asn Lys Arg Leu Ile Asp Met Met Val 
865                 870                 875                 880 


Asp Gln Val Ile Asn Asp Met Glu Ser Phe Lys Asp Asp Lys Val Ala 
                885                 890                 895     


Val Leu His Gln Ile Asp Ser Met Glu Glu Asn Ser Asp Lys Leu Ile 
            900                 905                 910         


Asp Asp Ile Leu Asn Asn Lys Lys Asn Thr Thr Lys Asn Lys Glu Asp 
        915                 920                 925             


Ile Ser Lys Leu Ile Asp Gln Leu Glu Asn Val Lys Lys Thr Phe Ala 
    930                 935                 940                 


Glu Glu Pro Gln Glu Pro Lys Ile Asp Lys Gly Lys Asn Asp Glu Phe 
945                 950                 955                 960 


Asn Thr Met Ser Ser Asn Leu Asp Lys Glu Ile Ser Arg Ile Ser Glu 
                965                 970                 975     


Lys Ser Thr Gln Leu Leu Ser Asp Thr Gln Glu Ser Lys Thr Ile Ala 
            980                 985                 990         


Asp Ser Val Ser Gly Gln Leu Asn  Gln Leu Asp Asn Asn  Val Asn Lys 
        995                 1000                 1005             


Leu His  Ala Thr Gly Arg Ala  Leu Gly Val Arg Ala  Asn Asp Leu 
    1010                 1015                 1020             


Asn Arg  Gln Met Ala Lys Asn  Asp Lys Asp Asn Glu  Leu Phe Ala 
    1025                 1030                 1035             


Lys Glu  Phe Lys Lys Val Leu  Gln Asn Ser Lys Asp  Gly Asp Arg 
    1040                 1045                 1050             


Gln Asn  Gln Ala Leu Lys Ala  Phe Met Ser Asn Pro  Val Gln Lys 
    1055                 1060                 1065             


Lys Asn  Leu Glu Asn Val Leu  Ala Asn Asn Gly Asn  Thr Asp 
    1070                 1075                 1080         


<210>  67
<211>  696
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  67

Met Asp Ile Gly Lys Lys His Val Ile Pro Lys Ser Gln Tyr Arg Arg 
1               5                   10                  15      


Lys Arg Arg Glu Phe Phe His Asn Glu Asp Arg Glu Glu Asn Leu Asn 
            20                  25                  30          


Gln His Gln Asp Lys Gln Asn Ile Asp Asn Thr Thr Ser Lys Lys Ala 
        35                  40                  45              


Asp Lys Gln Ile His Lys Asp Ser Ile Asp Lys His Glu Arg Phe Lys 
    50                  55                  60                  


Asn Ser Leu Ser Ser His Leu Glu Gln Arg Asn Arg Asp Val Asn Glu 
65                  70                  75                  80  


Asn Lys Ala Glu Glu Ser Lys Ser Asn Gln Asp Ser Lys Ser Ala Tyr 
                85                  90                  95      


Asn Arg Asp His Tyr Leu Thr Asp Asp Val Ser Lys Lys Gln Asn Ser 
            100                 105                 110         


Leu Asp Ser Val Asp Gln Asp Thr Glu Lys Ser Lys Tyr Tyr Glu Gln 
        115                 120                 125             


Asn Ser Glu Ala Thr Leu Ser Thr Lys Ser Thr Asp Lys Val Glu Ser 
    130                 135                 140                 


Thr Glu Met Arg Lys Leu Ser Ser Asp Lys Asn Lys Val Gly His Glu 
145                 150                 155                 160 


Glu Gln His Val Leu Ser Lys Pro Ser Glu His Asp Lys Glu Thr Arg 
                165                 170                 175     


Ile Asp Ser Glu Ser Ser Arg Thr Asp Ser Asp Ser Ser Met Gln Thr 
            180                 185                 190         


Glu Lys Ile Lys Lys Asp Ser Ser Asp Gly Asn Lys Ser Ser Asn Leu 
        195                 200                 205             


Lys Ser Glu Val Ile Ser Asp Lys Ser Asn Thr Val Pro Lys Leu Ser 
    210                 215                 220                 


Glu Ser Asp Asp Glu Val Asn Asn Gln Lys Pro Leu Thr Leu Pro Glu 
225                 230                 235                 240 


Glu Gln Lys Leu Lys Arg Gln Gln Ser Gln Asn Glu Gln Thr Lys Thr 
                245                 250                 255     


Tyr Thr Tyr Gly Asp Ser Glu Gln Asn Asp Lys Ser Asn His Glu Asn 
            260                 265                 270         


Asp Leu Ser His His Ile Pro Ser Ile Ser Asp Asp Lys Asp Asn Val 
        275                 280                 285             


Met Arg Glu Asn His Ile Val Asp Asp Asn Pro Asp Asn Asp Ile Asn 
    290                 295                 300                 


Thr Pro Ser Leu Ser Lys Thr Asp Asp Asp Arg Lys Leu Asp Glu Lys 
305                 310                 315                 320 


Ile His Val Glu Asp Lys His Lys Gln Asn Ala Asp Ser Ser Glu Thr 
                325                 330                 335     


Val Gly Tyr Gln Ser Gln Ser Thr Ala Ser His Arg Ser Thr Glu Lys 
            340                 345                 350         


Arg Asn Ile Ser Ile Asn Asp His Asp Lys Leu Asn Gly Gln Lys Thr 
        355                 360                 365             


Asn Thr Lys Thr Ser Ala Asn Asn Asn Gln Lys Lys Ala Thr Ser Lys 
    370                 375                 380                 


Leu Asn Lys Gly Arg Ala Thr Asn Asn Asn Tyr Ser Asp Ile Leu Lys 
385                 390                 395                 400 


Lys Phe Trp Met Met Tyr Trp Pro Lys Gly Ser Gly Gly Gly Ala Asp 
                405                 410                 415     


Ile Gly Ser Asn Thr Thr Val Lys Thr Gly Asp Leu Val Thr Tyr Asp 
            420                 425                 430         


Lys Glu Asn Gly Met Leu Lys Lys Val Phe Tyr Ser Phe Ile Asp Asp 
        435                 440                 445             


Lys Asn His Asn Lys Lys Leu Leu Val Ile Arg Thr Lys Gly Thr Ile 
    450                 455                 460                 


Ala Gly Gln Tyr Arg Val Tyr Ser Glu Glu Gly Ala Asn Lys Ser Gly 
465                 470                 475                 480 


Leu Ala Trp Pro Ser Ala Phe Lys Val Gln Leu Gln Leu Pro Asp Asn 
                485                 490                 495     


Glu Val Ala Gln Ile Ser Asp Tyr Tyr Pro Arg Asn Ser Ile Asp Thr 
            500                 505                 510         


Lys Glu Tyr Met Ser Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr 
        515                 520                 525             


Gly Asp Asp Thr Gly Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser 
    530                 535                 540                 


Ile Gly His Thr Leu Lys Tyr Val Gln Pro Asp Phe Lys Thr Ile Leu 
545                 550                 555                 560 


Glu Ser Pro Thr Asp Lys Lys Val Gly Trp Lys Val Ile Phe Asn Asn 
                565                 570                 575     


Met Val Asn Gln Asn Trp Gly Pro Tyr Asp Arg Asp Ser Trp Asn Pro 
            580                 585                 590         


Val Tyr Gly Asn Gln Leu Phe Met Lys Thr Arg Asn Gly Ser Met Lys 
        595                 600                 605             


Ala Ala Asp Asn Phe Leu Asp Pro Asn Lys Ala Ser Ser Leu Leu Ser 
    610                 615                 620                 


Ser Gly Phe Ser Pro Asp Phe Ala Thr Val Ile Thr Met Asp Arg Lys 
625                 630                 635                 640 


Ala Ser Lys Gln Gln Thr Asn Ile Asp Val Ile Tyr Glu Arg Val Arg 
                645                 650                 655     


Asp Asp Tyr Gln Leu His Trp Thr Ser Thr Asn Trp Lys Gly Thr Asn 
            660                 665                 670         


Thr Lys Asp Lys Trp Ile Asp Arg Ser Ser Glu Arg Tyr Lys Ile Asp 
        675                 680                 685             


Trp Glu Lys Glu Glu Met Thr Asn 
    690                 695     


<210>  68
<211>  763
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion protein

<400>  68

Asn Asn Val Asn Lys Asn Asp Arg Met Asn Asp Asn Asn Asp Ala Asp 
1               5                   10                  15      


Ala Gln Lys Tyr Thr Thr Thr Met Lys Asn Ala Asn Asn Thr Val Lys 
            20                  25                  30          


Ser Val Val Thr Val Glu Asn Glu Thr Ser Lys Asp Ser Ser Leu Pro 
        35                  40                  45              


Lys Asp Lys Ala Ser Gln Asp Glu Val Gly Ser Gly Val Val Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Asp Thr Leu Tyr Ile Val Thr Asn Ala His Val Val Gly 
65                  70                  75                  80  


Asp Lys Glu Asn Gln Lys Ile Thr Phe Ser Asn Asn Lys Ser Val Val 
                85                  90                  95      


Gly Lys Val Leu Gly Lys Asp Lys Trp Ser Asp Leu Ala Val Val Lys 
            100                 105                 110         


Ala Thr Ser Ser Asp Ser Ser Val Lys Glu Ile Ala Ile Gly Asp Ser 
        115                 120                 125             


Asn Asn Leu Val Leu Gly Glu Pro Ile Leu Val Val Gly Asn Pro Leu 
    130                 135                 140                 


Gly Val Asp Phe Lys Gly Thr Val Thr Glu Gly Ile Ile Ser Gly Leu 
145                 150                 155                 160 


Asn Arg Asn Val Pro Ile Asp Phe Asp Lys Asp Asn Lys Tyr Asp Met 
                165                 170                 175     


Leu Met Lys Ala Phe Gln Ile Asp Ala Ser Val Asn Pro Gly Asn Ala 
            180                 185                 190         


Gly Gly Ala Val Val Asn Arg Glu Gly Lys Leu Ile Gly Val Val Ala 
        195                 200                 205             


Ala Lys Ile Ser Met Pro Asn Val Glu Asn Met Ser Phe Ala Ile Pro 
    210                 215                 220                 


Val Asn Glu Val Gln Lys Ile Val Lys Asp Leu Glu Thr Lys Gly Lys 
225                 230                 235                 240 


Ile Asp Tyr Pro Asp Val Gly Val Lys Met Lys Asn Ile Ala Ser Leu 
                245                 250                 255     


Asn Ser Phe Glu Arg Gln Ala Val Lys Leu Pro Gly Lys Val Lys Asn 
            260                 265                 270         


Gly Val Val Val Asp Gln Val Asp Asn Asn Gly Leu Ala Asp Gln Ser 
        275                 280                 285             


Gly Leu Lys Lys Gly Asp Val Ile Thr Glu Leu Asp Gly Lys Leu Leu 
    290                 295                 300                 


Glu Asp Asp Leu Arg Phe Arg Gln Ile Ile Phe Ser His Lys Asp Asp 
305                 310                 315                 320 


Leu Lys Ser Ile Thr Ala Lys Ile Tyr Arg Asp Gly Lys Glu Lys Glu 
                325                 330                 335     


Ile Asn Ile Lys Leu Lys Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly 
            340                 345                 350         


Gly Ala Met Asp Ile Gly Lys Lys His Val Ile Pro Lys Ser Gln Tyr 
        355                 360                 365             


Arg Arg Lys Arg Arg Glu Phe Phe His Asn Glu Asp Arg Glu Glu Asn 
    370                 375                 380                 


Leu Asn Gln His Gln Asp Lys Gln Asn Ile Asp Asn Thr Thr Ser Lys 
385                 390                 395                 400 


Lys Ala Asp Lys Gln Ile His Lys Asp Ser Ile Asp Lys His Glu Arg 
                405                 410                 415     


Phe Lys Asn Ser Leu Ser Ser His Leu Glu Gln Arg Asn Arg Asp Val 
            420                 425                 430         


Asn Glu Asn Lys Ala Glu Glu Ser Lys Ser Asn Gln Asp Ser Lys Ser 
        435                 440                 445             


Ala Tyr Asn Arg Asp His Tyr Leu Thr Asp Asp Val Ser Lys Lys Gln 
    450                 455                 460                 


Asn Ser Leu Asp Ser Val Asp Gln Asp Thr Glu Lys Ser Lys Tyr Tyr 
465                 470                 475                 480 


Glu Gln Asn Ser Glu Ala Thr Leu Ser Thr Lys Ser Thr Asp Lys Val 
                485                 490                 495     


Glu Ser Thr Glu Met Arg Lys Leu Ser Ser Asp Lys Asn Lys Val Gly 
            500                 505                 510         


His Glu Glu Gln His Val Leu Ser Lys Pro Ser Glu His Asp Lys Glu 
        515                 520                 525             


Thr Arg Ile Asp Ser Glu Ser Ser Arg Thr Asp Ser Asp Ser Ser Met 
    530                 535                 540                 


Gln Thr Glu Lys Ile Lys Lys Asp Ser Ser Asp Gly Asn Lys Ser Ser 
545                 550                 555                 560 


Asn Leu Lys Ser Glu Val Ile Ser Asp Lys Ser Asn Thr Val Pro Lys 
                565                 570                 575     


Leu Ser Glu Ser Asp Asp Glu Val Asn Asn Gln Lys Pro Leu Thr Leu 
            580                 585                 590         


