                         SEQUENCE LISTING

<110>  Zhejiang Shimai Pharmaceutical Co, Ltd
 
<120>  ANTIBODIES AGAINST ENPP3 AND USES THEREOF

<130>  C22W1970

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 mAb LCDR1

<400>  1

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 mAb LCDR2

<400>  2

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 mAb LCDR3

<400>  3

Gly Val Trp Asp Ser Ser Leu Arg Ala Glu Leu 
1               5                   10      


<210>  4
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 mAb VL

<400>  4

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Asp Gly Leu Arg 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Glu Tyr Phe Cys Gly Val Trp Asp Ser Ser Leu 
                85                  90                  95      


Arg Ala Glu Leu Phe Ala Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  5
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 mAb Light chain

<400>  5

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Asp Gly Leu Arg 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Glu Tyr Phe Cys Gly Val Trp Asp Ser Ser Leu 
                85                  90                  95      


Arg Ala Glu Leu Phe Ala Gly Gly Thr Lys Val Thr Val Leu Ser Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 mAb HCDR1

<400>  6

Asn Ala Trp Met Ser 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 mAb HCDR2

<400>  7

Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 mAb HCDR3

<400>  8

Leu Ala Gly Pro Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  9
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 mAb VH

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  10
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 mAb Heavy chain

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE CD3 LCDR1

<400>  11

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE CD3 LCDR2

<400>  12

Gly Ala Asn Lys Arg Ala Pro 
1               5           


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE CD3 LCDR3

<400>  13

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  14
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE CD3 VL

<400>  14

Glu Ile Val Val Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Gly Leu Ile Gly Gly Ala Asn Lys Arg Ala Pro Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ser Gly Asp Glu Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn Leu Trp Val Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  15
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE light chain

<400>  15

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Asp Gly Leu Arg 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Glu Tyr Phe Cys Gly Val Trp Asp Ser Ser Leu 
                85                  90                  95      


Arg Ala Glu Leu Phe Ala Gly Gly Thr Lys Val Thr Val Leu Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Val Thr Gln 
        115                 120                 125             


Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser 
    130                 135                 140                 


Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp 
145                 150                 155                 160 


Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Ala 
                165                 170                 175     


Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ser 
            180                 185                 190         


Gly Asp Glu Ala Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly 
    210                 215                 220                 


Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
                245                 250                 255     


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
            260                 265                 270         


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
        275                 280                 285             


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
    290                 295                 300                 


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
305                 310                 315                 320 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
                325                 330                 335     


Gly Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
545                 550                 555                 


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A10 HBiTE CD3 HCDR1

<400>  16

Gly Phe Thr Phe Asn Thr Tyr 
1               5           


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE CD3 HCDR2

<400>  17

Arg Ser Lys Tyr Asn Asn Tyr Ala 
1               5               


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE CD3 HCDR3

<400>  18

His Gly Asn Phe Gly Ser Ser Tyr Val Ser Tyr Phe Ala Tyr 
1               5                   10                  


<210>  19
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE CD3 VH

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asn Phe Gly Ser Ser Tyr Val Ser Tyr Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  20
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE heavy chain

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
            180                 185                 190         


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        195                 200                 205             


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    210                 215                 220                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Gly Asn Phe Gly Ser Ser 
225                 230                 235                 240 


Tyr Val Ser Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
                245                 250                 255     


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
            260                 265                 270         


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
        275                 280                 285             


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
    290                 295                 300                 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
305                 310                 315                 320 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
                325                 330                 335     


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
            340                 345                 350         


Asp Lys Lys Val Glu Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro Glu 
        355                 360                 365             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    370                 375                 380                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
385                 390                 395                 400 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                405                 410                 415     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            420                 425                 430         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        435                 440                 445             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    450                 455                 460                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
465                 470                 475                 480 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                485                 490                 495     


Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            500                 505                 510         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        515                 520                 525             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys 
    530                 535                 540                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
545                 550                 555                 560 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                565                 570                 575     


Ser Leu Ser Pro Gly 
            580     


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE light chain linker

<400>  21

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A10 HBiTE heavy chain linker

<400>  22

Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  23
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
gaatgcggcc gcaaactaca agacagactt gcaaaagaag gcatgcacag ctcagcactg       60

ctctgttg                                                                68


<210>  24
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
tcagcactgc tctgttgcct ggtcctcctg actggggtga gggccgaggt gcagctggtg       60

ga                                                                      62


<210>  25
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
cggtgggcat gtgtgagttt tgtcacaaga tttgggctca actttct                     47


<210>  26
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  26
tcagcactgc tctgttgcct ggtcctcctg actggggtga gggcccagtc tgtcgtgacg       60

cagc                                                                    64


<210>  27
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
cgattctaga atcatgaaca ttctgtaggg gccactgtct tc                          42


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28
gacaaaactc acacatgccc accg                                              24


<210>  29
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
cgattctaga atcatttacc cggggacagg gagaggct                               38


<210>  30
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
gaatgcggcc gcaaactaca agacagactt gcaaaagaag gcatgcacag ctcagcactg       60

ctctgttg                                                                68


<210>  31
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
gccagagcca cctccgccgg atcctaggac ggtcaccttg gtccct                      46


<210>  32
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
ggatccgggg gttcaggcgg aggtggctct gg                                     32


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
ggatccggcg gaggtggctc tggc                                              24


<210>  34
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34
tgatctagaa ttaacccgga gacagggaga ggctct                                 36