Pro Glu Glu Gln Lys Leu Lys Arg Gln Gln Ser Gln Asn Glu Gln Thr 
        595                 600                 605             


Lys Thr Tyr Thr Tyr Gly Asp Ser Glu Gln Asn Asp Lys Ser Asn His 
    610                 615                 620                 


Glu Asn Asp Leu Ser His His Ile Pro Ser Ile Ser Asp Asp Lys Asp 
625                 630                 635                 640 


Asn Val Met Arg Glu Asn His Ile Val Asp Asp Asn Pro Asp Asn Asp 
                645                 650                 655     


Ile Asn Thr Pro Ser Leu Ser Lys Thr Asp Asp Asp Arg Lys Leu Asp 
            660                 665                 670         


Glu Lys Ile His Val Glu Asp Lys His Lys Gln Asn Ala Asp Ser Ser 
        675                 680                 685             


Glu Thr Val Gly Tyr Gln Ser Gln Ser Thr Ala Ser His Arg Ser Thr 
    690                 695                 700                 


Glu Lys Arg Asn Ile Ser Ile Asn Asp His Asp Lys Leu Asn Gly Gln 
705                 710                 715                 720 


Lys Thr Asn Thr Lys Thr Ser Ala Asn Asn Asn Gln Lys Lys Ala Thr 
                725                 730                 735     


Ser Lys Leu Asn Lys Gly Arg Ala Thr Asn Asn Asn Tyr Ser Asp Ile 
            740                 745                 750         


Leu Lys Lys Phe Trp Met Met Tyr Trp Pro Lys 
        755                 760             


<210>  69
<211>  1746
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fuson protein encoding DNA

<400>  69
aacaccaaca tcgagaacat tggcgatggt gcggaagtga ttaagcgtac cgaagacgtt       60

agcagcaaga aatggggcgt gacccagaac gttcaattcg acttcgtgaa ggataagaag      120

tacaacaagg atgcgctgat cgttaagatg cagggtttca ttaacagccg taccagcttt      180

agcgacgtta aaggcagcgg ttacgagctg accaagcgta tgatctggcc gttccaatat      240

aacattggcc tgaccaccaa agatccgaac gtgagcctga tcaactacct gccgaagaac      300

aaaattgaaa ccaccgacgt tggccagacc ctgggttata acatcggtgg caacttccaa      360

agcgcgccga gcattggtgg caacggtagc tttaactaca gcaaaaccat cagctacacc      420

cagaagagct atgtgagcga ggttgataaa caaaacagca agagcgtgaa atggggcgtt      480

aaggcgaacg aattcgtgac cccggacggt aagaaaagcg cgcacgatcg ttacctgttt      540

gttcaaagcc cgaacggtcc gaccggtagc gcgcgtgagt attttgcgcc ggacaaccag      600

ctgccgccgc tggtgcaaag cggcttcaac ccgagcttta ttaccaccct gagccacgaa      660

aagggcagca gcgataccag cgagtttgaa atcagctacg gtcgtaacct ggacattacc      720

tatgcgaccc tgttcccgcg taccggtatc tacgcggagc gtaaacacaa cgcgttcgtt      780

aaccgtaact ttgtggttcg ttatgaggtg aactggaaga cccacgaaat caaggttaaa      840

ggtcataacg gtagcggtgg cggtgcgagc gaaaccgaag tgagcgtgcg cagcgcgagc      900

agcgacattg gcagcaacac caccgtgaaa accggtgacc tggttaccta cgataaggaa      960

aacggtatgc tgaagaaagt gttctatagc tttatcgacg ataaaaacca caacaagaaa     1020

ctgctggtga tccgtaccaa gggcaccatt gcgggccagt accgtgttta tagcgaggaa     1080

ggcgcgaaca aaagcggtct ggcgtggccg agcgcgttta aggtgcagct gcaactgccg     1140

gacaacgagg ttgcgcaaat cagcgattac tatccgcgta acagcattga caccaaagaa     1200

tacatgagca ccctgaccta tggcttcaac ggtaacgtta ccggcgacga taccggcaag     1260

atcggcggtc tgattggcgc gaacgtgagc atcggtcaca ccctgaaata cgttcagccg     1320

gattttaaga ccattctgga gagcccgacc gacaagaaag tgggctggaa agttatcttc     1380

aacaacatgg tgaaccagaa ctggggtccg tacgaccgtg atagctggaa cccggtttat     1440

ggcaaccaac tgttcatgaa aacccgtaac ggtagcatga aggcggcgga caactttctg     1500

gatccgaaca aggcgagcag cctgctgagc agcggtttca gcccggattt tgcgaccgtg     1560

atcaccatgg accgtaaggc gagcaaacag caaaccaaca tcgatgtgat ttacgaacgt     1620

gttcgtgacg attatcaact gcactggacc agcaccaact ggaaaggtac caacaccaag     1680

gacaaatgga tcgatcgtag cagcgagcgt tacaagattg actgggaaaa agaggaaatg     1740

accaac                                                                1746


<210>  70
<211>  2337
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding DNA

<400>  70
atcgacagca agaacaaacc ggcgaacagc gatattaagt tcgaagtgac ccagaaaagc       60

gatgcggtta aagcgctgaa ggaactgccg aagagcgaga acgtgaaaaa catctaccag      120

gactatgcgg tgaccgacgt taaaaccgat aagaaaggtt ttacccacta caccctgcag      180

ccgagcgtgg acggtgttca tgcgccggat aaagaggtga aggttcacgc ggacaaaagc      240

ggcaaggtgg ttctgatcaa cggtgacacc gatgcgaaga aagtgaagcc gaccaacaaa      300

gttaccctga gcaaggacga tgcggcggac aaagcgttca aggcggttaa aattgataag      360

aacaaagcga agaacctgaa agacaaggtg atcaaggaga acaaagttga aattgacggt      420

gatagcaaca aatacgtgta taacgttgaa ctgatcaccg tgaccccgga gattagccac      480

tggaaagtta agatcgatgc gcagaccggc gagattctgg aaaagatgaa cctggtgaaa      540

gaggcggcgg aaaccggcaa aggcaagggc gttctgggcg acaccaagga tatcaacatt      600

aacagcatcg acggtggctt tagcctggaa gatctgaccc accagggtaa actgagcgcg      660

ttcagcttta acgaccagac cggccaagcg accctgatta ccaacgagga cgaaaacttc      720

gtgaaagatg aacagcgtgc gggtgttgat gcgaactact atgcgaagca aacctacgac      780

tactataaag atacctttgg ccgtgagagc tatgacaacc agggtagccc gatcgtgagc      840

ctgacccacg ttaacaacta cggtggccaa gataaccgta acaacgcggc gtggatcggc      900

gacaagatga tttatggtga cggcgatggt cgtaccttca ccagcctgag cggtgcgaac      960

gatgttgttg cgcatgcgct gacccatggt gtgacccagg aaaccgcgaa cctggagtac     1020

aaggatcaaa gcggcgcgct gaacgaaagc ttcagcgacg tgttcggtta ctttgttgac     1080

gatgaagact ttctgatggg cgaggatgtt tataccccgg gcaaagaagg tgacgcgctg     1140

cgtagcatga gcaacccgga gcagttcggt caaccggcgc acatgaagga ctacgtgttt     1200

accgagaaag ataacggtgg cgttcacacc aacagcggta tcccgaacaa ggcggcgtat     1260

aacgtgatcc aggcgattgg caaaagcaag agcgaacaaa tttactatcg tgcgctgacc     1320

gagtacctga ccagcaacag caacttcaag gacagcaaag atgcgctgta ccaggcggcg     1380

aaggacctgt atgatgagca gaccgcggaa caagtttatg aggcgtggaa cgaagtgggc     1440

gttgagggta gcggtggcgg tgcggcgcag gtggacgaag cgcagaagaa cgcgttctac     1500

caagttctga acatgccgaa cctgaacgcg gatcagcgta acggttttat ccaaagcctg     1560

aaggatgcgc cggcgaaaag cgcgaacgtg ctgggtgaag cgcagaagct gaacgacagc     1620

caagcgccga aagcggatgc gcagcaaaac aacgttaaca aggaccagaa aagcgcgttc     1680

tatgaaatcc tgaatatgcc gaatctgaac gaggcgcagc gtaacggttt tattcagagc     1740

ctgaaagacg cgccggcgaa aagcaccaac gtgctgggcg aagcgaagaa actgaacgag     1800

agccaggcgc cgaaggcgga caacaacgtt aacaaggaac agaagaacgc gttttatgag     1860

atcctgaata tgccgaacct gaacgaggaa caacgcaacg gttttattca atctttaaaa     1920

gacgcgccgg cgaagagcgc gaacctgctg agcgaggcga agaaactgaa tgagagccag     1980

gcgccgaaag cggacaacaa ggtgaacaaa gaacaaaaga acgcgttcta tgagatcctg     2040

cacctgccga atctgaatga agaacagcgt aacggcttta ttcagtcttt aaaagatgct     2100

cctgctaagt ctgcgaacct gctggcggag gcgaagaaac tgaacgacgc gcaggcgccg     2160

aaggcggata acaaagtgaa taaagagcag aagaacgctt tttatgagat tctgcacctg     2220

ccgaacctga ccgaggaaca acgtaatggc ttcattcaga gcctgaaaga tgcgccggcg     2280

aagagcaagg aaattctggc ggaagcgaag aaactgaatg acgcgcaggc gccgaaa        2337


<210>  71
<211>  2118
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding sequence

<400>  71
atggacatcg gtaagaaaca cgtgattccg aagagccagt accgtcgtaa acgtcgtgag       60

ttctttcaca acgaagaccg tgaggaaaac ctgaaccagc accaagataa gcagaacatt      120

gacaacacca ccagcaagaa agcggataag caaatccaca aagatagcat tgacaagcac      180

gagcgtttca aaaacagcct gagcagccac ctggagcagc gtaaccgtga cgtgaacgaa      240

aacaaggcgg aggaaagcaa aagcaaccaa gacagcaaaa gcgcgtacaa ccgtgatcac      300

tatctgaccg acgatgtgag caagaaacag aacagcctgg atagcgttga tcaagacacc      360

gaaaagagca aatactatga gcagaacagc gaagcgaccc tgagcaccaa gagcaccgac      420

aaagttgaga gcaccgaaat gcgtaagctg agcagcgata agaacaaagt gggccacgag      480

gaacagcacg ttctgagcaa gccgagcgag cacgataaag aaacccgtat cgacagcgag      540

agcagccgta ccgatagcga cagcagcatg caaaccgaaa agattaagaa agatagcagc      600

gacggtaaca agagcagcaa cctgaaaagc gaggtgatca gcgacaagag caacaccgtt      660

ccgaaactga gcgagagcga cgatgaagtt aacaaccaga aaccgctgac cctgccggag      720

gaacaaaagc tgaaacgtca gcaaagccag aacgagcaaa ccaagaccta cacctatggc      780

gatagcgagc agaacgacaa aagcaaccac gaaaacgacc tgagccacca catcccgagc      840

attagcgacg ataaggataa cgtgatgcgt gaaaaccaca tcgttgacga taacccggat      900

aacgacatta acaccccgag cctgagcaaa accgacgatg accgtaagct ggatgagaaa      960

atccacgtgg aagacaagca caaacagaac gcggatagca gcgaaaccgt tggctaccag     1020

agccaaagca ccgcgagcca ccgtagcacc gaaaagcgta acatcagcat taacgatcac     1080

gacaaactga acggtcagaa gaccaacacc aaaaccagcg cgaacaacaa ccaaaagaaa     1140

gcgaccagca agctgaacaa aggccgtgcg accaacaaca actacagcga catcctgaag     1200

aaattctgga tgatgtactg gccgaagggt agcggtggcg gtgcggcgca ggtggatgag     1260

gcgcagaaga acgcgttcta tcaggttctg aacatgccga acctgaacgc ggaccagcgt     1320

aacggcttta tccaaagcct gaaggatgcg ccggcgaaaa gcgcgaacgt gctgggtgaa     1380

gcgcagaagc tgaacgacag ccaagcgccg aaagcggatg cgcagcaaaa caacgttaac     1440

aaggaccaga agagcgcgtt ctacgagatc ctgaatatgc cgaatctgaa cgaagcgcag     1500

cgtaacggct ttattcaaag cctgaaggac gcgccggcga aaagcaccaa tgtgctgggc     1560

gaggcgaaga aactgaacga aagccaggcg ccgaaagcgg ataacaacgt taacaaggaa     1620

cagaagaacg cgttttatga aatcctgaat atgccgaacc tgaacgagga acaacgcaat     1680

ggtttcatcc agagcctgaa agatgcgccg gcgaagagcg cgaacctgct gagcgaagcg     1740

aagaaactga atgaaagcca ggcgccgaag gcggataaca aggtgaacaa agagcaaaag     1800

aacgcgttct acgaaatcct gcacctgccg aatctgaatg aggaacagcg taacggtttc     1860

atccaatctt taaaagatgc tcctgcgaaa agcgcgaacc tgctggcgga agcgaagaaa     1920

ctgaacgatg cgcaagcgcc gaaggcggac aacaaagtta acaaggagca gaagaacgcg     1980

ttttacgaga ttctgcacct gccgaacctg accgaggaac aacgcaacgg tttcatccaa     2040

agtttaaaag atgctcccgc gaaaagcaaa gagattctgg cggaggcgaa gaaactgaat     2100

gatgcgcagg cgccgaaa                                                   2118


<210>  72
<211>  2964
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding DNA

<400>  72
aaagttgcga agcagggcca atacaagaac caggatccga tcgtgctggt tcacggcttc       60

aacggtttta ccgacgatat taacccgagc gtgctggcgc actattgggg tggcaacaag      120

atgaacatcc gtcaagacct ggaggaaaac ggttataaag cgtacgaggc gagcattagc      180

gcgtttggca gcaactacga tcgtgcggtt gaactgtact attacatcaa gggtggccgt      240

gtggactatg gtgcggcgca tgcggcgaag tatggtcatg agcgttatgg taaaacctac      300

gaaggcatct ataaagactg gaagccgggt cagaaagtgc acctggttgg ccacagcatg      360

ggtggccaga ccattcgtca actggaggaa ctgctgcgta acggtagccg tgaggaaatc      420

gagtaccaaa agaaacacgg tggcgaaatt agcccgctgt tcaaaggcaa caacgataac      480

atgatcagca gcattaccac cctgggtacc ccgcacaacg gtacccatgc gagcgacctg      540

gcgggtaacg aggcgctggt tcgtcagatc gtgttcgata ttggcaagat gtttggtaac      600

aaaaacagcc gtgttgactt cggtctggcg cagtggggcc tgaagcaaaa accgaacgaa      660

agctatatcg attacgtgaa acgtgttaag cagagcaacc tgtggaagag caaagataac      720

ggtttttatg acctgacccg tgagggtgcg accgacctga accgtaagac cagcctgaac      780

ccgaacattg tttataaaac ctacaccggc gaagcgaccc acaaggcgct gaacagcgat      840

cgtcagaaag cggacctgaa catgttcttt ccgttcgtga tcaccggcaa cctgattggt      900

aaagcgaccg agaaggaatg gcgtgagaac gacggtctgg tgagcgttat cagcagccag      960

cacccgttta accaagcgta caccaacgcg accgataaaa tccagaaggg tatttggcaa     1020

gttaccccga ccaagcacga ctgggatcac gtggacttcg ttggccagga cagcagcgat     1080

accgtgcgta cccgtgagga actgcaagat ttttggcacc acctggcgga cgatctggtt     1140

aaaaccgaga aggtgaccga caccaaacaa ggtagcggtg gcggtgcgga taccccgcaa     1200

aaggacacca ccgcgaaaac caccagccac gacagcaaga aaagcaacga cgatgaaacc     1260

agcaaagata ccaccagcaa agacatcgat aaggcggaca acaacaacac cagcaaccag     1320

gacaacaacg ataagaaatt caagaccatt gacgatagca ccagcgacag caacaacatc     1380

atcgacttca tctacaagaa cctgccgcag accaacatta accaactgct gaccaagaac     1440

aaatacgacg ataactatag cctgaccacc ctgatccaga acctgttcaa cctgaacagc     1500

gacattagcg attatgagca accgcgtaac ggcgagaaga gcaccaacga tagcaacaag     1560

aacagcgaca acagcatcaa aaacgacacc gatacccaga gcagcaaaca agacaaggcg     1620

gataaccaga aagcgccgaa gagcaataac accaagccga gcaccagcaa caaacaaccg     1680

aacagcccga agccgaccca gccgaaccaa agcaacagcc aaccggcgag cgacgataaa     1740

gcgaaccaga agagcagcag caaagacaac caaagcatga gcgacagcgc gctggatagc     1800

atcctggacc agtacagcga ggatgcgaag aaaacccaga aggactatgc gagccaaagc     1860

aagaaagata aaaacgagaa gagcaacacc aaaaacccgc agctgccgac ccaagacgaa     1920

ctgaagcaca aaagcaagcc ggcgcagagc ttcaacaacg atgttaacca aaaggacacc     1980

cgtgcgacca gcctgtttga aaccgacccg agcatcagca acaacgacga tagcggccag     2040

ttcaacgtgg ttgacagcaa agatacccgt caatttgtta agagcattgc gaaagatgcg     2100

caccgtatcg gtcaggacaa cgatatttac gcgagcgtga tgatcgcgca agcgattctg     2160

gagagcgaca gcggccgtag cgcgctggcg aagagcccga accacaacct gttcggcatc     2220

aagggtgcgt ttgagggtaa cagcgtgccg ttcaacaccc tgcaggcgga tggtaacaag     2280

ctgtacagca ttaacgcggg ctttcgtaaa tatccgagca ccaaggagag cctgaaaaac     2340

tatagcgatc tgatcaagaa cggcattgac ggtaaccgta ccatctacaa gccgacctgg     2400

aaaagcgaag cggatagcta taaggacgcg accagccacc tgagcaaaac ctacgcgacc     2460

gacccgaact atgcgaagaa actgaacagc atcattaaac actaccagct gacccaattc     2520

gacgatgagc gtatgccgga cctggataaa tacgaacgta gcatcaagga ttatgacgat     2580

agcagcgacg agttcaagcc gtttcgtgaa gttagcgata gcatgccgta tccgcacggt     2640

cagagcacct ggtacgttta caaccgtatg aaacaatttg gcaccagcat tagcggcgac     2700

ctgggtgatg cgcacaactg gaacaaccgt gcgcagtatc gtgactacca agtgagccat     2760

accccgaagc gtcatgcggc ggtggttttc gaagcgggcc agtttggtgc ggatcaacac     2820

tacggtcacg tggcgttcgt tgagaaggtg aacagcgacg gcagcatcgt tattagcgaa     2880

agcaacgtga aaggcctggg tatcattagc catcgtacca tcaacgcggc ggcggcggag     2940

gaactgagct atattaccgg taaa                                            2964


<210>  73
<211>  3567
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding DNA

<400>  73
caaacaaagt acggagatca atcagaaaag gggtcacaaa gtgtaagcaa caagaacaac       60

aaaatccaca ttgcgatcgt taacgaggac caaccgacca cctataacgg taagaaagtg      120

gaactgggcc aggcgttcat caagcgtctg gcgaacgaga agaactacaa atttgaaacc      180

gtgacccgta acgttgcgga gagcggtctg aagaacggtg gctatcaagt gatgattgtt      240

atcccggaaa acttcagcaa actggcgatg cagctggacg cgaaaacccc gagcaagatt      300

agcctgcaat acaaaaccgc ggtgggccag aaggaagagg tggcgaaaaa caccgagaag      360

gtggttagca acgtgctgaa cgatttcaac aagaacctgg ttgaaattta cctgaccagc      420

atcattgaca acctgcacaa cgcgcagaag aacgtgggtg cgatcatgac ccgtgagcac      480

ggcgttaaca gcaaatttag caactatctg ctgaacccga ttaacgattt cccggaactg      540

tttaccgaca ccctggttaa cagcattagc gcgaacaaag atatcaccaa gtggttccaa      600

acctacaaca aaagcctgct gagcgcgaac agcgatacct ttcgtgtgaa caccgactat      660

aacgttagca ccctgatcga gaagcagaac agcctgttcg acgaacacaa caccgcgatg      720

gataaaatgc tgcaggacta caagagccaa aaagatagcg tggagctgga caactatatt      780

aacgcgctga agcagatgga cagccaaatc gatcagcaaa gcagcatgca agataccggt      840

aaagaggaat acaagcagac cgttaaagag aacctggaca aactgcgtga gatcattcag      900

agccaagaaa gcccgttcag caaaggcatg atcgaagatt atcgtaagca actgaccgag      960

agcctgcagg acgaactggc gaacaacaaa gacctgcagg atgcgctgaa cagcatcaag     1020

atgaacaacg cgcaatttgc ggagaacctg gaaaaacagc tgcacgacga tattgtgaag     1080

gagccggaca gcgataccac cttcatttac aacatgagca agcaggattt tatcgcggcg     1140

ggtctgaacg aggacgaagc gaacaaatat gaggcgatcg tgaaggaagc gaaacgttat     1200

aaaaacgagt acaacctgaa gaaaccgctg gcggaacaca ttaacctgac cgactacgat     1260

aaccaggttg cgcaagatac cagcagcctg attaacgacg gtgtgaaagt tcaacgtacc     1320

gagaccatta agagcaacga tatcaaccag ctgaccgtgg cgaccgatcc gcacttcaac     1380

tttgaaggtg acattaaaat caacggcaag aaatacgaca tcaaggatca gagcgtgcaa     1440

ctggacacca gcaacaaaga gtataaggtg gaagttaacg gtgttgcgaa actgaagaaa     1500

gacgcggaga aggatttcct gaaggacaaa accatgcacc tgcagctgct gtttggccag     1560

gcgaaccgtc aagatgaacc gaacgacaag aaagcgacca gcgtggttga cgttaccctg     1620

aaccacaacc tggatggtcg tctgagcaag gacgcgctga gccagcaact gagcgcgctg     1680

agccgtttcg atgcgcacta taaaatgtac accgacacca agggccgtga ggataaaccg     1740

tttgacaaca agcgtctgat tgatatgatg gtggaccaag ttatcaacga catggaaagc     1800

ttcaaagacg ataaggtggc ggttctgcac cagatcgata gcatggagga aaacagcgac     1860

aaactgattg acgatatcct gaacaacaag aaaaacacca ccaagaacaa agaggatatt     1920

agcaagctga tcgaccaact ggaaaacgtt aagaaaacct tcgcggagga accgcaggag     1980

ccgaaaatcg ataagggtaa aaacgacgaa tttaacacca tgagcagcaa cctggacaaa     2040

gagattagcc gtatcagcga aaagagcacc caactgctga gcgataccca ggagagcaag     2100

accattgcgg acagcgtgag cggccagctg aaccaactgg ataacaacgt taacaagctg     2160

catgcgaccg gtcgtgcgct gggtgtgcgt gcgaacgacc tgaaccgtca aatggcgaaa     2220

aacgacaagg ataacgagct gttcgcgaaa gaatttaaga aagttctgca gaacagcaag     2280

gacggtgatc gtcagaacca agcgctgaaa gcgttcatga gcaacccggt gcaaaagaaa     2340

aacctggaaa acgttctggc gaacaacggc aacaccgatg gtagcggtgg cggtgcgaaa     2400

gtggcgaagc agggtcaata caagaaccag gacccgattg tgctggttca cggcttcaac     2460

ggttttaccg acgatatcaa cccgagcgtt ctggcgcact attggggcgg taacaagatg     2520

aacattcgtc aggacctgga ggaaaacggt tataaagcgt acgaggcgag catcagcgcg     2580

tttggcagca actacgatcg tgcggtggaa ctgtactatt acatcaaggg cggtcgtgtt     2640

gactatggtg cggcgcatgc ggcgaaatat ggccacgagc gttatggcaa gacctacgaa     2700

ggcatctata aagactggaa gccgggtcaa aaagtgcacc tggttggcca cagcatgggc     2760

ggtcagacca ttcgtcaact ggaggaactg ctgcgtaacg gtagccgtga ggaaattgag     2820

tatcagaaga aacacggcgg tgaaatcagc ccgctgttca aaggcaacaa cgataacatg     2880

attagcagca tcaccaccct gggtaccccg cacaacggta cccatgcgag cgacctggcg     2940

ggtaacgagg cgctggtgcg tcagattgtt ttcgatatcg gcaaaatgtt tggtaacaag     3000

aacagccgtg tggacttcgg tctggcgcag tggggcctga agcaaaaacc gaacgaaagc     3060

tatatcgatt acgtgaaacg tgttaagcag agcaacctgt ggaagagcaa agataacggt     3120

ttttatgacc tgacccgtga gggtgcgacc gacctgaacc gtaagaccag cctgaacccg     3180

aacattgtgt ataaaaccta caccggtgaa gcgacccaca aagcgctgaa cagcgatcgt     3240

cagaaggcgg acctgaacat gttctttccg ttcgttatta ccggcaacct gatcggcaag     3300

gcgaccgaga aagaatggcg tgagaacgac ggcctggtta gcgttatcag cagccagcac     3360

ccgtttaacc aagcgtacac caacgcgacc gataaaattc agaagggtat ctggcaagtg     3420

accccgacca agcacgactg ggatcacgtg gacttcgttg gccaagacag cagcgatacc     3480

gttcgtaccc gtgaggaact gcaggatttt tggcaccacc tggcggacga tctggtgaaa     3540

accgaaaagg ttaccgacac caaacaa                                         3567


<210>  74
<211>  2415
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding DNA

<400>  74
atggatatag gtaagaaaca cgtaataccc aagtcacaat acaggagaaa acgtcgtgag       60

ttctttcaca acgaagaccg tgaggaaaac ctgaaccagc accaagataa gcagaacatc      120

gacaacacca ccagcaagaa agcggataag caaatccaca aagatagcat tgacaagcac      180

gagcgtttca aaaacagcct gagcagccac ctggagcagc gtaaccgtga cgtgaacgaa      240

aacaaggcgg aggaaagcaa aagcaaccaa gacagcaaaa gcgcgtacaa ccgtgatcac      300

tatctgaccg acgatgtgag caagaaacag aacagcctgg atagcgttga tcaagacacc      360

gaaaagagca aatactatga gcagaacagc gaagcgaccc tgagcaccaa gagcaccgac      420

aaagttgaga gcaccgaaat gcgtaagctg agcagcgata agaacaaagt gggtcacgag      480

gaacagcacg ttctgagcaa gccgagcgag cacgataaag aaacccgtat cgacagcgag      540

agcagccgta ccgatagcga cagcagcatg caaaccgaaa agattaagaa agatagcagc      600

gacggcaaca agagcagcaa cctgaaaagc gaggtgatca gcgacaagag caacaccgtt      660

ccgaaactga gcgagagcga cgatgaagtt aacaaccaga aaccgctgac cctgccggag      720

gaacaaaagc tgaaacgtca gcaaagccag aacgagcaaa ccaagaccta tacctacggt      780

gatagcgagc agaacgacaa aagcaaccac gaaaacgacc tgagccacca catcccgagc      840

attagcgacg ataaggataa cgtgatgcgt gaaaaccaca tcgttgacga taacccggat      900

aacgacatta acaccccgag cctgagcaaa accgacgatg accgtaagct ggatgagaaa      960

attcacgtgg aagacaagca caaacagaac gcggatagca gcgagaccgt tggctaccag     1020

agccaaagca ccgcgagcca ccgtagcacc gaaaagcgta acatcagcat taacgatcac     1080

gacaaactga acggtcagaa gaccaacacc aaaaccagcg cgaacaacaa ccaaaagaaa     1140

gcgaccagca agctgaacaa aggccgtgcg accaacaaca actacagcga catcctgaag     1200

aaattctgga tgatgtattg gccgaagggt agcggtggcg gtgcgaaggt ggcgaaacag     1260

ggccaataca aaaaccagga tccgatcgtg ctggttcacg gcttcaacgg ttttaccgat     1320

gacattaacc cgagcgttct ggcgcactat tggggcggta acaagatgaa catccgtcaa     1380

gacctggagg aaaacggtta taaagcgtac gaggcgagca ttagcgcgtt tggcagcaac     1440

tacgaccgtg cggtggaact gtactattac atcaagggcg gtcgtgttga ttatggtgcg     1500

gcgcatgcgg cgaagtatgg tcatgagcgt tatggtaaaa cctacgaagg catttataag     1560

gactggaaac cgggtcagaa agtgcacctg gttggccaca gcatgggcgg tcagaccatc     1620

cgtcaactgg aggaactgct gcgtaacggt agccgtgagg aaatcgagta tcaaaagaaa     1680

cacggcggtg aaattagccc gctgtttaaa ggcaacaacg acaacatgat cagcagcatt     1740

accaccctgg gtaccccgca caacggtacc catgcgagcg atctggcggg taacgaggcg     1800

ctggtgcgtc agatcgtttt cgacattggc aagatgtttg gtaacaaaaa cagccgtgtg     1860

gatttcggtc tggcgcagtg gggcctgaag caaaaaccga acgaaagcta tattgactac     1920

gtgaagcgtg ttaaacaaag caacctgtgg aagagcaaag ataacggttt ttacgacctg     1980

acccgtgagg gcgcgaccga tctgaaccgt aagaccagcc tgaacccgaa catcgtgtat     2040

aaaacctaca ccggtgaagc gacccacaag gcgctgaaca gcgatcgtca gaaagcggac     2100

ctgaacatgt tctttccgtt cgttatcacc ggcaacctga ttggcaaggc gaccgagaaa     2160

gaatggcgtg agaacgacgg cctggttagc gttatcagca gccagcaccc gtttaaccaa     2220

gcgtacacca acgcgaccga caagatccag aaaggtattt ggcaagtgac cccgaccaag     2280

cacgattggg accacgtgga tttcgttggc caggatagca gcgacaccgt tcgtacccgt     2340

gaggaactgc aagacttttg gcaccacctg gcggatgacc tggtgaagac cgaaaaagtt     2400

accgatacca aacaa                                                      2415


<210>  75
<211>  2637
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusoin protein encoding DNA

<400>  75
gatacacccc aaaaagatac aactgctaaa acaactagtc acgatagcaa gaaaagcaac       60

gacgatgaga ccagcaagga caccaccagc aaagacatcg ataaggcgga taacaacaac      120

accagcaacc aggacaacaa cgataagaaa ttcaagacca ttgacgatag caccagcgac      180

agcaacaaca tcatcgactt catctacaag aacctgccgc agaccaacat taaccaactg      240

ctgaccaaga acaaatacga cgataactat agcctgacca ccctgatcca gaacctgttc      300

aacctgaaca gcgacattag cgattatgag caaccgcgta acggcgagaa gagcaccaac      360

gatagcaaca agaacagcga caacagcatc aaaaacgaca ccgataccca gagcagcaaa      420

caagacaagg cggataacca gaaagcgccg aagagcaata acaccaagcc gagcaccagc      480

aacaaacaac cgaacagccc gaagccgacc cagccgaacc aaagcaacag ccaaccggcg      540

agcgacgata aagcgaacca gaagagcagc agcaaagaca accaaagcat gagcgacagc      600

gcgctggata gcatcctgga ccagtacagc gaagatgcga agaaaaccca gaaggactat      660

gcgagccaaa gcaagaaaga caaaaacgag aagagcaaca ccaaaaaccc gcagctgccg      720

acccaagatg aactgaagca caaaagcaag ccggcgcaga gcttcaacaa cgatgttaac      780

caaaaggaca cccgtgcgac cagcctgttt gagaccgacc cgagcatcag caacaacgac      840

gatagcggcc agttcaacgt ggttgacagc aaagataccc gtcaatttgt taagagcatt      900

gcgaaagacg cgcaccgtat cggccaggac aacgatattt acgcgagcgt gatgatcgcg      960

caagcgattc tggaaagcga tagcggtcgt agcgcgctgg cgaagagccc gaaccacaac     1020

ctgttcggca tcaagggtgc gtttgagggc aacagcgtgc cgttcaacac cctgcaggcg     1080

gacggcaaca agctgtacag cattaacgcg ggttttcgta aatatccgag caccaaggag     1140

agcctgaaaa actacagcga tctgatcaag aacggcattg acggtaaccg taccatctac     1200

aagccgacct ggaaaagcga agcggatagc tataaggacg cgaccagcca cctgagcaaa     1260

acctacgcga ccgatccgaa ctatgcgaag aaactgaaca gcatcattaa acactaccag     1320

ctgacccaat tcgacgatga gcgtatgccg gacctggata aatacgaacg tagcatcaag     1380

gattatgacg atagcagcga cgagttcaag ccgtttcgtg aagttagcga cagcatgccg     1440

tatccgcacg gccagagcac ctggtacgtt tataaccgta tgaaacaatt tggtaccagc     1500

attagcggcg acctgggtga tgcgcacaac tggaacaacc gtgcgcagta ccgtgactat     1560

caagttagcc ataccccgaa acgtcatgcg gcggtggttt ttgaggcggg ccagtttggt     1620

gcggaccaac actacggcca cgtggcgttc gttgagaagg tgaacagcga tggtagcatc     1680

gttattagcg aaagcaacgt gaaaggcctg ggtatcatta gccatcgtac catcaacgcg     1740

gcggcggcgg aggaactgag ctatattacc ggcaaaggta gcggtggcgg tgcggacatt     1800

ggtagcaaca ccaccgttaa gaccggtgat ctggtgacct acgacaaaga aaacggtatg     1860

ctgaagaaag ttttctatag cttcatcgac gataaaaacc acaacaagaa actgctggtt     1920

atccgtacca aaggcaccat tgcgggccag taccgtgtgt atagcgagga aggcgcgaac     1980

aagagcggtc tggcgtggcc gagcgcgttc aaagttcagc tgcaactgcc ggataacgag     2040

gtggcgcaaa tcagcgacta ctatccgcgt aacagcattg ataccaagga atacatgagc     2100

accctgacct atggctttaa cggtaacgtg accggcgacg ataccggtaa aatcggcggt     2160

ctgattggcg cgaacgttag cattggtcac accctgaagt acgtgcagcc ggacttcaaa     2220

accatcctgg agagcccgac cgataagaaa gttggctgga aagtgatttt taacaacatg     2280

gttaaccaga actggggtcc gtacgaccgt gatagctgga acccggtgta tggcaaccaa     2340

ctgttcatga agacccgtaa cggtagcatg aaagcggcgg ataactttct ggacccgaac     2400

aaagcgagca gcctgctgag cagcggtttc agcccggact ttgcgaccgt gatcaccatg     2460

gatcgtaaag cgagcaagca gcaaaccaac atcgacgtta tttacgaacg tgtgcgtgac     2520

gattatcagc tgcactggac cagcaccaac tggaaaggca ccaacaccaa ggataagtgg     2580

atcgaccgca gcagcgagcg ttacaagatt gattgggaaa aagaggaaat gaccaac        2637


<210>  76
<211>  2313
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding dna

<400>  76
atcgacagca agaacaaacc ggcgaacagc gatattaagt ttgaagtgac ccagaagagc       60

gatgcggtta aagcgctgaa ggaactgccg aagagcgaga acgtgaaaaa catctaccag      120

gactatgcgg tgaccgacgt taagaccgat aagaaaggtt tcacccacta caccctgcag      180

ccgagcgtgg acggtgttca tgcgccggat aaagaggtga aggttcacgc ggacaaaagc      240

ggcaaggtgg ttctgatcaa cggtgacacc gatgcgaaga aagtgaagcc gaccaacaaa      300

gttaccctga gcaaagacga tgcggcggac aaagcgttca aggcggttaa gatcgataag      360

aacaaggcga agaacctgaa agacaaggtg atcaaggaga acaaagttga aattgacggt      420

gatagcaaca agtacgtgta taacgttgaa ctgatcaccg tgaccccgga gattagccac      480

tggaaagtta agatcgacgc gcagaccggc gagattctgg aaaagatgaa cctggtgaaa      540

gaggcggcgg aaaccggcaa aggcaagggc gttctgggcg acaccaaaga tatcaacatt      600

aacagcatcg acggtggctt cagcctggaa gatctgaccc accagggcaa gctgagcgcg      660

ttcagcttta acgaccagac cggccaagcg accctgatta ccaacgagga cgaaaacttt      720

gtgaaagatg aacagcgtgc gggtgttgat gcgaactact atgcgaaaca aacctacgac      780

tactataagg ataccttcgg ccgtgagagc tatgacaacc agggtagccc gatcgtgagc      840

ctgacccacg ttaacaacta cggtggccaa gataaccgta acaacgcggc gtggatcggt      900

gacaagatga tttatggtga cggcgatggt cgtaccttca ccagcctgag cggtgcgaac      960

gatgttgttg cgcatgcgct gacccatggt gtgacccagg aaaccgcgaa cctggagtac     1020

aaagatcaaa gcggcgcgct gaacgaaagc ttcagcgacg tgttcggtta ctttgttgac     1080

gatgaagact ttctgatggg cgaggatgtt tataccccgg gcaaggaagg tgacgcgctg     1140

cgtagcatga gcaacccgga gcagttcggt caaccggcgc acatgaaaga ctacgtgttt     1200

accgagaagg ataacggtgg cgttcacacc aacagcggta tcccgaacaa agcggcgtat     1260

aacgtgatcc aggcgattgg caaaagcaag agcgaacaaa tttactatcg tgcgctgacc     1320

gagtacctga ccagcaacag caactttaag gacagcaaag atgcgctgta ccaggcggcg     1380

aaagacctgt atgatgagca gaccgcggaa caagtttatg aggcgtggaa cgaagtgggc     1440

gttgagggta gcggtggcgg tgcgaacacc aacatcgaaa acattggcga tggtgcggaa     1500

gtgatcaagc gtaccgagga cgttagcagc aagaaatggg gtgtgaccca gaacgttcaa     1560

ttcgacttcg tgaaggataa gaagtacaac aaggatgcgc tgatcgttaa gatgcagggc     1620

ttcattaaca gccgtaccag ctttagcgac gtgaaaggca gcggttacga actgaccaag     1680

cgtatgatct ggccgttcca atataacatt ggtctgacca ccaaagatcc gaacgtgagc     1740

ctgatcaact acctgccgaa aaacaagatt gaaaccaccg acgttggcca gaccctgggt     1800

tataacatcg gcggtaactt ccaaagcgcg ccgagcattg gcggtaacgg cagctttaac     1860

tacagcaaaa ccatcagcta cacccagaag agctatgtga gcgaagttga taaacaaaac     1920

agcaagagcg tgaaatgggg tgttaaggcg aacgagttcg tgaccccgga cggcaagaaa     1980

agcgcgcacg atcgttacct gtttgttcaa agcccgaacg gtccgaccgg tagcgcgcgt     2040

gaatattttg cgccggacaa ccagctgccg ccgctggtgc aaagcggttt caacccgagc     2100

tttattacca ccctgagcca cgagaagggt agcagcgata ccagcgagtt tgaaatcagc     2160

tacggccgta acctggacat tacctatgcg accctgttcc cgcgtaccgg tatctacgcg     2220

gagcgtaaac acaacgcgtt cgttaaccgt aactttgtgg ttcgttatga agtgaactgg     2280

aagacccacg agattaaagt taagggccac aac                                  2313


<210>  77
<211>  1710
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding DNA

<400>  77
aacaccaaca tcgagaacat tggcgatggt gcggaagtga ttaagcgtac cgaagacgtt       60

agcagcaaga aatggggcgt gacccagaac gttcaattcg acttcgtgaa ggataagaag      120

tacaacaagg atgcgctgat cgttaagatg cagggtttca ttaacagccg taccagcttt      180

agcgacgtta aaggcagcgg ttacgagctg accaagcgta tgatctggcc gttccaatat      240

aacattggcc tgaccaccaa agatccgaac gtgagcctga tcaactacct gccgaagaac      300

aaaattgaaa ccaccgacgt tggccagacc ctgggttata acatcggtgg caacttccaa      360

agcgcgccga gcattggtgg caacggtagc tttaactaca gcaaaaccat cagctacacc      420

cagaagagct atgtgagcga ggttgataaa caaaacagca agagcgtgaa atggggcgtt      480

aaggcgaacg aattcgtgac cccggacggt aagaaaagcg cgcacgatcg ttacctgttt      540

gttcaaagcc cgaacggtcc gaccggtagc gcgcgtgagt attttgcgcc ggacaaccag      600

ctgccgccgc tggtgcaaag cggcttcaac ccgagcttta ttaccaccct gagccacgaa      660

aagggcagca gcgataccag cgagtttgaa atcagctacg gtcgtaacct ggacattacc      720

tatgcgaccc tgttcccgcg taccggtatc tacgcggagc gtaaacacaa cgcgttcgtt      780

aaccgtaact ttgtggttcg ttatgaggtg aactggaaga cccacgaaat caaggttaaa      840

ggtcataacg gtagcggtgg cggtgcggac attggcagca acaccaccgt gaaaaccggt      900

gacctggtta cctacgataa ggaaaacggt atgctgaaga aagtgttcta tagctttatc      960

gacgataaaa accacaacaa gaaactgctg gtgatccgta ccaagggcac cattgcgggc     1020

cagtaccgtg tttatagcga ggaaggcgcg aacaaaagcg gtctggcgtg gccgagcgcg     1080

tttaaggtgc agctgcaact gccggacaac gaggttgcgc aaatcagcga ttactatccg     1140

cgtaacagca ttgacaccaa agaatacatg agcaccctga cctatggctt caacggtaac     1200

gttaccggcg acgataccgg caagatcggc ggtctgattg gcgcgaacgt gagcatcggt     1260

cacaccctga aatacgttca gccggatttt aagaccattc tggagagccc gaccgacaag     1320

aaagtgggct ggaaagttat cttcaacaac atggtgaacc agaactgggg tccgtacgac     1380

cgtgatagct ggaacccggt ttatggcaac caactgttca tgaaaacccg taacggtagc     1440

atgaaggcgg cggacaactt tctggatccg aacaaggcga gcagcctgct gagcagcggt     1500

ttcagcccgg attttgcgac cgtgatcacc atggaccgta aggcgagcaa acagcaaacc     1560

aacatcgatg tgatttacga acgtgttcgt gacgattatc aactgcactg gaccagcacc     1620

aactggaaag gtaccaacac caaggacaaa tggatcgatc gtagcagcga gcgttacaag     1680

attgactggg aaaaagagga aatgaccaac                                      1710


<210>  78
<211>  2337
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding DNA

<400>  78
atagattcaa agaacaagcc cgctaacagt gatataaagt tcgaagtgac ccagaaaagc       60

gatgcggtta aagcgctgaa ggaactgccg aagagcgaga acgtgaaaaa catctaccag      120

gactatgcgg tgaccgacgt taaaaccgat aagaaaggtt ttacccacta caccctgcag      180

ccgagcgtgg acggtgttca tgcgccggat aaagaggtga aggttcacgc ggacaaaagc      240

ggcaaggtgg ttctgatcaa cggtgacacc gatgcgaaga aagtgaagcc gaccaacaaa      300

gttaccctga gcaaggacga tgcggcggac aaagcgttca aggcggttaa aattgataag      360

aacaaagcga agaacctgaa agacaaggtg atcaaggaga acaaagttga aattgacggt      420

gatagcaaca aatacgtgta taacgttgaa ctgatcaccg tgaccccgga gattagccac      480

tggaaagtta agatcgatgc gcagaccggc gagattctgg aaaagatgaa cctggtgaaa      540

gaggcggcgg aaaccggcaa aggcaagggc gttctgggcg acaccaagga tatcaacatt      600

aacagcatcg acggtggctt tagcctggag gatctgaccc accaaggtaa actgagcgcg      660

ttcagcttta acgaccagac cggccaagcg accctgatta ccaacgagga cgaaaacttc      720

gtgaaagatg aacagcgtgc gggtgttgat gcgaactact atgcgaagca aacctacgac      780

tactataaag atacctttgg ccgtgagagc tatgacaacc agggtagccc gatcgtgagc      840

ctgacccacg ttaacaacta cggtggccaa gataaccgta acaacgcggc gtggatcggc      900

gacaagatga tttatggtga cggcgatggt cgtaccttca ccagcctgag cggtgcgaac      960

gatgttgttg cgcatgcgct gacccatggt gtgacccagg aaaccgcgaa cctggagtac     1020

aaggatcaaa gcggcgcgct gaacgaaagc ttcagcgacg tgttcggtta ctttgttgac     1080

gatgaagact ttctgatggg cgaggatgtt tataccccgg gcaaagaagg tgacgcgctg     1140

cgtagcatga gcaacccgga gcagttcggt caaccggcgc acatgaagga ctacgtgttt     1200

accgagaaag ataacggtgg cgttcacacc aacagcggta tcccgaacaa ggcggcgtat     1260

aacgtgatcc aggcgattgg caaaagcaag agcgaacaaa tttactatcg tgcgctgacc     1320

gagtacctga ccagcaacag caacttcaag gacagcaaag atgcgctgta ccaggcggcg     1380

aaggacctgt atgatgagca gaccgcggaa caagtttatg aggcgtggaa cgaagtgggc     1440

gttgagggta gcggtggcgg tgcggcgcag gtggacgaag cgcagaagaa cgcgttctac     1500

caggttctga acatgccgaa cctgaacgcg gatcagcgta acggttttat ccaaagcctg     1560

aaggatgcgc cgagccagag cgcgaaggtg ctgggtgaag cgcagaaact gaacgacagc     1620

caagcgccga aagcggatgc gcagcaaaac aacgttaaca aggaccagaa aagcgcgttc     1680

tatgaaatcc tgaatatgcc gaatctgaac gaggcgcagc gtaacggttt tattcagagc     1740

ctgaaagatg cgccgagcca aagcaccaaa gtgctgggcg aagcgaagaa actgaacgag     1800

agccaggcgc cgaaggcgga caacaacgtt aacaaggaac agaagaacgc gttttatgag     1860

atcctgaata tgccgaacct gaacgaggaa caacgcaacg gttttattca aagcctgaaa     1920

gacgcgccga gccaaagcgc gaaactgctg agcgaggcga agaaactgaa tgagagccag     1980

gcgccgaaag cggacaacaa ggtgaacaaa gaacaaaaga acgcgttcta tgagatcctg     2040

cacctgccga atctgaatga agaacagcgt aacggcttta ttcagtcttt aaaagatgct     2100

cctagccaga gcgcgaaact gctggcggag gcgaagaaac tgaacgatgc gcaggcgccg     2160

aaggcggata acaaagtgaa taaagaacag aagaacgcgt tctatgaaat tctgcacctg     2220

ccgaacctga ccgaggaaca acgtaatggc ttcattcaga gcctgaagga cgcgccgagc     2280

gttagcaaga aaattctggc ggaagcgaag aaactgaatg acgcgcaggc gccgaaa        2337


<210>  79
<211>  3246
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding DNA

<400>  79
aacaccaaca ttgagaacat cggcgatggt gcggaagtga tcaagcgtac cgaagacgtt       60

agcagcaaga aatggggcgt gacccagaac gttcaattcg acttcgtgaa ggataagaag      120

tacaacaagg atgcgctgat tgttaaaatg caaggtttca tcaacagccg taccagcttt      180

agcgacgtga agggcagcgg ttacgagctg accaaacgta tgatttggcc gttccagtat      240

aacatcggcc tgaccaccaa agatccgaac gtgagcctga ttaactacct gccgaagaac      300

aaaatcgaaa ccaccgacgt tggccaaacc ctgggttata acattggtgg caactttcaa      360

agcgcgccga gcatcggtgg caacggtagc tttaactaca gcaagaccat cagctacacc      420

cagaagagct acgtgagcga ggttgataaa cagaacagca agagcgtgaa atggggcgtt      480

aaggcgaacg aattcgtgac cccggatggt aagaaaagcg cgcacgaccg ttacctgttt      540

gttcaaagcc cgaacggtcc gaccggtagc gcgcgtgagt attttgcgcc ggacaaccag      600

ctgccgccgc tggtgcaaag cggcttcaac ccgagcttta ttaccaccct gagccacgaa      660

aaaggcagca gcgataccag cgagtttgaa attagctacg gtcgtaacct ggacatcacc      720

tatgcgaccc tgttcccgcg taccggtatc tacgcggagc gtaaacacaa cgcgttcgtt      780

aaccgtaact ttgtggttcg ttatgaggtg aactggaaga cccacgaaat taaggttaaa      840

ggtcataacg gtagcggtgg cggtgcgcag accaagtatg gcgatcaaag cgaaaaaggt      900

agccagagcg tgagcaacaa gaacaacaaa atccacattg cgatcgttaa cgaggaccaa      960

ccgaccacct ataacggcaa gaaagtggaa ctgggtcagg cgttcatcaa gcgtctggcg     1020

aacgagaaga actacaaatt tgaaaccgtg acccgtaacg ttgcggagag cggcctgaaa     1080

aacggcggtt atcaagtgat gattgttatc ccggaaaact ttagcaagct ggcgatgcag     1140

ctggacgcga aaaccccgag caagattagc ctgcaataca agaccgcggt gggtcagaaa     1200

gaggaagttg cgaaaaacac cgagaaggtg gttagcaacg tgctgaatga tttcaacaag     1260

aacctggttg aaatctacct gaccagcatc attgacaacc tgcacaacgc gcagaaaaac     1320

gtgggcgcga tcatgacccg tgagcacggt gttaacagca agttcagcaa ctatctgctg     1380

aacccgatta acgatttccc ggaactgttt accgacaccc tggttaacag cattagcgcg     1440

aacaaagata tcaccaagtg gtttcaaacc tacaacaaga gcctgctgag cgcgaacagc     1500

gataccttcc gtgtgaacac cgactataac gttagcaccc tgatcgagaa acagaacagc     1560

ctgttcgacg aacacaacac cgcgatggat aagatgctgc aggactacaa gagccaaaaa     1620

gatagcgtgg agctggacaa ctatattaac gcgctgaaac agatggacag ccaaatcgat     1680

cagcaaagca gcatgcaaga taccggcaaa gaggaataca agcagaccgt taaagagaac     1740

ctggacaagc tgcgtgagat cattcagagc caagaaagcc cgtttagcaa gggtatgatc     1800

gaagattatc gtaaacaact gaccgagagc ctgcaggacg aactggcgaa caacaaggac     1860

ctgcaggatg cgctgaacag catcaaaatg aacaacgcgc aattcgcgga gaacctggaa     1920

aagcagctgc acgacgatat tgtgaaagaa ccggacagcg ataccacctt catttacaac     1980

atgagcaaac aggattttat cgcggcgggt ctgaacgagg acgaagcgaa caagtatgag     2040

gcgatcgtga aggaagcgaa acgttacaag aacgagtata acctgaagaa accgctggcg     2100

gaacacatta acctgaccga ctacgataac caggttgcgc aagataccag cagcctgatc     2160

aacgacggtg tgaaggttca acgtaccgaa accattaaaa gcaacgatat caaccagctg     2220

accgtggcga ccgatccgca cttcaacttt gaaggcgaca ttaagatcaa cggtaagaaa     2280

tacgacatca aagatcagag cgtgcaactg gacaccagca acaaagagta taaggtggaa     2340

gttaacggcg ttgcgaagct gaagaaagac gcggagaaag atttcctgaa ggacaaaacc     2400

atgcacctgc agctgctgtt tggtcaggcg aaccgtcaag atgaaccgaa cgacaagaaa     2460

gcgaccagcg tggttgacgt taccctgaac cacaacctgg atggccgtct gagcaaagac     2520

gcgctgagcc agcaactgag cgcgctgagc cgttttgatg cgcactacaa gatgtatacc     2580

gacaccaagg gtcgtgagga taaaccgttc gacaacaagc gtctgattga tatgatggtg     2640

gaccaagtta tcaacgacat ggaaagcttc aaagacgata aggtggcggt tctgcaccag     2700

atcgatagca tggaggaaaa cagcgacaag ctgattgacg atatcctgaa caacaagaaa     2760

aacaccacca agaacaaaga ggatattagc aaactgatcg accaactgga aaacgttaag     2820

aaaacctttg cggaggaacc gcaggagccg aagatcgata agggcaaaaa cgacgaattc     2880

aacaccatga gcagcaacct ggacaaggag attagccgta tcagcgagaa gagcacccaa     2940

ctgctgagcg atacccagga gagcaaaacc attgcggaca gcgtgagcgg tcagctgaac     3000

caactggata acaacgttaa caagctgcat gcgaccggtc gtgcgctggg tgtgcgtgcg     3060

aacgacctga accgtcaaat ggcgaaaaac gacaaggata acgagctgtt cgcgaaggaa     3120

tttaagaaag ttctgcagaa cagcaaagac ggcgatcgtc agaaccaagc gctgaaggcg     3180

ttcatgagca acccggtgca gaagaaaaac ctggaaaacg ttctggcgaa caacggtaac     3240

accgac                                                                3246


<210>  80
<211>  2088
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding DNA

<400>  80
atggacatcg gtaagaaaca cgtgattccg aagagccagt accgtcgtaa acgtcgtgag       60

ttctttcaca acgaagatcg tgaggaaaac ctgaaccagc accaagataa gcagaacatc      120

gacaacacca ccagcaagaa agcggacaag caaatccaca aagatagcat tgacaagcac      180

gagcgtttca aaaacagcct gagcagccac ctggagcagc gtaaccgtga tgtgaacgaa      240

aacaaggcgg aggaaagcaa aagcaaccaa gacagcaaaa gcgcgtacaa ccgtgatcac      300

tatctgaccg acgatgtgag caagaaacag aacagcctgg acagcgttga tcaagacacc      360

gaaaagagca aatactatga gcagaacagc gaagcgaccc tgagcaccaa gagcaccgat      420

aaagttgaga gcaccgaaat gcgtaagctg agcagcgaca agaacaaagt gggtcacgag      480

gaacagcacg ttctgagcaa gccgagcgag cacgataaag aaacccgtat tgacagcgag      540

agcagccgta ccgatagcga cagcagcatg caaaccgaaa agatcaagaa agatagcagc      600

gacggcaaca agagcagcaa cctgaaaagc gaggtgatca gcgacaagag caacaccgtt      660

ccgaaactga gcgagagcga cgatgaagtt aacaaccaga aaccgctgac cctgccggag      720

gaacaaaagc tgaaacgtca gcaaagccag aacgagcaaa ccaagaccta cacctatggt      780

gatagcgagc agaacgacaa aagcaaccac gaaaacgatc tgagccacca catcccgagc      840

attagcgacg ataaggacaa cgtgatgcgt gaaaaccaca tcgttgacga taacccggat      900

aacgacatta acaccccgag cctgagcaaa accgacgatg accgtaagct ggatgagaaa      960

atccacgtgg aagacaagca caaacaaaac gcggatagca gcgaaaccgt tggctaccag     1020

agccaaagca ccgcgagcca ccgtagcacc gaaaagcgta acatcagcat taacgatcac     1080

gacaaactga acggtcagaa gaccaacacc aaaaccagcg cgaacaacaa ccaaaagaaa     1140

gcgaccagca agctgaacaa aggccgtgcg accaacaaca actacagcga tatcctgaag     1200

aaattctgga tgatgtactg gccgaaaggt agcggtggcg gtgcggacat tggtagcaac     1260

accaccgtga agaccggcga tctggttacc tacgacaaag aaaacggtat gctgaagaaa     1320

gtgttctata gctttattga tgacaagaac cacaacaaga aactgctggt gatccgtacc     1380

aaaggcacca ttgcgggcca gtaccgtgtt tatagcgagg aaggcgcgaa caagagcggt     1440

ctggcgtggc cgagcgcgtt caaagtgcag ctgcaactgc cggacaacga ggttgcgcaa     1500

atcagcgatt actatccgcg taacagcatt gacaccaagg aatacatgag caccctgacc     1560

tatggcttta acggtaacgt taccggcgat gacaccggta aaatcggcgg tctgattggc     1620

gcgaacgtga gcatcggtca caccctgaag tacgttcagc cggatttcaa aaccattctg     1680

gagagcccga ccgacaagaa agtgggttgg aaggttatct ttaacaacat ggtgaaccag     1740

aactggggcc cgtacgatcg tgacagctgg aacccggttt atggtaacca actgttcatg     1800

aagacccgta acggcagcat gaaagcggcg gataactttc tggacccgaa caaagcgagc     1860

agcctgctga gcagcggttt cagcccggat tttgcgaccg tgatcaccat ggaccgtaag     1920

gcgagcaaac agcaaaccaa catcgacgtg atttacgaac gtgttcgtga tgactatcag     1980

ctgcactgga ccagcaccaa ctggaagggc accaacacca aggataaatg gatcgaccgt     2040

agcagcgagc gttataagat tgactgggaa aaagaggaaa tgaccaac                  2088


<210>  81
<211>  2289
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein encoding DNA

<400>  81
aataacgtaa acaaaaacga cagaatgaac gacaataatg acgcagacgc tcaaaaatac       60

accactacaa tgaagaacgc taacaacaca gttaaatcag ttgttacagt tgaaaacgaa      120

acttcaaagg attcttcatt gccaaaggat aaagcatctc aagatgaagt tggttcaggt      180

gttgtttaca aaaaatctgg tgatacattg tacatcgtta ctaacgcaca tgttgttggt      240

gataaagaaa accaaaagat cacattctct aacaacaaat cagttgttgg caaggttttg      300

ggcaaggata agtggtctga tttagctgtt gttaaagcaa cttcttcaga ttcttcagtt      360

aaggaaatcg ctatcggtga ttcaaacaac ttggttttgg gtgaaccaat cttggttgtt      420

ggtaatccat taggtgttga tttcaagggt actgttacag aaggtatcat ctctggtttg      480

aacagaaatg ttccaatcga tttcgataag gataacaagt acgatatgtt gatgaaagca      540

tttcaaatcg atgcatcagt taaccctggt aatgcaggtg gtgctgttgt taatagagag      600

ggtaaattga ttggtgttgt tgctgcaaag atctctatgc caaacgttga aaacatgtca      660

ttcgctatcc cagttaacga agttcaaaag atcgttaagg atttagaaac taaaggtaaa      720

attgattacc cagatgttgg tgttaagatg aagaacatcg cttctttaaa ttctttcgaa      780

agacaagcag ttaaattgcc aggcaaggtt aagaacggtg ttgttgttga tcaagttgat      840

aacaacggtt tggctgatca atctggtttg aagaaaggtg atgttatcac agaattggat      900

ggtaaattgt tagaagatga tttaagattt agacaaatta ttttctctca taaagatgat      960

ttgaaatcaa ttactgcaaa aatttataga gatggcaagg aaaaggaaat caacatcaaa     1020

ttgaaaggtt ctggtggtgg tgctggttct ggtggtggtg ctatggatat cggtaaaaaa     1080

catgttatcc caaagtctca atacagaaga aagagaagag aatttttcca taacgaagat     1140

agagaagaaa atttgaatca acatcaagat aagcaaaaca tcgataacac tacttctaag     1200

aaagctgata agcaaatcca taaggattct atcgataaac atgaaagatt taaaaattca     1260

ttgtcttcac atttagaaca aagaaacaga gatgttaacg aaaacaaagc tgaagaatct     1320

aagtcaaacc aagattctaa gtcagcatac aacagagatc attacttgac agatgatgtt     1380

tctaaaaaac aaaattcttt ggattcagtt gatcaagata ctgaaaaatc taagtactac     1440

gaacaaaatt cagaagcaac tttatctaca aaatcaactg ataaggttga atctacagaa     1500

atgagaaaat tgtcttcaga taagaacaag gttggtcatg aagaacaaca tgttttgtct     1560

aagccatcag aacatgataa ggaaactaga atcgattctg aatcttcaag aacagattca     1620

gattcttcaa tgcaaactga aaagattaag aaagattctt ctgatggtaa caagtcttca     1680

aacttgaagt ctgaagttat ttctgataaa tcaaatacag ttccaaaatt gtctgaatca     1740

gatgatgaag ttaacaacca aaaaccattg actttgccag aagaacaaaa attgaagaga     1800

caacaatctc aaaacgaaca aactaagaca tacacttacg gtgattctga acaaaacgat     1860

aagtcaaacc atgaaaacga tttatcacat catattccat ctatctcaga tgataaggat     1920

aacgttatga gagaaaacca tatcgttgat gataacccag ataacgatat caacacacca     1980

tctttgtcaa agactgatga tgatagaaaa ttggatgaaa agatccatgt tgaagataag     2040

cataaacaaa atgctgattc ttcagaaaca gttggttatc aatctcaatc aacagcatct     2100

catagatcaa ctgaaaagag aaacatctct atcaacgatc atgataaatt gaatggtcaa     2160

aagacaaaca ctaagacatc tgctaacaat aatcaaaaga aagctacttc aaaattgaat     2220

aaaggtagag caactaacaa caactactcc gacatattga aaaaattctg gatgatgtat     2280

tggcctaaa                                                             2289


<210>  82
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  82

Asn Thr Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg 
1               5                   10                  15      


Thr Glu Asp Val Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys 
    50                  55                  60                  


Gly Ser Gly Tyr Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr 
65                  70                  75                  80  


Asn Ile Gly Leu Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr 
                85                  90                  95      


Leu Pro Lys Asn Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly 
            100                 105                 110         


Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn 
        115                 120                 125             


Gly Ser Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr 
    130                 135                 140                 


Val Ser Glu Val Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val 
145                 150                 155                 160 


Lys Ala Asn Glu Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp 
                165                 170                 175     


Arg Tyr Leu Phe Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg 
            180                 185                 190         


Glu Tyr Phe Ala Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly 
        195                 200                 205             


Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser 
    210                 215                 220                 


Asp Thr Ser Glu Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr 
225                 230                 235                 240 


Tyr Ala Thr Leu Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His 
                245                 250                 255     


Asn Ala Phe Val Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp 
            260                 265                 270         


Lys Thr His Glu Ile Lys Val Lys Gly His Asn Gly Ser Gly Gly Gly 
        275                 280                 285             


Ala Ala Gln Val Asp Glu Ala Gln Lys Asn Ala Phe Tyr Gln Val Leu 
    290                 295                 300                 


Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser 
305                 310                 315                 320 


Leu Lys Asp Ala Pro Ser Gln Ser Ala Lys Val Leu Gly Glu Ala Gln 
                325                 330                 335     


Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn 
            340                 345                 350         


Val Asn Lys Asp Gln Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro 
        355                 360                 365             


Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp 
    370                 375                 380                 


Ala Pro Ser Gln Ser Thr Lys Val Leu Gly Glu Ala Lys Lys Leu Asn 
385                 390                 395                 400 


Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Val Asn Lys Glu Gln Lys 
                405                 410                 415     


Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln 
            420                 425                 430         


Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser Gln Ser Ala 
        435                 440                 445             


Lys Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys 
    450                 455                 460                 


Ala Asp Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile 
465                 470                 475                 480 


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
                485                 490                 495     


Ser Leu Lys Asp Ala Pro Ser Gln Ser Ala Lys Leu Leu Ala Glu Ala 
            500                 505                 510         


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Val Asn 
        515                 520                 525             


Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
    530                 535                 540                 


Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro 
545                 550                 555                 560 


Ser Val Ser Lys Lys Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala 
                565                 570                 575     


Gln Ala Pro Lys 
            580 


<210>  83
<211>  889
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  83

Asp Thr Pro Gln Lys Asp Thr Thr Ala Lys Thr Thr Ser His Asp Ser 
1               5                   10                  15      


Lys Lys Ser Asn Asp Asp Glu Thr Ser Lys Asp Thr Thr Ser Lys Asp 
            20                  25                  30          


Ile Asp Lys Ala Asp Asn Asn Asn Thr Ser Asn Gln Asp Asn Asn Asp 
        35                  40                  45              


Lys Lys Phe Lys Thr Ile Asp Asp Ser Thr Ser Asp Ser Asn Asn Ile 
    50                  55                  60                  


Ile Asp Phe Ile Tyr Lys Asn Leu Pro Gln Thr Asn Ile Asn Gln Leu 
65                  70                  75                  80  


Leu Thr Lys Asn Lys Tyr Asp Asp Asn Tyr Ser Leu Thr Thr Leu Ile 
                85                  90                  95      


Gln Asn Leu Phe Asn Leu Asn Ser Asp Ile Ser Asp Tyr Glu Gln Pro 
            100                 105                 110         


Arg Asn Gly Glu Lys Ser Thr Asn Asp Ser Asn Lys Asn Ser Asp Asn 
        115                 120                 125             


Ser Ile Lys Asn Asp Thr Asp Thr Gln Ser Ser Lys Gln Asp Lys Ala 
    130                 135                 140                 


Asp Asn Gln Lys Ala Pro Lys Ser Asn Asn Thr Lys Pro Ser Thr Ser 
145                 150                 155                 160 


Asn Lys Gln Pro Asn Ser Pro Lys Pro Thr Gln Pro Asn Gln Ser Asn 
                165                 170                 175     


Ser Gln Pro Ala Ser Asp Asp Lys Ala Asn Gln Lys Ser Ser Ser Lys 
            180                 185                 190         


Asp Asn Gln Ser Met Ser Asp Ser Ala Leu Asp Ser Ile Leu Asp Gln 
        195                 200                 205             


Tyr Ser Glu Asp Ala Lys Lys Thr Gln Lys Asp Tyr Ala Ser Gln Ser 
    210                 215                 220                 


Lys Lys Asp Lys Asn Glu Lys Ser Asn Thr Lys Asn Pro Gln Leu Pro 
225                 230                 235                 240 


Thr Gln Asp Glu Leu Lys His Lys Ser Lys Pro Ala Gln Ser Phe Asn 
                245                 250                 255     


Asn Asp Val Asn Gln Lys Asp Thr Arg Ala Thr Ser Leu Phe Glu Thr 
            260                 265                 270         


Asp Pro Ser Ile Ser Asn Asn Asp Asp Ser Gly Gln Phe Asn Val Val 
        275                 280                 285             


Asp Ser Lys Asp Thr Arg Gln Phe Val Lys Ser Ile Ala Lys Asp Ala 
    290                 295                 300                 


His Arg Ile Gly Gln Asp Asn Asp Ile Tyr Ala Ser Val Met Ile Ala 
305                 310                 315                 320 


Gln Ala Ile Leu Glu Ser Asp Ser Gly Arg Ser Ala Leu Ala Lys Ser 
                325                 330                 335     


Pro Asn His Asn Leu Phe Gly Ile Lys Gly Ala Phe Glu Gly Asn Ser 
            340                 345                 350         


Val Pro Phe Asn Thr Leu Gln Ala Asp Gly Asn Lys Leu Tyr Ser Ile 
        355                 360                 365             


Asn Ala Gly Phe Arg Lys Tyr Pro Ser Thr Lys Glu Ser Leu Lys Asn 
    370                 375                 380                 


Tyr Ser Asp Leu Ile Lys Asn Gly Ile Asp Gly Asn Arg Thr Ile Tyr 
385                 390                 395                 400 


Lys Pro Thr Trp Lys Ser Glu Ala Asp Ser Tyr Lys Asp Ala Thr Ser 
                405                 410                 415     


His Leu Ser Lys Thr Tyr Ala Thr Asp Pro Asn Tyr Ala Lys Lys Leu 
            420                 425                 430         


Asn Ser Ile Ile Lys His Tyr Gln Leu Thr Gln Phe Asp Asp Glu Arg 
        435                 440                 445             


Met Pro Asp Leu Asp Lys Tyr Glu Arg Ser Ile Lys Asp Tyr Asp Asp 
    450                 455                 460                 


Ser Ser Asp Glu Phe Lys Pro Phe Arg Glu Val Ser Asp Ser Met Pro 
465                 470                 475                 480 


Tyr Pro His Gly Gln Ser Thr Trp Tyr Val Tyr Asn Arg Met Lys Gln 
                485                 490                 495     


Phe Gly Thr Ser Ile Ser Gly Asp Leu Gly Asp Ala His Asn Trp Asn 
            500                 505                 510         


Asn Arg Ala Gln Tyr Arg Asp Tyr Gln Val Ser His Thr Pro Lys Arg 
        515                 520                 525             


His Ala Ala Val Val Phe Glu Ala Gly Gln Phe Gly Ala Asp Gln His 
    530                 535                 540                 


Tyr Gly His Val Ala Phe Val Glu Lys Val Asn Ser Asp Gly Ser Ile 
545                 550                 555                 560 


Val Ile Ser Glu Ser Asn Val Lys Gly Leu Gly Ile Ile Ser His Arg 
                565                 570                 575     


Thr Ile Asn Ala Ala Ala Ala Glu Glu Leu Ser Tyr Ile Thr Gly Lys 
            580                 585                 590         


Gly Ser Gly Gly Gly Ala Ala Gln Val Asp Glu Ala Gln Lys Asn Ala 
        595                 600                 605             


Phe Tyr Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn 
    610                 615                 620                 


Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser Gln Ser Ala Lys Val 
625                 630                 635                 640 


Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp 
                645                 650                 655     


Ala Gln Gln Asn Asn Val Asn Lys Asp Gln Lys Ser Ala Phe Tyr Glu 
            660                 665                 670         


Ile Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile 
        675                 680                 685             


Gln Ser Leu Lys Asp Ala Pro Ser Gln Ser Thr Lys Val Leu Gly Glu 
    690                 695                 700                 


Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Val 
705                 710                 715                 720 


Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
                725                 730                 735     


Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala 
            740                 745                 750         


Pro Ser Gln Ser Ala Lys Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu 
        755                 760                 765             


Ser Gln Ala Pro Lys Ala Asp Asn Lys Val Asn Lys Glu Gln Lys Asn 
    770                 775                 780                 


Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg 
785                 790                 795                 800 


Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser Gln Ser Ala Lys 
                805                 810                 815     


Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala 
            820                 825                 830         


Asp Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu 
        835                 840                 845             


His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
    850                 855                 860                 


Leu Lys Asp Ala Pro Ser Val Ser Lys Lys Ile Leu Ala Glu Ala Lys 
865                 870                 875                 880 


Lys Leu Asn Asp Ala Gln Ala Pro Lys 
                885                 


<210>  84
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  84

Met Asp Ile Gly Lys Lys His Val Ile Pro Lys Ser Gln Tyr Arg Arg 
1               5                   10                  15      


Lys Arg Arg Glu Phe Phe His Asn Glu Asp Arg Glu Glu Asn Leu Asn 
            20                  25                  30          


Gln His Gln Asp Lys Gln Asn Ile Asp Asn Thr Thr Ser Lys Lys Ala 
        35                  40                  45              


Asp Lys Gln Ile His Lys Asp Ser Ile Asp Lys His Glu Arg Phe Lys 
    50                  55                  60                  


Asn Ser Leu Ser Ser His Leu Glu Gln Arg Asn Arg Asp Val Asn Glu 
65                  70                  75                  80  


Asn Lys Ala Glu Glu Ser Lys Ser Asn Gln Asp Ser Lys Ser Ala Tyr 
                85                  90                  95      


Asn Arg Asp His Tyr Leu Thr Asp Asp Val Ser Lys Lys Gln Asn Ser 
            100                 105                 110         


Leu Asp Ser Val Asp Gln Asp Thr Glu Lys Ser Lys Tyr Tyr Glu Gln 
        115                 120                 125             


Asn Ser Glu Ala Thr Leu Ser Thr Lys Ser Thr Asp Lys Val Glu Ser 
    130                 135                 140                 


Thr Glu Met Arg Lys Leu Ser Ser Asp Lys Asn Lys Val Gly His Glu 
145                 150                 155                 160 


Glu Gln His Val Leu Ser Lys Pro Ser Glu His Asp Lys Glu Thr Arg 
                165                 170                 175     


Ile Asp Ser Glu Ser Ser Arg Thr Asp Ser Asp Ser Ser Met Gln Thr 
            180                 185                 190         


Glu Lys Ile Lys Lys Asp Ser Ser Asp Gly Asn Lys Ser Ser Asn Leu 
        195                 200                 205             


Lys Ser Glu Val Ile Ser Asp Lys Ser Asn Thr Val Pro Lys Leu Ser 
    210                 215                 220                 


Glu Ser Asp Asp Glu Val Asn Asn Gln Lys Pro Leu Thr Leu Pro Glu 
225                 230                 235                 240 


Glu Gln Lys Leu Lys Arg Gln Gln Ser Gln Asn Glu Gln Thr Lys Thr 
                245                 250                 255     


Tyr Thr Tyr Gly Asp Ser Glu Gln Asn Asp Lys Ser Asn His Glu Asn 
            260                 265                 270         


Asp Leu Ser His His Ile Pro Ser Ile Ser Asp Asp Lys Asp Asn Val 
        275                 280                 285             


Met Arg Glu Asn His Ile Val Asp Asp Asn Pro Asp Asn Asp Ile Asn 
    290                 295                 300                 


Thr Pro Ser Leu Ser Lys Thr Asp Asp Asp Arg Lys Leu Asp Glu Lys 
305                 310                 315                 320 


Ile His Val Glu Asp Lys His Lys Gln Asn Ala Asp Ser Ser Glu Thr 
                325                 330                 335     


Val Gly Tyr Gln Ser Gln Ser Thr Ala Ser His Arg Ser Thr Glu Lys 
            340                 345                 350         


Arg Asn Ile Ser Ile Asn Asp His Asp Lys Leu Asn Gly Gln Lys Thr 
        355                 360                 365             


Asn Thr Lys Thr Ser Ala Asn Asn Asn Gln Lys Lys Ala Thr Ser Lys 
    370                 375                 380                 


Leu Asn Lys Gly Arg Ala Thr Asn Asn Asn Tyr Ser Asp Ile Leu Lys 
385                 390                 395                 400 


Lys Phe Trp Met Met Tyr Trp Pro Lys Gly Ser Gly Gly Gly Ala Ala 
                405                 410                 415     


Gln Val Asp Glu Ala Gln Lys Asn Ala Phe Tyr Gln Val Leu Asn Met 
            420                 425                 430         


Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
        435                 440                 445             


Asp Ala Pro Ser Gln Ser Ala Lys Val Leu Gly Glu Ala Gln Lys Leu 
    450                 455                 460                 


Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Val Asn 
465                 470                 475                 480 


Lys Asp Gln Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu 
                485                 490                 495     


Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro 
            500                 505                 510         


Ser Gln Ser Thr Lys Val Leu Gly Glu Ala Lys Lys Leu Asn Glu Ser 
        515                 520                 525             


Gln Ala Pro Lys Ala Asp Asn Asn Val Asn Lys Glu Gln Lys Asn Ala 
    530                 535                 540                 


Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg Asn 
545                 550                 555                 560 


Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser Gln Ser Ala Lys Leu 
                565                 570                 575     


Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp 
            580                 585                 590         


Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu His 
        595                 600                 605             


Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu 
    610                 615                 620                 


Lys Asp Ala Pro Ser Gln Ser Ala Lys Leu Leu Ala Glu Ala Lys Lys 
625                 630                 635                 640 


Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Val Asn Lys Glu 
                645                 650                 655     


Gln Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
            660                 665                 670         


Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ser Val 
        675                 680                 685             


Ser Lys Lys Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala 
    690                 695                 700                 


Pro Lys 
705     


<210>  85
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  85

Asn Thr Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg 
1               5                   10                  15      


Thr Glu Asp Val Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys 
    50                  55                  60                  


Gly Ser Gly Tyr Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr 
65                  70                  75                  80  


Asn Ile Gly Leu Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr 
                85                  90                  95      


Leu Pro Lys Asn Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly 
            100                 105                 110         


Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn 
        115                 120                 125             


Gly Ser Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr 
    130                 135                 140                 


Val Ser Glu Val Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val 
145                 150                 155                 160 


Lys Ala Asn Glu Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp 
                165                 170                 175     


Arg Tyr Leu Phe Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg 
            180                 185                 190         


Glu Tyr Phe Ala Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly 
        195                 200                 205             


Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser 
    210                 215                 220                 


Asp Thr Ser Glu Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr 
225                 230                 235                 240 


Tyr Ala Thr Leu Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His 
                245                 250                 255     


Asn Ala Phe Val Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp 
            260                 265                 270         


Lys Thr His Glu Ile Lys Val Lys Gly His Asn Gly Ser Gly Gly Gly 
        275                 280                 285             


Ala Ala Gln Val Asp Glu Ala Gln Lys Asn Ala Phe Tyr Gln Val Leu 
    290                 295                 300                 


Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser 
305                 310                 315                 320 


Leu Lys Asp Ala Pro Ala Lys Ser Ala Asn Val Leu Gly Glu Ala Gln 
                325                 330                 335     


Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn 
            340                 345                 350         


Val Asn Lys Asp Gln Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro 
        355                 360                 365             


Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp 
    370                 375                 380                 


Ala Pro Ala Lys Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn 
385                 390                 395                 400 


Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Val Asn Lys Glu Gln Lys 
                405                 410                 415     


Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln 
            420                 425                 430         


Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro Ala Lys Ser Ala 
        435                 440                 445             


Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys 
    450                 455                 460                 


Ala Asp Asn Lys Val Asn Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile 
465                 470                 475                 480 


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
                485                 490                 495     


Ser Leu Lys Asp Ala Pro Ala Lys Ser Ala Asn Leu Leu Ala Glu Ala 
            500                 505                 510         


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Val Asn 
        515                 520                 525             


Lys Glu Gln Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
    530                 535                 540                 


Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Ala Pro 
545                 550                 555                 560 


Ala Lys Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala 
                565                 570                 575     


Gln Ala Pro Lys 
            580 


<210>  86
<211>  1740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  86
aatactaata ttgaaaatat tggtgatggt gctgaagtaa tcaaacgtac ggaggatgta       60

agtagtaaga aatggggcgt tactcaaaat gtccaattcg actttgtaaa agataaaaaa      120

tataacaaag acgctttaat tgttaaaatg caaggtttta ttaattccag aacttcattt      180

tcagatgtga agggtagtgg atatgaatta actaaacgaa tgatttggcc attccaatat      240

aatataggac tgacgactaa agatccaaat gttagcttaa tcaattacct tcctaaaaac      300

aaaatagaaa ctactgatgt tggtcaaaca ttaggatata acattggagg taatttccag      360

tcagcaccat ctataggtgg caatggctca tttaattatt ctaaaacaat tagttatacc      420

caaaagagtt atgtcagtga agtagacaag caaaactcaa aatctgttaa atggggtgtt      480

aaagcaaacg aatttgttac gcctgatgga aaaaaatctg cgcatgatag atatttattc      540

gtacaaagtc caaatggtcc aacaggttca gcaagagaat attttgctcc tgataatcaa      600

ttgccacctt tagttcaaag tggctttaat ccatcgttta tcactacact atcacatgaa      660

aaaggttcaa gtgatacgag tgaatttgaa atttcatatg gtagaaactt agatattaca      720

tatgcgactt tattccctag aactggtatt tacgcagaaa gaaagcataa tgcatttgta      780

aatagaaact ttgtagttag atatgaagtt aattggaaaa cacacgaaat taaagtgaaa      840

ggacataatg gttctggcgg aggggctgcg caagtggatg aagctcaaaa aaatgctttt      900

tatcaagtct taaatatgcc taacttaaat gctgatcaac gcaatggttt tatccaaagc      960

cttaaagatg ctccaagcca aagtgctaaa gttttaggtg aagctcaaaa acttaatgac     1020

tctcaagctc caaaagctga tgcgcaacaa aataacgtga acaaagatca aaaaagcgcc     1080

ttctatgaaa tcttgaacat gcctaactta aacgaagcgc aacgtaacgg cttcattcaa     1140

agtcttaaag acgctccaag ccaaagcact aaagttttag gtgaagctaa aaaattaaac     1200

gaatctcaag caccgaaagc tgataacaat gtgaacaaag aacaaaaaaa tgctttctat     1260

gaaatcttga atatgcctaa cttaaacgaa gaacaacgca atggtttcat ccaaagctta     1320

aaagatgctc caagccaaag tgctaaacta ttgtcagaag ctaaaaagtt aaatgaatct     1380

caagcaccga aagcggataa caaagtgaac aaagaacaaa aaaatgcttt ctatgaaatc     1440

ttacatttac ctaacttaaa cgaagaacaa cgcaatggtt tcatccaaag cctaaaagat     1500

gctccaagcc aaagcgctaa acttttagca gaagctaaaa agctaaatga tgctcaagca     1560

ccaaaagctg acaacaaagt gaacaaagaa caaaaaaatg ctttctatga aattttacat     1620

ttacctaact taactgaaga acaacgtaac ggcttcatcc aaagccttaa agacgctcct     1680

tcagtgagca aaaaaatttt agcagaagct aaaaagctaa acgatgctca agcaccaaaa     1740


<210>  87
<211>  2667
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  87
gatacacctc aaaaagatac tacagctaag acaacatctc atgattcaaa aaaatctaat       60

gacgatgaaa cttctaagga tactacaagt aaagatattg ataaagcaga caacaataat      120

acaagtaacc aagacaataa cgacaaaaaa tttaaaacta tagacgacag cacttcagac      180

tctaacaata tcattgattt tatttataag aatttaccac aaaccaatat aaaccaattg      240

ctaaccaaaa ataaatacga tgataattac tcattaacaa ctttaatcca aaacctattc      300

aatttaaatt cggatatttc tgattacgaa caacctcgta atggcgaaaa gtcaacaaat      360

gattcgaata aaaacagtga caatagcatc aaaaatgaca ctgatacgca atcatctaaa      420

caagataaag cagacaatca aaaagcacct aaatcaaaca atacaaaacc aagtacatct      480

aataagcaac caaattcgcc aaagccaaca caacctaatc aatcaaatag tcaaccagca      540

agtgacgata aagcaaatca aaaatcttca tcgaaagata atcaatcaat gtcagattcg      600

gctttagact ctattttgga tcaatacagt gaagatgcaa agaaaacaca aaaagattat      660

gcatctcaat ctaaaaaaga caaaaatgaa aaatctaata caaagaatcc acagttacca      720

acacaagatg aattgaaaca taaatctaaa cctgctcaat cattcaataa cgatgttaat      780

caaaaggata cacgtgcaac atcattattc gaaacagatc ctagtatatc taacaatgat      840

gatagcggac aatttaacgt tgttgactca aaagatacac gtcaatttgt caaatcaatt      900

gctaaagatg cacatcgcat tggtcaagat aacgatattt atgcgtctgt catgattgcc      960

caagcaatct tagaatctga ctcaggtcgt agtgctttag ctaagtcacc aaaccataat     1020

ttattcggta tcaaaggtgc ttttgaaggg aattctgttc cttttaacac attacaggct     1080

gatggtaata aattgtatag tattaatgct ggattccgaa aatatccaag cacgaaagaa     1140

tcactaaaaa actactctga ccttattaaa aatggtattg atggcaatcg aacaatttat     1200

aaaccaacat ggaaatcgga agccgattct tataaagatg caacatcaca cttatctaaa     1260

acatatgcta cagatccaaa ctatgctaag aaattaaaca gtattattaa acactatcaa     1320

ttaactcagt ttgacgatga acgcatgcca gatttagata aatatgaacg ttctatcaag     1380

gattatgatg attcatcaga tgaattcaaa cctttccgtg aggtatctga tagtatgcca     1440

tatccacatg gtcaaagcac ttggtacgta tataaccgta tgaaacaatt tggtacatct     1500

atctcaggtg atttaggtga tgcacataat tggaataatc gagctcaata ccgtgattat     1560

caagtaagtc atacaccaaa acgtcatgct gctgttgtat ttgaggctgg acaatttggt     1620

gcagatcaac attacggtca tgtagcattt gttgaaaaag ttaacagtga tggttctatc     1680

gttatttcag aatccaatgt taaaggatta ggtatcattt ctcatagaac tatcaatgca     1740

gctgccgctg aagaattatc atatattaca ggtaaaggtt ctggcggagg ggctgcgcaa     1800

gtggatgaag ctcaaaaaaa tgctttttat caagtcttaa atatgcctaa cttaaatgct     1860

gatcaacgca atggttttat ccaaagcctt aaagatgctc caagccaaag tgctaaagtt     1920

ttaggtgaag ctcaaaaact taatgactct caagctccaa aagctgatgc gcaacaaaat     1980

aacgtgaaca aagatcaaaa aagcgccttc tatgaaatct tgaacatgcc taacttaaac     2040

gaagcgcaac gtaacggctt cattcaaagt cttaaagacg ctccaagcca aagcactaaa     2100

gttttaggtg aagctaaaaa attaaacgaa tctcaagcac cgaaagctga taacaatgtg     2160

aacaaagaac aaaaaaatgc tttctatgaa atcttgaata tgcctaactt aaacgaagaa     2220

caacgcaatg gtttcatcca aagcttaaaa gatgctccaa gccaaagtgc taaactattg     2280

tcagaagcta aaaagttaaa tgaatctcaa gcaccgaaag cggataacaa agtgaacaaa     2340

gaacaaaaaa atgctttcta tgaaatctta catttaccta acttaaacga agaacaacgc     2400

aatggtttca tccaaagcct aaaagatgct ccaagccaaa gcgctaaact tttagcagaa     2460

gctaaaaagc taaatgatgc tcaagcacca aaagctgaca acaaagtgaa caaagaacaa     2520

aaaaatgctt tctatgaaat tttacattta cctaacttaa ctgaagaaca acgtaacggc     2580

ttcatccaaa gccttaaaga cgctccttca gtgagcaaaa aaattttagc agaagctaaa     2640

aagctaaacg atgctcaagc accaaaa                                         2667


<210>  88
<211>  2118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  88
atggatattg gtaaaaaaca tgtaattcct aaaagtcagt accgacgtaa gcgtcgtgaa       60

ttcttccaca acgaagacag agaagaaaat ttaaatcaac atcaagataa acaaaatata      120

gataatacaa catcaaaaaa agcagataag caaatacata aagattcaat tgataagcac      180

gaacgtttta aaaatagttt atcatcgcat ttagaacaga gaaaccgtga tgttaatgag      240

aataaagctg aagaaagtaa aagtaatcag gatagtaagt cagcatataa cagagatcat      300

tatttaacag acgatgtatc taaaaaacaa aattcattag attcagtgga ccaagataca      360

gagaaatcaa aatattatga gcaaaattct gaagcgactt tatcaactaa atcaaccgat      420

aaagtagaat caactgaaat gagaaagcta agttcagata aaaacaaagt tggtcatgaa      480

gagcaacatg tactttctaa accttcagaa catgataaag agactagaat tgattctgag      540

tcttcaagaa ctgattcaga cagctcgatg cagacagaga aaataaaaaa agacagttca      600

gatggaaata aaagtagtaa tctgaaatct gaagtaatat cagacaaatc aaatacagta      660

ccaaaattgt cggaatctga tgatgaagta aataatcaga agccattaac tttaccggaa      720

gaacagaaat tgaaaagaca gcaaagtcaa aatgagcaaa caaaaaccta tacatatggt      780

gatagcgaac aaaatgacaa gtctaatcat gaaaatgatt taagtcatca tataccatcg      840

ataagtgatg ataaagataa cgtcatgaga gaaaatcata ttgttgacga taatcctgat      900

aatgatatca atacaccatc attatcaaaa acagatgacg atcgaaaact tgatgaaaaa      960

attcatgttg aagataaaca taaacaaaat gcagactcgt ctgaaacggt gggatatcaa     1020

agtcagtcaa ctgcatctca tcgtagcact gaaaaaagaa atatttctat taatgaccat     1080

gataaattaa acggtcaaaa aacaaataca aagacatcgg caaataataa tcaaaaaaag     1140

gctacatcaa aattgaacaa agggcgcgct acgaataata attatagtga cattttgaaa     1200

aagttttgga tgatgtattg gcctaaaggt tctggcggag gggctgcgca agtggatgaa     1260

gctcaaaaaa atgcttttta tcaagtctta aatatgccta acttaaatgc tgatcaacgc     1320

aatggtttta tccaaagcct taaagatgct ccaagccaaa gtgctaaagt tttaggtgaa     1380

gctcaaaaac ttaatgactc tcaagctcca aaagctgatg cgcaacaaaa taacgtgaac     1440

aaagatcaaa aaagcgcctt ctatgaaatc ttgaacatgc ctaacttaaa cgaagcgcaa     1500

cgtaacggct tcattcaaag tcttaaagac gctccaagcc aaagcactaa agttttaggt     1560

gaagctaaaa aattaaacga atctcaagca ccgaaagctg ataacaatgt gaacaaagaa     1620

caaaaaaatg ctttctatga aatcttgaat atgcctaact taaacgaaga acaacgcaat     1680

ggtttcatcc aaagcttaaa agatgctcca agccaaagtg ctaaactatt gtcagaagct     1740

aaaaagttaa atgaatctca agcaccgaaa gcggataaca aagtgaacaa agaacaaaaa     1800

aatgctttct atgaaatctt acatttacct aacttaaacg aagaacaacg caatggtttc     1860

atccaaagcc taaaagatgc tccaagccaa agcgctaaac ttttagcaga agctaaaaag     1920

ctaaatgatg ctcaagcacc aaaagctgac aacaaagtga acaaagaaca aaaaaatgct     1980

ttctatgaaa ttttacattt acctaactta actgaagaac aacgtaacgg cttcatccaa     2040

agccttaaag acgctccttc agtgagcaaa aaaattttag cagaagctaa aaagctaaac     2100

gatgctcaag caccaaaa                                                   2118


<210>  89
<211>  1740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  89
aatactaata ttgaaaatat tggtgatggt gctgaagtaa tcaaacgtac ggaggatgta       60

agtagtaaga aatggggcgt tactcaaaat gtccaattcg actttgtaaa agataaaaaa      120

tataacaaag acgctttaat tgttaaaatg caaggtttta ttaattccag aacttcattt      180

tcagatgtga agggtagtgg atatgaatta actaaacgaa tgatttggcc attccaatat      240

aatataggac tgacgactaa agatccaaat gttagcttaa tcaattacct tcctaaaaac      300

aaaatagaaa ctactgatgt tggtcaaaca ttaggatata acattggagg taatttccag      360

tcagcaccat ctataggtgg caatggctca tttaattatt ctaaaacaat tagttatacc      420

caaaagagtt atgtcagtga agtagacaag caaaactcaa aatctgttaa atggggtgtt      480

aaagcaaacg aatttgttac gcctgatgga aaaaaatctg cgcatgatag atatttattc      540

gtacaaagtc caaatggtcc aacaggttca gcaagagaat attttgctcc tgataatcaa      600

ttgccacctt tagttcaaag tggctttaat ccatcgttta tcactacact atcacatgaa      660

aaaggttcaa gtgatacgag tgaatttgaa atttcatatg gtagaaactt agatattaca      720

tatgcgactt tattccctag aactggtatt tacgcagaaa gaaagcataa tgcatttgta      780

aatagaaact ttgtagttag atatgaagtt aattggaaaa cacacgaaat taaagtgaaa      840

ggacataatg gttctggcgg aggggctgcg caagtggatg aagctcaaaa aaatgctttt      900

tatcaagtct taaatatgcc taacttaaat gctgatcaac gcaatggttt tatccaaagc      960

cttaaagatg caccagcaaa aagtgctaac gttttaggtg aagctcaaaa acttaatgac     1020

tctcaagctc caaaagctga tgcgcaacaa aataacgtga acaaagatca aaaaagcgcc     1080

ttctatgaaa tcttgaacat gcctaactta aacgaagcgc aacgtaacgg cttcattcaa     1140

agtcttaaag acgcaccagc aaaaagcact aacgttttag gtgaagctaa aaaattaaac     1200

gaatctcaag caccgaaagc tgataacaat gtgaacaaag aacaaaaaaa tgctttctat     1260

gaaatcttga atatgcctaa cttaaacgaa gaacaacgca atggtttcat ccaaagctta     1320

aaagatgcac cagcaaaaag tgctaaccta ttgtcagaag ctaaaaagtt aaatgaatct     1380

caagcaccga aagcggataa caaagtgaac aaagaacaaa aaaatgcttt ctatgaaatc     1440

ttacatttac ctaacttaaa cgaagaacaa cgcaatggtt tcatccaaag cctaaaagat     1500

gcaccagcaa aaagcgctaa ccttttagca gaagctaaaa agctaaatga tgctcaagca     1560

ccaaaagctg acaacaaagt gaacaaagaa caaaaaaatg ctttctatga aattttacat     1620

ttacctaact taactgaaga acaacgtaac ggcttcatcc aaagccttaa agacgcacct     1680

gcaaaaagca aagaaatttt agcagaagct aaaaagctaa acgatgctca agcaccaaaa     1740


